Germinal Center
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Subject Areas on Research
- A model for migratory B cell oscillations from receptor down-regulation induced by external chemokine fields.
- A refined cell-of-origin classifier with targeted NGS and artificial intelligence shows robust predictive value in DLBCL.
- AID expression during B-cell development: searching for answers.
- Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome.
- Alternative pathways for the selection of antigen-specific peripheral T cells.
- An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL.
- Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting.
- Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers.
- Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma.
- B-cell lymphoma with hyaline vascular Castleman disease-like features: a clinicopathologic study.
- BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma.
- CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19.
- CD28 is required for germinal center formation.
- CD4 T follicular helper cell dynamics during SIV infection.
- CXCL13 is a plasma biomarker of germinal center activity.
- Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults.
- Complex Antigens Drive Permissive Clonal Selection in Germinal Centers.
- Continuous Culture of Mouse Primary B Lymphocytes by Forced Expression of Bach2.
- Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.
- Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection.
- Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses.
- Crosstalk Between T and B Cells in the Germinal Center After Transplantation.
- Cutting Edge: c-Maf Is Required for Regulatory T Cells To Adopt RORγt+ and Follicular Phenotypes.
- Dependence of germinal center B cells on expression of CD21/CD35 for survival.
- Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma.
- Diffuse large B-cell lymphoma.
- Distinctive characteristics of germinal center B cells.
- Do germinal centers have a role in the generation of lymphomas?
- Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma.
- EBV-positive diffuse large B-cell lymphoma of the elderly is an aggressive post-germinal center B-cell neoplasm characterized by prominent nuclear factor-kB activation.
- EBV+ high-grade B cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: a multi-institutional study.
- Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.
- Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes.
- Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice.
- Epstein-Barr virus perpetuates B cell germinal center dynamics and generation of autoimmune-associated phenotypes in vitro.
- Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies.
- Flow cytometric analysis of immunoglobulin heavy chain expression in B-cell lymphoma and reactive lymphoid hyperplasia.
- Follicular lymphoma with hyaline-vascular Castleman disease-like follicles and CD20 positive follicular dendritic cells.
- Follicular lymphoma with hyaline-vascular Castleman-like features: analysis of 6 cases and review of the literature.
- GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.
- Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells.
- Gene profiling of canine B-cell lymphoma reveals germinal center and postgerminal center subtypes with different survival times, modeling human DLBCL.
- Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells.
- Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination.
- Germinal center B cell depletion diminishes CD4+ follicular T helper cells in autoimmune mice.
- Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density.
- Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells.
- Germinal center responses to complex antigens.
- HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth.
- Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence.
- Humoral immune responses in L-selectin-deficient mice.
- IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade.
- IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF.
- Immunoglobulin gene hypermutation in germinal centers is independent of the RAG-1 V(D)J recombinase.
- Immunologic characteristics of HIV-infected individuals who make broadly neutralizing antibodies.
- Immunosenescence and germinal center reaction.
- Impact of Th1 CD4 Follicular Helper T Cell Skewing on Antibody Responses to an HIV-1 Vaccine in Rhesus Macaques.
- In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance.
- In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection.
- Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans.
- Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.
- Intracellular BH3 Profiling Reveals Shifts in Antiapoptotic Dependency in Human B Cell Maturation and Mitogen-Stimulated Proliferation.
- Life and death in germinal centers (redux).
- Long-primed germinal centres with enduring affinity maturation and clonal migration.
- Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19.
- Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice.
- Lymphocyte development and selection in germinal centers.
- Mantle cell lymphoma with plasma cell differentiation.
- MicroRNA-155 controls vincristine sensitivity and predicts superior clinical outcome in diffuse large B-cell lymphoma.
- Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells.
- Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses.
- PD-L1 expression is low in large B-cell lymphoma with MYC or double-hit translocation.
- Patients with diffuse large B-cell lymphoma of germinal center origin with BCL2 translocations have poor outcome, irrespective of MYC status: a report from an International DLBCL rituximab-CHOP Consortium Program Study.
- Plexin-D1 is a novel regulator of germinal centers and humoral immune responses.
- Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.
- Predicted and inferred waiting times for key mutations in the germinal centre reaction: evidence for stochasticity in selection.
- Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients.
- Primary Bone Lymphoma Exhibits a Favorable Prognosis and Distinct Gene Expression Signatures Resembling Diffuse Large B-Cell Lymphoma Derived From Centrocytes in the Germinal Center.
- Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells.
- Recall of B cell memory depends on relative locations of prime and boost immunization.
- Redemption of autoreactive B cells.
- Regulation of the B cell response to T-dependent antigens by classical pathway complement.
- Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein.
- Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice.
- Remembrance of things past.
- Role of germinal centers for the induction of broadly-reactive memory B cells.
- SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis.
- Simian-Human Immunodeficiency Virus SHIV.CH505-Infected Infant and Adult Rhesus Macaques Exhibit Similar Env-Specific Antibody Kinetics, despite Distinct T-Follicular Helper and Germinal Center B Cell Landscapes.
- Spontaneous Differentiation of T Follicular Helper Cells in LATY136F Mutant Mice.
- Spontaneous formation of germinal centers in autoimmune mice.
- Stromal gene signatures in large-B-cell lymphomas.
- Studies of the humoral immune response.
- Surface plasmon resonance measurements of plasma antibody avidity during primary and secondary responses to anthrax protective antigen.
- T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.
- TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection.
- TET2 Deficiency Sets the Stage for B-cell Lymphoma.
- TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures.
- TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation.
- Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes.
- Tetraspanin CD37 protects against the development of B cell lymphoma.
- The Association of Intratumoral Germinal Centers with early-stage non-small cell lung cancer.
- The First B-Cell Tolerance Checkpoint in Mice and Humans: Control by AID.
- The GS Protein-coupled A2a Adenosine Receptor Controls T Cell Help in the Germinal Center.
- The biology of human lymphoid malignancies revealed by gene expression profiling.
- The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells.
- The germinal center reaction.
- The germinal center: a crucible for lymphocyte selection.
- The polyphony of BACH2.
- Toll-like receptor 3 adjuvant in combination with virus-like particles elicit a humoral response against HIV.
- V(D)J recombinase activity in a subset of germinal center B lymphocytes.
- Vaccination establishes clonal relatives of germinal center T cells in the blood of humans.
- What is your diagnosis? Lupus profundus.
- mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.
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Keywords of People
- Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology
- Knechtle, Stuart Johnston, William R. Kenan, Jr. Distinguished Professor, Medicine, Nephrology
- Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology