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Subject Areas on Research
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5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer.
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A DNA methylation biomarker of alcohol consumption.
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A Flexible, Efficient Binomial Mixed Model for Identifying Differential DNA Methylation in Bisulfite Sequencing Data.
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A new assay to quantify in vivo repair of G:T mispairs by base excision repair.
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A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease.
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A variant in the CHEK2 promoter at a methylation site relieves transcriptional repression and confers reduced risk of lung cancer.
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Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells.
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Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors.
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An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa.
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Analysis of CpG methylation in the killifish CYP1A promoter.
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Analysis of DNA methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation.
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Bacterial infection remodels the DNA methylation landscape of human dendritic cells.
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Bayesian genome- and epigenome-wide association studies with gene level dependence.
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Bisulfite sequencing of cloned alleles.
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Body mass index associated with genome-wide methylation in breast tissue.
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CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells.
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CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP.
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Cadmium exposure and the epigenome: Exposure-associated patterns of DNA methylation in leukocytes from mother-baby pairs.
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Callipyge mutation affects gene expression in cis: a potential role for chromatin structure.
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Cannabinoid exposure and altered DNA methylation in rat and human sperm.
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Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in sperm.
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Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.
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Chromosomes with high gene density are preferentially repaired in human cells.
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Comparative analysis reveals distinctive epigenetic features of the human cerebellum.
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Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis.
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Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking.
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Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica.
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CpG island methylator phenotype is associated with response to adjuvant irinotecan-based therapy for stage III colon cancer.
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CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease.
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Cysteine-tailed class I-binding peptides bind to CpG adjuvant and enhance primary CTL responses.
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DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation.
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DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States.
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DNA hypermethylation within TERT promoter upregulates TERT expression in cancer.
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DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies.
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DNA methylation and ovarian cancer. I. Analysis of CpG island hypermethylation in human ovarian cancer using differential methylation hybridization.
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DNA methylation of imprinted gene control regions in the regression of low-grade cervical lesions.
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DNA methylation profiling in the Carolina Breast Cancer Study defines cancer subclasses differing in clinicopathologic characteristics and survival.
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DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan.
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DNA methylation signatures reflect aging in patients with nonalcoholic steatohepatitis.
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DNA methyltransferase levels and altered CpG methylation in the total genome and in the GSTP1 gene in human glioma cells transfected with sense and antisense DNA methyltransferase cDNA.
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DNA-based immunotherapy to treat atopic disease.
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DNA-remethylation around a STAT5-binding enhancer in the alphaS1-casein promoter is associated with abrupt shutdown of alphaS1-casein synthesis during acute mastitis.
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Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2.
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Dietary omega-3 fatty acid intake impacts peripheral blood DNA methylation -anti-inflammatory effects and individual variability in a pilot study.
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Differential DNA methylation patterns in human Schlemm's canal endothelial cells with glaucoma.
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Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape.
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Discovery of MLL1 binding units, their localization to CpG Islands, and their potential function in mitotic chromatin.
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Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver.
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Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes.
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Dynamic DNA methylation across diverse human cell lines and tissues.
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Early nurture epigenetically tunes the oxytocin receptor.
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Epigenetic Signatures of Cigarette Smoking.
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Epigenetic alterations in cytochrome P450 oxidoreductase (Por) in sperm of rats exposed to tetrahydrocannabinol (THC).
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Epigenetic deregulation in pediatric acute lymphoblastic leukemia.
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Epigenetic dysregulation of SHANK3 in brain tissues from individuals with autism spectrum disorders.
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Epigenetic regulation of AXL and risk of childhood asthma symptoms.
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Epigenome-Wide Association Study for All-Cause Mortality in a Cardiovascular Cohort Identifies Differential Methylation in Castor Zinc Finger 1 (CASZ1).
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Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci.
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Epigenome-wide association study of metabolic syndrome in African-American adults.
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Epigenome-wide meta-analysis of DNA methylation and childhood asthma.
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Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort.
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Establishing the epigenetic status of the Prader-Willi/Angelman imprinting center in the gametes and embryo.
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Evaluating DNA methylation age on the Illumina MethylationEPIC Bead Chip.
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Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene.
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Gene markers in brain tumors: what the epileptologist should know.
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Gene segment selection in V(D)J recombination: accessibility and beyond.
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Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma.
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Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates.
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Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis.
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Genetic variation of DNA methyltransferase-3A contributes to protection against persistent MRSA bacteremia in patients.
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Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression.
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Genome-scale screen for DNA methylation-based detection markers for ovarian cancer.
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Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types.
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Genome-wide methylation analyses in glioblastoma multiforme.
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Genome-wide methylation analysis identifies genes specific to breast cancer hormone receptor status and risk of recurrence.
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Genome-wide quantification of the effects of DNA methylation on human gene regulation.
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Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.
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Genomic sweeping for hypermethylated genes.
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Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children's health research.
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High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer.
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High quality methylome-wide investigations through next-generation sequencing of DNA from a single archived dry blood spot.
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High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer.
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Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation.
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Host response to infection: the role of CpG DNA in induction of cyclooxygenase 2 and nitric oxide synthase 2 in murine macrophages.
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Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells.
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Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer.
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Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma.
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Hypo-CpG methylation controls PTEN expression and cell apoptosis in irradiated lung.
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IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1.
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Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome.
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Identification of recurrent USP48 and BRAF mutations in Cushing's disease.
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Immunization with the Haemophilus ducreyi trimeric autotransporter adhesin DsrA with alum, CpG or imiquimod generates a persistent humoral immune response that recognizes the bacterial surface.
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Immunostimulatory properties of genomic DNA from different bacterial species.
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Imprinted expression of the canine IGF2R, in the absence of an anti-sense transcript or promoter methylation.
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Imprinting evolution and the price of silence.
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Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior.
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In vitro assay of immunostimulatory activities of plasmid vectors.
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In-utero epigenetic factors are associated with early-onset myopia in young children.
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Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy.
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Induction of immune activation by a novel immunomodulatory oligonucleotide without thymocyte apoptosis.
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Inhibition of murine macrophage IL-12 production by natural and synthetic DNA.
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Initial sequencing and analysis of the human genome.
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Initial sequencing and comparative analysis of the mouse genome.
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Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA).
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Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylation.
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Mechanisms of immune stimulation by bacterial DNA.
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Meta-analyses identify DNA methylation associated with kidney function and damage.
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Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.
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Methylation subtypes and large-scale epigenetic alterations in gastric cancer.
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Methylation-specific PCR.
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Methylomics of gene expression in human monocytes.
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Mutational fingerprints of aging.
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Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas.
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Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells.
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Prediction of genome-wide DNA methylation in repetitive elements.
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Primary immunodeficiency mutation databases.
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Prognostic methylation markers for overall survival in cytogenetically normal patients with acute myeloid leukemia treated on SWOG trials.
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Promoter hypermethylation profile of kidney cancer.
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Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells.
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Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis.
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Regulation of the metastasis suppressor gene MKK4 in ovarian cancer.
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Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease.
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Replicated umbilical cord blood DNA methylation loci associated with gestational age at birth.
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Resource base influences genome-wide DNA methylation levels in wild baboons (Papio cynocephalus).
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Retroviral DNA integration: viral and cellular determinants of target-site selection.
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Sperm DNA methylation altered by THC and nicotine: Vulnerability of neurodevelopmental genes with bivalent chromatin.
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Stimulation of thymocyte proliferation by phosphorothioate DNA oligonucleotides.
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T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation.
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TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk.
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Targeting UDP-α-D-glucose 6-dehydrogenase inhibits glioblastoma growth and migration.
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Telomere-to-telomere assembly of a complete human X chromosome.
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Temporal association of ORCA/LRWD1 to late-firing origins during G1 dictates heterochromatin replication and organization.
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The Cancer Genome Atlas expression profiles of low-grade gliomas.
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The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer.
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The Role of EBV-Induced Hypermethylation in Gastric Cancer Tumorigenesis.
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The antigenic properties of bacterial DNA in normal and aberrant immunity.
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The effects of CpG DNA on HMGB1 release by murine macrophage cell lines.
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The expression of plasma nucleosomes in mice undergoing in vivo apoptosis.
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The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.
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The influence of base sequence on the immunostimulatory properties of DNA.
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The mouse Snrpn minimal promoter and its human orthologue: activity and imprinting.
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The neuronatin gene resides in a "micro-imprinted" domain on human chromosome 20q11.2.
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The role of cpg sequences in the induction of anti-DNA antibodies.
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The role of the macrophage scavenger receptor in immune stimulation by bacterial DNA and synthetic oligonucleotides.
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Transcription initiation patterns indicate divergent strategies for gene regulation at the chromatin level.
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Transcriptomic profiles of aging in purified human immune cells.
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Utility of a molecular prescreening program in advanced colorectal cancer for enrollment on biomarker-selected clinical trials.
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Whole Blood DNA Methylation Signatures of Diet Are Associated With Cardiovascular Disease Risk Factors and All-Cause Mortality.
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Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.
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Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers.
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Whole-genome fingerprint of the DNA methylome during human B cell differentiation.
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lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Gunn, Michael Dee,
Professor of Medicine,
Immunology
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Pang, Herbert,
Adjunct Assistant Professor in the Department of Biostatistics & Bioinformatics,
Biostatistics & Bioinformatics
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Shinohara, Mari L.,
Associate Professor of Immunology,
Cell Biology
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Yan, Hai,
Adjunct Professor of Pathology,
Pathology