-
Subject Areas on Research
-
A bistable circuit involving SCARECROW-RETINOBLASTOMA integrates cues to inform asymmetric stem cell division.
-
A combinatorial mechanism for determining the specificity of E2F activation and repression.
-
A new trick for Cyclin-Cdk: activation of STAT.
-
All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners.
-
Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2.
-
An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation.
-
An oligonucleotide decoy for transcription factor E2F inhibits mesangial cell proliferation in vitro.
-
Analysis of Cdc6 function in the assembly of mammalian prereplication complexes.
-
Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons.
-
Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6.
-
C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway.
-
CDK12 Activity-Dependent Phosphorylation Events in Human Cells.
-
CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.
-
CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control.
-
CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity.
-
Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition.
-
Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
-
Cell cycle-regulated transcription: effectively using a genomics toolbox.
-
Cell cycle. Checking two steps.
-
Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells.
-
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors.
-
Cyclin-binding motifs are essential for the function of p21CIP1.
-
Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network.
-
Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6.
-
Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation.
-
E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.
-
Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation.
-
Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas.
-
Enhanced malignant tumorigenesis in Cdk4 transgenic mice.
-
Escaping G1 restraints on neoplasia--Cdk4 regulation by Ras and NF-kappa B.
-
Evidence that a free-running oscillator drives G1 events in the budding yeast cell cycle.
-
Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression.
-
Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex.
-
Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint.
-
Genome-wide association and functional follow-up reveals new loci for kidney function.
-
Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.
-
Glioblastoma-related gene mutations and over-expression of functional epidermal growth factor receptors in SKMG-3 glioma cells.
-
Global control of cell-cycle transcription by coupled CDK and network oscillators.
-
Heat-shock-specific phosphorylation and transcriptional activity of RNA polymerase II.
-
Human CDK12 and CDK13, multi-tasking CTD kinases for the new millenium.
-
IFN-gamma induction of p21(WAF1) is required for cell cycle inhibition and suppression of apoptosis.
-
IFNalpha induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells.
-
IFNgamma inhibition of cell growth in glioblastomas correlates with increased levels of the cyclin dependent kinase inhibitor p21WAF1/CIP1.
-
IP7 guards the CDK gate.
-
Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans.
-
Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis.
-
Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors.
-
Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells.
-
Initial testing (stage 1) of the cyclin dependent kinase inhibitor SCH 727965 (dinaciclib) by the pediatric preclinical testing program.
-
Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides.
-
Intragenic modifiers of hereditary spastic paraplegia due to spastin gene mutations.
-
Intrinsic and cyclin-dependent kinase-dependent control of spindle pole body duplication in budding yeast.
-
Kin28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II.
-
Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues.
-
Loss of G(1)/S checkpoint in human immunodeficiency virus type 1-infected cells is associated with a lack of cyclin-dependent kinase inhibitor p21/Waf1.
-
Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors.
-
Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint.
-
Multi-step control of spindle pole body duplication by cyclin-dependent kinase.
-
Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor.
-
NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.
-
Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1.
-
Over-expression of cyclin D1 regulates Cdk4 protein synthesis.
-
Overexpression of p21(waf1) in human T-cell lymphotropic virus type 1-infected cells and its association with cyclin A/cdk2.
-
Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function.
-
PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation.
-
Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies.
-
Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population.
-
Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect.
-
Preferential re-replication of Drosophila heterochromatin in the absence of geminin.
-
Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites.
-
Reaction mechanism of human DNA repair excision nuclease.
-
Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates.
-
Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I.
-
Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control.
-
Senescent fibroblasts resist apoptosis by downregulating caspase-3.
-
Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1.
-
Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae.
-
Spatiotemporal regulation of cell-cycle genes by SHORTROOT links patterning and growth.
-
Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer.
-
The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4.
-
The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.
-
The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B.
-
The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex.
-
Transcription networks and cyclin/CDKs: the yin and yang of cell cycle oscillators.
-
Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.
-
Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines.
-
Type I interferon induction of the Cdk-inhibitor p21WAF1 is accompanied by ordered G1 arrest, differentiation and apoptosis of the Daudi B-cell line.
-
UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner.
-
Keywords of People
-
Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
-
Hartemink, Alexander J.,
Professor in the Department of Computer Science,
Biology
-
Lew, Daniel Julio,
James B. Duke Distinguished Professor of Pharmacology and Cancer Biology,
Cell Biology