DNA Adducts
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Subject Areas on Research
- 5-Azacytidine induced methyltransferase-DNA adducts block DNA replication in vivo.
- Adenomas induced by polycyclic aromatic hydrocarbons in strain A/J mouse lung correlate with time-integrated DNA adduct levels.
- An ERCC4 regulatory variant predicts grade-3 or -4 toxicities in patients with advanced non-small cell lung cancer treated by platinum-based therapy.
- An analysis of DNA repair as a determinant of survival in patients with non-small-cell lung cancer.
- Antibody-based nanoprobe for measurement of a fluorescent analyte in a single cell.
- Apoptosis and P53 induction in human lung fibroblasts exposed to chromium (VI): effect of ascorbate and tocopherol.
- Arrest of replication by mammalian DNA polymerases alpha and beta caused by chromium-DNA lesions.
- Association between plasma BPDE-Alb adduct concentrations and DNA damage of peripheral blood lymphocytes among coke oven workers.
- Comparative in vitro and in vivo benzo[a]pyrene-DNA adduct formation and its relationship to CYP1A activity in two species of ictalurid catfish.
- Comparative metabolism and excretion of benzo(a)pyrene in 2 species of ictalurid catfish.
- Correlation between base-excision repair gene polymorphisms and levels of in-vitro BPDE-induced DNA adducts in cultured peripheral blood lymphocytes.
- Critical role of chromium (Cr)-DNA interactions in the formation of Cr-induced polymerase arresting lesions.
- DNA adducts in human pancreatic tissues and their potential role in carcinogenesis.
- DNA adducts of decarbamoyl mitomycin C efficiently kill cells without wild-type p53 resulting from proteasome-mediated degradation of checkpoint protein 1.
- DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer.
- DNA repair phenotype and cancer susceptibility--a mini review.
- Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis.
- Detection of 2-amino-1-methyl-6-phenylimidazo [4,5-b]-pyridine (PhIP)-DNA adducts in human pancreatic tissues.
- Detection of acrolein-derived cyclic DNA adducts in human cells by monoclonal antibodies.
- Differential impact of ionic and coordinate covalent chromium (Cr)-DNA binding on DNA replication.
- Differential sensitivity of chromium-mediated DNA interstrand crosslinks and DNA-protein crosslinks to disruption by alkali and EDTA.
- Diphenhydramine increases the therapeutic window for platinum drugs by simultaneously sensitizing tumor cells and protecting normal cells.
- Early wound healing exhibits cytokine surge without evidence of hypoxia.
- Effect of DNA conformation on cisplatin adduct formation.
- Effects of dietary N-(4-hydroxyphenyl)retinamide on N-nitrosomethylbenzylamine metabolism and esophageal tumorigenesis in the Fischer 344 rat.
- Effects of glutathione on chromium-induced DNA crosslinking and DNA polymerase arrest.
- Etiology of the mutational spectrum of ras genes in human carcinomas.
- Fanconi anemia complementation group A cells are hypersensitive to chromium(VI)-induced toxicity.
- Following an environmental carcinogen N2-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase.
- Formaldehyde and leukemia: epidemiology, potential mechanisms, and implications for risk assessment.
- Frameshifts and deletions during in vitro translesion synthesis past Pt-DNA adducts by DNA polymerases beta and eta.
- Genotoxicity in Atlantic killifish (Fundulus heteroclitus) from a PAH-contaminated Superfund site on the Elizabeth River, Virginia.
- Genotypes and haplotypes of ERCC1 and ERCC2/XPD genes predict levels of benzo[a]pyrene diol epoxide-induced DNA adducts in cultured primary lymphocytes from healthy individuals: a genotype-phenotype correlation analysis.
- Human mitochondrial DNA polymerase gamma exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers
- Hypoxia impedes the formation of chromium DNA-adducts in a cell-free system.
- In vitro BPDE-induced DNA adducts in peripheral lymphocytes as a risk factor for squamous cell carcinoma of the head and neck.
- In vitro benzo[a]pyrene diol epoxide-induced DNA adducts and risk of squamous cell carcinoma of head and neck.
- In vitro induction of benzo(a)pyrene diol epoxide-DNA adducts in peripheral lymphocytes as a susceptibility marker for human lung cancer.
- In vivo and in vitro inhibition of CYP1A-dependent activity in Fundulus heteroclitus by the polynuclear aromatic hydrocarbon fluoranthene.
- Incision of trivalent chromium [Cr(III)]-induced DNA damage by Bacillus caldotenax UvrABC endonuclease.
- Induction of apoptotic cell death by particulate lead chromate: differential effects of vitamins C and E on genotoxicity and survival.
- Induction of hepatic CYP1A in channel catfish increases binding of 2-aminoanthracene to DNA in vitro and in vivo.
- Internalization of carcinogenic lead chromate particles by cultured normal human lung epithelial cells: formation of intracellular lead-inclusion bodies and induction of apoptosis.
- Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer.
- Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells.
- Mutagenesis by exocyclic alkylamino purine adducts in Escherichia coli.
- Mutation spectrum of 2-chloroethyl methanesulfonate in Drosophila melanogaster premeiotic germ cells.
- Nucleotide excision repair functions in the removal of chromium-induced DNA damage in mammalian cells.
- Observing translesion synthesis of an aromatic amine DNA adduct by a high-fidelity DNA polymerase.
- Psoralen Derivatives with Enhanced Potency.
- Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems.
- Reduced DNA repair capacity for removing tobacco carcinogen-induced DNA adducts contributes to risk of head and neck cancer but not tumor characteristics.
- Reduced DNA repair of benzo[a]pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients.
- Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study.
- Replication of N2-ethyldeoxyguanosine DNA adducts in the human embryonic kidney cell line 293.
- Sensitive quantitation of chromium-DNA adducts by inductively coupled plasma mass spectrometry with a direct injection high-efficiency nebulizer.
- Sensitivity to DNA damage induced by benzo(a)pyrene diol epoxide and risk of lung cancer: a case-control analysis.
- Smoking, DNA repair capacity and risk of nonsmall cell lung cancer.
- Structure of a high fidelity DNA polymerase bound to a benzo[a]pyrene adduct that blocks replication.
- Targeting N-cadherin enhances antitumor activity of cytotoxic therapies in melanoma treatment.
- The N2-ethylguanine and the O6-ethyl- and O6-methylguanine lesions in DNA: contrasting responses from the "bypass" DNA polymerase eta and the replicative DNA polymerase alpha.
- Transport properties of pancreatic cancer describe gemcitabine delivery and response.
- Tumor multiplicity, DNA adducts and K-ras mutation pattern of 5-methylchrysene in strain A/J mouse lung.
- Vehicular Traffic-Related Polycyclic Aromatic Hydrocarbon Exposure and Breast Cancer Incidence: The Long Island Breast Cancer Study Project (LIBCSP).