Dipeptidyl Peptidase 4
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Subject Areas on Research
- Angiostatin directly inhibits human prostate tumor cell invasion by blocking plasminogen binding to its cellular receptor, CD26.
- Anti-tumor necrosis factor-alpha therapy augments dipeptidyl peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis.
- Association of plasminogen with dipeptidyl peptidase IV and Na+/H+ exchanger isoform NHE3 regulates invasion of human 1-LN prostate tumor cells.
- CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation.
- Cell surface adenosine deaminase binds and stimulates plasminogen activation on 1-LN human prostate cancer cells.
- Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis.
- Characterization of human serum dipeptidyl peptidase IV (CD26) and analysis of its autoantibodies in patients with rheumatoid arthritis and other autoimmune diseases.
- Characterization of the plasminogen receptors of normal and rheumatoid arthritis human synovial fibroblasts.
- Circulating Levels of Soluble Dipeptidyl Peptidase-4 Are Dissociated from Inflammation and Induced by Enzymatic DPP4 Inhibition.
- Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV.
- Dipeptidyl peptidase IV (DPP IV/CD26) is a cell-surface plasminogen receptor.
- Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26.
- Expression of renal cell protein markers is dependent on initial mechanical culture conditions.
- Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways.
- Gut peptides in the treatment of diabetes mellitus.
- In vitro and in vivo antitumor effect of the anti-CD26 monoclonal antibody 1F7 on human CD30+ anaplastic large cell T-cell lymphoma Karpas 299.
- Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic Mice.
- Interaction of plasminogen with dipeptidyl peptidase IV initiates a signal transduction mechanism which regulates expression of matrix metalloproteinase-9 by prostate cancer cells.
- New combination treatments in the management of diabetes: focus on sitagliptin-metformin.
- Novel genetic loci associated with hippocampal volume.
- Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans.
- Preclinical developments in type 2 diabetes.
- Rapid hepatic metabolism blunts the endocrine action of portally infused GLP-1 in male rats.
- Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus.
- Streptokinase promotes development of dipeptidyl peptidase IV (CD26) autoantibodies after fibrinolytic therapy in myocardial infarction patients.
- Suppression of food intake by glucagon-like peptide-1 receptor agonists: relative potencies and role of dipeptidyl peptidase-4.
- The binding site of human adenosine deaminase for CD26/Dipeptidyl peptidase IV: the Arg142Gln mutation impairs binding to cd26 but does not cause immune deficiency.
- The incretins and beta-cell health: contrasting glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 as a path to understand islet function in diabetes.
- The regulation of the lymphatic secretion of glucagon-like peptide-1 (GLP-1) by intestinal absorption of fat and carbohydrate.
- The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs.
- Utilizing the GLP-1 signaling system to treat diabetes: sorting through the pharmacologic approaches.