DNA Footprinting
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Subject Areas on Research
- A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter.
- A developmental switch from TCR delta enhancer to TCR alpha enhancer function during thymocyte maturation.
- A hot spot for hydrogen peroxide-induced damage in the human hypoxia-inducible factor 1 binding site of the PGK 1 gene.
- An integrated encyclopedia of DNA elements in the human genome.
- Analyses of promoter-proximal pausing by RNA polymerase II on the hsp70 heat shock gene promoter in a Drosophila nuclear extract.
- Base-pairing potential identified by in vitro selection predicts the kinked RNA backbone observed in the crystal structure of the alfalfa mosaic virus RNA-coat protein complex.
- Characterization of the SarA virulence gene regulator of Staphylococcus aureus.
- Characterization of the rat type III hexokinase gene promoter. A functional octamer 1 motif is critical for basal promoter activity.
- Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue.
- Cooperation among multiple transcription factors is required for access to minimal T-cell receptor alpha-enhancer chromatin in vivo.
- DNase I sensitivity QTLs are a major determinant of human expression variation.
- Distinct roles for c-Myb and core binding factor/polyoma enhancer-binding protein 2 in the assembly and function of a multiprotein complex on the TCR delta enhancer in vivo.
- Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters.
- Explicit DNase sequence bias modeling enables high-resolution transcription factor footprint detection.
- GABP and PU.1 compete for binding, yet cooperate to increase CD18 (beta 2 leukocyte integrin) transcription.
- Identification of an enhancer element in the estrogen receptor upstream region: implications for regulation of ER transcription in breast cancer.
- Mapping of peroxyl radical induced damage on genomic DNA.
- Phylogenetic footprint analysis of IGF2 in extant mammals.
- Predicting cell-type-specific gene expression from regions of open chromatin.
- The CovR response regulator of group A streptococcus (GAS) acts directly to repress its own promoter.
- The accessible chromatin landscape of the human genome.
- The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding.
- The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove.
- Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1.
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Keywords of People
- Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Immunology