Chemokine CCL2

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  Subject Areas on Research

  • A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury. 
  • A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension. 
  • Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth. 
  • Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes. 
  • Associations between the chemokine biomarker CCL2 and knee osteoarthritis outcomes: the Johnston County Osteoarthritis Project. 
  • Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. 
  • C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration. 
  • CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. 
  • Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy. 
  • Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. 
  • Combined expression of A1 and A20 achieves optimal protection of renal proximal tubular epithelial cells. 
  • Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver. 
  • Cytokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy. 
  • Discriminating between latent and active tuberculosis with multiple biomarker responses. 
  • Dual action of TGF-beta1 on nasal-polyp derived fibroblasts. 
  • Early biomarkers of stroke. 
  • Effect of mutant IkappaB on cytokine-induced activation of NF-kappaB in cultured human RPE cells. 
  • Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors. 
  • Effects of oxidized LDL on mononuclear phagocytes: inhibition of induction of four inflammatory cytokine gene RNAs, release of NO, and cytolysis of tumor cells. 
  • Elevations of inflammatory proteins in neonatal blood are associated with obesity and overweight among 2-year-old children born extremely premature. 
  • Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy women. 
  • Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation. 
  • Evaluation of host immune responses to pulmonary cryptococcosis using a temperature-sensitive C. neoformans calcineurin A mutant strain. 
  • Excess risk of temporomandibular disorder associated with cigarette smoking in young adults. 
  • Exosomal CCL2 from Tubular Epithelial Cells Is Critical for Albumin-Induced Tubulointerstitial Inflammation. 
  • Exploitation of Synthetic mRNA To Drive Immune Effector Cell Recruitment and Functional Reprogramming In Vivo. 
  • Heme: a novel inducer of MCP-1 through HO-dependent and HO-independent mechanisms. 
  • Host and environmental factors affect pulmonary responses measured in bronchoalveolar lavage. 
  • Human immunodeficiency virus (HIV) infects human arterial smooth muscle cells in vivo and in vitro: implications for the pathogenesis of HIV-mediated vascular disease. 
  • Human immunodeficiency virus (HIV)-1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant protein-1 expression: implications for the pathogenesis of HIV/hepatitis C virus-induced liver fibrosis. 
  • IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria. 
  • Impact of carbohydrate restriction in the context of obesity on prostate tumor growth in the Hi-Myc transgenic mouse model. 
  • In vivo myocardial protection from ischemia/reperfusion injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. 
  • Inflammation in coronary artery disease. 
  • Inflammation, platelets, and glycoprotein IIb/IIIa inhibitors. 
  • Interleukin-6 and type I interferon-regulated genes and chemokines mark disease activity in dermatomyositis. 
  • Isolation and structures of novel fungal metabolites as chemokine receptor (CCR2) antagonists. 
  • JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. 
  • Low-level endotoxin induces potent inflammatory activation of human blood vessels: inhibition by statins. 
  • Lung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host defense to Streptococcus pneumoniae infection in mice: role of the CCL2-CCR2 axis. 
  • MCP1 SNPs and pulmonary tuberculosis in cohorts from West Africa, the USA and Argentina: lack of association or epistasis with IL12B polymorphisms. 
  • Mice that overexpress CC chemokine ligand 2 in their lungs show increased protective immunity to infection with Mycobacterium bovis bacille Calmette-Guérin. 
  • Moderate-intensity aerobic training program improves insulin sensitivity and inflammatory markers in a pilot study of morbidly obese minority teens. 
  • Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques. 
  • Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation. 
  • Nitric oxide is necessary for CC-class chemokine expression in endotoxin-stimulated ANA-1 murine macrophages. 
  • Organizing pneumonia in mice and men. 
  • Osteoblasts produce monocyte chemoattractant protein-1 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissue. 
  • PECAM-1 dampens cytokine levels during LPS-induced endotoxemia by regulating leukocyte trafficking. 
  • Pathogenesis of pneumococcal pneumonia in cyclophosphamide-induced leukopenia in mice. 
  • Peripheral blood cytokine and chemokine profiles in juvenile localized scleroderma: T-helper cell-associated cytokine profiles. 
  • RANK, RANKL, OPG, and M-CSF expression in stromal cells during corneal wound healing. 
  • RNA-Seq and ChIP-Seq reveal SQSTM1/p62 as a key mediator of JunB suppression of NF-κB-dependent inflammation. 
  • Regulation of I-309 gene expression in human monocytes by endogenous interleukin-1. 
  • Regulation of endotoxin-induced proinflammatory activation in human coronary artery cells: expression of functional membrane-bound CD14 by human coronary artery smooth muscle cells. 
  • Relationship between markers of platelet activation and inflammation with disease activity in Wegener's granulomatosis. 
  • Role of C-C motif ligand 2 and C-C motif receptor 2 in murine pulmonary graft-versus-host disease after lipopolysaccharide inhalations. 
  • Safety, pharmacokinetics, and pharmacodynamic properties of oral DEBIO1143 (AT-406) in patients with advanced cancer: results of a first-in-man study. 
  • Serial measurement of monocyte chemoattractant protein-1 after acute coronary syndromes: results from the A to Z trial. 
  • Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation. 
  • Serum levels of fibroblast growth factor 23 are elevated in patients with active Lupus nephritis. 
  • Soluble ICAM-1, MCP-1, and MIP-2 protein secretion by rat pleural mesothelial cells following exposure to amosite asbestos. 
  • Spinal CCL2 Promotes Central Sensitization, Long-Term Potentiation, and Inflammatory Pain via CCR2: Further Insights into Molecular, Synaptic, and Cellular Mechanisms. 
  • Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1. 
  • Suppression of NF-kappaB-dependent proinflammatory gene expression in human RPE cells by a proteasome inhibitor. 
  • Suppression of tumor formation in vivo by expression of the JE gene in malignant cells. 
  • TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling. 
  • The chemokines IL-8, monocyte chemoattractant protein-1, and I-309 are monomers at physiologically relevant concentrations. 
  • The effect of inflammatory cell-derived MCP-1 loss on neuronal survival during chronic neuroinflammation. 
  • The relation of severity of depressive symptoms to monocyte-associated proinflammatory cytokines and chemokines in apparently healthy men. 
  • Upregulation of IL-1β, IL-6, and CCL-2 by a novel mouse model of pancreatic ischemia-reperfusion injury. 
  • Urinary Exosomes and Exosomal CCL2 mRNA as Biomarkers of Active Histologic Injury in IgA Nephropathy. 
  • Urine osteoprotegerin and monocyte chemoattractant protein-1 in lupus nephritis. 
  • Vein graft neointimal hyperplasia is exacerbated by tumor necrosis factor receptor-1 signaling in graft-intrinsic cells. 
  • Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury. 
  • [LMP-420, a new therapeutic approach for cerebral malaria?]. 
  • β2- and β3-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines. 
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  Keywords of People

  • Ferrari, Guido, Associate Professor of Surgery, Molecular Genetics and Microbiology
  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Krangel, Michael S., Mary Bernheim Distinguished Professor of Immunology, Immunology
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma