Cell Cycle Proteins

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  Subject Areas on Research

  • A 57,000-mol-wt protein uniquely present in nonproliferating cells and senescent human fibroblasts. 
  • A CDC6 protein-binding peptide selected using a bacterial two-hybrid-like system is a cell cycle inhibitor. 
  • A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer. 
  • A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma. 
  • A Role for Protease Activated Receptor Type 3 (PAR3) in Nociception Demonstrated Through Development of a Novel Peptide Agonist. 
  • A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation. 
  • A combinatorial mechanism for determining the specificity of E2F activation and repression. 
  • A conserved G₁ regulatory circuit promotes asynchronous behavior of nuclei sharing a common cytoplasm. 
  • A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition. 
  • A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch. 
  • A feedback loop in the polo-like kinase activation pathway. 
  • A festival of cell-cycle controls. 
  • A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo. 
  • A genetic variant within MDM4 3'UTR miRNA binding site is associated with HPV16-positive tumors and survival of oropharyngeal cancer. 
  • A human protein related to yeast Cdc6p. 
  • A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. 
  • A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer. 
  • A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. 
  • A new face on apoptosis: death-associated protein 3 and PDCD9 are mitochondrial ribosomal proteins. 
  • A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization. 
  • A new role for ATM: regulating mitochondrial function and mitophagy. 
  • A noncanonical role for the CKI-RB-E2F cell-cycle signaling pathway in plant effector-triggered immunity. 
  • A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage. 
  • A novel function of VCP (valosin-containing protein; p97) in the control of N-glycosylation of proteins in the endoplasmic reticulum. 
  • A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation. 
  • A novel role for the cyclin-dependent kinase inhibitor p27(Kip1) in angiotensin II-stimulated vascular smooth muscle cell hypertrophy. 
  • A rat liver 57-kDa protein is identified to share antigenic determinants with statin, a marker for nonproliferating cells. 
  • A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest. 
  • A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. 
  • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. 
  • A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism. 
  • ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy. 
  • ATM Regulation of the Cohesin Complex Is Required for Repression of DNA Replication and Transcription in the Vicinity of DNA Double-Strand Breaks. 
  • ATM activation in normal human tissues and testicular cancer. 
  • ATM binds to beta-adaptin in cytoplasmic vesicles. 
  • ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. 
  • ATM polymorphisms predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. 
  • ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes. 
  • ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. 
  • ATM--a key determinant of multiple cellular responses to irradiation. 
  • ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. 
  • ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. 
  • ATM: genome stability, neuronal development, and cancer cross paths. 
  • ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. 
  • ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. 
  • Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. 
  • Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease. 
  • Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. 
  • Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. 
  • Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase inhibitor p15INK4B and Sp1. 
  • Acute myeloid leukemia ontogeny is defined by distinct somatic mutations. 
  • Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. 
  • Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. 
  • AgSwe1p regulates mitosis in response to morphogenesis and nutrients in multinucleated Ashbya gossypii cells. 
  • Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. 
  • Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression. 
  • Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae. 
  • An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells. 
  • An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci. 
  • An oligonucleotide decoy for transcription factor E2F inhibits mesangial cell proliferation in vitro. 
  • An opposite role for tau in circadian rhythms revealed by mathematical modeling. 
  • Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. 
  • Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer. 
  • Aneuploidy of chromosome 9 and the tumor suppressor genes p16(INK4) and p15(INK4B) detected by in situ hybridization in locally advanced prostate cancer. 
  • Angiotensin II type 2 receptor mediates programmed cell death. 
  • Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. 
  • Anxiety-like behaviors in mice lacking GIT2. 
  • Apoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin. 
  • Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation. 
  • Are all nonproliferating cells similar? 
  • Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. 
  • Arsenic trioxide synergizes with everolimus (Rad001) to induce cytotoxicity of ovarian cancer cells through increased autophagy and apoptosis. 
  • Assessment of autoantibodies to meningioma in a population-based study. 
  • Association between the V109G polymorphism of the p27 gene and the risk and progression of oral squamous cell carcinoma. 
  • Association of CHFR promoter methylation with disease recurrence in locally advanced colon cancer. 
  • Association of germline rare pathogenic mutations in guideline-recommended genes with prostate cancer progression: A meta-analysis. 
  • Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. 
  • Associations between prenatal physical activity, birth weight, and DNA methylation at genomically imprinted domains in a multiethnic newborn cohort. 
  • Asymmetric cell divisions promote stratification and differentiation of mammalian skin. 
  • Asynchronous nuclear division cycles in multinucleated cells. 
  • Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. 
  • Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis. 
  • Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis. 
  • Aven-dependent activation of ATM following DNA damage. 
  • BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression. 
  • BET Inhibitors Suppress ALDH Activity by Targeting ALDH1A1 Super-Enhancer in Ovarian Cancer. 
  • BET bromodomain inhibition of MYC-amplified medulloblastoma. 
  • BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. 
  • BMI1 enhancer polymorphism underlies chromosome 10p12.31 association with childhood acute lymphoblastic leukemia. 
  • BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation. 
  • Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin. 
  • Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway. 
  • Biomarker modulation following short-term vorinostat in women with newly diagnosed primary breast cancer. 
  • Borg proteins control septin organization and are negatively regulated by Cdc42. 
  • Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer. 
  • CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation. 
  • CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling. 
  • CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. 
  • CD28 costimulatory signal induces protein arginine methylation in T cells. 
  • CDK-Regulated Phase Separation Seeded by Histone Genes Ensures Precise Growth and Function of Histone Locus Bodies. 
  • CTLA-4-Mediated inhibition of early events of T cell proliferation. 
  • Calponin-3 deficiency augments contractile activity, plasticity, fibrogenic response and Yap/Taz transcriptional activation in lens epithelial cells and explants. 
  • Candidate genes on murine chromosome 8 are associated with susceptibility to Staphylococcus aureus infection in mice and are involved with Staphylococcus aureus septicemia in humans. 
  • Casein kinase I in the mammalian circadian clock. 
  • Cdc37/Hsp90 protein-mediated regulation of IRE1α protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells. 
  • Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. 
  • Cell biology: A BID for the pathway. 
  • Cell cycle deregulation and xeroderma pigmentosum group C cell transformation. 
  • Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. 
  • Cell cycle kinetic effects of tamoxifen on human breast cancer cells. Flow cytometric analyses of DNA content, BrdU labeling, Ki-67, PCNA, and statin expression. 
  • Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae. 
  • Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through phosphatidylinositol 3-kinase and mammalian target of rapamycin. 
  • Cell cycle. Checking two steps. 
  • Cell cycle: Flies teach an old dogma new tricks. 
  • Cell-Cycle-Dependent Chromatin Dynamics at Replication Origins. 
  • Cellularization in Drosophila melanogaster is disrupted by the inhibition of rho activity and the activation of Cdc42 function. 
  • Characterization of 57 kDa statin as a true marker for growth arrest in tissue by its disappearance from regenerating liver. 
  • Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR. 
  • Characterization of the energy-dependent, mating factor-activated Ca2+ influx in Saccharomyces cerevisiae. 
  • Characterization of the porcine ATM gene: towards the generation of a novel non-murine animal model for Ataxia-Telangiectasia. 
  • Characterization of the repeat-tract instability and mutator phenotypes conferred by a Tn3 insertion in RFC1, the large subunit of the yeast clamp loader. 
  • Characterization of the statin-like S1 and rat elongation factor 1 alpha as two distinctly expressed messages in rat. 
  • Characterization of two populations of statin and the relationship of their syntheses to the state of cell proliferation. 
  • Checkpoints couple transcription network oscillator dynamics to cell-cycle progression. 
  • Chloroquine improves survival and hematopoietic recovery after lethal low-dose-rate radiation. 
  • Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation. 
  • Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest. 
  • Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration. 
  • Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer. 
  • Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. 
  • CoA synthase regulates mitotic fidelity via CBP-mediated acetylation. 
  • Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement. 
  • Cohesin: it's not just for chromosomes anymore. 
  • Combined p53-related genetic variants together with HPV infection increase oral cancer risk. 
  • Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer. 
  • Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans. 
  • Comparison of gene expression profiles induced by coarse, fine, and ultrafine particulate matter. 
  • Condensin and cohesin display different arm conformations with characteristic hinge angles. 
  • Contact-inhibition-induced quiescent state is marked by intense nuclear expression of statin. 
  • Control of cellular GADD34 levels by the 26S proteasome. 
  • Control of division in Chlamydomonas by cyclin B/CDKB1 and the anaphase-promoting complex. 
  • Control of filamentous fungal cell shape by septins and formins. 
  • Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. 
  • Control of septin filament flexibility and bundling by subunit composition and nucleotide interactions. 
  • Control of thymic T cell maturation, deletion and egress by the RNA-binding protein HuR. 
  • Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. 
  • Cornelia de Lange syndrome in diverse populations. 
  • Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization. 
  • DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway. 
  • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. 
  • DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture. 
  • DNA replication checkpoint control of Wee1 stability by vertebrate Hsl7. 
  • Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response. 
  • Definition of a FoxA1 Cistrome that is crucial for G1 to S-phase cell-cycle transit in castration-resistant prostate cancer. 
  • Deletions and point mutations of p16,p15 gene in primary tumors and tumor cell lines. 
  • Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. 
  • Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. 
  • Destabilization of the VCP-Ufd1-Npl4 complex is associated with decreased levels of ERAD substrates. 
  • Differential cellular localization of CELSR2 and ING4 and correlations with hormone receptor status in breast cancer. 
  • Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus. 
  • Differential susceptibility of yeast S and M phase CDK complexes to inhibitory tyrosine phosphorylation. 
  • Differing molecular pathology of pancreatic adenocarcinoma in Egyptian and United States patients. 
  • Disappearance of statin, a protein marker for non-proliferating and senescent cells, following serum-stimulated cell cycle entry. 
  • Disappearance of the telomere dysfunction-induced stress response in fully senescent cells. 
  • Discovery of thiophene inhibitors of polo-like kinase. 
  • Disruption of origin chromatin structure by helicase activation in the absence of DNA replication. 
  • Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects. 
  • Disruption of the gene encoding the mitogen-regulated translational modulator PHAS-I in mice. 
  • Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. 
  • Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. 
  • Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6. 
  • Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. 
  • Distribution of optineurin sequence variations in an ethnically diverse population of low-tension glaucoma patients from the United States. 
  • Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes. 
  • Down-regulation of statin, a nonproliferation-specific nuclear protein, and up-regulation of c-myc after initiation of programmed cell death in mouse fibroblasts. 
  • Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells. 
  • Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading. 
  • Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity. 
  • Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease. 
  • E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. 
  • E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites. 
  • Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae. 
  • Endonucleolytic function of MutLalpha in human mismatch repair. 
  • Endothelial healing in vein grafts: proliferative burst unimpaired by genetic therapy of neointimal disease. 
  • Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: the PREVENT single-centre, randomised, controlled trial. 
  • Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways. 
  • Expanding the clinical phenotype in patients with disease causing variants associated with atypical Usher syndrome. 
  • Expression and assay of recombinant ATM. 
  • Expression of a constitutively active Ca2+/calmodulin-dependent kinase in Aspergillus nidulans spores prevents germination and entry into the cell cycle. 
  • Expression of cell cycle related proteins--proliferating cell nuclear antigen (PCNA) and statin--during adaptation and de-adaptation of EUE cells to a hypertonic medium. 
  • Expression of p27 in residual rectal cancer after preoperative chemoradiation predicts long-term outcome. 
  • Expression of proliferation-specific genes in the mucosa adjacent to colon carcinoma. 
  • Expression of statin, a non-proliferation-dependent nuclear protein, in the postnatal rat brain: evidence for substantial retention of neuroglial proliferative capacity with aging. 
  • Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression. 
  • Expression of the non-proliferation-specific protein, statin, in grey matter neuroglia of the aging rat brain. 
  • Expression of the noncatalytic domain of the NIMA kinase causes a G2 arrest in Aspergillus nidulans. 
  • Expression of the protein tyrosine phosphatase, phosphatase of regenerating liver 1, in the outer segments of primate cone photoreceptors. 
  • Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids. 
  • FBW2 targets GCMa to the ubiquitin-proteasome degradation system. 
  • FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity. 
  • Familial variable expression of dilated cardiomyopathy in Alström syndrome: a report of four sibs. 
  • Fetal antisense oligonucleotide therapy for congenital deafness and vestibular dysfunction. 
  • Fission yeast Cyk3p is a transglutaminase-like protein that participates in cytokinesis and cell morphogenesis. 
  • Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut. 
  • Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. 
  • Fragments of ATM which have dominant-negative or complementing activity. 
  • FtsZ filament capping by MciZ, a developmental regulator of bacterial division. 
  • Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus. 
  • Functional genome-wide siRNA screen identifies KIAA0586 as mutated in Joubert syndrome. 
  • Functional variations in the ATM gene and susceptibility to differentiated thyroid carcinoma. 
  • GIT1 regulates synaptic structural plasticity underlying learning. 
  • Gene expression phenotypic models that predict the activity of oncogenic pathways. 
  • Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. 
  • Gene inhibition and gene augmentation for the treatment of vascular proliferative disorders. 
  • Gene therapy with an E2F transcription factor decoy inhibits cell cycle progression in rat anti-Thy 1 glomerulonephritis. 
  • Generation of S phase-dependent DNA double-strand breaks by Cr(VI) exposure: involvement of ATM in Cr(VI) induction of gamma-H2AX. 
  • Genetic polymorphisms of ataxia telangiectasia mutated and breast cancer risk. 
  • Genetic polymorphisms of p21 are associated with risk of squamous cell carcinoma of the head and neck. 
  • Genetic targeting for cardiovascular therapeutics: are we near the summit or just beginning the climb? 
  • Genetic variant in DNA repair gene GTF2H4 is associated with lung cancer risk: a large-scale analysis of six published GWAS datasets in the TRICL consortium. 
  • Genetic variants in p53-related genes confer susceptibility to second primary malignancy in patients with index squamous cell carcinoma of head and neck. 
  • Genetic variants of GADD45A, GADD45B and MAPK14 predict platinum-based chemotherapy-induced toxicities in Chinese patients with non-small cell lung cancer. 
  • Genetics of adult glaucoma. 
  • Genomic instability and endoreduplication triggered by RAD17 deletion. 
  • Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells. 
  • Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells. 
  • Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. 
  • Glaucoma genetics. 
  • Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease. 
  • Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation. 
  • Glycogen-branching enzyme deficiency leads to abnormal cardiac development: novel insights into glycogen storage disease IV. 
  • Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. 
  • Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. 
  • HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. 
  • HDAC6 modulates cell motility by altering the acetylation level of cortactin. 
  • HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea. 
  • HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. 
  • HSV-1 amplicon vector-mediated expression of ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype. 
  • Hedgehog regulates yes-associated protein 1 in regenerating mouse liver. 
  • Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells. 
  • Heterochromatin and RNAi act independently to ensure genome stability in Mucorales human fungal pathogens. 
  • High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. 
  • High-content image informatics of the structural nuclear protein NuMA parses trajectories for stem/progenitor cell lineages and oncogenic transformation. 
  • High-content imaging-based screening of microenvironment-induced changes to stem cells. 
  • Highly coordinated gene regulation in mouse skeletal muscle regeneration. 
  • Hippo pathway effectors YAP and TAZ and their association with skeletal muscle ageing. 
  • Histochemical localization of Statin--a non-proliferation-specific nuclear protein--in nuclei of normal and abnormal human thyroid tissue. 
  • How the kinetochore couples microtubule force and centromere stretch to move chromosomes. 
  • Hsp90, an unlikely ally in the war on cancer. 
  • Human Rad9 is required for the activation of S-phase checkpoint and the maintenance of chromosomal stability. 
  • Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response. 
  • Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2. 
  • Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. 
  • Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. 
  • Identification of a novel NBN truncating mutation in a family with hereditary prostate cancer. 
  • Identification of resting cells by dual-parameter flow cytometry of statin expression and DNA content. 
  • Identification of substrate specificity determinants for the cell cycle-regulated NIMA protein kinase. 
  • Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1. 
  • Immunohistochemical analysis of statin in colorectal adenocarcinoma, polyps, and normal mucosa. 
  • Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis. 
  • Impaired fear response in mice lacking GIT1. 
  • Implications for proteasome nuclear localization revealed by the structure of the nuclear proteasome tether protein Cut8. 
  • In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1. 
  • In vitro expression levels of cell-cycle checkpoint proteins are associated with cellular DNA repair capacity in peripheral blood lymphocytes: a multivariate analysis. 
  • Inactivation of the tumor suppressor genes causing the hereditary syndromes predisposing to head and neck cancer via promoter hypermethylation in sporadic head and neck cancers. 
  • Increased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression. 
  • Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma. 
  • Influence of ATM function on telomere metabolism. 
  • Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function. 
  • Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells. 
  • Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis. 
  • Initial testing (stage 1) of the Polo-like kinase inhibitor volasertib (BI 6727), by the Pediatric Preclinical Testing Program. 
  • Inositol diphosphate signaling regulates telomere length. 
  • Insulin inhibits dexamethasone effect on angiotensinogen gene expression and induction of hypertrophy in rat kidney proximal tubular cells in high glucose. 
  • Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins. 
  • Interaction of FANCD2 and NBS1 in the DNA damage response. 
  • Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. 
  • Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway. 
  • Interphase cohesin regulation ensures mitotic fidelity after genome reduplication. 
  • Interplay between septin organization, cell cycle and cell shape in yeast. 
  • Interplay of septin amphipathic helices in sensing membrane-curvature and filament bundling. 
  • Intrinsic Antiviral Activity of Optineurin Prevents Hyperproliferation of a Primary Herpes Simplex Virus Type 2 Infection. 
  • Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. 
  • Involvement of the checkpoint protein Mec1p in silencing of gene expression at telomeres in Saccharomyces cerevisiae. 
  • Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. 
  • Ionizing radiation activates the ATM kinase throughout the cell cycle. 
  • Isolation and characterization of the rat chromosomal gene for a polypeptide (pS1) antigenically related to statin. 
  • Isolation and initial characterization of the BRCA2 promoter. 
  • Isoproterenol downregulation of statin-related gene expression in the rat parotid gland. 
  • L-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome. 
  • Lack of association between UBQLN1 and Alzheimer disease. 
  • Lack of association of mutations in optineurin with disease in patients with adult-onset primary open-angle glaucoma. 
  • Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues. 
  • Layers of regulation of cell-cycle gene expression in the budding yeast Saccharomyces cerevisiae. 
  • Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood. 
  • Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae. 
  • Lipid rafts in protein sorting and cell polarity in budding yeast Saccharomyces cerevisiae. 
  • Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes. 
  • Long-term stabilization of vein graft wall architecture and prolonged resistance to experimental atherosclerosis after E2F decoy oligonucleotide gene therapy. 
  • Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy. 
  • Loss of G(1)/S checkpoint in human immunodeficiency virus type 1-infected cells is associated with a lack of cyclin-dependent kinase inhibitor p21/Waf1. 
  • Loss of atm radiosensitizes multiple p53 null tissues. 
  • Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells. 
  • Lysosomal degradation of depolarized mitochondria is rate-limiting in OPTN-dependent neuronal mitophagy. 
  • MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages. 
  • MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. 
  • MDM4 genetic variants and risk of gastric cancer in an Eastern Chinese population. 
  • MRCK-1 Drives Apical Constriction in C. elegans by Linking Developmental Patterning to Force Generation. 
  • Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import. 
  • Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast. 
  • Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4. 
  • Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains. 
  • Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. 
  • Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate. 
  • Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage. 
  • Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14. 
  • Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila. 
  • MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex. 
  • Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. 
  • MicroRNA-155 controls vincristine sensitivity and predicts superior clinical outcome in diffuse large B-cell lymphoma. 
  • Microcephaly with altered cortical layering in GIT1 deficiency revealed by quantitative neuroimaging. 
  • Mitochondrial dysfunction in ataxia-telangiectasia. 
  • Modifying effect of MDM4 variants on risk of HPV16-associated squamous cell carcinoma of oropharynx. 
  • Modulation of Xenopus oocyte-expressed phospholemman-induced ion currents by co-expression of protein kinases. 
  • Modulation of nuclear statin expression in rat thyroid follicle cell following administration of thyroid stimulating hormone. 
  • Molecular analysis of P16(Ink4)/CDKN2 and P15(INK4B)/MTS2 genes in primary human testicular germ cell tumors. 
  • Molecular genetic parameters in pathogenesis and prognosis of testicular germ cell tumors. 
  • Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin. 
  • Mouse double minute 4 variants modify susceptibility to risk of recurrence in patients with squamous cell carcinoma of the oropharynx. 
  • Multicenter Phase II Trial of the WEE1 Inhibitor Adavosertib in Refractory Solid Tumors Harboring CCNE1 Amplification. 
  • Multifaceted recognition of vertebrate Rev1 by translesion polymerases ζ and κ. 
  • Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia. 
  • Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. 
  • Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. 
  • Multiple signaling pathways involving ATM. 
  • Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture. 
  • Myc requires distinct E2F activities to induce S phase and apoptosis. 
  • Myocilin and optineurin coding variants in Hispanics of Mexican descent with POAG. 
  • Myosins motor Miranda. 
  • NADPH oxidase 4: walking the walk with Poldip2. 
  • NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. 
  • NMR structural characterization of the CDK inhibitor p19INK4d. 
  • Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. 
  • Network calisthenics: control of E2F dynamics in cell cycle entry. 
  • Newborns of obese parents have altered DNA methylation patterns at imprinted genes. 
  • Nomenclature: vertebrate mediators of TGFbeta family signals. 
  • Not-so-pseudo a substrate: Acm1-mediated inhibition of the APC. 
  • NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions. 
  • NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures. 
  • Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity. 
  • Nuclear anarchy: asynchronous mitosis in multinucleated fungal hyphae. 
  • Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon. 
  • Nuclear export of mammalian PERIOD proteins. 
  • Nuclear tyrosine kinases: from Abl to WEE1. 
  • Nucleo-cytoplasmic interactions that control nuclear envelope breakdown and entry into mitosis in the sea urchin zygote. 
  • Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair. 
  • Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding. 
  • OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection. 
  • Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. 
  • Ophthalmologic findings in Cornelia de Lange syndrome: a genotype-phenotype correlation study. 
  • Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors. 
  • Optimizing aptamer activity for gene therapy applications using expression cassette SELEX. 
  • Optineurin coding variants in Ghanaian patients with primary open-angle glaucoma. 
  • Origin of bistability underlying mammalian cell cycle entry. 
  • Our cells get stressed too! Implications for human disease. 
  • Overexpression of a Brassica rapa NGATHA gene in Arabidopsis thaliana negatively affects cell proliferation during lateral organ and root growth. 
  • Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina. 
  • P53, cell cycle control and apoptosis: implications for cancer. 
  • PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia. 
  • PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation. 
  • PHAS-I as a link between mitogen-activated protein kinase and translation initiation. 
  • PIN1, the cell cycle and cancer. 
  • PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans. 
  • PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. 
  • PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. 
  • Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. 
  • Pcp1p, an Spc110p-related calmodulin target at the centrosome of the fission yeast Schizosaccharomyces pombe. 
  • Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. 
  • Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon. 
  • Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations. 
  • Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. 
  • Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. 
  • Phosphorylation of the cyclin b1 cytoplasmic retention sequence by mitogen-activated protein kinase and Plx. 
  • Physiological electric fields control the G1/S phase cell cycle checkpoint to inhibit endothelial cell proliferation. 
  • Pilot and feasibility study: prospective proteomic profiling of mammary epithelial cells from high-risk women provides evidence of activation of pro-survival pathways. 
  • Polo-like kinase 1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass. 
  • Polymorphisms and haplotypes of the NBS1 gene are associated with risk of sporadic breast cancer in non-Hispanic white women  
  • Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population. 
  • Polymorphisms of MDM4 and risk of squamous cell carcinoma of the head and neck. 
  • Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype. 
  • Posttranslational control of Cdc25 degradation terminates Drosophila's early cell-cycle program. 
  • Potential functional variants in SMC2 and TP53 in the AURORA pathway genes and risk of pancreatic cancer. 
  • Potentially functional variants in nucleotide excision repair pathway genes predict platinum treatment response of Chinese ovarian cancer patients. 
  • Pre-established Chromatin Interactions Mediate the Genomic Response to Glucocorticoids. 
  • Preferential re-replication of Drosophila heterochromatin in the absence of geminin. 
  • Prognostic methylation markers for overall survival in cytogenetically normal patients with acute myeloid leukemia treated on SWOG trials. 
  • Prognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancer. 
  • Prognostic value of cell-cycle markers in ocular adnexal lymphoma: an assessment of 230 cases. 
  • Proliferative activity at colonic anastomoses as determined by statin. A nonproliferation-specific nuclear protein. 
  • Proliferative activity of colonic mucosa at different distances from primary adenocarcinoma as determined by the presence of statin: a nonproliferation-specific nuclear protein. 
  • Properties and regulation of the cell cycle-specific NIMA protein kinase of Aspergillus nidulans. 
  • Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. 
  • Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer. 
  • Protein kinase CK2 phosphorylates the cell cycle regulatory protein Geminin. 
  • Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase. 
  • Protein phosphatase 1 regulates the stability of the circadian protein PER2. 
  • Protein phosphatase 5 is required for ATR-mediated checkpoint activation. 
  • Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress. 
  • Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi. 
  • Purification and biochemical characterization of statin, a nonproliferation specific protein from rat liver. 
  • Quantitative, noninvasive imaging of radiation-induced DNA double-strand breaks in vivo. 
  • Quiescent and cycling cell compartments in the senescent and Alzheimer-diseased human brain. 
  • RCC1, a regulator of mitosis, is essential for DNA replication. 
  • RINT-1 interacts with MSP58 within nucleoli and plays a role in ribosomal gene transcription. 
  • Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks. 
  • Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells. 
  • Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway. 
  • Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. 
  • Rapid assembly dynamics of the Escherichia coli FtsZ-ring demonstrated by fluorescence recovery after photobleaching. 
  • Rapid disappearance of statin, a nonproliferating and senescent cell-specific protein, upon reentering the process of cell cycling. 
  • Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis. 
  • Ratiometric GPCR signaling enables directional sensing in yeast. 
  • Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells. 
  • Reciprocal control of Forkhead box O 3a and c-Myc via the phosphatidylinositol 3-kinase pathway coordinately regulates p27Kip1 levels. 
  • Reduced ATR or Chk1 expression leads to chromosome instability and chemosensitization of mismatch repair-deficient colorectal cancer cells. 
  • Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer. 
  • Regulation of T cell function by microRNA-720. 
  • Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes. 
  • Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background. 
  • Regulation of mitotic chromosome cohesion by Haspin and Aurora B. 
  • Regulation of nuclear Prointerleukin-16 and p27(Kip1) in primary human T lymphocytes. 
  • Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. 
  • Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1. 
  • Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding. 
  • Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. 
  • Requirement of the prolyl isomerase Pin1 for the replication checkpoint. 
  • Respiratory pathology in the Optn-/- mouse model of Amyotrophic Lateral Sclerosis. 
  • Restricted substrate specificity for the geranylgeranyltransferase-I enzyme in Cryptococcus neoformans: implications for virulence. 
  • Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids. 
  • Reversible protein phosphorylation regulates circadian rhythms. 
  • Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA. 
  • Robust control of mitotic spindle orientation in the developing epidermis. 
  • Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. 
  • Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae. 
  • Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses. 
  • Role of the Hof1-Cyk3 interaction in cleavage-furrow ingression and primary-septum formation during yeast cytokinesis. 
  • Role of the Nijmegen breakage syndrome 1 gene in familial and sporadic prostate cancer. 
  • Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma. 
  • Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. 
  • Rumenectomy-induced proliferation in duodenal villous epithelium is mechanistically related to the disappearance of statin, a non-proliferation-specific nuclear protein. 
  • SCARECROW-LIKE28 modulates organ growth in Arabidopsis by controlling mitotic cell cycle exit, endoreplication, and cell expansion dynamics. 
  • Salicylic acid activates DNA damage responses to potentiate plant immunity. 
  • Seeking truth on Monte Verita. Workshop on the molecular biology and biochemistry of septins and septin function. 
  • Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells. 
  • Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing. 
  • Septin ring size scaling and dynamics require the coiled-coil region of Shs1p. 
  • Septins may form a ubiquitous family of cytoskeletal filaments. 
  • Sequence divergence of coiled coils--structural rods, myosin filament packing, and the extraordinary conservation of cohesins. 
  • Serial analysis of gene expression (SAGE) in normal human trabecular meshwork. 
  • Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background. 
  • Shifting gears and putting on the brakes: Female germ cells transition into meiosis. 
  • Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. 
  • Sir2 suppresses transcription-mediated displacement of Mcm2-7 replicative helicases at the ribosomal DNA repeats. 
  • Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control. 
  • Skp2 regulates Myc protein stability and activity. 
  • Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis. 
  • Sok2 regulates yeast pseudohyphal differentiation via a transcription factor cascade that regulates cell-cell adhesion. 
  • Somatic variants in diverse genes leads to a spectrum of focal cortical malformations. 
  • Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets. 
  • Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. 
  • Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis. 
  • Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte. 
  • Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis. 
  • Statin expression associated with terminally differentiating and postreplicative lens epithelial cells. 
  • Statin expression in the untreated and SarCNU-exposed human glioma cell line, SK-MG-1. 
  • Statin immunolocalization in human brain tumors. Detection of noncycling cells using a novel marker of cell quiescence. 
  • Statin, a nonproliferation-specific protein, is associated with the nuclear envelope and is heterogeneously distributed in cells leaving quiescent state. 
  • Statin, a protein specifically present in nonproliferating cells, is a phosphoprotein and forms a complex with a 45-kilodalton serine/threonine kinase. 
  • Statin--a novel marker of nonproliferation. Expression in nonneoplastic lymphoid tissues and follicular lymphomas. 
  • Statistical analysis of the concordance of immunohistochemical stains with the final diagnosis in spitzoid neoplasms. 
  • Structural and Functional Analyses Reveal Insights into the Molecular Properties of the Escherichia coli Z Ring Stabilizing Protein, ZapC. 
  • Structural evidence that the P/Q domain of ZipA is an unstructured, flexible tether between the membrane and the C-terminal FtsZ-binding domain. 
  • Structural organization of the human MS4A gene cluster on Chromosome 11q12. 
  • Structure and regulation of the mouse ing1 gene. Three alternative transcripts encode two phd finger proteins that have opposite effects on p53 function. 
  • Structure of the Z Ring-associated Protein, ZapD, Bound to the C-terminal Domain of the Tubulin-like Protein, FtsZ, Suggests Mechanism of Z Ring Stabilization through FtsZ Cross-linking. 
  • Structure-function analysis of Cdc25Twine degradation at the Drosophila maternal-to-zygotic transition. 
  • Substrate specificities and identification of putative substrates of ATM kinase family members. 
  • Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11. 
  • Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells. 
  • Synergistic derepression of gibberellin signaling by removing RGA and GAI function in Arabidopsis thaliana. 
  • Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. 
  • TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein. 
  • TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse. 
  • TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin. 
  • TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. 
  • Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. 
  • Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. 
  • Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. 
  • Targeting sonic hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-like kinases. 
  • Targeting the ATM Kinase to Enhance the Efficacy of Radiotherapy and Outcomes for Cancer Patients. 
  • Temporal relationships of statin and terminin expression in ventral lobe of rat prostate following castration. 
  • Th1 cytokine interferon gamma improves response in HER2 breast cancer by modulating the ubiquitin proteasomal pathway. 
  • The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae. 
  • The ATM-dependent DNA damage signaling pathway. 
  • The Arabidopsis RGA gene encodes a transcriptional regulator repressing the gibberellin signal transduction pathway. 
  • The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation. 
  • The FtsZ protofilament and attachment of ZipA--structural constraints on the FtsZ power stroke. 
  • The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. 
  • The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. 
  • The Transient Inactivation of the Master Cell Cycle Phosphatase Cdc14 Causes Genomic Instability in Diploid Cells of Saccharomyces cerevisiae. 
  • The association of polymorphisms of CDT1 and GMNN gene with the risk of breast cancer in Chinese women: a case-control analysis. 
  • The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. 
  • The coiled coils of cohesin are conserved in animals, but not in yeast. 
  • The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis. 
  • The differential expression of statin in the nuclei of human colonic crypts adjacent to a cancer: an immunohistochemical study. 
  • The differentiation process of intestinal epithelial cells is associated with the appearance of statin, a non-proliferation-specific nuclear protein. 
  • The disappearance of a cyclin-like protein and the appearance of statin is correlated with the onset of differentiation during myogenesis in vitro. 
  • The extracellular matrix protein agrin promotes heart regeneration in mice. 
  • The genetics of primary open-angle glaucoma: a review. 
  • The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways. 
  • The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint. 
  • The many substrates and functions of ATM. 
  • The mechanism of nucleotide excision repair-mediated UV-induced mutagenesis in nonproliferating cells. 
  • The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1. 
  • The nucleocapsid region of HIV-1 Gag cooperates with the PTAP and LYPXnL late domains to recruit the cellular machinery necessary for viral budding. 
  • The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts. 
  • The peptidyl-prolyl isomerase Pin1. 
  • The relationship of expression of statin, the nuclear protein of nonproliferating cells, to the differentiation and cell cycle of astroglia in cultures and in situ. 
  • The role of Dbf4-dependent protein kinase in DNA polymerase ζ-dependent mutagenesis in Saccharomyces cerevisiae. 
  • The role of N-cadherin/c-Jun/NDRG1 axis in the progression of prostate cancer. 
  • The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair. 
  • The septin cortex at the yeast mother-bud neck. 
  • The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis. 
  • The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. 
  • The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. 
  • The ubiquilin 1 gene and Alzheimer's disease. 
  • The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B. 
  • Therapeutic applications of transcription factor decoy oligonucleotides. 
  • Topology and control of the cell-cycle-regulated transcriptional circuitry. 
  • Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells. 
  • Transforming growth factor beta 1 dysregulation in a human oral carcinoma tumour progression model. 
  • Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site. 
  • Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element. 
  • Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines. 
  • Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. 
  • Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. 
  • Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms. 
  • Ultrastructural Analysis of Vesicular Transport in Electrotransfection. 
  • Up-regulation of GRP78 and antiapoptotic signaling in murine peritoneal macrophages exposed to insulin. 
  • VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. 
  • VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. 
  • Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci. 
  • Visual impairment in an optineurin mouse model of primary open-angle glaucoma. 
  • Visualization of replication initiation and elongation in Drosophila. 
  • Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery. 
  • WTAP Targets the METTL3 m6A-Methyltransferase Complex to Cytoplasmic Hepatitis C Virus RNA to Regulate Infection. 
  • Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts. 
  • Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia. 
  • Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome. 
  • ZipA and FtsA* stabilize FtsZ-GDP miniring structures. 
  • beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. 
  • cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I. 
  • p27 and cyclin D1 abnormalities in uterine papillary serous carcinoma. 
  • p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma. 
  • p53 and ATM: cell cycle, cell death, and cancer. 
  • p53: a two-faced cancer gene. 
• 

  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Gordan, Raluca Mihaela, Associate Professor in Biostatistics & Bioinformatics, Computer Science
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Cell Biology
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology