Inflammation Mediators

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  Subject Areas on Research

  • A Randomized Dose-Escalation Study of the Safety and Anti-Inflammatory Activity of the p38 Mitogen-Activated Protein Kinase Inhibitor Dilmapimod in Severe Trauma Subjects at Risk for Acute Respiratory Distress Syndrome. 
  • A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury. 
  • A mouse macrophage lipidome. 
  • A review of the application of inflammatory biomarkers in epidemiologic cancer research. 
  • Activation of EGF receptors mediates pulmonary vasoconstriction induced by residual oil fly ash. 
  • Acute effects of hyperinsulinemia and hyperglycemia on vascular inflammatory biomarkers and endothelial function in overweight and obese humans. 
  • Acute phase reaction in healthy volunteers after bronchoscopy with lavage. 
  • Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo. 
  • Adventures within the speckled band: heterogeneity, angiogenesis, and balanced inflammation in the tuberculous granuloma. 
  • Aerobic exercise attenuates airway inflammatory responses in a mouse model of atopic asthma. 
  • Age-related differences in biomarkers of acute inflammation during hospitalization for sepsis. 
  • Airway epithelium as an effector of inflammation: molecular regulation of secondary mediators. 
  • Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroids. 
  • Altered pulmonary response to hyperoxia in Clara cell secretory protein deficient mice. 
  • An Empirical Dietary Inflammatory Pattern Score Is Associated with Circulating Inflammatory Biomarkers in a Multi-Ethnic Population of Postmenopausal Women in the United States. 
  • Angiotensin II Type 1 receptor antibodies are associated with inflammatory cytokines and poor clinical outcomes in pediatric kidney transplantation. 
  • Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice. 
  • Anti-inflammatory effect of physical training in heart failure: role of TNF-alpha and IL-10. 
  • Anti-inflammatory signaling during ex vivo liver perfusion improves the preservation of pig liver grafts before transplantation. 
  • Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infection. 
  • Aortoesophageal fistula after thoracic aortic stent-graft placement: a rare but catastrophic complication of a novel emerging technique. 
  • Apolipoprotein E and neurological disease: therapeutic potential and pharmacogenomic interactions. 
  • Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A. 
  • Aprotinin and the systemic inflammatory response after cardiopulmonary bypass. 
  • Architectural and biochemical expressions of mustard gas keratopathy: preclinical indicators and pathogenic mechanisms. 
  • Are inflammatory factors related to retinal vessel caliber? The Beaver Dam Eye Study. 
  • Articular ankle fracture results in increased synovitis, synovial macrophage infiltration, and synovial fluid concentrations of inflammatory cytokines and chemokines. 
  • Attendance at religious services, interleukin-6, and other biological parameters of immune function in older adults. 
  • Augmented TNF-alpha and IL-10 production by primed human monocytes following interaction with oxidatively modified autologous erythrocytes. 
  • BLyS and APRIL in rheumatoid arthritis. 
  • Bacillus anthracis peptidoglycan stimulates an inflammatory response in monocytes through the p38 mitogen-activated protein kinase pathway. 
  • Biology of intracranial aneurysms: role of inflammation. 
  • Biomarker analysis by fluorokine multianalyte profiling distinguishes patients requiring intervention from patients with long-term quiescent coronary artery disease: a potential approach to identify atherosclerotic disease progression. 
  • Biomarkers in the diagnosis of anaphylaxis: making nature disclose her mysteries. 
  • Biomarkers of inflammation - LBP and TLR- predict progression of knee osteoarthritis in the DOXY clinical trial. 
  • Biopsychosocial influence on shoulder pain: Rationale and protocol for a pre-clinical trial. 
  • Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure. 
  • Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasia? 
  • Bone marrow chimeras and c-fms conditional ablation (Mafia) mice reveal an essential role for resident myeloid cells in lipopolysaccharide/TLR4-induced corneal inflammation. 
  • Brain death significantly reduces isolated pancreatic islet yields and functionality in vitro and in vivo after transplantation in rats. 
  • CD40 signaling of monocyte inflammatory cytokine synthesis through an ERK1/2-dependent pathway. A target of interleukin (il)-4 and il-10 anti-inflammatory action. 
  • CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes. 
  • CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis. 
  • Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. 
  • Calpain inhibition decreases inflammatory protein expression in vessel walls in a model of chronic myocardial ischemia. 
  • Changes in biomarkers of inflammation and bone turnover and associations with clinical efficacy following infliximab plus methotrexate therapy in patients with early rheumatoid arthritis. 
  • Chronic Systemic Immune Dysfunction in African-Americans with Small Vessel-Type Ischemic Stroke. 
  • Cigarette smoke and inflammation: role in cerebral aneurysm formation and rupture. 
  • Circulating adhesion molecules and inflammatory mediators in demyelination: a review. 
  • Circulating biomarkers for abdominal aortic aneurysm: what did we learn in the last decade? 
  • Coagulopathy and inflammation in neonatal heart surgery: mechanisms and strategies. 
  • Colchicine effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): study protocol for a randomized controlled trial. 
  • Commensal microbiota stimulate systemic neutrophil migration through induction of serum amyloid A. 
  • Complement activation and cardiac surgery: a novel target for improving outcomes. 
  • Control of IFN-alphaA by CD73: implications for mucosal inflammation. 
  • Coupling endoplasmic reticulum stress to cell death program in isolated human pancreatic islets: effects of gene transfer of Bcl-2. 
  • Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL/6 mouse brain. 
  • Cysteinyl leukotrienes in allergic inflammation: strategic target for therapy. 
  • DIO2 modifies inflammatory responses in chondrocytes. 
  • Differential Induction of Immunogenic Cell Death and Interferon Expression in Cancer Cells by Structured ssRNAs. 
  • Differential expression of systemic inflammatory mediators in amputees with chronic residual limb pain. 
  • Direct-contact co-culture between smooth muscle and endothelial cells inhibits TNF-alpha-mediated endothelial cell activation. 
  • Does obesity produce a distinct asthma phenotype? 
  • Drebrin regulates angiotensin II-induced aortic remodelling. 
  • Dynamic contrast-enhanced MRI promotes early detection of toxin-induced acute kidney injury. 
  • Early Immune Response to Acute Gastric Fluid Aspiration in a Rat Model of Lung Transplantation. 
  • Effect of Alemtuzumab (CAMPATH 1-H) in patients with inclusion-body myositis. 
  • Effect of interleukin-1β on the expression of actin isoforms in cultured mouse astroglia. 
  • Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer. 
  • Effect of size fractionation on the toxicity of amosite and Libby amphibole asbestos. 
  • Effects of CoA-independent transacylase inhibitors on the production of lipid inflammatory mediators. 
  • Effects of regular endurance exercise on GlycA: Combined analysis of 14 exercise interventions. 
  • Effects of vorapaxar on platelet reactivity and biomarker expression in non-ST-elevation acute coronary syndromes. The TRACER Pharmacodynamic Substudy. 
  • Eicosanoids: lipid mediators of inflammation in transplantation. 
  • Emerging biomarkers in heart failure. 
  • Epicardial adipose tissue and carotid artery disease: Protocol for systematic review and meta-analysis. 
  • Exacerbation of systemic inflammation and increased cerebral infarct volume with cardiopulmonary bypass after focal cerebral ischemia in the rat. 
  • Exercise therapy as treatment for cardiovascular and oncologic disease after a diagnosis of early-stage cancer. 
  • Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections. 
  • Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis. 
  • Exposure to traffic pollution, acute inflammation and autonomic response in a panel of car commuters. 
  • Extrinsic coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide. 
  • Gait abnormalities and inflammatory cytokines in an autologous nucleus pulposus model of radiculopathy. 
  • Gene therapy to manipulate effector T cell trafficking to tumors for immunotherapy. 
  • GlycA Is a Novel Biomarker of Inflammation and Subclinical Cardiovascular Disease in Psoriasis. 
  • Gout, hyperuricemia, and the risk of cardiovascular disease: cause and effect? 
  • Hepcidin expression in human airway epithelial cells is regulated by interferon-γ. 
  • Human peripheral mononuclear cells do not show proinflammatory patterns of cytokine transcription in early trauma: a preliminary report. 
  • Hypersecretion of mucin in response to inflammatory mediators by guinea pig tracheal epithelial cells in vitro is blocked by inhibition of nitric oxide synthase. 
  • Immune mechanisms in inflammatory and degenerative eye disease. 
  • Impact of vitamin D supplementation on inflammatory markers in African Americans: results of a four-arm, randomized, placebo-controlled trial. 
  • Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation. 
  • Induction and Characterization of the Allergic Eye Disease Mouse Model. 
  • Induction of an Inflammatory Response in Primary Hepatocyte Cultures from Mice. 
  • Inflammation and circulating endothelial progenitor cells in patients with coronary artery disease and residual platelet reactivity. 
  • Inflammation and elevated levels of fibroblast growth factor 23 are independent risk factors for death in chronic kidney disease. 
  • Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis. 
  • Inflammation markers and their trajectories after deep vein thrombosis in relation to risk of post-thrombotic syndrome. 
  • Inflammatory Cytokines and Matrix Metalloproteinases in the Synovial Fluid After Intra-articular Ankle Fracture. 
  • Inflammatory Microenvironment Persists After Bone Healing in Intra-articular Ankle Fractures. 
  • Inflammatory Response of Human Gestational Membranes to Ureaplasma parvum Using a Novel Dual-Chamber Tissue Explant System. 
  • Inflammatory cytokines and cellular metabolites as synovial fluid biomarkers of posttraumatic ankle arthritis. 
  • Inflammatory markers in schizophrenia: comparing antipsychotic effects in phase 1 of the clinical antipsychotic trials of intervention effectiveness study. 
  • Influence of platelet reactivity and inflammation on peri-procedural myonecrosis in East Asian patients undergoing elective percutaneous coronary intervention. 
  • Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis. 
  • Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis. 
  • Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury. 
  • Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells. 
  • Ischemia/reperfusion injury in microvascular surgery. 
  • Late stage erythroid precursor production is impaired in mice with chronic inflammation. 
  • Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis. 
  • Leptin metabolically licenses T cells for activation to link nutrition and immunity. 
  • Leptin selectively augments thymopoiesis in leptin deficiency and lipopolysaccharide-induced thymic atrophy. 
  • Lessons of War: Turning Data Into Decisions. 
  • Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats. 
  • Lipomatosis-associated inflammation and excess collagen may contribute to lower relative resting energy expenditure in women with adiposis dolorosa. 
  • Liver disease in menopause. 
  • MAP kinase and pain. 
  • MARCKS-related peptide modulates in vivo the secretion of airway Muc5ac. 
  • Mast cell activation by Mycobacterium tuberculosis: mediator release and role of CD48. 
  • Mast cell modulation of immune responses to bacteria. 
  • Mast cell-derived particles deliver peripheral signals to remote lymph nodes. 
  • Mast cells and basophils in innate immunity. 
  • Mechanisms of inflammation and leukocyte activation. 
  • Mechanisms of nonimmunological histamine and tryptase release from human cutaneous mast cells. 
  • Mechanisms of prostanoid synthesis in human synovial cells: cytokine-peptide synergism. 
  • Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation. 
  • Mitochondrial Quality Control as a Therapeutic Target. 
  • Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. 
  • Multiple markers of inflammation and weight status: cross-sectional analyses throughout childhood. 
  • Multiplex assay reliability and long-term intra-individual variation of serologic inflammatory biomarkers. 
  • Murine CMV induces type 1 IFN that impairs differentiation of MDSCs critical for transplantation tolerance. 
  • Neuroinflammation and Central Sensitization in Chronic and Widespread Pain. 
  • Neuroinflammation in Alzheimer's disease. 
  • Neutral effect on markers of heart failure, inflammation, endothelial activation and function, and vagal tone after high-dose HMG-CoA reductase inhibition in non-diabetic patients with non-ischemic cardiomyopathy and average low-density lipoprotein level. 
  • Nitric oxide as an inflammatory mediator in autoimmune MRL-lpr/lpr mice. 
  • Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair. 
  • Novel role of platelet reactivity in adverse left ventricular remodelling after ST-segment elevation myocardial infarction: The REMODELING Trial. 
  • Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice. 
  • Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods. 
  • ONZIN deficiency attenuates contact hypersensitivity responses in mice. 
  • Oxygen, nitric oxide and articular cartilage. 
  • Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation. 
  • Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation. 
  • Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery. 
  • Persistent systemic inflammation in chronic critical illness. 
  • Phenotypic and functional maturation of dendritic cells mediated by heparan sulfate. 
  • Plasma des-acyl ghrelin, but not plasma HMW adiponectin, is a useful cardiometabolic marker for predicting atherosclerosis in elderly hypertensive patients. 
  • Poor oral health is associated with coronary heart disease and elevated systemic inflammatory and haemostatic factors. 
  • Proinflammatory actions of thromboxane receptors to enhance cellular immune responses. 
  • Proinflammatory cytokines increase in sepsis after anti-adhesion molecule therapy. 
  • Proinflammatory state, hepcidin, and anemia in older persons. 
  • Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes. 
  • Pulmonary and systemic host response to Streptococcus pneumoniae and Klebsiella pneumoniae bacteremia in normal and immunosuppressed mice. 
  • Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague-Dawley rats. 
  • Pulmonary surfactant mitigates silver nanoparticle toxicity in human alveolar type-I-like epithelial cells. 
  • Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations. 
  • Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery. 
  • Regulation of chondrocytic gene expression by biomechanical signals. 
  • Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure: A Scientific Statement From the American Heart Association. 
  • Role of Fn14 in acute alcoholic steatohepatitis in mice. 
  • Role of inflammation in nonalcoholic steatohepatitis. 
  • Role of mast cells in inflammatory bowel disease and inflammation-associated colorectal neoplasia in IL-10-deficient mice. 
  • Role of miR-204 in the regulation of apoptosis, endoplasmic reticulum stress response, and inflammation in human trabecular meshwork cells. 
  • Serum C-reactive protein level and prehypertension in two Asian populations. 
  • Serum Calprotectin as a Novel Biomarker in Abdominal Aortic Aneurysm Pathogenesis and Progression: Preliminary Data from Experimental Model in Rats. 
  • Serum levels of the proinflammatory cytokines interleukin-1 beta (IL-1beta), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls. 
  • Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis. 
  • Soluble Inflammatory Markers and Risk of Incident Fractures in Older Adults: The Cardiovascular Health Study. 
  • Soluble urokinase-type plasminogen activator receptor: a useful biomarker for coronary artery disease and clinical outcomes? 
  • Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation. 
  • Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation. 
  • Statin therapy and thromboxane generation in patients with coronary artery disease treated with high-dose aspirin. 
  • Suppression of the c-Jun N-terminal kinase pathway by 17beta-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction. 
  • Sustained stress response after oxidative stress in trabecular meshwork cells. 
  • Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain. 
  • TB: the Yin and Yang of lipid mediators. 
  • TSG-6 - a double-edged sword for osteoarthritis (OA). 
  • Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis. 
  • Targeted therapies and outcomes data: the inflammatory hypothesis matures. 
  • Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis. 
  • Targets to tackle--the pathophysiology of the disease. 
  • Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice. 
  • The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy. 
  • The Evolving Role of Specialized Pro-resolving Mediators in Modulating Neuroinflammation in Perioperative Neurocognitive Disorders. 
  • The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia. 
  • The Phosphate Binder Ferric Citrate and Mineral Metabolism and Inflammatory Markers in Maintenance Dialysis Patients: Results From Prespecified Analyses of a Randomized Clinical Trial. 
  • The anti-inflammatory actions of platelet endothelial cell adhesion molecule-1 do not involve regulation of endothelial cell NF-kappa B. 
  • The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators. 
  • The impact of heparin compounds on cellular inflammatory responses: a construct for future investigation and pharmaceutical development. 
  • The influence of oxygen tension on the induction of nitric oxide and prostaglandin E2 by mechanical stress in articular cartilage. 
  • The involvement of superoxide and iNOS-derived NO in cardiac dysfunction induced by pro-inflammatory cytokines. 
  • The molecular mechanisms underlying the proinflammatory actions of thiazolidinediones in human macrophages. 
  • The nephritogenic immune response. 
  • The role of biomechanics and inflammation in cartilage injury and repair. 
  • Time course of LPS-induced gene expression in a mouse model of genitourinary inflammation. 
  • Time-Dependent Effects on Synovial Fluid Composition During the Acute Phase of Human Intra-articular Ankle Fracture. 
  • Tollip SNP rs5743899 modulates human airway epithelial responses to rhinovirus infection. 
  • Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes. 
  • Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol. 
  • Upregulation of IL-1β, IL-6, and CCL-2 by a novel mouse model of pancreatic ischemia-reperfusion injury. 
  • [Bradykinin modulates ion channel in inflammatory pain]. 
  • mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice. 
  • p38 MAPK, microglial signaling, and neuropathic pain. 
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  Keywords of People

  • Eppensteiner, John C, Medical Instructor in the Department of Surgery, Surgery, Emergency Medicine
  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Innovation & Entrepreneurship
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • Olson, Steven Arthur, Professor of Orthopaedic Surgery, Orthopaedics
  • Pastva, Amy Martha, Associate Professor in Orthopaedic Surgery, Cell Biology
  • Sanchez-Perez, Luis Ariel, Assistant Professor of Neurosurgery, Neurosurgery
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology
  • Taylor, Gregory Alan, Associate Professor in Medicine, Immunology
  • Tobin, David M., Associate Professor of Molecular Genetics and Microbiology, Immunology
  • Turi, Jennifer Lilly, Associate Professor of Pediatrics, Pediatrics, Critical Care Medicine
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, in the School of Medicine, Immunology