Neovascularization, Physiologic

• 

  Subject Areas on Research

  • A clinical model of dermal wound angiogenesis. 
  • A comparative histologic study of rapid three-dimensional zygomatic suture expansion osteogenesis. 
  • A novel role for erythropoietin during fibrin-induced wound-healing response. 
  • A phase I dose-escalation study of imatinib mesylate (Gleevec/STI571) plus capecitabine (Xeloda) in advanced solid tumors. 
  • ALK1 signalling analysis identifies angiogenesis related genes and reveals disparity between TGF-beta and constitutively active receptor induced gene expression. 
  • AMH induces mesonephric cell migration in XX gonads. 
  • ATTRACT. 
  • Acute local subcutaneous VEGF165 injection for augmentation of skin flap viability: efficacy and mechanism. 
  • Adenoviral-mediated gene transfer induces sustained pericardial VEGF expression in dogs: effect on myocardial angiogenesis. 
  • Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature. 
  • Alteration in angiogenic and anti-angiogenic forms of vascular endothelial growth factor-A in skeletal muscle of patients with intermittent claudication following exercise training. 
  • An engineered vascular endothelial growth factor-activating transcription factor induces therapeutic angiogenesis in ApoE knockout mice with hindlimb ischemia. 
  • Angiogenesis in skeletal muscle precede improvements in peak oxygen uptake in peripheral artery disease patients. 
  • Angiogenesis pathway inhibitors. 
  • Angiogenesis-like activity of endothelial cells co-cultured with VEGF-producing smooth muscle cells. 
  • Angiogenesis. 
  • Angiogenesis: an adaptive dynamic biological patterning problem. 
  • Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2. 
  • Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia. 
  • Angiogenic therapy for coronary artery and peripheral arterial disease. 
  • Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide. 
  • Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase. 
  • Angiotensin II promotes development of the renal microcirculation through AT1 receptors. 
  • Animal models of bleeding and tissue repair. 
  • Antiangiogenic agents in combination with chemotherapy for the treatment of epithelial ovarian cancer. 
  • Astrocytes follow ganglion cell axons to establish an angiogenic template during retinal development. 
  • Beyond angiogenesis: the role of endothelium in the bone marrow vascular niche. 
  • Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation. 
  • Biofunctional materials for directing vascular development. 
  • Biomimetic Hydrogels with Immobilized EphrinA1 for Therapeutic Angiogenesis 
  • Biomimetic hydrogels with pro-angiogenic properties. 
  • Branch order regression for modeling brain vasculature. 
  • Building bridges, not walls: spinal cord regeneration in zebrafish. 
  • CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections. 
  • Calcineurin: a central controller of signalling in eukaryotes. 
  • Captopril suppresses post-transplantation angiogenic activity in rat allograft coronary vessels. 
  • Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization after Acute Myocardial Infarction. 
  • Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs. 
  • Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart. 
  • Cell-Demanded VEGF Release via Nanocapsules Elicits Different Receptor Activation Dynamics and Enhanced Angiogenesis 
  • Characterization of adipose-derived mesenchymal stem cell combinations for vascularized bone engineering. 
  • Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. 
  • Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor. 
  • Combat Wound Initiative program. 
  • Commentary: Connecting the dots: Coronary artery development as a combination of vasculogenesis and angiogenesis. 
  • Comparison of mixed and lamellar coculture spatial arrangements for tissue engineering capillary networks in vitro. 
  • Complete reversal of ischemic wall motion abnormalities by combined use of gene therapy with transmyocardial laser revascularization. 
  • Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence. 
  • Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation. 
  • Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels. 
  • Cross-linking of porcine acellular dermal matrices negatively affects induced neovessel formation using platelet-rich plasma in a rat model of hernia repair. 
  • Current insights on the biology and clinical aspects of VEGF regulation. 
  • Current perceptions of cardiovascular gene therapy. 
  • Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus. 
  • Developing aptamers into therapeutics. 
  • Development of the coronary blood supply: changing concepts and current ideas. 
  • Differential regulation of the fibroblast growth factor (FGF) family by alpha(2)-macroglobulin: evidence for selective modulation of FGF-2-induced angiogenesis. 
  • Direct myocardial revascularization and angiogenesis--how many patients might be eligible? 
  • Directing and Potentiating Stem Cell-Mediated Angiogenesis and Tissue Repair by Cell Surface E-Selectin Coating. 
  • Dose response of angiogenesis to basic fibroblast growth factor in rat corneal pocket assay: I. Experimental characterizations. 
  • Dose response of angiogenesis to basic fibroblast growth factor in rat corneal pocket assay: II. Numerical simulations. 
  • Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke. 
  • EGFR in enterocytes & endothelium and HIF1α in enterocytes are dispensable for massive small bowel resection induced angiogenesis. 
  • Early wound healing exhibits cytokine surge without evidence of hypoxia. 
  • Effect of age on biomaterial-mediated in situ bone tissue regeneration. 
  • Effect of basic fibroblast growth factor on angiogenesis and growth of isografted bone: quantitative in vitro-in vivo analysis in mice. 
  • Effect of basic fibroblast growth factor on myocardial angiogenesis in dogs with mature collateral vessels. 
  • Effects of radiation on the levels of MMP-2, MMP-9 and TIMP-1 during morphogenic glial-endothelial cell interactions. 
  • Efficacy and mechanism of adenovirus-mediated VEGF-165 gene therapy for augmentation of skin flap viability. 
  • Electrical stimulation directly induces pre-angiogenic responses in vascular endothelial cells by signaling through VEGF receptors. 
  • Emerging roles for lysophospholipid mediators in pregnancy. 
  • Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells. 
  • Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis. 
  • Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. 
  • Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for k1-5-induced antiangiogenesis. 
  • Endothelial progenitor cells: markers of vascular reparative capacity. 
  • Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. 
  • Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia. 
  • Enhanced HIF2α expression during human trophoblast differentiation into syncytiotrophoblast suppresses transcription of placental growth factor. 
  • Enhanced therapeutic neovascularization by CD31-expressing cells and embryonic stem cell-derived endothelial cells engineered with chitosan hydrogel containing VEGF-releasing microtubes 
  • Environmental oxygen regulates astrocyte proliferation to guide angiogenesis during retinal development. 
  • Ephrin-Eph signaling as a potential therapeutic target for the treatment of myocardial infarction. 
  • Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium. 
  • Exercise-induced angiogenesis-related growth and transcription factors in skeletal muscle, and their modification in muscle pathology. 
  • Four-dimensional analysis of vascularization during primary development of an organ, the gonad. 
  • Foveal avascular zone and foveal pit formation after preterm birth. 
  • Functional significance of Tie2 signaling in the adult vasculature. 
  • Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium. 
  • Genetic targeting for cardiovascular therapeutics: are we near the summit or just beginning the climb? 
  • Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4. 
  • Growth factors for therapeutic angiogenesis in peripheral arterial disease. 
  • HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity. 
  • Harnessing Macrophages for Vascularization in Tissue Engineering. 
  • Healing of a free tracheal autograft is enhanced by topical vascular endothelial growth factor in an experimental rabbit model. 
  • Heating or freezing bone. Effects on angiogenesis induction and growth potential in mice. 
  • Hyaluronic acid and fibrin hydrogels with concentrated DNA/PEI polyplexes for local gene delivery 
  • IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation. 
  • Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. 
  • Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development. 
  • Improved Angiogenesis in Response to Localized Delivery of Macrophage-Recruiting Molecules. 
  • In mice with type 2 diabetes, a vascular endothelial growth factor (VEGF)-activating transcription factor modulates VEGF signaling and induces therapeutic angiogenesis after hindlimb ischemia. 
  • In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia, vasculature and fluorescent reporters. 
  • In vivo photoactivation of caged-thrombin. 
  • Incorporation of active DNA/cationic polymer polyplexes into hydrogel scaffolds 
  • Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation. 
  • Induction and maintenance of increased VEGF protein by chronic motor nerve stimulation in skeletal muscle. 
  • Induction of angiogenesis after TMR: a comparison of holmium: YAG, CO2, and excimer lasers. 
  • Induction of angiogenic immediate early genes by activation of FP prostanoid receptors in cultured human ciliary smooth muscle cells. 
  • Insulin resistance and alterations in angiogenesis: additive insults that may lead to preeclampsia. 
  • Intramyocardial, autologous CD34+ cell therapy for refractory angina. 
  • Intravital imaging of mouse embryos. 
  • Investigating the Osteoinductive Potential of a Decellularized Xenograft Bone Substitute. 
  • Investigation of neovascularization in three-dimensional porous scaffolds in vivo by a combination of multiscale photoacoustic microscopy and optical coherence tomography. 
  • Laser-assisted indocyanine green dye angiography accurately predicts the split-thickness graft timing of integra artificial dermis. 
  • Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function. 
  • Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells. 
  • Lymphatic angiogenesis induced by transmyocardial laser revascularization. 
  • Mekk3 is essential for early embryonic cardiovascular development. 
  • Methods for Acute and Subacute Murine Hindlimb Ischemia. 
  • Micron-scale spatially patterned, covalently immobilized vascular endothelial growth factor on hydrogels accelerates endothelial tubulogenesis and increases cellular angiogenic responses. 
  • Micropatterning of poly(ethylene glycol) diacrylate hydrogels with biomolecules to regulate and guide endothelial morphogenesis. 
  • Mineralized Biomaterials Mediated Repair of Bone Defects Through Endogenous Cells. 
  • Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression. 
  • Modulation of endothelial cell morphogenesis in vitro by MMP-9 during glial-endothelial cell interactions. 
  • Molecular approaches for the treatment of atherosclerosis. 
  • More than skin deep: connecting melanocyte pigmentation and angiogenic diseases. 
  • Neovascularization after transmyocardial laser revascularization in a model of chronic ischemia. 
  • Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding. 
  • New genetic loci link adipose and insulin biology to body fat distribution. 
  • Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes. 
  • Numerical simulations of angiogenesis in the cornea. 
  • Obesity and altered angiogenic-related gene expression in endometrial cancer. 
  • Organogenesis: molecular mechanisms of tubulogenesis. 
  • Osteopontin expression and adventitial angiogenesis induced by local vascular endothelial growth factor 165 reduces experimental aortic calcification. 
  • PI-3 kinase-PTEN signaling node: an intercept point for the control of angiogenesis. 
  • PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects. 
  • PTH receptor signaling in osteoblasts regulates endochondral vascularization in maintenance of postnatal growth plate. 
  • Paracrine mechanisms in adult stem cell signaling and therapy. 
  • Percolation, morphogenesis, and burgers dynamics in blood vessels formation. 
  • Peripheral mobilization of recipient bone marrow-derived endothelial progenitor cells enhances pancreatic islet revascularization and engraftment after intraportal transplantation. 
  • Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway. 
  • Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas. 
  • Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. 
  • Platelet microparticle delivered microRNA-Let-7a promotes the angiogenic switch. 
  • Platelet rich plasma concentration improves biologic mesh incorporation and decreases multinucleated giant cells in a dose dependent fashion. 
  • Platelet rich plasma enhances tissue incorporation of biologic mesh. 
  • Polymorphisms in genes involved in inflammatory and angiogenic pathways and the risk of hemorrhagic presentation of brain arteriovenous malformations. 
  • Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation. 
  • Progenitor cell mobilization enhances bone healing by means of improved neovascularization and osteogenesis. 
  • Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment. 
  • Quantitative analysis of angiogenesis and growth of bone: effect of indomethacin exposure in a combined in vitro-in vivo approach. 
  • ROS production and angiogenic regulation by macrophages in response to heat therapy. 
  • Randomized trial of aspirin, sibrafiban, or both for secondary prevention after acute coronary syndromes. 
  • Rate of vascularization of coralline hydroxyapatite spherical implants pretreated with saline/gentamicin, rTGF-beta 2, and autogenous plasma. 
  • Regulation of endothelial cell activation and angiogenesis by injectable peptide nanofibers. 
  • Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy. 
  • Restoring hemostatic thrombin generation at the time of cutaneous wounding does not normalize healing in hemophilia B. 
  • Role of repulsive factors in vascularization dynamics. 
  • Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity. 
  • Seeing stars: Development and function of retinal astrocytes. 
  • Separating the wheat from the chaff: focus on "in silico data filtering to identify new angiogenesis targets from a large in vitro gene profile data set". 
  • Sequential paracrine mechanisms are necessary for the therapeutic benefits of stem cell therapy. 
  • Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. 
  • Some things I thought I knew about tissue factor that turn out to be wrong. 
  • Stem cell use in a patient with an ischemic foot ulcer: a case study. 
  • Stiffness of Protease Sensitive and Cell Adhesive PEG Hydrogels Promotes Neovascularization In Vivo. 
  • Structural adaptation of normal and tumour vascular networks. 
  • Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density. 
  • Superoxide-mediated actin response in post-hypoxic endothelial cells. 
  • Sustained VEGF delivery via PLGA nanoparticles promotes vascular growth. 
  • Synergistic actions of hematopoietic and mesenchymal stem/progenitor cells in vascularizing bioengineered tissues. 
  • Synthetic biomimetic hydrogels incorporated with ephrin-A1 for therapeutic angiogenesis. 
  • Temporal modulation of collective cell behavior controls vascular network topology. 
  • Teratogenic, bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine. 
  • The NADH oxidase ENOX1, a critical mediator of endothelial cell radiosensitization, is crucial for vascular development. 
  • The RENEW Trial: Efficacy and Safety of Intramyocardial Autologous CD34(+) Cell Administration in Patients With Refractory Angina. 
  • The chicken chorioallantoic membrane model in biology, medicine and bioengineering 
  • The clotting system - a major player in wound healing. 
  • The contribution of macrophages to normal and pathological pregnancies. 
  • The effect of vascular endothelial growth factor (VEGF) presentation within fibrin matrices on endothelial cell branching 
  • The effects of ZD6474, an inhibitor of VEGF signaling, on cutaneous wound healing in mice. 
  • The influence of hyperbaric oxygen therapy and irradiation on hydroxyapatite ocular implant exposure and fibrovascular ingrowth in New Zealand white rabbits. 
  • The multifunctional Ca²⁺/calmodulin-dependent kinase IIδ (CaMKIIδ) regulates arteriogenesis in a mouse model of flow-mediated remodeling. 
  • The relationship between hypoxia and angiogenesis. 
  • The role of Hedgehog signaling in fibrogenic liver repair. 
  • The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle. 
  • Therapeutic angiogenesis in chronically ischemic porcine myocardium: comparative effects of bFGF and VEGF. 
  • Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation. 
  • Thrombospondin-1, vascular endothelial growth factor and fibroblast growth factor-2 are key functional regulators of angiogenesis in the prostate. 
  • Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke. 
  • Thyroid hormones and 3,5-diiodothyropropionic acid: new keys for new locks. 
  • Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues. 
  • Tissue engraftment of hypoxic-preconditioned adipose-derived stem cells improves flap viability. 
  • Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis. 
  • Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration. 
  • Transvascular drug delivery in solid tumors. 
  • Umbilical Cord Blood-Derived Mononuclear Cells Exhibit Pericyte-Like Phenotype and Support Network Formation of Endothelial Progenitor Cells In Vitro. 
  • Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells. 
  • VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling. 
  • Vascular development during distraction osteogenesis proceeds by sequential intramuscular arteriogenesis followed by intraosteal angiogenesis. 
  • Vascular endothelial growth factor and dexamethasone release from nonfouling sensor coatings affect the foreign body response. 
  • Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide. 
  • Vascular interference: a blockade to tumor epithelial growth. 
  • Vascular leukocytes: a population with angiogenic and immunossuppressive properties highly represented in ovarian cancer. 
  • Vascularization of engineered tissues: approaches to promote angio-genesis in biomaterials. 
  • Wound healing in haemophilia--breaking the vicious cycle. 
  • miR-21 improves the neurological outcome after traumatic brain injury in rats. 
  • microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential. 
• 

  Keywords of People

  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Muh, Carrie Rebecca, Adjunct Assistant Professor in the Department of Neurosurgery, Neurosurgery
  • Velkey, John Matthew, Assistant Professor of the Practice of Medical Education in the Department of Cell Biology, Cell Biology