Nicotinic Agonists

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  Subject Areas on Research

  • 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling. 
  • A Pilot Trial Examining African American and White Responses to Algorithm-Guided Smoking Cessation Medication Selection in Persons Living with HIV. 
  • A clinical practice guideline for treating tobacco use and dependence: A US Public Health Service report. The Tobacco Use and Dependence Clinical Practice Guideline Panel, Staff, and Consortium Representatives. 
  • A randomized trial of nicotine replacement therapy in combination with reduced-nicotine cigarettes for smoking cessation. 
  • A randomized, placebo-controlled study investigating the nicotinic α7 agonist, RG3487, for cognitive deficits in schizophrenia. 
  • A study of the potential confounding effects of diet, caffeine, nicotine and lorazepam on the stability of plasma and urinary homovanillic acid levels in patients with schizophrenia. 
  • A unique role for striatal serotonergic systems in the withdrawal from adolescent nicotine administration. 
  • AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats. 
  • Acute effects of nicotine and mecamylamine on tobacco withdrawal symptoms, cigarette reward and ad lib smoking. 
  • Acute nicotine interactions with nicotinic and muscarinic antagonists: working and reference memory effects in the 16-arm radial maze. 
  • Adapting smoking cessation treatment according to initial response to precessation nicotine patch. 
  • Additive and synergistic effects of fetal nicotine and dexamethasone exposure on cholinergic synaptic function in adolescence and adulthood: Implications for the adverse consequences of maternal smoking and pharmacotherapy of preterm delivery. 
  • Administration of nicotine to adolescent rats evokes regionally selective upregulation of CNS alpha 7 nicotinic acetylcholine receptors. 
  • Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase. 
  • Adolescent nicotine exposure causes persistent upregulation of nicotinic cholinergic receptors in rat brain regions. 
  • Adolescent nicotine exposure produces immediate and long-term changes in CNS noradrenergic and dopaminergic function. 
  • Adolescent nicotine: deficits in immune function. 
  • Adolescent vs. adult-onset nicotine self-administration in male rats: duration of effect and differential nicotinic receptor correlates. 
  • Adolescents and adults differ in the immediate and long-term impact of nicotine administration and withdrawal on cardiac norepinephrine. 
  • Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos. 
  • Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells. 
  • An animal model of adolescent nicotine exposure: effects on gene expression and macromolecular constituents in rat brain regions. 
  • Antidepressant effects of nicotine in an animal model of depression. 
  • Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats. 
  • Asthma exacerbation after administration of nicotine nasal spray for smoking cessation. 
  • Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty. 
  • Characterization of the facilitative effects of perinatal choline supplementation on timing and temporal memory. 
  • Cholinergic receptors in heart and brainstem of rats exposed to nicotine during development: implications for hypoxia tolerance and perinatal mortality. 
  • Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. 
  • Chronic nicotine and dizocilpine effects on nicotinic and NMDA glutamatergic receptor regulation: interactions with clozapine actions and attentional performance in rats. 
  • Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding. 
  • Chronic nicotine interactions with clozapine and risperidone and attentional function in rats. 
  • Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain. 
  • Co-expression of nAChRs and molecules of the bitter taste transduction pathway by epithelial cells of intrapulmonary airways. 
  • Cognitive and Behavioral Impairments Evoked by Low-Level Exposure to Tobacco Smoke Components: Comparison with Nicotine Alone. 
  • Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia. 
  • Combination Varenicline/Bupropion Treatment Benefits Highly Dependent Smokers in an Adaptive Smoking Cessation Paradigm. 
  • Combination treatment with varenicline and bupropion in an adaptive smoking cessation paradigm. 
  • Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior. 
  • Denicotinized cigarettes: a new tool to combat cigarette addiction? 
  • Design considerations for a study to evaluate the impact of smoking cessation treatment on stimulant use outcomes in stimulant-dependent individuals. 
  • Development of nicotinic drug therapy for cognitive disorders. 
  • Differential effects of non-nicotine tobacco constituent compounds on nicotine self-administration in rats. 
  • Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine self-administration in female rats. 
  • Dissociating the nicotine and airway sensory effects of smoking. 
  • Do heavy smokers need a higher replacement dose of nicotine to quit? 
  • EEG, physiology, and task-related mood fail to resolve across 31 days of smoking abstinence: relations to depressive traits, nicotine exposure, and dependence. 
  • Effect of R3487/MEM3454, a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats. 
  • Effect of secondhand smoke on occupancy of nicotinic acetylcholine receptors in brain. 
  • Effects of AZD3480, a neuronal nicotinic acetylcholine receptor agonist, and donepezil on dizocilpine-induced attentional impairment in rats. 
  • Effects of chronic nicotine and methylphenidate in adults with attention deficit/hyperactivity disorder. 
  • Effects of nicotinic dimethylaminoethyl esters on working memory performance of rats in the radial-arm maze. 
  • Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys. 
  • Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats. 
  • Effects of tobacco smoke constituents, anabasine and anatabine, on memory and attention in female rats. 
  • Effects of training dose on the relationship between discriminative-stimulus and self-reported drug effects of d-amphetamine in humans. 
  • Effects of varenicline and cognitive bias modification on neural response to smoking-related cues: study protocol for a randomized controlled study. 
  • Excitatory and inhibitory circuitry in the superficial gray layer of the superior colliculus. 
  • Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer's disease. 
  • Gain modulation by nicotine in macaque v1. 
  • Haloperidol reduces smoking of both nicotine-containing and denicotinized cigarettes. 
  • High affinity binding of [3H]epibatidine to rat brain membranes. 
  • IV nicotine self-administration in rats using a consummatory operant licking response: sensitivity to serotonergic, glutaminergic and histaminergic drugs. 
  • Idazoxan blocks the nicotine-induced reversal of the memory impairment caused by the NMDA glutamate receptor antagonist dizocilpine. 
  • Impact of adolescent nicotine exposure on adenylyl cyclase-mediated cell signaling: enzyme induction, neurotransmitter-specific effects, regional selectivities, and the role of withdrawal. 
  • Increased subjective and reinforcing effects of initial nicotine exposure in young adults with attention deficit hyperactivity disorder (ADHD) compared to matched peers: results from an experimental model of first-time tobacco use. 
  • Induction of tyrosine hydroxylase in the locus coeruleus of transgenic mice in response to stress or nicotine treatment: lack of activation of tyrosine hydroxylase promoter activity. 
  • Interaction of nicotinic and histamine H(3) systems in the radial-arm maze repeated acquisition task. 
  • Ketanserin attenuates nicotine-induced working memory improvement in rats. 
  • Ketanserin, a 5-HT2 receptor antagonist, decreases nicotine self-administration in rats. 
  • Lasting effects of nicotine treatment and withdrawal on serotonergic systems and cell signaling in rat brain regions: separate or sequential exposure during fetal development and adulthood. 
  • Lorcaserin for Smoking Cessation and Associated Weight Gain: A Randomized 12-Week Clinical Trial. 
  • Lorcaserin, a 5-HT2C agonist, decreases nicotine self-administration in female rats. 
  • Loss of neonatal hypoxia tolerance after prenatal nicotine exposure: implications for sudden infant death syndrome. 
  • Mecamylamine acutely increases human intravenous nicotine self-administration. 
  • Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism. 
  • Metallothionein expression and neurocognitive function in mice. 
  • Mimicking maternal smoking and pharmacotherapy of preterm labor: fetal nicotine exposure enhances the effect of late gestational dexamethasone treatment on noradrenergic circuits. 
  • Mode of action: disruption of brain cell replication, second messenger, and neurotransmitter systems during development leading to cognitive dysfunction--developmental neurotoxicity of nicotine. 
  • Molecular genetics of successful smoking cessation: convergent genome-wide association study results. 
  • Neonatal 6-hydroxydopamine lesions of the frontal cortex in rats: persisting effects on locomotor activity, learning and nicotine self-administration. 
  • Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats. 
  • Neuroanatomical circuitry mediating the sensory impact of nicotine in the central nervous system. 
  • Neurobehavioral impairments caused by developmental imidacloprid exposure in zebrafish. 
  • Nicotine administration in adolescence reprograms the subsequent response to nicotine treatment and withdrawal in adulthood: sex-selective effects on cerebrocortical serotonergic function. 
  • Nicotine and clozapine actions on pre-pulse inhibition deficits caused by N-methyl-D-aspartate (NMDA) glutamatergic receptor blockade. 
  • Nicotine and clozapine effects on attentional performance impaired by the NMDA antagonist dizocilpine in female rats. 
  • Nicotine and non-nicotine smoking factors differentially modulate craving, withdrawal and cerebral blood flow as measured with arterial spin labeling. 
  • Nicotine effects on learning in zebrafish: the role of dopaminergic systems. 
  • Nicotine enhances stimulus detection performance of middle- and old-aged rats: a longitudinal study. 
  • Nicotine exposure in adolescence alters the response of serotonin systems to nicotine administered subsequently in adulthood. 
  • Nicotine for postoperative analgesia: a systematic review and meta-analysis. 
  • Nicotine increases anterior insula activation to expected and unexpected outcomes among nonsmokers. 
  • Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution. 
  • Nicotine increases size and severity of experimental choroidal neovascularization. 
  • Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors. 
  • Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos. 
  • Nicotine preloading: the importance of a pre-cessation reduction in smoking behavior. 
  • Nicotine replacement and behavioral therapy for smoking cessation in pregnancy. 
  • Nicotine therapy in adulthood reverses the synaptic and behavioral deficits elicited by prenatal exposure to phenobarbital. 
  • Nicotine treatment of mild cognitive impairment: a 6-month double-blind pilot clinical trial. 
  • Nicotine-alcohol interactions and cognitive function in rats. 
  • Nicotine-dizocilpine interactions and working and reference memory performance of rats in the radial-arm maze. 
  • Nicotine-haloperidol interactions and cognitive performance in schizophrenics. 
  • Nicotine-mecamylamine treatment for smoking cessation: the role of pre-cessation therapy. 
  • Nicotinic acetylcholine involvement in cognitive function in animals. 
  • Nicotinic acetylcholine receptor stimulation impairs epidermal permeability barrier function and recovery and modulates cornified envelope proteins. 
  • Nicotinic alpha7- or beta2-containing receptor knockout: effects on radial-arm maze learning and long-term nicotine consumption in mice. 
  • Nicotinic antagonist effects in the mediodorsal thalamic nucleus: regional heterogeneity of nicotinic receptor involvement in cognitive function. 
  • Nicotinic attention-deficit/hyperactivity disorder treatment. 
  • Nicotinic involvement in memory function in zebrafish. 
  • Nicotinic receptor subtypes and cognitive function. 
  • Nicotinic receptors in the habenula: importance for memory. 
  • Nicotinic system involvement in Alzheimer's and Parkinson's diseases. Implications for therapeutics. 
  • Nicotinic treatment for cognitive dysfunction. 
  • Nicotinic treatment for degenerative neuropsychiatric disorders such as Alzheimer's disease and Parkinson's disease. 
  • Nicotinic, muscarinic and dopaminergic actions in the ventral hippocampus and the nucleus accumbens: effects on spatial working memory in rats. 
  • Nicotinic-glutamatergic interactions and attentional performance on an operant visual signal detection task in female rats. 
  • Novel insights for systemic inflammation in sepsis and hemorrhage. 
  • Olanzapine interactions with nicotine and mecamylamine in rats: effects on memory function. 
  • Oral sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, reduces nicotine self-administration in rats. 
  • Outcomes from an outpatient smoking-cessation clinic. 
  • Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of age. 
  • Pharmacologic and sensorimotor components of satiation in cigarette smoking. 
  • Phase 2 Trial of an Alpha-7 Nicotinic Receptor Agonist (TC-5619) in Negative and Cognitive Symptoms of Schizophrenia. 
  • Pre-cessation varenicline treatment vs post-cessation NRT: an uneven playing field. 
  • Prenatal nicotine alters the developmental neurotoxicity of postnatal chlorpyrifos directed toward cholinergic systems: better, worse, or just "different?". 
  • Prenatal nicotine effects on memory in rats: pharmacological and behavioral challenges. 
  • Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal. 
  • Prenatal nicotine exposure alters the responses to subsequent nicotine administration and withdrawal in adolescence: Serotonin receptors and cell signaling. 
  • Prenatal nicotine exposure evokes alterations of cell structure in hippocampus and somatosensory cortex. 
  • Public health clinical demonstration project for smoking cessation in american veterans who served since september 11, 2001. 
  • Randomized trial comparing mindfulness training for smokers to a matched control. 
  • Randomized, Double-Blind, Placebo-Controlled Study of Encenicline, an α7 Nicotinic Acetylcholine Receptor Agonist, as a Treatment for Cognitive Impairment in Schizophrenia. 
  • Rapid assessment of cardiovascular risk among users of smoking cessation drugs within the US Food and Drug Administration's Mini-Sentinel program. 
  • Reduction of nicotine self-administration by chronic nicotine infusion with H1 histamine blockade in female rats. 
  • Regional brain activity correlates of nicotine dependence. 
  • Resolving postoperative neuroinflammation and cognitive decline. 
  • Response to Gorelick. 
  • Reversal of clozapine effects on working memory in rats with fimbria-fornix lesions. 
  • Role of insular cortex D₁ and D₂ dopamine receptors in nicotine self-administration in rats. 
  • Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats. 
  • Scientific and clinical challenges in sepsis. 
  • Silver acetate interactions with nicotine and non-nicotine smoke components. 
  • Smoking and ischemic stroke: a role for nicotine? 
  • Teratogenic, bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine. 
  • The Effects of Nicotine and Tobacco Use on Brain Reward Function: Interaction With Nicotine Dependence Severity. 
  • The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation. 
  • The anti-inflammatory potential of selective cholinergic agonists. 
  • The effect of nicotine and trauma context on acoustic startle in smokers with and without posttraumatic stress disorder. 
  • The importance of nicotinic acetylcholine receptors in schizophrenia, bipolar disorder and Tourette's syndrome. 
  • The neuronal strategy for inflammation. 
  • The role of alpha7 and alpha4beta2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish. 
  • The vagus nerve and the nicotinic anti-inflammatory pathway. 
  • Transdermal nicotine attenuates depression symptoms in nonsmokers: a double-blind, placebo-controlled trial. 
  • Transdermal nicotine for analgesia after radical retropubic prostatectomy. 
  • Validation of an extracerebral reference region approach for the quantification of brain nicotinic acetylcholine receptors in squirrel monkeys with PET and 2-18F-fluoro-A-85380. 
  • Varenicline effects on craving, cue reactivity, and smoking reward. 
  • Varenicline-induced drug eruption with resulting palmar/plantar hyperhidrosis and dysesthesia. 
  • Ventral hippocampal alpha 7 nicotinic receptor blockade and chronic nicotine effects on memory performance in the radial-arm maze. 
  • Ventral hippocampal alpha4beta2 nicotinic receptors and chronic nicotine effects on memory. 
  • Ventral hippocampal alpha7 and alpha4beta2 nicotinic receptor blockade and clozapine effects on memory in female rats. 
  • Ventral hippocampal ibotenic acid lesions block chronic nicotine-induced spatial working memory improvement in rats. 
  • Zebrafish assessment of cognitive improvement and anxiolysis: filling the gap between in vitro and rodent models for drug development. 
  • Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits. 
  • beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. 
  • α4β2 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats. 
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  Keywords of People

  • Acheson, Shawn K., Adjunct Assistant Professor in the Department of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences