Cyclin-Dependent Kinases

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  Subject Areas on Research

  • A bistable circuit involving SCARECROW-RETINOBLASTOMA integrates cues to inform asymmetric stem cell division. 
  • A combinatorial mechanism for determining the specificity of E2F activation and repression. 
  • Absence of somatic changes in p21 gene in non-Hodgkin's lymphoma and chronic myelogenous leukemia. 
  • All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners. 
  • Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2. 
  • An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation. 
  • C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway. 
  • CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. 
  • CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control. 
  • Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition. 
  • Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. 
  • Cell cycle-regulated transcription: effectively using a genomics toolbox. 
  • Cell cycle. Checking two steps. 
  • Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells. 
  • Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. 
  • Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network. 
  • Deletion of cyclin-dependent kinase 4 inhibitor genes P15 and P16 in non-Hodgkin's lymphoma. 
  • Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6. 
  • E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. 
  • Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation. 
  • Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas. 
  • Escaping G1 restraints on neoplasia--Cdk4 regulation by Ras and NF-kappa B. 
  • Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression. 
  • Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex. 
  • Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint. 
  • GiA Roots: software for the high throughput analysis of plant root system architecture. 
  • Global control of cell-cycle transcription by coupled CDK and network oscillators. 
  • Heat-shock-specific phosphorylation and transcriptional activity of RNA polymerase II. 
  • IFN-gamma induction of p21(WAF1) is required for cell cycle inhibition and suppression of apoptosis. 
  • IFNalpha induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells. 
  • IFNgamma inhibition of cell growth in glioblastomas correlates with increased levels of the cyclin dependent kinase inhibitor p21WAF1/CIP1. 
  • IP7 guards the CDK gate. 
  • Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans. 
  • Influence of human p16(INK4) and p21(CIP1) on the in vitro activity of recombinant Plasmodium falciparum cyclin-dependent protein kinases. 
  • Initial testing (stage 1) of the cyclin dependent kinase inhibitor SCH 727965 (dinaciclib) by the pediatric preclinical testing program. 
  • Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. 
  • Intragenic modifiers of hereditary spastic paraplegia due to spastin gene mutations. 
  • Intrinsic and cyclin-dependent kinase-dependent control of spindle pole body duplication in budding yeast. 
  • Kin28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II. 
  • Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. 
  • Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint. 
  • Molecular genetic correlates of p16, cdk4, and pRb immunohistochemistry in glioblastomas. 
  • NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. 
  • Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1. 
  • Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function. 
  • PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. 
  • Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population. 
  • Preferential re-replication of Drosophila heterochromatin in the absence of geminin. 
  • Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population. 
  • Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites. 
  • Regulation of CDK7-carboxyl-terminal domain kinase activity by the tumor suppressor p16(INK4A) contributes to cell cycle regulation. 
  • Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I. 
  • Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control. 
  • Requirements for cell cycle arrest by p16INK4a. 
  • Senescent fibroblasts resist apoptosis by downregulating caspase-3. 
  • Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1. 
  • Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. 
  • Spatiotemporal regulation of cell-cycle genes by SHORTROOT links patterning and growth. 
  • Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. 
  • The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. 
  • The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. 
  • The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B. 
  • The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex. 
  • Transcription networks and cyclin/CDKs: the yin and yang of cell cycle oscillators. 
  • Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. 
  • Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells. 
  • Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines. 
  • Type I interferon induction of the Cdk-inhibitor p21WAF1 is accompanied by ordered G1 arrest, differentiation and apoptosis of the Daudi B-cell line. 
  • UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner. 
  • p16(INK4a) expression begins early in human colon neoplasia and correlates inversely with markers of cell proliferation. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Computer Science
  • Lew, Daniel Julio, James B. Duke Professor of Pharmacology and Cancer Biology, Cell Biology