Sepsis

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  Subject Areas on Research

  • A Prospective Study of Community Mediators on the Risk of Sepsis After Cancer. 
  • A community approach to mortality prediction in sepsis via gene expression analysis. 
  • A computer based index for the prediction of operative survival in patients with cirrhosis and portal hypertension. 
  • A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group. 
  • A hospital-based prevalence survey of bloodstream infections in febrile patients in Malawi: implications for diagnosis and therapy. 
  • A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS. 
  • A prospective study of cancer survivors and risk of sepsis within the REGARDS cohort. 
  • A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis. 
  • A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation. 
  • A safer system for percutaneous subclavian venous catheterization in newborn infants. 
  • A scoring system derived from electronic health records to identify patients at high risk for noninvasive ventilation failure. 
  • A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group. 
  • A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis. 
  • ACR Appropriateness Criteria Fever Without Source or Unknown Origin-Child. 
  • APOE genotype affects outcome in a murine model of sepsis: implications for a new treatment strategy. 
  • APOE polymorphism is associated with risk of severe sepsis in surgical patients. 
  • Absence of bacteremia after insertion or removal of intrauterine devices. 
  • Achromobacter xylosoxidans bacteremia. 
  • Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice. 
  • Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis. 
  • Activity of cefamandole, cefoxitin, ampicillin and gentamicin against 419 bacteria isolated from blood of patients with sepsis. 
  • Acute Kidney Injury in Pediatric Severe Sepsis: An Independent Risk Factor for Death and New Disability. 
  • Acute suppurative parotitis associated with anaerobic bacteremia. 
  • Adaptive leadership: a novel approach for family decision making. 
  • Admission cell free DNA levels predict 28-day mortality in patients with severe sepsis in intensive care. 
  • Advancing Diagnostics to Address Antibacterial Resistance: The Diagnostics and Devices Committee of the Antibacterial Resistance Leadership Group. 
  • Adverse Events After Routine Immunization of Extremely Low-Birth-Weight Infants. 
  • Age-related differences in biomarkers of acute inflammation during hospitalization for sepsis. 
  • Alpha-chemokine receptor blockade reduces high mobility group box 1 protein-induced lung inflammation and injury and improves survival in sepsis. 
  • An evaluation of sepsis Web sites for patient and family education. 
  • An integrated clinico-metabolomic model improves prediction of death in sepsis. 
  • Analysis of Factors Associated With In-hospital Mortality in Lung Cancer Chemotherapy Patients With Neutropenia. 
  • Analysis of enteric coagulase-negative staphylococci from neonates with necrotizing enterocolitis. 
  • Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis. 
  • Antibiotic stewardship: reassessment of guidelines for management of neonatal sepsis. 
  • Antibiotic use and misuse in the neonatal intensive care unit. 
  • Antibiotic use and the prevention and management of infectious complications in stone disease. 
  • Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons. 
  • Antibody to intercellular adhesion molecule 1 (CD54) decreases survival and not lung injury in baboons with sepsis. 
  • Antifungal Susceptibility and Clinical Outcome in Neonatal Candidiasis. 
  • Antithrombin: anti-inflammatory properties and clinical applications. 
  • Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis. 
  • Are we finally ready for outpatient management of febrile neutropenia? 
  • Assessing the relative burden of hospital-acquired infections in a network of community hospitals. 
  • Association between the choice of IV crystalloid and in-hospital mortality among critically ill adults with sepsis*. 
  • Association of 17α-Hydroxyprogesterone Caproate and Risk of Infection. 
  • Association of Pneumonia, Wound Infection, and Sepsis with Clinical Outcomes after Acute Traumatic Spinal Cord Injury. 
  • Atrial fibrillation among Medicare beneficiaries hospitalized with sepsis: incidence and risk factors. 
  • Atrioventricular-node inflammation--mechanism of sudden death in protracted meningococcemia. 
  • Autochthonous ST405 NDM-5 producing Escherichia coli causing fatal sepsis in Northern Italy. 
  • BacT/Alert: an automated colorimetric microbial detection system. 
  • Bacteremia, Sepsis, and Infective Endocarditis Associated with Staphylococcus aureus. 
  • Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury. 
  • Bench-to-bedside review: sepsis - from the redox point of view. 
  • Beyond thrombosis: the versatile platelet in critical illness. 
  • Blockade of tissue factor: treatment for organ injury in established sepsis. 
  • Blood cultures and antibiotic use in a neonatal intensive care unit. 
  • Blood stream infection is associated with altered heptavalent pneumococcal conjugate vaccine immune responses in very low birth weight infants. 
  • Blood-based Diagnosis of Invasive Fungal Infections in Immunocompromised/Oncology Patients. 
  • Blurred Lines: Dysbiosis and Probiotics in the ICU. 
  • Calciphylaxis from nonuremic causes: a systematic review. 
  • Candida virulence properties and adverse clinical outcomes in neonatal candidiasis. 
  • Candidal sepsis and meningitis in a very-low-birth-weight infant successfully treated with fluconazole and flucytosine. 
  • Candidate genes on murine chromosome 8 are associated with susceptibility to Staphylococcus aureus infection in mice and are involved with Staphylococcus aureus septicemia in humans. 
  • Catheter-related bloodstream infections in children. 
  • Catheter-related sepsis refractory to antibiotics treated successfully with adjunctive urokinase infusion. 
  • Cause Unknown, Treatment Uncertain, Outcome Poor: An Encounter With Kidney Failure in the Developing World. 
  • Cause specific mortality patterns among the oldest old: multiple cause of death trends 1968 to 1980. 
  • Causes of late mortality in pediatric liver transplant recipients. 
  • Central line "attention" is their best prevention. 
  • Central line-associated infections as defined by the Centers for Medicare and Medicaid Services' Hospital-acquired condition versus standard infection control surveillance: why hospital compare seems conflicted. 
  • Chemotherapy. 
  • Chlorhexidine Gluconate Bathing Reduces the Incidence of Bloodstream Infections in Adults Undergoing Inpatient Hematopoietic Cell Transplantation. 
  • Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. 
  • Cholinergic regulatory lymphocytes re-establish neuromodulation of innate immune responses in sepsis. 
  • Clinical comparison of an agar slide blood culture bottle with tryptic soy broth and a conventional blood culture bottle with supplemented peptone broth. 
  • Clinical course and outcome predictors of critically ill infants with complete DiGeorge anomaly following thymus transplantation. 
  • Clinical importance of "breakthrough" bacteremia. 
  • Clinical importance of polymicrobial bacteremia. 
  • Clinical outcomes after ureteroscopic lithotripsy in patients who initially presented with urosepsis: matched pair comparison with elective ureteroscopy. 
  • Clinical predictors of major infections after cardiac surgery. 
  • Clinical relevance of procalcitonin and C-reactive protein as infection markers in renal impairment: a cross-sectional study. 
  • Clostridium septicum abscess in hepatic metastases: successful medical management. 
  • Coagulopathy in COVID-19. 
  • Comparative evaluation of Oxoid Signal and BACTEC radiometric blood culture systems for the detection of bacteremia and fungemia. 
  • Comparative evaluation of radiometric tryptic soy broth versus radiometric tryptic soy broth with 10% sucrose for detection of bacteremia and fungemia in pediatric patients. 
  • Comparative evaluation of supplemented peptone broth with sodium polyanetholesulfonate and trypticase soy broth with sodium amylosulfate for detection of septicemia. 
  • Comparative in-vitro activity of MK0787 (N-formimidoyl thienamycin) against 540 blood culture isolates. 
  • Comparison of Pediatric Severe Sepsis Managed in U.S. and European ICUs. 
  • Comparison of in vitro activity of moxalactam (LY127935) with cefazolin, amikacin, tobramycin, carbenicillin, piperacillin, and ticarcillin against 420 blood culture isolates. 
  • Compliance With the National SEP-1 Quality Measure and Association With Sepsis Outcomes: A Multicenter Retrospective Cohort Study. 
  • Considerations for Clinical Trials of Staphylococcus aureus Bloodstream Infection in Adults. 
  • Contemporary trends in global mortality of sepsis among young infants less than 90 days old: protocol for a systematic review and meta-analysis. 
  • Controlled clinical comparison of new pediatric medium with adsorbent polymeric beads (PF Plus) versus charcoal-containing PF medium in the BacT/alert blood culture system. 
  • Controlled comparison of a new Becton Dickinson agar slant blood culture system with Roche Septi-Chek for the detection of bacteremia and fungemia. 
  • Controlled evaluation of BACTEC Plus 26 and Roche Septi-Chek aerobic blood culture bottles. 
  • Controlled evaluation of Trypticase soy broth in agar slide and conventional blood culture systems. 
  • Controlled evaluation of blood culture medium containing gelatin and V-factor-analog for detection of septicemia in children. 
  • Controlled evaluation of hypertonic sucrose medium at a 1:5 ratio of blood to broth for detection of bacteremia and fungemia in supplemented peptone broth. 
  • Controlled evaluation of hypertonic sucrose medium for detection of bacteremia and fungemia in supplemented peptone broth. 
  • Controlled evaluation of modified radiometric blood culture medium supplemented with gelatin for detection of bacteremia and fungemia. 
  • Controlled evaluation of supplemented peptone and Bactec blood culture broths for the detection of bacteremia and fungemia. 
  • Controlled evaluation of the agar-slide and radiometric blood culture systems for the detection of bacteremia and fungemia. 
  • Controlled evaluation of the effect of atmosphere of incubation on detection of bacteremia and fungemia in supplemented peptone broth. 
  • Controlled evaluation of the volume of blood cultured in detection of bacteremia and fungemia. 
  • Controlled evaluation of trypticase soy broth with and without gelatin and yeast extract in the detection of bacteremia and fungemia. 
  • Correlation of serum bactericidal activity with antimicrobial agent level and minimal bactericidal concentration. 
  • Cost and time savings following introduction of rejection criteria for clinical specimens. 
  • Cost-effectiveness of recombinant human activated protein C and the influence of severity of illness in the treatment of patients with severe sepsis. 
  • Critical care perspective on immunotherapy in lung transplantation. 
  • Culture-negative prosthetic valve endocarditis with concomitant septicemia due to a nontoxigenic Corynebacterium diphtheriae biotype gravis isolate in a patient with multiple risk factors. 
  • Cutaneous Burn Injury Promotes Shifts in the Bacterial Microbiome in Autologous Donor Skin: Implications for Skin Grafting Outcomes. 
  • Cutaneous manifestations of systemic infection in children. 
  • Damage- and pathogen-associated molecular patterns play differential roles in late mortality after critical illness. 
  • Defining sepsis on the wards: results of a multi-centre point-prevalence study comparing two sepsis definitions. 
  • Delayed Sternal Closure in Infant Heart Surgery-The Importance of Where and When: An Analysis of the STS Congenital Heart Surgery Database. 
  • Delirium is a robust predictor of morbidity and mortality among critically ill patients treated in the cardiac intensive care unit. 
  • Depressed interleukin-12-producing activity by monocytes correlates with adverse clinical course and a shift toward Th2-type lymphocyte pattern in severely injured male trauma patients. 
  • Derangement of the endothelial glycocalyx in sepsis. 
  • Derivation of a screen to identify severe sepsis and septic shock in the ED-BOMBARD vs. SIRS and qSOFA. 
  • Device-related infections in children. 
  • Diagnosis and management of sepsis-induced coagulopathy and disseminated intravascular coagulation. 
  • Diagnostic methods to determine microbiology of postpartum endometritis in South Asia: laboratory methods protocol used in the Postpartum Sepsis Study: a prospective cohort study. 
  • Differential diagnoses for sepsis-induced disseminated intravascular coagulation: communication from the SSC of the ISTH. 
  • Differential regulation of the PGC family of genes in a mouse model of Staphylococcus aureus sepsis. 
  • Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study. 
  • Discriminative value of inflammatory biomarkers for suspected sepsis. 
  • Disease caused by a marine Vibrio. Clinical characteristics and epidemiology. 
  • Disease progression in hemodynamically stable patients presenting to the emergency department with sepsis. 
  • Disseminated Nocardia caviae with positive blood cultures. 
  • Does IVIg administration yield improved immune function in very premature neonates? 
  • Does method of sternal repair influence long-term outcome of postoperative mediastinitis? 
  • Dopamine mediates vagal modulation of the immune system by electroacupuncture. 
  • Dopaminergic Control of Inflammation and Glycemia in Sepsis and Diabetes. 
  • Duration of empirical antibiotic therapy for infants suspected of early-onset sepsis. 
  • E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators. 
  • Early Blood Transfusions in Sepsis: Unchanged Survival and Increased Costs. 
  • Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units. 
  • Early propranolol treatment induces lung heme-oxygenase-1, attenuates metabolic dysfunction, and improves survival following experimental sepsis. 
  • Early sepsis does not increase the risk of late sepsis in very low birth weight neonates. 
  • Eastern equine encephalitis leading to multi-organ failure and sepsis. 
  • Effect of Catheter Dwell Time on Risk of Central Line-Associated Bloodstream Infection in Infants. 
  • Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. 
  • Effect of agitation and terminal subcultures on yield and speed of detection of the Oxoid Signal blood culture system versus the BACTEC radiometric system. 
  • Effect of altered headspace atmosphere on yield and speed of detection of the Oxoid Signal blood culture system versus the BACTEC radiometric system. 
  • Effect of an interleukin-1 receptor antagonist on the hemodynamic manifestations of group B streptococcal sepsis. 
  • Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial. 
  • Effectiveness of Granulocyte Colony-Stimulating Factor in Hospitalized Infants with Neutropenia. 
  • Effects of ATP-magnesium chloride on the cardiopulmonary manifestations of group B streptococcal sepsis in the piglet. 
  • Effects of HSP70.1/3 gene knockout on acute respiratory distress syndrome and the inflammatory response following sepsis. 
  • Effects of a leukotriene antagonist on the early hemodynamic manifestations of group B streptococcal sepsis in piglets. 
  • Effects of anti-CD18 monoclonal antibody, R15.7, on the cardiopulmonary manifestations of group B streptococcal sepsis in piglets. 
  • Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia. 
  • Effects of treatment with pentoxifylline on the cardiovascular manifestations of group B streptococcal sepsis in the piglet. 
  • Eicosanoids and the hemodynamic course of live Escherichia coli-induced sepsis in baboons. 
  • Elevated serum levels of matrix metalloproteinase-9 (MMP-9) in Kawasaki disease. 
  • Elucidating the role of genomics in neonatal sepsis. 
  • Emergency response teams in and outside of medicine-structurally crafted to be worlds apart. 
  • Emergent ureteric stent vs percutaneous nephrostomy for obstructive urolithiasis with sepsis: patterns of use and outcomes from a 15-year experience. 
  • Empirical antibiotic therapy for suspected early-onset bacterial sepsis. 
  • Endogenous Klebsiella endophthalmitis: case report. 
  • Endotoxin mediated-iNOS induction causes insulin resistance via ONOO⁻ induced tyrosine nitration of IRS-1 in skeletal muscle. 
  • Enteral glutamine supplementation for very low birth weight infants decreases morbidity. 
  • Epidemiology and outcome of major postoperative infections following cardiac surgery: risk factors and impact of pathogen type. 
  • Epidemiology of bloodstream infections in a bacille Calmette-Guérin-vaccinated pediatric population in Malawi. 
  • Epidemiology, Clinical and Microbiologic Profile and Risk Factors for Inpatient Mortality in Pediatric Severe Sepsis in the United States From 2003 to 2014: A Large Population Analysis. 
  • Ertapenem for the treatment of bloodstream infections due to ESBL-producing Enterobacteriaceae: a multinational pre-registered cohort study. 
  • Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. 
  • Etiology and complications of thrombocytopenia in hospitalized medical patients. 
  • Evaluation of modified trypticase soy broth versus supplemented peptone broth in the detection of bacteremia and fungemia. 
  • Evaluation of partial and total splenectomy in children with sickle cell disease using an Internet-based registry. 
  • Exercise activates vagal induction of dopamine and attenuates systemic inflammation. 
  • Experience with minimal complications in implanted catheters in children. 
  • Extracellular Mitochondrial DNA and N-Formyl Peptides in Trauma and Critical Illness: A Systematic Review. 
  • Familial deficiency of the seventh component of complement associated with recurrent bacteremic infections due to Neisseria. 
  • Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis. 
  • Field evaluation and comparison of five methods of sampling lead dust on carpets. 
  • Fluoroquinolone prophylaxis reduces febrile neutropenia, bloodstream infections from mucosal translocations, and intensive care admissions in high risk hematological patients, a single center experience. 
  • GLUTAMINE PREVENTS ACTIVATION OF NF-kappaB AND STRESS KINASE PATHWAYS, ATTENUATES INFLAMMATORY CYTOKINE RELEASE, AND PREVENTS ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) FOLLOWING SEPSIS. 
  • Gardnerella vaginalis bacteremia: a review of thirty cases. 
  • Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans. 
  • Genome-wide association study of sepsis in extremely premature infants. 
  • Genomic analyses: a neonatology perspective. 
  • Glucocorticoid therapy in sepsis/shock caused by gram-negative microorganisms. 
  • Glucose Activates Vagal Control of Hyperglycemia and Inflammation in Fasted Mice. 
  • Glutamine attenuates inflammation and NF-kappaB activation via Cullin-1 deneddylation. 
  • Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expression. 
  • Glutamine in critical illness: the time has come, the time is now. 
  • Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1. 
  • Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemia. 
  • Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression. 
  • Glutamine: role in gut protection in critical illness. 
  • Gram-negative sepsis and endotoxic shock (lecture). 
  • Group A Streptococcus puerperal sepsis: an emerging obstetric infection? 
  • Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression. 
  • Hemoglobin conformation couples erythrocyte S-nitrosothiol content to O2 gradients. 
  • Hepatic and pancreatic resection in patients with end-stage renal disease: a propensity analysis. 
  • High Levels of Morbidity and Mortality Among Pediatric Hematopoietic Cell Transplant Recipients With Severe Sepsis: Insights From the Sepsis PRevalence, OUtcomes, and Therapies International Point Prevalence Study. 
  • High-mobility group box 1 (HMGB1) protein: friend and foe. 
  • High-mobility group box-1 isoforms as potential therapeutic targets in sepsis. 
  • Hmgb-1 as a therapeutic target for infectious and inflammatory disorders. 
  • Hospital charges and length of stay associated with septicemia among children hospitalized for leukemia treatment in the United States. 
  • Host gene expression profiling and in vivo cytokine studies to characterize the role of linezolid and vancomycin in methicillin-resistant Staphylococcus aureus (MRSA) murine sepsis model. 
  • Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis. 
  • Identification of Extremely Premature Infants at Low Risk for Early-Onset Sepsis. 
  • Identification of Metabolic Changes in Ileum, Jejunum, Skeletal Muscle, Liver, and Lung in a Continuous I.V. Pseudomonas aeruginosa Model of Sepsis Using Nontargeted Metabolomics Analysis. 
  • Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab. 
  • Immunization with Salmonella enterica serovar Typhimurium-derived outer membrane vesicles delivering the pneumococcal protein PspA confers protection against challenge with Streptococcus pneumoniae. 
  • Immunomodulatory and antimicrobial efficacy of intravenous immunoglobulin in bone marrow transplantation. 
  • Immunotherapy in neonatal sepsis: advances in treatment and prophylaxis. 
  • Immunothrombotic Activity of Damage-Associated Molecular Patterns and Extracellular Vesicles in Secondary Organ Failure Induced by Trauma and Sterile Insults. 
  • Impact of Early-Onset Sepsis and Antibiotic Use on Death or Survival with Neurodevelopmental Impairment at 2 Years of Age among Extremely Preterm Infants. 
  • Impact of encephalopathy on mortality in the sepsis syndrome. The Veterans Administration Systemic Sepsis Cooperative Study Group. 
  • Impaired systemic tetrahydrobiopterin bioavailability and increased dihydrobiopterin in adult falciparum malaria: association with disease severity, impaired microvascular function and increased endothelial activation. 
  • Importance of intravenous fluid dose and composition in surgical ICU patients. 
  • In Reply: Incidence and Predictive Factors of Sepsis Following Adult Spinal Deformity Surgery. 
  • In vitro and in silico analysis of annexin V binding to lymphocytes as a biomarker in emergency department sepsis studies. 
  • In vitro resistance to thrombin-induced platelet microbicidal protein among clinical bacteremic isolates of Staphylococcus aureus correlates with an endovascular infectious source. 
  • In-hospital outcomes of premature infants with severe bronchopulmonary dysplasia. 
  • Inadequate oral feeding as a barrier to discharge in moderately preterm infants. 
  • Incidence and Predictive Factors of Sepsis Following Adult Spinal Deformity Surgery. 
  • Incident stroke and mortality associated with new-onset atrial fibrillation in patients hospitalized with severe sepsis. 
  • Incorporating Interprofessional Evidenced-Based Sepsis Simulation Education for Certified Nursing Assistants (CNAs) and Licensed Care Providers Within Long-term Care Settings for Process and Quality Improvement. 
  • Increased expression of Toll-like receptors 2, 3, 4 and 7 mRNA in the kidney and intestine of a septic mouse model. 
  • Increased plasma arginase activity in human sepsis: association with increased circulating neutrophils. 
  • Increased use of surgical energy promotes methicillin-resistant Staphylococcus aureus colonization in rabbits following open ventral hernia mesh repair. 
  • Infection in late preterm infants. 
  • Infections in patients with cystic fibrosis following lung transplantation. 
  • Infectious complications after pulsatile-flow and continuous-flow left ventricular assist device implantation. 
  • Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis. 
  • Innovative bridging of the rural-urban divide: comparison of scope, safety, and impact of collaborative rural surgery camps and an urban surgical program. 
  • Internal Validation of the Sepsis in Obstetrics Score to Identify Risk of Morbidity From Sepsis in Pregnancy. 
  • Intravenous fluids in sepsis: what to use and what to avoid. 
  • Invasive bacterial and fungal infections among hospitalized HIV-infected and HIV-uninfected adults and adolescents in northern Tanzania. 
  • Iron deficiency in young Lebanese children: association with elevated blood lead levels. 
  • Isotonic fluids for volume resuscitation: is it really 6 liters of one, half a dozen of another? 
  • JAK2 inhibition prevents innate immune responses and rescues animals from sepsis. 
  • Lactobacillus rhamnosus GG and Bifidobacterium longum attenuate lung injury and inflammatory response in experimental sepsis. 
  • Late-onset sepsis in very low birth weight infants from singleton and multiple-gestation births. 
  • Left upper quadrant pain and intermittent bacteremia. 
  • Letter: Pneumococcemia with sarcoid-infiltrated spleen. 
  • Letter: Staphylococcal septicaemia and C.N.S. involvement. 
  • Limulus amebocyte lysate test in neonates. 
  • Lipopolysaccharide Potentiates Insulin-Driven Hypoglycemic Shock. 
  • Long-term follow-up of continuous flow left ventricular assist devices: complications and predisposing risk factors. 
  • Long-term outcomes following development of new-onset atrial fibrillation during sepsis. 
  • Long-term treatment with ruxolitinib for patients with myelofibrosis: 5-year update from the randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial. 
  • Major infection after pediatric cardiac surgery: a risk estimation model. 
  • Marrow transplantation for chronic myeloid leukemia: a randomized study comparing cyclophosphamide and total body irradiation with busulfan and cyclophosphamide. 
  • Mast cell stabilization improves survival by preventing apoptosis in sepsis. 
  • Maternal Deaths Due to Sepsis in the State of Michigan, 1999-2006. 
  • Maternal Morbidity After Previable Prelabor Rupture of Membranes. 
  • Maternal Super Obesity and Neonatal Morbidity after Term Cesarean Delivery. 
  • Maternal sepsis mortality and morbidity during hospitalization for delivery: temporal trends and independent associations for severe sepsis. 
  • Maternal sepsis update. 
  • Mediating Effects of Frailty Indicators on the Risk of Sepsis After Cancer. 
  • Meningococcemia and acquired complement deficiency. Association in patients with hepatic failure. 
  • Metabolomic derangements are associated with mortality in critically ill adult patients. 
  • Methicillin-resistant Staphylococcus aureus bloodstream infection surveillance: National Healthcare Safety Network's laboratory-identified event reporting versus traditional laboratory-confirmed bloodstream infection surveillance. 
  • Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. 
  • Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis. 
  • Mitochondrial respiration after sepsis and prolonged hypoxia. 
  • Modulation of cytokines and chemokines, limited pulmonary vascular bed permeability, and prevention of septicemia and death with ceftriaxone and interleukin-10 in pneumococcal pneumonia. 
  • Morbidity and mortality after pancreaticoduodenectomy in patients with borderline resectable type C clinical classification. 
  • Multiple nosocomial infections. An incidence study. 
  • Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis. 
  • Near-miss maternal mortality: cardiac dysfunction as the principal cause of obstetric intensive care unit admissions. 
  • Neisseria meningitidis and Neisseria gonorrhoeae bacteremia associated with C6, C7, or C8 deficiency. 
  • Neisseria meningitidis bacteremia in association with deficiency of the sixth component of complement. 
  • Neonatal Candida meningitis: significance of cerebrospinal fluid parameters and blood cultures. 
  • Neurodevelopmental outcome of extremely low birth weight infants with Candida infection. 
  • Neuroimmune perspectives in sepsis. 
  • New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey. 
  • New developments in geriatric surgery. 
  • New or Progressive Multiple Organ Dysfunction Syndrome in Pediatric Severe Sepsis: A Sepsis Phenotype With Higher Morbidity and Mortality. 
  • Newly Named Klebsiella aerogenes (formerly Enterobacter aerogenes) Is Associated with Poor Clinical Outcomes Relative to Other Enterobacter Species in Patients with Bloodstream Infection. 
  • Newly Proposed Sepsis-Induced Coagulopathy Precedes International Society on Thrombosis and Haemostasis Overt-Disseminated Intravascular Coagulation and Predicts High Mortality. 
  • Non-O1, non-O139 Vibrio cholerae septicemia at a tertiary care center in Beirut, Lebanon; a case report and review. 
  • Nosocomial infection in the NICU: a medical complication or unavoidable problem? 
  • Nosocomial infections in the elderly. Increased risk per hospital day. 
  • Nosocomial infections within the first month of solid organ transplantation. 
  • Novel insights for systemic inflammation in sepsis and hemorrhage. 
  • Nurse staffing and adverse events in hospitalized children. 
  • Nutrition Therapy in Sepsis. 
  • Nutrition, cancer, and intravenous hyperalimentation. 
  • Organ protective mechanisms common to extremes of physiology: a window through hibernation biology. 
  • Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis. 
  • Outcome of Immediate Versus Early Antibiotics in Severe Sepsis and Septic Shock: A Systematic Review and Meta-analysis. 
  • Outcomes of left ventricular assist device implantation as destination therapy in the post-REMATCH era: implications for patient selection. 
  • Overview of first-line amikacin therapy for urologic infections. 
  • Oxidative metabolism in rat hepatocytes and mitochondria during sepsis. 
  • Oxidative stress and adenine nucleotide control of mitochondrial permeability transition. 
  • Pelvic exenteration for the treatment of locally advanced colorectal and bladder malignancies in the modern era. 
  • Peripheral Blood Mononuclear Cells Demonstrate Mitochondrial Damage Clearance During Sepsis. 
  • Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis. 
  • Personality Traits and Performance Contracts: Evidence from a Field Experiment among Maternity Care Providers in India 
  • Phenoxybenzamine in septic shock. 
  • Phosphate-containing polyethylene glycol polymers prevent lethal sepsis by multidrug-resistant pathogens. 
  • Poor Oral Health Linked with Increased Risk of Infectious Complications in Adults with Leukemia. 
  • Postprocedure sepsis in imaging-guided percutaneous hepatic abscess drainage: how often does it occur? 
  • Potential Impact of the 2016 Consensus Definitions of Sepsis and Septic Shock on Future Sepsis Research. 
  • Predicting Mortality for Adolescent and Adult Patients with Fever in Resource-Limited Settings. 
  • Prediction of Early Death in Patients With Sepsis-Associated Coagulation Disorder Treated With Antithrombin Supplementation. 
  • Prehospital sepsis care: Understanding provider knowledge, behaviors, and attitudes. 
  • Presence of gingivitis and periodontitis significantly increases hospital charges in patients undergoing heart valve surgery. 
  • Prevalence of congenital or acquired complement deficiency in patients with sporadic meningococcal disease. 
  • Prevalence, Underlying Causes, and Preventability of Sepsis-Associated Mortality in US Acute Care Hospitals. 
  • Prevention and treatment of nosocomial sepsis in the NICU. 
  • Probiotic administration reduces mortality and improves intestinal epithelial homeostasis in experimental sepsis. 
  • Proinflammatory cytokines increase in sepsis after anti-adhesion molecule therapy. 
  • Propensity matched comparison of outcomes in older and younger patients after coronary artery bypass graft surgery. 
  • Prophylaxis with oral penicillin in children with sickle cell anemia. A randomized trial. 
  • Proposal of a two-step process for the diagnosis of sepsis-induced disseminated intravascular coagulation. 
  • Protecting the permeability pore and mitochondrial biogenesis. 
  • Protection of the endothelial glycocalyx by antithrombin in an endotoxin-induced rat model of sepsis. 
  • Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate. 
  • Pseudomonas putrefaciens bacteremia. 
  • Pseudomonas septicemia with nodules and bullae. 
  • Quality measures in high-risk pregnancies: Executive Summary of a Cooperative Workshop of the Society for Maternal-Fetal Medicine, National Institute of Child Health and Human Development, and the American College of Obstetricians and Gynecologists. 
  • RE: The prothrombin time ratio is not a more effective marker for evaluating sepsis-induced coagulopathy than fibrin-related markers: Response to the Letter-to-the-Editor by Dr Wada. 
  • Random forest modeling can predict infectious complications following trauma laparotomy. 
  • Rapid detection of Enterococcus spp. direct from blood culture bottles using Enterococcus QuickFISH method: a multicenter investigation. 
  • Rare cause of back pain: Staphylococcus aureus vertebral osteomyelitis complicated by recurrent epidural abscess and severe sepsis. 
  • Reactive oxygen species produced by liver mitochondria of rats in sepsis. 
  • Recent advances in the research and management of sepsis-associated DIC. 
  • Recent and innovative methods for detection of bacteremia and fungemia. 
  • Recognition, prevention, and treatment of home total parenteral nutrition central venous access complications. 
  • Recombinant human soluble thrombomodulin in patients with sepsis-associated coagulopathy (SCARLET): an updated meta-analysis. 
  • Recovery from disseminated candidiasis in a premature neonate. 
  • Recurrent pseudobacteremias traced to a radiometric blood culture device. 
  • Reducing central venous catheter-related bloodstream infections in children with cancer. 
  • Rejection criteria for endotracheal aspirates from pediatric patients. 
  • Relationship between B-type natriuretic peptide and adverse outcome in patients with clinical evidence of sepsis presenting to the emergency department. 
  • Relevance of the number of positive bottles in determining clinical significance of coagulase-negative staphylococci in blood cultures. 
  • Reoperation for bleeding in patients undergoing coronary artery bypass surgery: incidence, risk factors, time trends, and outcomes. 
  • Response. 
  • Reversing established sepsis with antagonists of endogenous high-mobility group box 1. 
  • Risk Factors for Mortality in Pediatric Postsurgical versus Medical Severe Sepsis. 
  • Risk Factors for Postpartum Septic Pelvic Thrombophlebitis: A Multicenter Cohort. 
  • Risk Factors, Etiologies, and Screening Tools for Sepsis in Pregnant Women: A Multicenter Case-Control Study. 
  • Risk factors and prevention of late-onset sepsis in premature infants. 
  • Risk factors for ineffective therapy in patients with bloodstream infection. 
  • Safety and potential efficacy of an aerosolized surfactant in human sepsis-induced adult respiratory distress syndrome. 
  • Safety of histamine-2 receptor blockers in hospitalized VLBW infants. 
  • Safety profile of recombinant factor VIIa. 
  • Scientific and clinical challenges in sepsis. 
  • Seasonal variation in the etiology of bloodstream infections in a febrile inpatient population in a developing country. 
  • Sepsis Resuscitation in Resource-Limited Settings. 
  • Sepsis in Pregnancy: Identification and Management. 
  • Sepsis in the interventional radiology patient. 
  • Sepsis in the interventional radiology patient. 
  • Sepsis in young infants with congenital heart disease. 
  • Sepsis may not be a risk factor for mortality in patients with acute kidney injury treated with continuous renal replacement therapy. 
  • Sepsis redefined: the search for surrogate markers. 
  • Sepsis, multiple organ failure, and death due to Pandoraea pnomenusa infection after lung transplantation. 
  • Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation. 
  • Sepsis-Induced Coagulopathy and Japanese Association for Acute Medicine DIC in Coagulopathic Patients with Decreased Antithrombin and Treated by Antithrombin. 
  • Sepsis-induced Coagulopathy and Disseminated Intravascular Coagulation. 
  • Sepsis-induced disseminated intravascular coagulation, symmetrical peripheral gangrene, and amputations. 
  • Septic risk increases with apheresis platelet storage time. 
  • Serious infections among unselected patients with ST-elevation myocardial infarction treated with contemporary primary percutaneous coronary intervention. 
  • Serotypes and penicillin susceptibility of pneumococci isolated from blood. 
  • Short-course therapy for bloodstream infections in immunocompetent adults. 
  • Short-course therapy for catheter-associated Staphylococcus aureus bacteremia. 
  • Significance of blood stream infection after lung transplantation: analysis in 176 consecutive patients. 
  • Simultaneous pancreas/kidney transplantation--a comparison of enteric and bladder drainage of exocrine pancreatic secretions. 
  • Site Variability in Regulatory Oversight for an International Study of Pediatric Sepsis. 
  • Six subphenotypes in septic shock: Latent class analysis of the PROWESS Shock study. 
  • Six-month follow-up of patients with in-hospital thrombocytopenia during heparin-based anticoagulation (from the Complications After Thrombocytopenia Caused by Heparin [CATCH] registry). 
  • Sleeping to survive?: The impact of volatile anesthetics on mortality in sepsis. 
  • Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis. 
  • Staphylococcus aureus sepsis and mitochondrial accrual of the 8-oxoguanine DNA glycosylase DNA repair enzyme in mice. 
  • Staphylococcus aureus sepsis induces early renal mitochondrial DNA repair and mitochondrial biogenesis in mice. 
  • Staphylococcus aureus septicemia mimicking fulminant Rocky Mountain spotted fever. 
  • Statins and delirium during critical illness: a multicenter, prospective cohort study. 
  • Structural basis for the proinflammatory cytokine activity of high mobility group box 1. 
  • Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis. 
  • Sustenance of endothelial cell stability in septic mice through appropriate activation of transient receptor potential vanilloid-4. 
  • Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: infection and sepsis. 
  • The "cytokine profile": a code for sepsis. 
  • The Association of Nutrition Status Expressed as Body Mass Index z Score With Outcomes in Children With Severe Sepsis: A Secondary Analysis From the Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study. 
  • The GENESIS project (GENeralized Early Sepsis Intervention Strategies): a multicenter quality improvement collaborative. 
  • The Ibadan conjoined twins: a report of omphalopagus twins and a review of cases reported in Nigeria over 60 years. 
  • The authors reply. 
  • The authors reply. 
  • The authors reply. 
  • The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. I. Laboratory and epidemiologic observations. 
  • The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. II. Clinical observations, with special reference to factors influencing prognosis. 
  • The decline of typhoid and the rise of non-typhoid salmonellae and fungal infections in a changing HIV landscape: bloodstream infection trends over 15 years in southern Vietnam. 
  • The development and evaluation of a community-based clinical diagnosis tool and treatment regimen for postpartum sepsis in Bangladesh and Pakistan. 
  • The diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin in the prediction of acute kidney injury in emergency department patients with suspected sepsis. 
  • The dynamics of disease progression in sepsis: Markov modeling describing the natural history and the likely impact of effective antisepsis agents. 
  • The effect of prophylactic intravenous immune globulin on the incidence of septicemia in marrow transplant recipients. 
  • The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. 
  • The epidemiology of chronic critical illness in the United States*. 
  • The immune consequences of trauma. 
  • The impact of caspase-12 on susceptibility to candidemia. 
  • The impact of septicemia occurring during hospitalization for renal transplantation procedures on outcomes in adults in United States. 
  • The neuronal strategy for inflammation. 
  • The recommended dose of idarucizumab may not always be sufficient for sustained reversal of dabigatran. 
  • The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up. 
  • The role of leukotrienes in the late hemodynamic manifestations of group B streptococcal sepsis in piglets. 
  • The role of the maternal-fetal medicine subspecialist in review and prevention of maternal deaths. 
  • The smart activatable P2&3TT probe allows accurate, fast, and highly sensitive detection of Staphylococcus aureus in clinical blood culture samples. 
  • The value of an infectious diseases specialist. 
  • Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis. 
  • Thrombomodulin in disseminated intravascular coagulation and other critical conditions-a multi-faceted anticoagulant protein with therapeutic potential. 
  • Timing of Multiorgan Dysfunction among Hospitalized Infants with Fatal Fulminant Sepsis. 
  • Tissue expansion of the lower limb: complications in a cohort of 103 cases. 
  • Toll-Like Receptors -2, -3, -4 and -7 Expression Patterns in the Liver of a CLP-Induced Sepsis Mouse Model. 
  • Toll-like receptors in the pathogenesis of human disease. 
  • Torulopsis glabrata fungemia--a clinical pathological study. 
  • Total parenteral nutrition in pancreatic disease. 
  • Total parenteral nutrition. 
  • Total shoulder arthroplasty in patients with HIV infection: complications, comorbidities, and trends. 
  • Tracheostomy After Operations for Congenital Heart Disease: An Analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database. 
  • Tracking down systemic viral infections. 
  • Treatment with neuromuscular blocking agents and the risk of in-hospital mortality among mechanically ventilated patients with severe sepsis. 
  • Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses. 
  • Ultrastructural changes in skeletal muscle mitochondria in gram-negative sepsis. 
  • Unique Case of Disseminated Plague With Multifocal Osteomyelitis. 
  • Unphosphorylated STAT3 modulates alpha 7 nicotinic receptor signaling and cytokine production in sepsis. 
  • Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters. 
  • Untangling Health Trajectories among Patients with Sepsis. 
  • Urinary tract infection concordance with positive blood and cerebrospinal fluid cultures in the neonatal intensive care unit. 
  • Urologic sepsis/shock. 
  • Use of extracorporeal membrane oxygenation and associated outcomes in children hospitalized for sepsis in the United States: A large population-based study. 
  • Use of the complete blood cell count in early-onset neonatal sepsis. 
  • Use of the complete blood cell count in late-onset neonatal sepsis. 
  • Usefulness of Measuring Changes in SOFA Score for the Prediction of 28-Day Mortality in Patients With Sepsis-Associated Disseminated Intravascular Coagulation. 
  • Utility of extended blood culture incubation for isolation of Haemophilus, Actinobacillus, Cardiobacterium, Eikenella, and Kingella organisms: a retrospective multicenter evaluation. 
  • VA/Q abnormalities during gram negative sepsis. 
  • Vancomycin Heteroresistance and Clinical Outcomes in Bloodstream Infections Caused by Coagulase-Negative Staphylococci. 
  • Variability in determining sepsis time zero and bundle compliance rates for the centers for medicare and medicaid services SEP-1 measure. 
  • Very late onset infections in the neonatal intensive care unit. 
  • Very low birth weight neonates who survive early-onset sepsis do not have an increased risk of developing late-onset sepsis. 
  • Very low birth weight preterm infants with early onset neonatal sepsis: the predominance of gram-negative infections continues in the National Institute of Child Health and Human Development Neonatal Research Network, 2002-2003. 
  • Virulence of endemic nonpigmented northern Australian Staphylococcus aureus clone (clonal complex 75, S. argenteus) is not augmented by staphyloxanthin. 
  • What's in a name? Eponyms in head and neck imaging. 
  • What's new in Shock, July 2011? 
  • [Clinical comprehension of anaerobic bacteria]. 
  • β2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system. 
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  Keywords of People

  • Abbruzzese, James, D. C. I. Distinguished Professor of Medical Oncology, Medicine, Medical Oncology
  • Al-Hegelan, Mashael, Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine
  • Anderson, Ruth A., Professor Emerita in the School of Nursing, School of Nursing
  • Bao, Evangeline, Student, Basic Science Departments
  • Bartz, Raquel Rae, Associate Professor of Anesthesiology, Medicine, Pulmonary, Allergy, and Critical Care Medicine
  • Cohen-Wolkowiez, Michael, Professor of Pediatrics, Pediatrics, Infectious Diseases
  • Cunningham, Coleen Kathryn, Adjunct Professor in the Department of Pediatrics, Pediatrics
  • Kraft, Bryan David, Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine
  • Kussin, Peter Samuel, Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Science & Society
  • Levy, Jerrold Henry, Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Moehring, Rebekah, Associate Professor of Medicine, Medicine, Infectious Diseases
  • Moretti, Eugene William, Professor of Anesthesiology, School of Nursing
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery
  • Steinbach, William J., Samuel L. Katz Distinguished Professor of Pediatrics, Molecular Genetics and Microbiology
  • Tsalik, Ephraim, Associate Professor of Medicine, Molecular Genetics and Microbiology
  • Turner, David Ashley, Consulting Professor in the Department of Pediatrics, Pediatrics, Critical Care Medicine