APACHE

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  Subject Areas on Research

  • A brief report: the use of high-frequency oscillatory ventilation for severe pulmonary contusion. 
  • A comparison of three techniques for rapid model development: an application in patient risk-stratification. 
  • A descriptive evaluation of transfusion practices in patients receiving mechanical ventilation. 
  • A trial of thyroxine in acute renal failure. 
  • APOE polymorphism is associated with risk of severe sepsis in surgical patients. 
  • Acute pancreatitis and fulminant hepatic failure. 
  • Acute renal failure in recipients of organ transplantation and nontransplantation patients: comparison of characteristics and mortality. 
  • Admission cell free DNA levels predict 28-day mortality in patients with severe sepsis in intensive care. 
  • Aggressive versus conservative initiation of antimicrobial treatment in critically ill surgical patients with suspected intensive-care-unit-acquired infection: a quasi-experimental, before and after observational cohort study. 
  • An evaluation of factors influencing Bayesian learning systems. 
  • Association of gender with outcomes in critically ill patients. 
  • Circulating tetrahydrobiopterin concentrations in patients with septic shock. 
  • Comparison of caspofungin and amphotericin B for invasive candidiasis. 
  • Cost-effectiveness of recombinant human activated protein C and the influence of severity of illness in the treatment of patients with severe sepsis. 
  • Costs and outcomes among hemodialysis-dependent patients with methicillin-resistant or methicillin-susceptible Staphylococcus aureus bacteremia. 
  • D-dimer assay predicts mortality in critically ill patients without disseminated intravascular coagulation or venous thromboembolic disease. 
  • Decompressive laparotomy for refractory intracranial hypertension after traumatic brain injury. 
  • Delirium is a robust predictor of morbidity and mortality among critically ill patients treated in the cardiac intensive care unit. 
  • Development and preliminary evaluation of a telephone-based mindfulness training intervention for survivors of critical illness. 
  • Early acute lung injury: criteria for identifying lung injury prior to the need for positive pressure ventilation*. 
  • Early predictors of in-hospital death in infective endocarditis. 
  • Effect of neuromuscular blockers and opiates on the cerebrovascular response to endotracheal suctioning in adults with severe head injuries. 
  • Elevated troponin I levels in acute liver failure: is myocardial injury an integral part of acute liver failure? 
  • Evaluation of risk indices in continuous-flow left ventricular assist device patients. 
  • Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutrition. 
  • Identification of comatose patients at high risk for death or severe disability. SUPPORT Investigators. Understand Prognoses and Preferences for Outcomes and Risks of Treatments. 
  • Improvements in pulmonary and general critical care reduces mortality following ventilator-associated pneumonia. 
  • Necrotizing pancreatitis: diagnosis and management. 
  • Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients. 
  • Optimizing the dose of glutamine dipeptides and antioxidants in critically ill patients: a phase I dose-finding study. 
  • Outcome of lung transplant patients admitted to the medical ICU. 
  • Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments) 
  • Outcomes of Acute Kidney Injury in Patients With Severe ARDS Due to Influenza A(H1N1) pdm09 Virus. 
  • Patients with DNR orders in the operating room: surgery, resuscitation, and outcomes. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. 
  • Patterns of use of perioperative angiotensin-converting enzyme inhibitors in coronary artery bypass graft surgery with cardiopulmonary bypass: effects on in-hospital morbidity and mortality. 
  • Predictors of the severity of acute pancreatitis in patients with HIV infection or AIDS. 
  • Preventive use of noninvasive ventilation after extubation: a prospective, multicenter randomized controlled trial. 
  • Prognostic accuracy of Acute Physiology and Chronic Health Evaluation II scores in critically ill cancer patients. 
  • Prognostic and diagnostic value of plasma soluble suppression of tumorigenicity-2 concentrations in acute respiratory distress syndrome. 
  • Prognostic value of plasma N-terminal probrain natriuretic peptide levels in the acute respiratory distress syndrome. 
  • Relationship of body mass index to subsequent mortality among seriously ill hospitalized patients. SUPPORT Investigators. The Study to Understand Prognoses and Preferences for Outcome and Risks of Treatments. 
  • Risk factors for mortality in patients admitted to intensive care units with pneumonia. 
  • Risk factors for nosocomial pneumonia: comparing adult critical-care populations. 
  • Safety and potential efficacy of an aerosolized surfactant in human sepsis-induced adult respiratory distress syndrome. 
  • Standard subcutaneous dosing of unfractionated heparin for venous thromboembolism prophylaxis in surgical ICU patients leads to subtherapeutic factor Xa inhibition. 
  • The SUPPORT prognostic model. Objective estimates of survival for seriously ill hospitalized adults. Study to understand prognoses and preferences for outcomes and risks of treatments. 
  • The effect of tracheostomy delay time on outcome of patients with prolonged mechanical ventilation: A STROBE-compliant retrospective cohort study. 
  • The effectiveness of right heart catheterization in the initial care of critically ill patients. SUPPORT Investigators. 
  • The surgical intensive care unit optimal mobility score predicts mortality and length of stay. 
  • The utility of acute physiology and chronic health evaluation II scores for prediction of mortality among intensive care unit (ICU) and non-ICU patients with methicillin-resistant Staphylococcus aureus bacteremia. 
  • Towards precision medicine: Accurate predictive modeling of infectious complications in combat casualties. 
  • Transfusion of fresh frozen plasma in critically ill surgical patients is associated with an increased risk of infection. 
  • Withholding versus withdrawing life-sustaining treatment: patient factors and documentation associated with dialysis decisions. 
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  Keywords of People

  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Innovation & Entrepreneurship