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Subject Areas on Research
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A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice.
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A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice.
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A glycoengineered anti-CD19 antibody with potent antibody-dependent cellular cytotoxicity activity in vitro and lymphoma growth inhibition in vivo.
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A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE.
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A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation.
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A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.
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Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.
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Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis.
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Association of a functional CD19 polymorphism with susceptibility to systemic sclerosis.
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B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse.
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B lymphocytes contribute to autoimmune disease pathogenesis: current trends and clinical implications.
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B lymphocytes differentially influence acute and chronic allograft rejection in mice.
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B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae.
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B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody.
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Biochemical and immunological abnormalities in purine nucleoside phosphorylase deficient mice.
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CD19 CAR-T expressing PD-1/CD28 chimeric switch receptor as a salvage therapy for DLBCL patients treated with different CD19-directed CAR T-cell therapies.
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CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation.
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CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation.
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CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling.
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CD19 and CD22 regulate a B lymphocyte signal transduction pathway that contributes to autoimmunity.
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CD19 can regulate B lymphocyte signal transduction independent of complement activation.
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CD19 expression in B cells is important for suppression of contact hypersensitivity.
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CD19 expression in B cells regulates atopic dermatitis in a mouse model.
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CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19.
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CD19 hyperexpression augments Sle1-induced humoral autoimmunity but not clinical nephritis.
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CD19 maps to a region of conservation between human chromosome 16 and mouse chromosome 7.
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CD19 regulates B lymphocyte responses to transmembrane signals.
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CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity.
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CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.
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CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes.
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CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification.
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CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma.
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CD19 regulates the development of bleomycin-induced pulmonary fibrosis in a mouse model.
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CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction.
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CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling.
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CD19-CD21 complex regulates an intrinsic Src family kinase amplification loop that links innate immunity with B-lymphocyte intracellular calcium responses.
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CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse.
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CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes.
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CD19: a promising B cell target for rheumatoid arthritis.
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CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression.
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Characterization of an Epstein-Barr virus receptor on human epithelial cells.
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Collagen type-V is a danger signal associated with primary graft dysfunction in lung transplantation.
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Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement.
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Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction.
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Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation.
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Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease.
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High frequency of immunophenotype changes in acute myeloid leukemia at relapse: implications for residual disease detection (Cancer and Leukemia Group B Study 8361).
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Humoral autoimmunity in mice overexpressing B cell surface CD19: vital role for MHC class II.
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IL-10-producing regulatory B10 cells inhibit intestinal injury in a mouse model.
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Immune signatures in follicular lymphoma.
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Immunological findings in thymoma and thymoma-related syndromes.
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Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease.
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Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response.
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Innate and adaptive receptors interact to balance humoral immunity.
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Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.
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Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset.
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Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily.
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Loss of tolerance of anti-dsDNA B cells in mice overexpressing CD19.
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Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds.
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Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop.
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NCCN Guidelines® Insights: B-Cell Lymphomas, Version 5.2021.
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Ordinary Differential Equation Models for Adoptive Immunotherapy.
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Peripheral eosinophil counts predict efficacy of anti-CD19 CAR-T cell therapy against B-lineage non-Hodgkin lymphoma.
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Prolonged B-cell depletion in MuSK myasthenia gravis following rituximab treatment.
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Quantitative determination of surface antibody binding capacities of immune subsets present in peripheral blood of healthy adult donors.
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Quantitative genetic variation in CD19 expression correlates with autoimmunity.
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Real-world evidence of tisagenlecleucel for pediatric acute lymphoblastic leukemia and non-Hodgkin lymphoma.
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Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19.
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Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase.
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Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice.
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Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis.
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Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity.
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Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions.
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Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation.
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Risk of HBV reactivation post CD19-CAR-T cell therapy in DLBCL patients with concomitant chronic HBV infection.
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Role of the CD19 and CD21/35 receptor complex in innate immunity, host defense and autoimmunity.
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Similar CD19 dysregulation in two autoantibody-associated autoimmune diseases suggests a shared mechanism of B-cell tolerance loss.
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Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain.
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Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes.
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T cells or active Epstein-Barr virus infection in the development of lymphoproliferative disease in human B cell-injected severe combined immunodeficient mice.
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The CD19 signal transduction complex of B lymphocytes. Deletion of the CD19 cytoplasmic domain alters signal transduction but not complex formation with TAPA-1 and Leu 13.
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The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation.
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The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity.
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The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system.
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The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.
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The CD19/CD21 signal transduction complex of B lymphocytes.
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The Tumor Microenvironment Regulates CD19 and CD20 Immunotherapy for Lymphoma.
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The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19.
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The human fetal lymphocyte lineage: identification by CD27 and LIN28B expression in B cell progenitors.
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The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment.
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Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia.
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Tissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent B-lymphocyte development.
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Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway.
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Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning.