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Subject Areas on Research
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2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling.
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A Pilot Trial Examining African American and White Responses to Algorithm-Guided Smoking Cessation Medication Selection in Persons Living with HIV.
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A clinical practice guideline for treating tobacco use and dependence: A US Public Health Service report. The Tobacco Use and Dependence Clinical Practice Guideline Panel, Staff, and Consortium Representatives.
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A randomized trial of nicotine replacement therapy in combination with reduced-nicotine cigarettes for smoking cessation.
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A randomized, placebo-controlled study investigating the nicotinic α7 agonist, RG3487, for cognitive deficits in schizophrenia.
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A study of the potential confounding effects of diet, caffeine, nicotine and lorazepam on the stability of plasma and urinary homovanillic acid levels in patients with schizophrenia.
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A unique role for striatal serotonergic systems in the withdrawal from adolescent nicotine administration.
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AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats.
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Acute effects of nicotine and mecamylamine on tobacco withdrawal symptoms, cigarette reward and ad lib smoking.
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Acute effects of the selective cholinergic channel activator (nicotinic agonist) ABT-418 in Alzheimer's disease.
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Acute nicotine interactions with nicotinic and muscarinic antagonists: working and reference memory effects in the 16-arm radial maze.
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Adapting smoking cessation treatment according to initial response to precessation nicotine patch.
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Additive and synergistic effects of fetal nicotine and dexamethasone exposure on cholinergic synaptic function in adolescence and adulthood: Implications for the adverse consequences of maternal smoking and pharmacotherapy of preterm delivery.
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Administration of nicotine to adolescent rats evokes regionally selective upregulation of CNS alpha 7 nicotinic acetylcholine receptors.
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Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase.
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Adolescent nicotine exposure causes persistent upregulation of nicotinic cholinergic receptors in rat brain regions.
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Adolescent nicotine exposure produces immediate and long-term changes in CNS noradrenergic and dopaminergic function.
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Adolescent nicotine: deficits in immune function.
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Adolescent vs. adult-onset nicotine self-administration in male rats: duration of effect and differential nicotinic receptor correlates.
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Adolescents and adults differ in the immediate and long-term impact of nicotine administration and withdrawal on cardiac norepinephrine.
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Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos.
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Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells.
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An animal model of adolescent nicotine exposure: effects on gene expression and macromolecular constituents in rat brain regions.
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Antidepressant effects of nicotine in an animal model of depression.
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Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats.
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Asthma exacerbation after administration of nicotine nasal spray for smoking cessation.
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Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty.
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CT Findings and Patterns of e-Cigarette or Vaping Product Use-Associated Lung Injury: A Multicenter Cohort of 160 Cases.
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Characterization of the facilitative effects of perinatal choline supplementation on timing and temporal memory.
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Cholinergic receptors in heart and brainstem of rats exposed to nicotine during development: implications for hypoxia tolerance and perinatal mortality.
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Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates.
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Chronic nicotine and dizocilpine effects on nicotinic and NMDA glutamatergic receptor regulation: interactions with clozapine actions and attentional performance in rats.
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Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding.
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Chronic nicotine interactions with clozapine and risperidone and attentional function in rats.
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Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain.
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Co-expression of nAChRs and molecules of the bitter taste transduction pathway by epithelial cells of intrapulmonary airways.
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Cognitive and Behavioral Impairments Evoked by Low-Level Exposure to Tobacco Smoke Components: Comparison with Nicotine Alone.
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Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia.
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Combination Varenicline/Bupropion Treatment Benefits Highly Dependent Smokers in an Adaptive Smoking Cessation Paradigm.
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Combination treatment with varenicline and bupropion in an adaptive smoking cessation paradigm.
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Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior.
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Denicotinized cigarettes: a new tool to combat cigarette addiction?
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Design considerations for a study to evaluate the impact of smoking cessation treatment on stimulant use outcomes in stimulant-dependent individuals.
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Development of nicotinic drug therapy for cognitive disorders.
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Differential effects of non-nicotine tobacco constituent compounds on nicotine self-administration in rats.
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Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine self-administration in female rats.
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Dissociating the nicotine and airway sensory effects of smoking.
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Do heavy smokers need a higher replacement dose of nicotine to quit?
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EEG, physiology, and task-related mood fail to resolve across 31 days of smoking abstinence: relations to depressive traits, nicotine exposure, and dependence.
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Effect of R3487/MEM3454, a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats.
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Effect of secondhand smoke on occupancy of nicotinic acetylcholine receptors in brain.
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Effects of AZD3480, a neuronal nicotinic acetylcholine receptor agonist, and donepezil on dizocilpine-induced attentional impairment in rats.
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Effects of chronic nicotine and methylphenidate in adults with attention deficit/hyperactivity disorder.
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Effects of nicotinic dimethylaminoethyl esters on working memory performance of rats in the radial-arm maze.
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Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys.
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Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats.
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Effects of tobacco smoke constituents, anabasine and anatabine, on memory and attention in female rats.
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Effects of training dose on the relationship between discriminative-stimulus and self-reported drug effects of d-amphetamine in humans.
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Effects of varenicline and cognitive bias modification on neural response to smoking-related cues: study protocol for a randomized controlled study.
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Engineered site-directed labeling of nicotinic acetylcholine receptors using reactive epibatidine derivatives: appraisal of epibatidine-docking models in neuronal and muscular receptors.
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Excitatory and inhibitory circuitry in the superficial gray layer of the superior colliculus.
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Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer's disease.
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Gain modulation by nicotine in macaque v1.
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Haloperidol reduces smoking of both nicotine-containing and denicotinized cigarettes.
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High affinity binding of [3H]epibatidine to rat brain membranes.
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IV nicotine self-administration in rats using a consummatory operant licking response: sensitivity to serotonergic, glutaminergic and histaminergic drugs.
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Idazoxan blocks the nicotine-induced reversal of the memory impairment caused by the NMDA glutamate receptor antagonist dizocilpine.
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Impact of adolescent nicotine exposure on adenylyl cyclase-mediated cell signaling: enzyme induction, neurotransmitter-specific effects, regional selectivities, and the role of withdrawal.
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Increased subjective and reinforcing effects of initial nicotine exposure in young adults with attention deficit hyperactivity disorder (ADHD) compared to matched peers: results from an experimental model of first-time tobacco use.
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Induction of tyrosine hydroxylase in the locus coeruleus of transgenic mice in response to stress or nicotine treatment: lack of activation of tyrosine hydroxylase promoter activity.
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Interaction of nicotinic and histamine H(3) systems in the radial-arm maze repeated acquisition task.
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Ketanserin attenuates nicotine-induced working memory improvement in rats.
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Ketanserin, a 5-HT2 receptor antagonist, decreases nicotine self-administration in rats.
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Lasting effects of nicotine treatment and withdrawal on serotonergic systems and cell signaling in rat brain regions: separate or sequential exposure during fetal development and adulthood.
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Lorcaserin for Smoking Cessation and Associated Weight Gain: A Randomized 12-Week Clinical Trial.
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Lorcaserin, a 5-HT2C agonist, decreases nicotine self-administration in female rats.
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Loss of neonatal hypoxia tolerance after prenatal nicotine exposure: implications for sudden infant death syndrome.
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Mecamylamine acutely increases human intravenous nicotine self-administration.
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Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism.
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Metallothionein expression and neurocognitive function in mice.
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Mimicking maternal smoking and pharmacotherapy of preterm labor: fetal nicotine exposure enhances the effect of late gestational dexamethasone treatment on noradrenergic circuits.
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Mode of action: disruption of brain cell replication, second messenger, and neurotransmitter systems during development leading to cognitive dysfunction--developmental neurotoxicity of nicotine.
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Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
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Neonatal 6-hydroxydopamine lesions of the frontal cortex in rats: persisting effects on locomotor activity, learning and nicotine self-administration.
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Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats.
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Neuroanatomical circuitry mediating the sensory impact of nicotine in the central nervous system.
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Neurobehavioral impairments caused by developmental imidacloprid exposure in zebrafish.
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Nicotine administration in adolescence reprograms the subsequent response to nicotine treatment and withdrawal in adulthood: sex-selective effects on cerebrocortical serotonergic function.
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Nicotine and clozapine actions on pre-pulse inhibition deficits caused by N-methyl-D-aspartate (NMDA) glutamatergic receptor blockade.
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Nicotine and clozapine effects on attentional performance impaired by the NMDA antagonist dizocilpine in female rats.
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Nicotine and non-nicotine smoking factors differentially modulate craving, withdrawal and cerebral blood flow as measured with arterial spin labeling.
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Nicotine effects on learning in zebrafish: the role of dopaminergic systems.
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Nicotine enhances stimulus detection performance of middle- and old-aged rats: a longitudinal study.
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Nicotine exposure in adolescence alters the response of serotonin systems to nicotine administered subsequently in adulthood.
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Nicotine for postoperative analgesia: a systematic review and meta-analysis.
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Nicotine increases anterior insula activation to expected and unexpected outcomes among nonsmokers.
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Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution.
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Nicotine increases size and severity of experimental choroidal neovascularization.
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Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors.
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Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos.
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Nicotine preloading: the importance of a pre-cessation reduction in smoking behavior.
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Nicotine replacement and behavioral therapy for smoking cessation in pregnancy.
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Nicotine therapy in adulthood reverses the synaptic and behavioral deficits elicited by prenatal exposure to phenobarbital.
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Nicotine treatment of mild cognitive impairment: a 6-month double-blind pilot clinical trial.
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Nicotine-alcohol interactions and cognitive function in rats.
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Nicotine-dizocilpine interactions and working and reference memory performance of rats in the radial-arm maze.
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Nicotine-haloperidol interactions and cognitive performance in schizophrenics.
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Nicotine-mecamylamine treatment for smoking cessation: the role of pre-cessation therapy.
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Nicotinic acetylcholine involvement in cognitive function in animals.
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Nicotinic acetylcholine receptor stimulation impairs epidermal permeability barrier function and recovery and modulates cornified envelope proteins.
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Nicotinic alpha7- or beta2-containing receptor knockout: effects on radial-arm maze learning and long-term nicotine consumption in mice.
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Nicotinic antagonist effects in the mediodorsal thalamic nucleus: regional heterogeneity of nicotinic receptor involvement in cognitive function.
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Nicotinic attention-deficit/hyperactivity disorder treatment.
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Nicotinic involvement in memory function in zebrafish.
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Nicotinic receptor subtypes and cognitive function.
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Nicotinic receptors in the habenula: importance for memory.
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Nicotinic stimulation of splenic T cells is protective in endoscopic retrograde cholangiopancreatography-induced acute pancreatitis in mice.
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Nicotinic system involvement in Alzheimer's and Parkinson's diseases. Implications for therapeutics.
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Nicotinic treatment for cognitive dysfunction.
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Nicotinic treatment for degenerative neuropsychiatric disorders such as Alzheimer's disease and Parkinson's disease.
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Nicotinic, muscarinic and dopaminergic actions in the ventral hippocampus and the nucleus accumbens: effects on spatial working memory in rats.
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Nicotinic-glutamatergic interactions and attentional performance on an operant visual signal detection task in female rats.
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Novel insights for systemic inflammation in sepsis and hemorrhage.
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Olanzapine interactions with nicotine and mecamylamine in rats: effects on memory function.
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Oral sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, reduces nicotine self-administration in rats.
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Outcomes from an outpatient smoking-cessation clinic.
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Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of age.
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Pharmacologic and sensorimotor components of satiation in cigarette smoking.
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Phase 2 Trial of an Alpha-7 Nicotinic Receptor Agonist (TC-5619) in Negative and Cognitive Symptoms of Schizophrenia.
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Pre-cessation varenicline treatment vs post-cessation NRT: an uneven playing field.
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Prenatal nicotine alters the developmental neurotoxicity of postnatal chlorpyrifos directed toward cholinergic systems: better, worse, or just "different?".
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Prenatal nicotine effects on memory in rats: pharmacological and behavioral challenges.
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Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal.
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Prenatal nicotine exposure alters the responses to subsequent nicotine administration and withdrawal in adolescence: Serotonin receptors and cell signaling.
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Prenatal nicotine exposure evokes alterations of cell structure in hippocampus and somatosensory cortex.
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Public health clinical demonstration project for smoking cessation in american veterans who served since september 11, 2001.
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Randomized trial comparing mindfulness training for smokers to a matched control.
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Randomized, Double-Blind, Placebo-Controlled Study of Encenicline, an α7 Nicotinic Acetylcholine Receptor Agonist, as a Treatment for Cognitive Impairment in Schizophrenia.
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Rapid assessment of cardiovascular risk among users of smoking cessation drugs within the US Food and Drug Administration's Mini-Sentinel program.
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Reduction of nicotine self-administration by chronic nicotine infusion with H1 histamine blockade in female rats.
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Regional brain activity correlates of nicotine dependence.
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Resolving postoperative neuroinflammation and cognitive decline.
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Response to Gorelick.
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Reversal of clozapine effects on working memory in rats with fimbria-fornix lesions.
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Role of insular cortex D₁ and D₂ dopamine receptors in nicotine self-administration in rats.
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Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats.
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Scientific and clinical challenges in sepsis.
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Silver acetate interactions with nicotine and non-nicotine smoke components.
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Smoking and ischemic stroke: a role for nicotine?
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Teratogenic, bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine.
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The Effects of Nicotine and Tobacco Use on Brain Reward Function: Interaction With Nicotine Dependence Severity.
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The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation.
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The anti-inflammatory potential of selective cholinergic agonists.
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The effect of nicotine and trauma context on acoustic startle in smokers with and without posttraumatic stress disorder.
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The importance of nicotinic acetylcholine receptors in schizophrenia, bipolar disorder and Tourette's syndrome.
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The neuronal strategy for inflammation.
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The role of alpha7 and alpha4beta2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish.
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The vagus nerve and the nicotinic anti-inflammatory pathway.
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Transdermal nicotine attenuates depression symptoms in nonsmokers: a double-blind, placebo-controlled trial.
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Transdermal nicotine for analgesia after radical retropubic prostatectomy.
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Validation of an extracerebral reference region approach for the quantification of brain nicotinic acetylcholine receptors in squirrel monkeys with PET and 2-18F-fluoro-A-85380.
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Varenicline effects on craving, cue reactivity, and smoking reward.
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Varenicline-induced drug eruption with resulting palmar/plantar hyperhidrosis and dysesthesia.
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Ventral hippocampal alpha 7 nicotinic receptor blockade and chronic nicotine effects on memory performance in the radial-arm maze.
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Ventral hippocampal alpha4beta2 nicotinic receptors and chronic nicotine effects on memory.
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Ventral hippocampal alpha7 and alpha4beta2 nicotinic receptor blockade and clozapine effects on memory in female rats.
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Ventral hippocampal ibotenic acid lesions block chronic nicotine-induced spatial working memory improvement in rats.
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Zebrafish assessment of cognitive improvement and anxiolysis: filling the gap between in vitro and rodent models for drug development.
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Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits.
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beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.
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α4β2 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats.