Antigens, CD44

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  Subject Areas on Research

  • A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding. 
  • A new twist to the leukocyte adhesion cascade: intimate cooperation is key. 
  • A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis. 
  • ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma. 
  • Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma. 
  • An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. 
  • Aqueous humor sCD44 concentration and visual field loss in primary open-angle glaucoma. 
  • Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers. 
  • Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin. 
  • Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier. 
  • CD44 deficiency leads to enhanced neutrophil migration and lung injury in Escherichia coli pneumonia in mice. 
  • CD44 is a negative regulator of acute pulmonary inflammation and lipopolysaccharide-TLR signaling in mouse macrophages. 
  • CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. 
  • CD44+/CD24- breast cancer cells isolated from MCF-7 cultures exhibit enhanced angiogenic properties. 
  • CD44-SLC1A2 gene fusions in gastric cancer. 
  • Cellular CD44S as a determinant of human immunodeficiency virus type 1 infection and cellular tropism. 
  • Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells. 
  • Characterization of C1q receptor expression on human phagocytic cells: effects of PDBu and fMLP. 
  • Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. 
  • Coordinator's report--section 2D3. 
  • Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-alpha and is inhibited by IL-4 and IL-13. 
  • Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. 
  • Distribution of CD44 variant isoforms in human skin: differential expression in components of benign and malignant epithelia. 
  • Effectiveness of plasma treatment on gastric cancer cells. 
  • Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix. 
  • Erythrocyte adhesion receptors: blood group antigens and related molecules. 
  • Erythrocyte blood group antigens: not so simple after all. 
  • Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone. 
  • Expression of CD44 and variant isoforms in cultured human retinal pigment epithelial cells. 
  • Expression of CD44 molecules and CD44 ligands during human thymic fetal development: expression of CD44 isoforms is developmentally regulated. 
  • Expression of CD44 variants in human inflammatory synovitis. 
  • Expression of cell adhesion molecule CD44 in primary tumors of the liver: an immunohistochemical study. 
  • Expression of the cell adhesion molecule CD44 in gastric adenocarcinomas. 
  • Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor). 
  • Gαs proteins activate p72(Syk) and p60-c-Src tyrosine kinases to mediate sickle red blood cell adhesion to endothelium via LW-αvβ3 and CD44-CD44 interactions. 
  • HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44. 
  • Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer. 
  • Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44. 
  • Hyaluronan and its catabolic products in tissue injury and repair. 
  • Hyaluronan as an immune regulator in human diseases. 
  • Hyaluronan fragments contribute to the ozone-primed immune response to lipopolysaccharide. 
  • Hyaluronan in tissue injury and repair. 
  • Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice. 
  • Hypophosphorylation of aqueous humor sCD44 and primary open-angle glaucoma. 
  • In vitro culture of human peripheral blood monocytes induces hyaluronan binding and up-regulates monocyte variant CD44 isoform expression. 
  • Induction of IL-12 and chemokines by hyaluronan requires adhesion-dependent priming of resident but not elicited macrophages. 
  • Inhibition of HIV type 1 infection of mononuclear phagocytes by anti-CD44 antibodies. 
  • Inter-α-inhibitor impairs TSG-6-induced hyaluronan cross-linking. 
  • Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). 
  • Leukocyte phenotypic changes in an in vitro model of ABO hemolytic transfusion reaction. 
  • Lutheran antigens, CD44-related antigens, and Lutheran regulatory genes. 
  • Lyphocyte migration in L-selectin-deficient mice. Altered subset migration and aging of the immune system. 
  • MEK1/2 inhibitors reverse acute vascular occlusion in mouse models of sickle cell disease. 
  • Measurement of an adhesion molecule as an indicator of inflammatory disease activity. Up-regulation of the receptor for hyaluronate (CD44) in rheumatoid arthritis. 
  • Monocyte adhesion in patients with bone marrow fibrosis is required for the production of fibrogenic cytokines. Potential role for interleukin-1 and TGF-beta. 
  • N-terminal and central regions of the human CD44 extracellular domain participate in cell surface hyaluronan binding. 
  • Neonates support lymphopenia-induced proliferation. 
  • Nuclear translocation of β-catenin correlates with CD44 upregulation in Helicobacter pylori-infected gastric carcinoma. 
  • Osteopontin increases CD44 expression and cell adhesion in RAW 264.7 murine leukemia cells. 
  • Osteopontin inhibits expression of cytochrome c oxidase in RAW 264.7 murine macrophages. 
  • Osteopontin-dependent CD44v6 expression and cell adhesion in HepG2 cells. 
  • Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice. 
  • Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin, disrupting interactions of radixin with actin and CD44. 
  • RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. 
  • Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies. 
  • Resolution of lung inflammation by CD44. 
  • Role of adhesion molecules in the pathogenesis of rheumatoid arthritis. 
  • Role of hyaluronan and hyaluronan-binding proteins in human asthma. 
  • Serum levels of soluble CD44 in primary Sjögren's syndrome. 
  • Serum protein expression predicts recurrence in patients with early-stage lung cancer after resection. 
  • Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44. 
  • Sickle red cells induce adhesion of lymphocytes and monocytes to endothelium. 
  • Signaling properties of hyaluronan receptors. 
  • Single-nucleotide polymorphisms of stemness genes predicted to regulate RNA splicing, microRNA and oncogenic signaling are associated with prostate cancer survival. 
  • Stage-specific functions of E-proteins at the β-selection and T-cell receptor checkpoints during thymocyte development. 
  • Steroid induction of therapy-resistant cytokeratin-5-positive cells in estrogen receptor-positive breast cancer through a BCL6-dependent mechanism. 
  • Suppression of inflammatory corneal lymphangiogenesis by application of topical corticosteroids. 
  • TNFalpha and IL-4 regulation of hyaluronan binding to monocyte CD44 involves posttranslational modification of CD44. 
  • The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. 
  • The Prognostic Value of CD44 Expression in Epithelial-Mesenchymal Transition: Preliminary Data from Patients with Gastric and Esophageal Cancer. 
  • The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma. 
  • The role of Toll-like receptors in non-infectious lung injury. 
  • The role of hyaluronic acid in atherosclerosis and intimal hyperplasia. 
  • The transmembrane hyaluronate receptor (CD44): multiple functions, multiple forms. 
  • Tumor initiating cells in esophageal squamous cell carcinomas express high levels of CD44. 
  • [Expression of presenilin 1 on the cell surface in motile polarized cells]. 
  • sCD44 overexpression increases intraocular pressure and aqueous outflow resistance. 
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  Keywords of People

  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Zennadi, Rahima, Associate Professor in Medicine, Pathology