Chemokines

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  Subject Areas on Research

  • A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 
  • A cell-intrinsic role for Mst1 in regulating thymocyte egress. 
  • A genomic- and proteomic-based hypothesis on the eclectic effects of systemic interleukin-2 administration in the context of melanoma-specific immunization. 
  • A model for migratory B cell oscillations from receptor down-regulation induced by external chemokine fields. 
  • Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1. 
  • Active scaffolds for on-demand drug and cell delivery. 
  • Aerobic exercise attenuates airway inflammatory responses in a mouse model of atopic asthma. 
  • Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. 
  • Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency. 
  • Alpha-chemokine receptor blockade reduces high mobility group box 1 protein-induced lung inflammation and injury and improves survival in sepsis. 
  • An Engineered Tumor-on-a-Chip Device with Breast Cancer-Immune Cell Interactions for Assessing T-cell Recruitment. 
  • Analysis of the immune responses in chimpanzees infected with HIV type 1 isolates. 
  • Anti-VEGF treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype. 
  • Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats. 
  • Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines. 
  • Articular ankle fracture results in increased synovitis, synovial macrophage infiltration, and synovial fluid concentrations of inflammatory cytokines and chemokines. 
  • Assessing activation states in microglia. 
  • Assessment of the utility of biomarkers of osteoarthritis in the guinea pig. 
  • Associations between maternal cytokine levels during gestation and measures of child cognitive abilities and executive functioning. 
  • Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. 
  • Bacillus anthracis spores stimulate cytokine and chemokine innate immune responses in human alveolar macrophages through multiple mitogen-activated protein kinase pathways. 
  • Biased agonism as a mechanism for differential signaling by chemokine receptors. 
  • Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation. 
  • Biologic predictors of clinical improvement in rituximab-treated refractory myositis. 
  • Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. 
  • CD44 regulates macrophage recruitment to the lung in lipopolysaccharide-induced airway disease. 
  • CD62-PSGL-1 interactions regulate cytokine chemokine and apoptotic networks in cardiac allograft recipients. 
  • CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines. 
  • CXCL10/IP-10 is a biomarker and mediator for Kawasaki disease. 
  • CXCR3 and CCR5 ligands in rheumatoid arthritis synovium. 
  • CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer. 
  • Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses. 
  • Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells. 
  • Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course. 
  • Changes in the levels of chemokines and cytokines in the placentas of women with Plasmodium falciparum malaria. 
  • Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis. 
  • Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and β-arrestin 2 in inflammatory macrophages. 
  • Chemokine Signaling in Allergic Contact Dermatitis: Toward Targeted Therapies. 
  • Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment. 
  • Chemokine ligand and receptor expression in the pregnant uterus: reciprocal patterns in complementary cell subsets suggest functional roles. 
  • Chemokine mediated control of dendritic cell migration and function. 
  • Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT. 
  • Chemokine-adjuvanted electroporated DNA vaccine induces substantial protection from simian immunodeficiency virus vaginal challenge. 
  • Chemokines and B-cell homing to follicles. 
  • Chemokines as adjuvants for immunotherapy: implications for immune activation with CCL3. 
  • Chemokines have diverse abilities to form solid phase gradients. 
  • Clara cell secretory protein-deficient mice differ from wild-type mice in inflammatory chemokine expression to oxygen and ozone, but not to endotoxin. 
  • Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. 
  • Control of thymic T cell maturation, deletion and egress by the RNA-binding protein HuR. 
  • Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure. 
  • Cromolyn ameliorates acute and chronic injury in a rat lung transplant model. 
  • Cross-sectional detection of acute HIV infection: timing of transmission, inflammation and antiretroviral therapy. 
  • Cytokine profiling using monocytes/macrophages cultured on common biomaterials with a range of surface chemistries. 
  • Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha/beta. 
  • Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases. 
  • Development of a membrane-anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain. 
  • Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines, and chemokines. 
  • Effect of preexposure to ultrafine carbon black on respiratory syncytial virus infection in mice. 
  • Effects of oxidized LDL on mononuclear phagocytes: inhibition of induction of four inflammatory cytokine gene RNAs, release of NO, and cytolysis of tumor cells. 
  • Elevation of CXCR3-binding chemokines in urine indicates acute renal-allograft dysfunction. 
  • Emerging targets in neuroinflammation-driven chronic pain. 
  • Endothelial heparan sulfate controls chemokine presentation in recruitment of lymphocytes and dendritic cells to lymph nodes. 
  • Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy women. 
  • Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. 
  • FACS analysis of neuronal-glial interactions in the nucleus accumbens following morphine administration. 
  • Fetal-derived adrenomedullin mediates the innate immune milieu of the placenta. 
  • Gene Expression Profile of Dendritic Cell-Tumor Cell Hybrids Determined by Microarrays and Its Implications for Cancer Immunotherapy. 
  • Gene therapy to manipulate effector T cell trafficking to tumors for immunotherapy. 
  • Genetic and cellular evidence of decreased inflammation associated with reduced incidence of posttraumatic arthritis in MRL/MpJ mice. 
  • Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis. 
  • Hexa-acylated lipid A is required for host inflammatory response to Neisseria gonorrhoeae in experimental gonorrhea. 
  • High-resolution, noninvasive longitudinal live imaging of immune responses. 
  • Highly conserved gene expression profiles in humans with allergic rhinitis altered by immunotherapy. 
  • Host-Pathogen Interactions and Chronic Lung Allograft Dysfunction. 
  • Human lung innate immune response to Bacillus anthracis spore infection. 
  • IFN-beta1a inhibits the secretion of Th17-polarizing cytokines in human dendritic cells via TLR7 up-regulation. 
  • Immunological biomarkers in dermatomyositis. 
  • Immunology of infection caused by Cryptococcus neoformans. 
  • Immunotherapy for HIV. 
  • Impact of early life exposure to ionizing radiation on influenza vaccine response in an elderly Japanese cohort. 
  • In vitro resistance to thrombin-induced platelet microbicidal protein among clinical bacteremic isolates of Staphylococcus aureus correlates with an endovascular infectious source. 
  • In vitro resistance to thrombin-induced platelet microbicidal protein in isolates of Staphylococcus aureus from endocarditis patients correlates with an intravascular device source. 
  • In vivo cytokine-associated responses to biomaterials. 
  • Inflammatory and antioxidant gene expression in C57BL/6J mice after lethal and sublethal ozone exposures. 
  • Interferon-regulated chemokine score associated with improvement in disease activity in refractory myositis patients treated with rituximab. 
  • Interleukin-6 and type I interferon-regulated genes and chemokines mark disease activity in dermatomyositis. 
  • Intracellular CMTM2 negatively regulates human immunodeficiency virus type-1 transcription through targeting the transcription factors AP-1 and CREB. 
  • Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes. 
  • Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys. 
  • Microglial-neuronal interactions during neurodegenerative diseases. 
  • Modulation of cytokines and chemokines, limited pulmonary vascular bed permeability, and prevention of septicemia and death with ceftriaxone and interleukin-10 in pneumococcal pneumonia. 
  • Molecular characterization of inflammatory genes in sentinel and nonsentinel nodes in melanoma. 
  • Molecular correlates in urine for the obesity and prostatic inflammation of BPH/LUTS patients. 
  • Molecular editing of cellular responses by the high-affinity receptor for IgE. 
  • Monocyte polarization in children with falciparum malaria: relationship to nitric oxide insufficiency and disease severity. 
  • NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans. 
  • Nitric oxide is necessary for CC-class chemokine expression in endotoxin-stimulated ANA-1 murine macrophages. 
  • Noncytolytic CD8 T cell-mediated suppression of HIV replication. 
  • Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine. 
  • Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression. 
  • Ozone and pulmonary innate immunity. 
  • PDGF-AA mediates mesenchymal stromal cell chemotaxis to the head and neck squamous cell carcinoma tumor microenvironment. 
  • Pathogenesis of pneumococcal pneumonia in cyclophosphamide-induced leukopenia in mice. 
  • Pathogenic effector functions of ACPA: Where do we stand? 
  • Performance status in elderly patients with acute myeloid leukemia: exploring gene expression signatures of cytokines and chemokines. 
  • Peripheral blood cytokine and chemokine profiles in juvenile localized scleroderma: T-helper cell-associated cytokine profiles. 
  • Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein. 
  • Phosphoethanolamine decoration of Neisseria gonorrhoeae lipid A plays a dual immunostimulatory and protective role during experimental genital tract infection. 
  • Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors. 
  • Prevalence of chemokine and chemokine receptor polymorphisms in seroprevalent children with symptomatic HIV-1 infection in the United States. 
  • Profiling heparin-chemokine interactions using synthetic tools. 
  • Pulmonary immune responses to Propionibacterium acnes in C57BL/6 and BALB/c mice. 
  • Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2. 
  • Regulation of I-309 gene expression in human monocytes by endogenous interleukin-1. 
  • Regulation of corneal inflammation by neutrophil-dependent cleavage of keratan sulfate proteoglycans as a model for breakdown of the chemokine gradient. 
  • Regulation of human chemokine receptors CXCR4. Role of phosphorylation in desensitization and internalization. 
  • Regulation of lung injury and repair by Toll-like receptors and hyaluronan. 
  • Resolution of lung inflammation by CD44. 
  • Responses of serum chemokines to dramatic changes of air pollution levels, a panel study. 
  • Results from a human renal allograft tolerance trial evaluating T-cell depletion with alemtuzumab combined with deoxyspergualin. 
  • Role of Immune Response, Inflammation, and Tumor Immune Response-Related Cytokines/Chemokines in Melanoma Progression. 
  • Role of T cell recruitment and chemokine-regulated intra-graft T cell motility patterns in corneal allograft rejection. 
  • Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines. 
  • Selective modification of antigen-specific T cells by RNA electroporation. 
  • Serum levels of TARC, MDC, IL-10, and soluble CD163 in Hodgkin lymphoma: a SWOG S0816 correlative study. 
  • Serum proteins reflecting inflammation, injury and repair as biomarkers of disease activity in ANCA-associated vasculitis. 
  • Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm. 
  • Study of gastric fluid induced cytokine and chemokine expression in airway smooth muscle cells and airway remodeling. 
  • TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α. 
  • The effects of HHV-8 vMIP-II on SIVmac251 infection and replication competent and incompetent SIVmac239Delta3 vectors. 
  • The immunologic constant of rejection. 
  • The inflammatory milieu in idiopathic inflammatory myositis. 
  • The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis. 
  • The relation of severity of depressive symptoms to monocyte-associated proinflammatory cytokines and chemokines in apparently healthy men. 
  • The role of chemokines in hypertension and consequent target organ damage. 
  • The role(s) of cytokines/chemokines in urinary bladder inflammation and dysfunction. 
  • The transcriptomic response of rat hepatic stellate cells to endotoxin: implications for hepatic inflammation and immune regulation. 
  • Therapeutic opportunities to prevent post-traumatic arthritis: Lessons from the natural history of arthritis after articular fracture. 
  • Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses. 
  • Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion. 
  • Ultrafine carbon black particles enhance respiratory syncytial virus-induced airway reactivity, pulmonary inflammation, and chemokine expression. 
  • Vein graft neointimal hyperplasia is exacerbated by tumor necrosis factor receptor-1 signaling in graft-intrinsic cells. 
  • Visualization and characterization of inflammatory cell recruitment and migration through the corneal stroma in endotoxin-induced keratitis. 
  • mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination. 
  • p38 MAPK, microglial signaling, and neuropathic pain. 
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  Keywords of People

  • Bilbo, Staci D., Professor of Psychology and Neuroscience, Psychology and Neuroscience
  • Chen, Jun, Associate Professor of Medicine, Duke Cancer Institute
  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Immunology
  • MacLeod, Amanda S, Associate Professor in Dermatology, Immunology
  • Olson, Steven Arthur, Professor of Orthopaedic Surgery, Orthopaedics
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology
  • Sanchez-Perez, Luis Ariel, Assistant Professor of Neurosurgery, Neurosurgery
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, in the School of Medicine, Immunology