GABA Antagonists

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  Subject Areas on Research

  • A circuit model for saccadic suppression in the superior colliculus. 
  • A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors. 
  • Amyloid precursor protein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural cells. 
  • An in vitro study of horizontal connections in the intermediate layer of the superior colliculus. 
  • Atypical neuroleptic malignant syndrome caused by clozapine and venlafaxine: early brief treatment with dantrolene. 
  • Changes in intracellular chloride after oxygen-glucose deprivation of the adult hippocampal slice: effect of diazepam. 
  • Characterization of the antiabsence effects of SCH 50911, a GABA-B receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate, and pentylenetetrazole models. 
  • Clozapine-, but not haloperidol-, induced increases in deltaFosB-like immunoreactivity are completely blocked in the striatum of mice lacking D3 dopamine receptors. 
  • Development of intrinsic and synaptic properties in a forebrain nucleus essential to avian song learning. 
  • Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih. 
  • Differential actions of diazepam and zolpidem in basolateral and central amygdala nuclei. 
  • Disinhibition in rat superior colliculus mediated by GABAc receptors. 
  • Distribution of GABAA receptors in the limbic system of alcohol-preferring and non-preferring rats: in situ hybridisation histochemistry and receptor autoradiography. 
  • Effect of helium and heliox on glutamate decarboxylase activity. 
  • Excitatory and inhibitory circuitry in the superficial gray layer of the superior colliculus. 
  • Facilitation of granule cell epileptiform activity by mossy fiber-released zinc in the pilocarpine model of temporal lobe epilepsy. 
  • Fast endocytosis is inhibited by GABA-mediated chloride influx at a presynaptic terminal. 
  • High-frequency organization and synchrony of activity in the purkinje cell layer of the cerebellum. 
  • High-threshold Ca2+ currents in rat hippocampal interneurones and their selective inhibition by activation of GABA(B) receptors. 
  • Hippocampal long-term potentiation and spatial learning in the rat: effects of GABAB receptor blockade. 
  • Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells. 
  • Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity. 
  • Imaging of 4-AP-induced, GABA(A)-dependent spontaneous synchronized activity mediated by the hippocampal interneuron network. 
  • Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon. 
  • Impaired firing and sodium channel function in CA1 hippocampal interneurons after transient cerebral ischemia. 
  • Increased GABAergic function in mouse models of Huntington's disease: reversal by BDNF. 
  • Inhibition of GABA-gated chloride channels in brain by the arachidonic acid metabolite, thromboxane A2. 
  • Magnitude and ethanol sensitivity of tonic GABAA receptor-mediated inhibition in dentate gyrus changes from adolescence to adulthood. 
  • Modest increase in extracellular potassium unmasks effect of recurrent mossy fiber growth. 
  • NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity. 
  • Neural network of structures in which GABAB receptors regulate absence seizures in the lethargic (lh/lh) mouse model. 
  • Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors. 
  • Optical imaging of visual cortex epileptic foci and propagation pathways. 
  • Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress. 
  • Penicillin effects on iontophoretic responses in Aplysia californica. 
  • Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs. 
  • Properties of the pathways from the lateral amygdal nucleus to basolateral nucleus and amygdalostriatal transition area. 
  • Recurrent mossy fiber pathway in rat dentate gyrus: synaptic currents evoked in presence and absence of seizure-induced growth. 
  • Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn. 
  • Respiratory and telencephalic modulation of vocal motor neurons in the zebra finch. 
  • Role of NMDA, non-NMDA, and GABA receptors in signal propagation in the amygdala formation. 
  • Selective gamma-aminobutyric acid type A receptor antagonism reverses isoflurane ischemic neuroprotection. 
  • Short-term frequency-dependent plasticity at recurrent mossy fiber synapses of the epileptic brain. 
  • Strong single-fiber sensory inputs to olfactory cortex: implications for olfactory coding. 
  • Synaptic connections from multiple subfields contribute to granule cell hyperexcitability in hippocampal slice cultures. 
  • Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses. 
  • The role of GABAB mechanisms in animal models of absence seizures. 
  • gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. 
  • gamma-Aminobutyric acid-A receptors contribute to isoflurane neuroprotection in organotypic hippocampal cultures. 
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  Keywords of People

  • Schwartz-Bloom, Rochelle D., Professor Emeritus of Pharmacology & Cancer Biology, Duke Science & Society
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology