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Subject Areas on Research
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3D Culture Facilitates VEGF-Stimulated Endothelial Differentiation of Adipose-Derived Stem Cells.
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3D patterned stem cell differentiation using thermo-responsive methylcellulose hydrogel molds.
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A bioactive titanium foam scaffold for bone repair.
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A genetically defined normal human somatic cell system to study ras oncogenesis in vivo and in vitro.
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A laminin and nerve growth factor-laden three-dimensional scaffold for enhanced neurite extension.
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A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and Notch signaling.
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A method to replicate the microstructure of heart tissue in vitro using DTMRI-based cell micropatterning.
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A model of giant vacuole dynamics in human Schlemm's canal endothelial cells.
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A new method for selection of angular aqueous plexus cells from porcine eyes: a model for Schlemm's canal endothelium.
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A novel flow-perfusion bioreactor supports 3D dynamic cell culture.
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A novel human cancer culture model for the study of prostate cancer.
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A novel neoplastic primary tumor-derived human prostate epithelial cell line.
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A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies.
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A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment.
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A synthetic matrix with independently tunable biochemistry and mechanical properties to study epithelial morphogenesis and EMT in a lung adenocarcinoma model.
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A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance.
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Abundant expression of ponsin, a focal adhesion protein, in lens and downregulation of its expression by impaired cytoskeletal signaling.
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Active immunization using dendritic cells mixed with tumor cells inhibits the growth of primary breast cancer.
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African and Asian strains of Zika virus differ in their ability to infect and lyse primitive human placental trophoblast.
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Agonist-stimulated beta-adrenergic receptor internalization requires dynamic cytoskeletal actin turnover.
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Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells.
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An Engineered Tumor-on-a-Chip Device with Breast Cancer-Immune Cell Interactions for Assessing T-cell Recruitment.
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An avian model for the reversal of neurobehavioral teratogenicity with neural stem cells.
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Analysis of oxygen transport in a diffusion-limited model of engineered heart tissue.
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Analysis of pH gradients resulting from mass transport limitations in engineered heart tissue.
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Analytical and biological methods for probing the blood-brain barrier.
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Analyzing transcription dynamics during the budding yeast cell cycle.
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Antibacterial efficacy of exogenous nitric oxide on periodontal pathogens.
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Bcl-xL is an oncogenic driver in colorectal cancer.
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Bimatoprost, prostamide activity, and conventional drainage.
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Bioactive hydrogel substrates: probing leukocyte receptor-ligand interactions in parallel plate flow chamber studies.
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Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche and facilitate HSC expansion in culture.
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Bioengineered human blood vessels.
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Blastomere isolation and transplantation.
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Blebbistatin, a novel inhibitor of myosin II ATPase activity, increases aqueous humor outflow facility in perfused enucleated porcine eyes.
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Blood vessels engineered from human cells.
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Bombesin-like peptides modulate alveolarization and angiogenesis in bronchopulmonary dysplasia.
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Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines.
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CD2-mediated IL-12-dependent signals render human gamma delta-T cells resistant to mitogen-induced apoptosis, permitting the large-scale ex vivo expansion of functionally distinct lymphocytes: implications for the development of adoptive immunotherapy strategies.
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Captopril suppresses post-transplantation angiogenic activity in rat allograft coronary vessels.
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Cardiac tissue engineering: cell seeding, cultivation parameters, and tissue construct characterization.
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Cardiomyocyte cultures with controlled macroscopic anisotropy: a model for functional electrophysiological studies of cardiac muscle.
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Cardiomyoplasty: the prospect of human stem cells.
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Cartilage tissue engineering: Directed differentiation of embryonic stem cells in three-dimensional hydrogel culture.
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Caspase-3 dependent cleavage and activation of skeletal muscle phosphorylase b kinase.
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Cell Line Authentication in Vision Research and Beyond: A Tale Retold.
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Cell culture block array for immunocytochemical study of protein expression in cultured cells.
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Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration.
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Characterization of Adipogenic Chemicals in Three Different Cell Culture Systems: Implications for Reproducibility Based on Cell Source and Handling.
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Characterization of a genetically engineered elastin-like polypeptide for cartilaginous tissue repair.
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Characterization of cytoskeleton-enriched protein fraction of the trabecular meshwork and ciliary muscle cells.
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Characterization of multiple CD34+ cell populations in cord blood.
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Characterization of umbilical cord blood-derived late outgrowth endothelial progenitor cells exposed to laminar shear stress.
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Chemotaxis-driven assembly of endothelial barrier in a tumor-on-a-chip platform.
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Chlorpyrifos developmental neurotoxicity: interaction with glucocorticoids in PC12 cells.
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Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide.
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Chondrogenic differentiation of human embryonic germ cell derived cells in hydrogels.
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Chondrogenic differentiation of human embryonic stem cell-derived cells in arginine-glycine-aspartate-modified hydrogels.
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Chondroitin sulfate based niches for chondrogenic differentiation of mesenchymal stem cells.
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Circulating tumor cell-derived organoids: Current challenges and promises in medical research and precision medicine.
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Clinical importance of increased sensitivity of BacT/Alert FAN aerobic and anaerobic blood culture bottles.
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Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor.
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Combined PI3K/Akt and Smad2 Activation Promotes Corneal Endothelial Cell Proliferation.
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Consensus recommendations for trabecular meshwork cell isolation, characterization and culture.
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Continuous operation of foamed emulsion bioreactors treating toluene vapors.
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Control protocol for robust in vitro glial scar formation around microwires: essential roles of bFGF and serum in gliosis.
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Controlled clinical laboratory comparison of BACTEC plus aerobic/F resin medium with BacT/Alert aerobic FAN medium for detection of bacteremia and fungemia.
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Controlled differentiation of stem cells.
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Controlling Particle Fraction in Microporous Annealed Particle Scaffolds for 3D Cell Culture.
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Cooperative nutrient accumulation sustains growth of mammalian cells.
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Covalent immobilization of stem cell factor and stromal derived factor 1α for in vitro culture of hematopoietic progenitor cells.
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Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration.
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Cultivation in rotating bioreactors promotes maintenance of cardiac myocyte electrophysiology and molecular properties.
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Culture of echinoderm larvae through metamorphosis.
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Culture of endodermal stem/progenitor cells of the mouse tongue.
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Culture of hepatocytes on fructose-modified chitosan scaffolds.
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Culture of primary rat hepatocytes within porous chitosan scaffolds.
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Current technology for the derivation of pluripotent stem cell lines from human embryos.
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Cytokine profiling using monocytes/macrophages cultured on common biomaterials with a range of surface chemistries.
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Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies.
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Design and characterization of poly(ethylene glycol) photopolymerizable semi-interpenetrating networks for chondrogenesis of human mesenchymal stem cells.
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Design and validation of a dynamic cell-culture system for bone biology research and exogenous tissue-engineering applications.
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Design, evaluation, and application of engineered skeletal muscle.
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Detection and identification of bacteria using antibiotic susceptibility and a multi-array electrochemical sensor with pattern recognition.
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Detection of necrosis by release of lactate dehydrogenase activity.
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Development and characterization of melanoma cell lines established by fine-needle aspiration biopsy: advances in the monitoring of patients with metastatic melanoma.
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Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiation.
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Differences in O2 availability resolve the apparent discrepancies in metabolic intrinsic optical signals in vivo and in vitro.
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Differential P1-purinergic modulation of human Schlemm's canal inner-wall cells.
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Differentiation and characterization of human iPSC-derived vascular endothelial cells under physiological shear stress.
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Differentiation of mammalian skeletal muscle cells cultured on microcarrier beads in a rotating cell culture system.
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Direct Conversion of Human Pluripotent Stem Cells to Osteoblasts With a Small Molecule.
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Directed intermixing in multicomponent self-assembling biomaterials.
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Dorsal root ganglia neurite extension is inhibited by mechanical and chondroitin sulfate-rich interfaces.
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Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD.
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Dye-coupling in three-dimensional histoculture of rat lingual frenulum.
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Effects of chronic exposure to simulated microgravity on skeletal muscle cell proliferation and differentiation.
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Effects of epidermal growth factor on fibroblast migration through biomimetic hydrogels.
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Effects of novel ethacrynic acid derivatives on human trabecular meshwork cell shape, actin cytoskeletal organization, and transcellular fluid flow.
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Effects of recirculating flow on U-937 cell adhesion to human umbilical vein endothelial cells.
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Efficacy and safety of ex vivo cultured adult human mesenchymal stem cells (Prochymal™) in pediatric patients with severe refractory acute graft-versus-host disease in a compassionate use study.
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Efficient Culture of Human Naive and Memory B Cells for Use as APCs.
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Elastic hydrogel as a sensor for detection of mechanical stress generated by single cells grown in three-dimensional environment.
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Electrotaxis of Glioblastoma and Medulloblastoma Spheroidal Aggregates.
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Emerging Technologies for Gut Microbiome Research.
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Endochondral bone formation from hydrogel carriers loaded with BMP2-transduced cells.
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Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis.
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Endothelialization of microporous YIGSR/PEG-modified polyurethaneurea.
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Engineering skeletal myoblasts: roles of three-dimensional culture and electrical stimulation.
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Enhanced chondrogenic differentiation of murine embryonic stem cells in hydrogels with glucosamine.
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Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution.
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Establishing lymphoblastoid cell lines from frozen blood of extremely old individuals.
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Establishment of stably EBV-transformed cell lines from residual clinical blood samples for use in performance evaluation and quality assurance in molecular genetic testing.
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Establishment of three-dimensional cultures of human pancreatic duct epithelial cells.
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Estrogen receptor beta protects against in vivo injury in RPE cells.
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Evaluation of culture conditions for in vitro meniscus repair model systems using bone marrow-derived mesenchymal stem cells.
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Ex Vivo Expansion or Manipulation of Stem Cells to Improve Outcome of Umbilical Cord Blood Transplantation.
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Ex vivo expansion of murine and human hematopoietic stem cells.
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Expansion of tumor-T cell pairs from fine needle aspirates of melanoma metastases.
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Fabrication of combinatorial polymer scaffold libraries.
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Fanconi anemia complementation group A cells are hypersensitive to chromium(VI)-induced toxicity.
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Feasibility of vitrification as a storage method for tissue-engineered blood vessels.
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Functional imaging in bulk tissue specimens using optical emission tomography: fluorescence preservation during optical clearing.
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Fungal diagnostics in pneumonia.
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Gene delivery through cell culture substrate adsorbed DNA complexes
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Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers.
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Gene therapy in tissue-engineered blood vessels.
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Genome-wide localization of replication factors.
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Glucose uptake in muscle cell cultures from endurance-trained men.
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Hard top soft bottom microfluidic devices for cell culture and chemical analysis.
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Hematopoietic stem cells.
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High dose factor VIIa improves clot structure and stability in a model of haemophilia B.
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High-content imaging-based screening of microenvironment-induced changes to stem cells.
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Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.
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Human dendritic cells, pulsed with either melanoma tumor cell lysates or the gp100 peptide(280-288), induce pairs of T-cell cultures with similar phenotype and lytic activity.
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Human organoids: a new dimension in cell biology.
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Hydrogel Design of Experiments Methodology to Optimize Hydrogel for iPSC-NPC Culture
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Hypophosphorylation of the architectural chromatin protein DEK in death-receptor-induced apoptosis revealed by the isotope coded protein label proteomic platform.
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Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon.
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Immunosurveillance by antiangiogenesis: tumor growth arrest by T cell-derived thrombospondin-1.
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Immunotherapy of malignant brain tumors.
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Improved methodologies for the study of adipose biology: insights gained and opportunities ahead.
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In Vitro Differentiation of Tumor-Associated Macrophages from Monocyte Precursors with Modified Melanoma-Conditioned Medium.
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In vitro investigation of the hepatobiliary disposition mechanisms of the antifungal agent micafungin in humans and rats.
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Induction of an Inflammatory Response in Primary Hepatocyte Cultures from Mice.
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Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies.
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Influence of discrete and continuous culture conditions on human mesenchymal stem cell lineage choice in RGD concentration gradient hydrogels.
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Internalization is essential for the antiapoptotic effects of exogenous thymosin beta-4 on human corneal epithelial cells.
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Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells.
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Islets for all?
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Isolation and characterization of stem cells from the human parathyroid gland.
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Isolation and generation of human dendritic cells.
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Isolation of oligodendrocyte-like cells from human umbilical cord blood.
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Isolation of primary open-angle glaucomatous trabecular meshwork cells from whole eye tissue.
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Isolation, culture, and characterization of endothelial cells from Schlemm's canal.
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L form bacteria growth in low-osmolality medium.
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Laser-scanning lithography (LSL) for the soft lithographic patterning of cell-adhesive self-assembled monolayers.
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Magnesium sulfate inhibits the oxytocin-induced production of inositol 1,4,5-trisphosphate in cultured human myometrial cells.
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Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems.
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Mast cell stabilization improves survival by preventing apoptosis in sepsis.
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Measurement of Reactive Oxygen Species by Fluorescent Probes in Pancreatic Cancer Cells.
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Measuring Hepatitis C Virus Envelopment by Using a Proteinase K Protection Assay.
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Mechanical culture conditions effect gene expression: gravity-induced changes on the space shuttle.
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Mechanical load stimulates expression of novel genes in vivo and in vitro in avian flexor tendon cells.
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Mechanoelectrical excitation by fluid jets in monolayers of cultured cardiac myocytes.
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Megalin binds and internalizes angiotensin-(1-7).
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Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.
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Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers.
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Micropatterning of poly(ethylene glycol) diacrylate hydrogels.
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Molecular characterization of hypoxia-hypothermia-conditioned human endothelial cells and their interaction with human monocytes.
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Morphology and ultrastructure of differentiating three-dimensional mammalian skeletal muscle in a collagen gel.
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Mouse primordial germ cells. Isolation and in vitro culture.
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Mouse primordial germ cells: isolation and in vitro culture.
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Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices.
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Multilayer microfluidic PEGDA hydrogels.
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Murine bone marrow stromal cells pulsed with homologous tumor-derived exosomes inhibit proliferation of liver cancer cells.
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Mylar and Teflon-AF as cell culture substrates for studying endothelial cell adhesion.
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N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator.
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N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions.
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Nanoparticles and their applications in cell and molecular biology.
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Nanoprobes and nanobiosensors for monitoring and imaging individual living cells.
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Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10).
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No detectable DNA excision repair in UV-exposed hepatocytes from two catfish species.
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Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.
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Novel human bronchial epithelial cell lines for cystic fibrosis research.
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Novel micropatterned cardiac cell cultures with realistic ventricular microstructure.
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Oncogenic mutations in ras create HLA-A2.1 binding peptides but affect their extracellular antigen processing.
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Optimized suspension culture: the rotating-wall vessel.
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Organ-specific metastases obtained by culturing colorectal cancer cells on tissue-specific decellularized scaffolds.
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PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity.
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Packed red blood cells suppress T-cell proliferation through a process involving cell-cell contact.
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Pentosan polysulfate decreases prostate smooth muscle proliferation and extracellular matrix turnover.
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Pharmacokinetics of combined gene therapy expressing constitutive human GM-CSF and hyperthermia-regulated human IL-12.
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Physically Associated Synthetic Hydrogels with Long-Term Covalent Stabilization for Cell Culture and Stem Cell Transplantation
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Physiologic pulsatile flow bioreactor conditioning of poly(ethylene glycol)-based tissue engineered vascular grafts.
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Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung.
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Poly(ethylene glycol) hydrogel system supports preadipocyte viability, adhesion, and proliferation.
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Polylysine-functionalised thermoresponsive chitosan hydrogel for neural tissue engineering.
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Porphyromonas gingivalis-mediated Epithelial Cell Entry of HIV-1.
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Potential human health effects associated with laboratory exposures to Pfiesteria piscicida.
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Preclinical Study of AUY922, a Novel Hsp90 Inhibitor, in the Treatment of Esophageal Adenocarcinoma.
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Production of Cardiomyocytes by microRNA-Mediated Reprogramming in Optimized Reprogramming Media.
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Protein-patterned hydrogels: Customized cell microenvironments.
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Proteomic Analysis of Primary Human Airway Epithelial Cells Exposed to the Respiratory Toxicant Diacetyl.
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Protocol to Generate Senescent Cells from the Mouse Hepatic Cell Line AML12 to Study Hepatic Aging.
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Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse.
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Rapid Reprogramming of Primary Human Astrocytes into Potent Tumor-Initiating Cells with Defined Genetic Factors.
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Rapid and Efficient Generation of Transgene-Free iPSC from a Small Volume of Cryopreserved Blood.
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Regulated heat shock protein 27 expression in human retinal pigment epithelium.
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Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium.
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Relevance and safety of telomerase for human tissue engineering.
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Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo.
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Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility.
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Roles of adherent myogenic cells and dynamic culture in engineered muscle function and maintenance of satellite cells.
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SUMO2/3 conjugation is an endogenous neuroprotective mechanism.
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Scaffold-free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels.
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Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia.
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Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival.
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Select de novo gene and protein expression during renal epithelial cell culture in rotating wall vessels is shear stress dependent.
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Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity.
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Selective aggregation assays for embryonic brain cells and cell lines.
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Self-Assembling Peptide Gels for 3D Prostate Cancer Spheroid Culture.
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Simulated microgravity-mediated reversion of murine lymphoma immune evasion.
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Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells.
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Single-pass, closed-system rapid expansion of lymphocyte cultures for adoptive cell therapy.
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Skeletal muscle-on-a-chip: an in vitro model to evaluate tissue formation and injury.
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Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts.
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Soluble factor effects on glial cell reactivity at the surface of gel-coated microwires.
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Sources of human and murine hematopoietic stem cells.
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Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy.
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Stem cell transplantation (cord blood transplants).
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Strategy for the development of a matched set of transport-competent, angiotensin receptor-deficient proximal tubule cell lines.
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Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones.
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Studying the influence of angiogenesis in in vitro cancer model systems.
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Sulforaphane induces inhibition of human umbilical vein endothelial cells proliferation by apoptosis.
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Suppression of inflammatory corneal lymphangiogenesis by application of topical corticosteroids.
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Surface- and Hydrogel-Mediated Delivery of Nucleic Acid Nanoparticles.
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Synergistic effect of shear stress and streptavidin-biotin on the expression of endothelial vasodilator and cytoskeleton genes.
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Synthesis and in vitro evaluation of enzymatically cross-linked elastin-like polypeptide gels for cartilaginous tissue repair.
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Systemic nitric oxide production in human malaria. II. Analysis of mononuclear cell nitric oxide synthase type 2 antigen expression.
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Systems biology for organotypic cell cultures.
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Technology evaluation: Stem-cell therapy, Aastrom Biosciences Inc.
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The effect of enzymatically degradable poly (ethylene glycol) hydrogels on smooth muscle cell phenotype
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The effects of static and intermittent compression on nitric oxide production in articular cartilage explants.
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The homozygous CX3CR1-M280 mutation impairs human monocyte survival.
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The many faces of the trabecular meshwork cell.
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The role of mast cells in host defense and their subversion by bacterial pathogens.
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The role of the macrophage scavenger receptor in immune stimulation by bacterial DNA and synthetic oligonucleotides.
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The role of tregs in human glioma patients and their inhibition with a novel STAT-3 inhibitor.
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The use of micropatterning to control smooth muscle myosin heavy chain expression and limit the response to transforming growth factor β1 in vascular smooth muscle cells.
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The use of mild trypsinization conditions in the detachment of endothelial cells to promote subsequent endothelialization on synthetic surfaces.
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Three dimensional tubular structure self-assembled by vascular mesenchymal cells at stiffness interfaces of hydrogels
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Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition.
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Three-dimensional culture systems in cancer research: Focus on tumor spheroid model.
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Three-dimensional direct writing of B35 neuronal cells.
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Tissue engineering of functional skeletal muscle: challenges and recent advances.
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Ultra-high expression of a thermally responsive recombinant fusion protein in E. coli.
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Up-regulated P21CIP1 expression is part of the regulation quantitatively controlling serum deprivation-induced apoptosis.
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Use of serum-free media to minimize apoptosis of chronic lymphocytic leukemia cells during in vitro culture.
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Utility of telomerase-pot1 fusion protein in vascular tissue engineering.
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Viral infection of human progenitor and liver-derived cells encapsulated in three-dimensional PEG-based hydrogel.
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X-ray imaging optimization of 3D tissue engineering scaffolds via combinatorial fabrication methods.
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c-Jun promotes whereas JunB inhibits epidermal neoplasia.
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Keywords of People
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Allori, Alexander C,
Associate Professor of Surgery,
Surgery, Plastic, Maxillofacial, and Oral Surgery
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Biomedical Engineering
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Sunday, Mary Elizabeth Anne,
Professor of Pathology,
Cell Biology
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Wray, Gregory Allan,
Professor of Biology,
Evolutionary Anthropology