Interleukin-13

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  Subject Areas on Research

  • 2-O, 3-O-desulfated heparin inhibits neutrophil elastase-induced HMGB-1 secretion and airway inflammation. 
  • Aberrant production of IL-13 by T cells promotes exocrinopathy in Id3 knockout mice. 
  • Ablation of the leptin receptor in myeloid cells impairs pulmonary clearance of Streptococcus pneumoniae and alveolar macrophage bactericidal function. 
  • Airway fibroblasts in asthma manifest an invasive phenotype. 
  • Allergen-induced airway disease is mouse strain dependent. 
  • Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes. 
  • Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer. 
  • Both Hematopoietic- and Non-hematopoietic-derived {beta}-arrestin-2 Regulates Murine Allergic Airway Disease. 
  • Characterization of skin cytokines in bullous pemphigoid and pemphigus vulgaris. 
  • Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions. 
  • Contribution of IL-13 to early exocrinopathy in Id3-/- mice. 
  • Convection-enhanced delivery of cintredekin besudotox (interleukin-13-PE38QQR) followed by radiation therapy with and without temozolomide in newly diagnosed malignant gliomas: phase 1 study of final safety results. 
  • Cytokine expression by invariant natural killer T cells is tightly regulated throughout development and settings of type-2 inflammation. 
  • Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-alpha and is inhibited by IL-4 and IL-13. 
  • Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group. 
  • ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. 
  • Effect of Aging on Adipose Tissue Inflammation in the Knee Joints of F344BN Rats. 
  • Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study. 
  • Effect of preexposure to ultrafine carbon black on respiratory syncytial virus infection in mice. 
  • Effects of allergic airway disease on mouse adenovirus type 1 respiratory infection. 
  • Exposure to particulate hexavalent chromium exacerbates allergic asthma pathology. 
  • Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus. 
  • IL-13 and IL-1beta promote lung fibroblast growth through coordinated up-regulation of PDGF-AA and PDGF-Ralpha. 
  • IL-13 in asthma and allergic disease: asthma phenotypes and targeted therapies. 
  • IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension. 
  • IL-6 receptor α defines effector memory CD8+ T cells producing Th2 cytokines and expanding in asthma. 
  • Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin. 
  • Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13. 
  • Interleukin-13 disrupts type 2 pneumocyte stem cell activity. 
  • Interleukin-13 induces collagen type-1 expression through matrix metalloproteinase-2 and transforming growth factor-β1 in airway fibroblasts in asthma. 
  • Interleukin-13 stimulates the proliferation of lung myofibroblasts via a signal transducer and activator of transcription-6-dependent mechanism: a possible mechanism for the development of airway fibrosis in asthma. 
  • Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning. 
  • Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. 
  • Molecular characterization of inflammatory genes in sentinel and nonsentinel nodes in melanoma. 
  • Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts. 
  • Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma. 
  • Poor drug distribution as a possible explanation for the results of the PRECISE trial. 
  • Role for hedgehog pathway in regulating growth and function of invariant NKT cells. 
  • Role of CCR5 in the pathogenesis of IL-13-induced inflammation and remodeling. 
  • Role of JAK3 in CD40-mediated signaling. 
  • Role of Matrix Metalloproteinases-1 and -2 in Interleukin-13-Suppressed Elastin in Airway Fibroblasts in Asthma. 
  • Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling. 
  • Safety of intraparenchymal convection-enhanced delivery of cintredekin besudotox in early-phase studies. 
  • The IL-2 receptor gamma c chain does not function as a subunit shared by the IL-4 and IL-13 receptors. Implication for the structure of the IL-4 receptor. 
  • The Role of T Helper Type 2 (Th2) Cytokines in the Pathogenesis of Eosinophilic Granulomatosis with Polyangiitis (eGPA): an Illustrative Case and Discussion. 
  • The benefits of restraint: a pivotal role for IL-13 in hepatic glucose homeostasis. 
  • The extracellular matrix protein mindin regulates trafficking of murine eosinophils into the airspace. 
  • The role of IL-13 in the generation of dendritic cells in vitro. 
  • β-Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, Professor Emeritus of Pediatrics, Pediatrics, Allergy and Immunology
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology