HSP70 Heat-Shock Proteins

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  Subject Areas on Research

  • A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch. 
  • A new (heat) shocking player in cardiac hypertrophy. 
  • Adenosine nucleotides and the regulation of GRP94-client protein interactions. 
  • Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells. 
  • Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells. 
  • An Enrichment Strategy For Sepsis Clinical Trials. 
  • An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target. 
  • Analyses of promoter-proximal pausing by RNA polymerase II on the hsp70 heat shock gene promoter in a Drosophila nuclear extract. 
  • Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers. 
  • Association of hsp70-2 and hsp-hom gene polymorphisms with risk of acute high-altitude illness in a Chinese population. 
  • Barrett's esophagus and β-carotene therapy: symptomatic improvement in GERD and enhanced HSP70 expression in esophageal mucosa. 
  • Benzo(a)pyrene inhibits expression of inducible heat shock protein 70 in vascular endothelial cells. 
  • Biochemical, cell biological and immunological issues surrounding the endoplasmic reticulum chaperone GRP94/gp96. 
  • Calreticulin displays in vivo peptide-binding activity and can elicit CTL responses against bound peptides. 
  • Capturing intrinsic nanomechanics of allostery. 
  • Cardioprotective effects of 70-kDa heat shock protein in transgenic mice. 
  • Chaperone-mediated cross-priming: a hitchhiker's guide to vesicle transport (review). 
  • Characterization of a recombinant adenovirus vector encoding heat-inducible feline interleukin-12 for use in hyperthermia-induced gene-therapy. 
  • Combining Prognostic and Predictive Enrichment Strategies to Identify Children With Septic Shock Responsive to Corticosteroids. 
  • Come forth CD1d: Hsp110 in the regulation of intestinal epithelial CD1d expression. 
  • Continuous contractile activity induces fiber type specific expression of HSP70 in skeletal muscle. 
  • Correlation of lymphocyte heat shock protein 70 levels with neurologic deficits in elderly patients with cerebral infarction. 
  • Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody. 
  • Development of a Grp94 inhibitor. 
  • Early gene changes in myocardial ischemia. 
  • Effects of HSP70.1/3 gene knockout on acute respiratory distress syndrome and the inflammatory response following sepsis. 
  • Effects of handling on heat shock protein expression in rainbow trout (Oncorhynchus mykiss). 
  • Endoplasmic reticulum chaperone GRP94 subunit assembly is regulated through a defined oligomerization domain. 
  • Enhancement of cancer radiation therapy by use of adenovirus-mediated secretable glucose-regulated protein 94/gp96 expression. 
  • Evolution. Chaperones as buffering agents? 
  • Exogenous Hsp70 delays senescence and improves cognitive function in aging mice. 
  • Expression of HSP70 in peripheral lymphocytes of the patients with allergic rhinitis. 
  • FGF signaling regulates rod photoreceptor cell maintenance and regeneration in zebrafish. 
  • Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury. 
  • Fluorescent-Linked Enzyme Chemoproteomic Strategy (FLECS) for Identifying HSP70 Inhibitors. 
  • Focal gene induction in the liver of rats by a heat-inducible promoter using focused ultrasound hyperthermia: preliminary results. 
  • Frequency-specific association of antibodies against heat shock proteins 60 and 70 with noise-induced hearing loss in Chinese workers. 
  • GFP-moesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila. 
  • GRP94-associated enzymatic activities. Resolution by chromatographic fractionation. 
  • GRP94/gp96 elicits ERK activation in murine macrophages. A role for endotoxin contamination in NF-kappa B activation and nitric oxide production. 
  • Global transcriptional and proteomic analysis of the Sig1 heat shock regulon of Deinococcus radiodurans. 
  • Glucose-regulated protein 94/glycoprotein 96 elicits bystander activation of CD4+ T cell Th1 cytokine production in vivo. 
  • Glutamine attenuates endotoxin-induced lung metabolic dysfunction: potential role of enhanced heat shock protein 70. 
  • Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expression. 
  • Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity. 
  • Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1. 
  • Glutamine prevents apoptosis in intestinal epithelial cells and induces differential protective pathways in heat and oxidant injury models. 
  • Glutamine protects intestinal epithelial cells: role of inducible HSP70. 
  • Glutamine therapy improves outcome of in vitro and in vivo experimental colitis models. 
  • Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression. 
  • Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control. 
  • HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. 
  • HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells. 
  • Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades. 
  • Heat shock protein 70 (HSP70) does not prevent the inhibition of cell growth in DU-145 cells treated with TGF-beta1. 
  • Heat shock protein 70-binding protein 1 is highly expressed in high-grade gliomas, interacts with multiple heat shock protein 70 family members, and specifically binds brain tumor cell surfaces. 
  • Heat shock proteins HSP27 and HSP70 are present in the skin and are important mediators of allergic contact hypersensitivity. 
  • Heat-induced gene expression as a novel targeted cancer gene therapy strategy. 
  • High intensity focused ultrasound-induced gene activation in solid tumors. 
  • Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy. 
  • Hsp70 and the Cochaperone StiA (Hop) Orchestrate Hsp90-Mediated Caspofungin Tolerance in Aspergillus fumigatus. 
  • Human erythrocyte clathrin and clathrin-uncoating protein. 
  • Hypopharyngeal pepsin and Sep70 as diagnostic markers of laryngopharyngeal reflux: preliminary study. 
  • Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. 
  • Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94. 
  • Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity. 
  • Improved Risk Stratification in Pediatric Septic Shock Using Both Protein and mRNA Biomarkers. PERSEVERE-XP. 
  • Increased expression of the glucose-regulated gene encoding the Mr 78,000 glucose-regulated protein in chemically and radiation-transformed C3H 10T1/2 mouse embryo cells. 
  • Induction of the human heat shock promoter HSP70B by nutritional stress: implications for cancer gene therapy. 
  • Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules. 
  • Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. 
  • Interaction of endoplasmic reticulum chaperone GRP94 with peptide substrates is adenine nucleotide-independent. 
  • Involvement of two putative alternative sigma factors in stress response of the radioresistant bacterium Deinococcus radiodurans. 
  • John M. Kinney International Award for General Nutrition. Glutamine, heat shock protein, and inflammation--opportunity from the midst of difficulty. 
  • L-Threonine induces heat shock protein expression and decreases apoptosis in heat-stressed intestinal epithelial cells. 
  • Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone, GRP94. I. Evidence for allosteric regulation of ligand binding. 
  • Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone, GRP94. II. Ligand-mediated activation of GRP94 molecular chaperone and peptide binding activity. 
  • Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer. 
  • Molecular markers of early Parkinson's disease based on gene expression in blood. 
  • Mortalin is regulated by APOE in hippocampus of AD patients and by human APOE in TR mice. 
  • Nutrition Modulation of Cardiotoxicity and Anticancer Efficacy Related to Doxorubicin Chemotherapy by Glutamine and ω-3 Polyunsaturated Fatty Acids. 
  • Optimized regimen for expression of heat-inducible Cre in mice. 
  • Oral glutamine enhances heat shock protein expression and improves survival following hyperthermia. 
  • Order out of disorder: working cycle of an intrinsically unfolded chaperone. 
  • Overexpressed heat shock protein 70 protects cells against DNA damage caused by ultraviolet C in a dose-dependent manner. 
  • Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions. 
  • P38MAP kinase, but not phosphoinositol-3 kinase, signal downstream of glutamine-mediated fibronectin-integrin signaling after intestinal injury. 
  • Parenteral glutamine increases serum heat shock protein 70 in critically ill patients. 
  • Parkin mediates the degradation-independent ubiquitination of Hsp70. 
  • Pediatric Sepsis Biomarker Risk Model-II: Redefining the Pediatric Sepsis Biomarker Risk Model With Septic Shock Phenotype. 
  • Pharmacologically dosed oral glutamine reduces myocardial injury in patients undergoing cardiac surgery: a randomized pilot feasibility trial. 
  • Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death. 
  • Plasma antibodies against heat shock protein 70 correlate with the incidence and severity of asthma in a Chinese population. 
  • Plasma antibodies to heat shock protein 60 and heat shock protein 70 are associated with increased risk of electrocardiograph abnormalities in automobile workers exposed to noise. 
  • Plasma levels of heat shock protein 70 in patients with prostate cancer: a potential biomarker for prostate cancer. 
  • Preparation of apoptotic tumor cells with replication-incompetent HSV augments the efficacy of dendritic cell vaccines. 
  • Purification and partial molecular characterization of GRP94, an ER resident chaperone. 
  • RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism. 
  • Receptor mediated and fluid phase pathways for internalization of the ER Hsp90 chaperone GRP94 in murine macrophages. 
  • Regulation and localization of HSP70 and HSP25 in the kidney of rats undergoing long-term administration of angiotensin II. 
  • Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes. 
  • Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. 
  • Rhodopsin maturation antagonized by dominant rhodopsin mutants. 
  • Role of chaperones in antigen processing. 
  • Role of heat shock protein and cytokine expression as markers of clinical outcomes with glutamine-supplemented parenteral nutrition in surgical ICU patients. 
  • SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin. 
  • Selective externalization of an ATP-binding protein structurally related to the clathrin-uncoating ATPase/heat shock protein in vesicles containing terminal transferrin receptors during reticulocyte maturation. 
  • Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. 
  • Sep70/Pepsin expression in hypopharynx combined with hypopharyngeal multichannel intraluminal impedance increases diagnostic sensitivity of laryngopharyngeal reflux. 
  • Serum and lymphocyte levels of heat shock protein 70 in aging: a study in the normal Chinese population. 
  • Spatial profiles of hsp70 proteins in Asian clam (Potamocorbula amurensis) in northern San Francisco Bay may be linked to natural rather than anthropogenic stressors. 
  • Structural transitions accompanying the activation of peptide binding to the endoplasmic reticulum Hsp90 chaperone GRP94. 
  • Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation. 
  • Systemic vector leakage and transgene expression by intratumorally injected recombinant adenovirus vectors. 
  • Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model. 
  • The 70-kDa heat shock cognate protein (Hsc73) gene is enhanced by ovarian hormones in the ventromedial hypothalamus. 
  • The 8.5-kb PstI allele of the stress protein gene, Hsp70-2: an independent risk factor for systemic lupus erythematosus in African Americans? 
  • The biological foundation of the genetic association of TOMM40 with late-onset Alzheimer's disease. 
  • The glutamine story: where are we now? 
  • The immunological properties of endoplasmic reticulum chaperones: a conflict of interest? 
  • The messenger and the message: gp96 (GRP94)-peptide interactions in cellular immunity. 
  • The pediatric sepsis biomarker risk model: potential implications for sepsis therapy and biology. 
  • To find the road traveled to tumor immunity: the trafficking itineraries of molecular chaperones in antigen-presenting cells. 
  • Transfer of GRP94(Gp96)-associated peptides onto endosomal MHC class I molecules. 
  • Transient regulation of c-fos, alpha B-crystallin, and hsp70 in muscle during recovery from contractile activity. 
  • Tumor-intrinsic NLRP3-HSP70-TLR4 axis drives premetastatic niche development and hyperprogression during anti-PD-1 immunotherapy. 
  • [Using Hsp70 promoter to regulate target gene expression in tumor]. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute