Cyclin-Dependent Kinases

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  Subject Areas on Research

  • A bistable circuit involving SCARECROW-RETINOBLASTOMA integrates cues to inform asymmetric stem cell division. 
  • A cell cycle timer for asymmetric spindle positioning. 
  • A combinatorial mechanism for determining the specificity of E2F activation and repression. 
  • A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex. 
  • A new trick for Cyclin-Cdk: activation of STAT. 
  • Absence of somatic changes in p21 gene in non-Hodgkin's lymphoma and chronic myelogenous leukemia. 
  • All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners. 
  • All-trans-retinoic acid mediates G1 arrest but not apoptosis of normal human mammary epithelial cells. 
  • Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2. 
  • An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation. 
  • An oligonucleotide decoy for transcription factor E2F inhibits mesangial cell proliferation in vitro. 
  • Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. 
  • Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6. 
  • Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. 
  • C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway. 
  • CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. 
  • CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control. 
  • CDK5 regulates cell adhesion and migration in corneal epithelial cells. 
  • CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. 
  • CTLA-4-Mediated inhibition of early events of T cell proliferation. 
  • Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition. 
  • Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. 
  • Cell cycle-regulated transcription: effectively using a genomics toolbox. 
  • Cell cycle. Checking two steps. 
  • Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells. 
  • Collaborative role of E2F transcriptional activity and G1 cyclindependent kinase activity in the induction of S phase. 
  • Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. 
  • Cyclin-binding motifs are essential for the function of p21CIP1. 
  • Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network. 
  • Deletion of cyclin-dependent kinase 4 inhibitor genes P15 and P16 in non-Hodgkin's lymphoma. 
  • Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6. 
  • Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. 
  • E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. 
  • E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. 
  • Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation. 
  • Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas. 
  • Enhanced malignant tumorigenesis in Cdk4 transgenic mice. 
  • Escaping G1 restraints on neoplasia--Cdk4 regulation by Ras and NF-kappa B. 
  • Evidence that a free-running oscillator drives G1 events in the budding yeast cell cycle. 
  • Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression. 
  • Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex. 
  • Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint. 
  • Genome-wide association and functional follow-up reveals new loci for kidney function. 
  • Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer. 
  • Glioblastoma-related gene mutations and over-expression of functional epidermal growth factor receptors in SKMG-3 glioma cells. 
  • Global control of cell-cycle transcription by coupled CDK and network oscillators. 
  • Heat-shock-specific phosphorylation and transcriptional activity of RNA polymerase II. 
  • Human CDK12 and CDK13, multi-tasking CTD kinases for the new millenium. 
  • IFN-gamma induction of p21(WAF1) is required for cell cycle inhibition and suppression of apoptosis. 
  • IFNalpha induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells. 
  • IFNgamma inhibition of cell growth in glioblastomas correlates with increased levels of the cyclin dependent kinase inhibitor p21WAF1/CIP1. 
  • IP7 guards the CDK gate. 
  • Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans. 
  • Identification of distinct roles for separate E1A domains in disruption of E2F complexes. 
  • Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. 
  • Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis. 
  • Immature stage B cells enter but do not progress beyond the early G1 phase of the cell cycle in response to antigen receptor signaling. 
  • Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. 
  • Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors. 
  • Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells. 
  • Initial testing (stage 1) of the cyclin dependent kinase inhibitor SCH 727965 (dinaciclib) by the pediatric preclinical testing program. 
  • Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. 
  • Intragenic modifiers of hereditary spastic paraplegia due to spastin gene mutations. 
  • Intrinsic and cyclin-dependent kinase-dependent control of spindle pole body duplication in budding yeast. 
  • Kin28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II. 
  • Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues. 
  • Loss of G(1)/S checkpoint in human immunodeficiency virus type 1-infected cells is associated with a lack of cyclin-dependent kinase inhibitor p21/Waf1. 
  • Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. 
  • Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint. 
  • Multi-step control of spindle pole body duplication by cyclin-dependent kinase. 
  • Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor. 
  • Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. 
  • NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. 
  • NMR structural characterization of the CDK inhibitor p19INK4d. 
  • Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1. 
  • Over-expression of cyclin D1 regulates Cdk4 protein synthesis. 
  • Overexpression of p21(waf1) in human T-cell lymphotropic virus type 1-infected cells and its association with cyclin A/cdk2. 
  • Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function. 
  • PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. 
  • Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies. 
  • Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population. 
  • Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect. 
  • Preferential re-replication of Drosophila heterochromatin in the absence of geminin. 
  • Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites. 
  • Reaction mechanism of human DNA repair excision nuclease. 
  • Regulation of CDK7-carboxyl-terminal domain kinase activity by the tumor suppressor p16(INK4A) contributes to cell cycle regulation. 
  • Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates. 
  • Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I. 
  • Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control. 
  • Requirements for cell cycle arrest by p16INK4a. 
  • Senescent fibroblasts resist apoptosis by downregulating caspase-3. 
  • Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1. 
  • Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. 
  • Spatiotemporal regulation of cell-cycle genes by SHORTROOT links patterning and growth. 
  • Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. 
  • The Haemophilus influenzae Hia adhesin is an autotransporter protein that remains uncleaved at the C terminus and fully cell associated. 
  • The Rb-related p107 protein can suppress E2F function independently of binding to cyclin A/cdk2. 
  • The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. 
  • The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. 
  • The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B. 
  • The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex. 
  • Transcription networks and cyclin/CDKs: the yin and yang of cell cycle oscillators. 
  • Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. 
  • Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines. 
  • Two-faced cyclins with eyes on the targets. 
  • Type I interferon induction of the Cdk-inhibitor p21WAF1 is accompanied by ordered G1 arrest, differentiation and apoptosis of the Daudi B-cell line. 
  • UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology
  • Lew, Daniel Julio, James B. Duke Professor of Pharmacology and Cancer Biology, Cell Biology