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Subject Areas on Research
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A Mec17-Myosin II Effector Axis Coordinates Microtubule Acetylation and Actin Dynamics to Control Primary Cilium Biogenesis.
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A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury.
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APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy.
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Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy.
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Altered expression of myosin heavy chain in human skeletal muscle in chronic heart failure.
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Altered expression of myosin heavy chain in the vastus lateralis muscle in patients with COPD.
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An MYH9 human disease model in flies: site-directed mutagenesis of the Drosophila non-muscle myosin II results in hypomorphic alleles with dominant character.
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Angiotensin-II mediates nonmuscle myosin II activation and expression and contributes to human keloid disease progression.
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BRG1 is a biomarker of hypertrophic cardiomyopathy in human heart specimens.
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Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels.
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Carbon monoxide, skeletal muscle oxidative stress, and mitochondrial biogenesis in humans.
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Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes.
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Cell Density and Joint microRNA-133a and microRNA-696 Inhibition Enhance Differentiation and Contractile Function of Engineered Human Skeletal Muscle Tissues.
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Correction of multiple striated muscles in murine Pompe disease through adeno-associated virus-mediated gene therapy.
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Cultivation in rotating bioreactors promotes maintenance of cardiac myocyte electrophysiology and molecular properties.
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Dawn of the Epi-LncRNAs: new path from Myheart.
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Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain.
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Differential effects of exercise training in men and women with chronic heart failure.
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Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization.
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Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.
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Do Adipocytes Emerge from Mural Progenitors?
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Early de novo DNA methylation and prolonged demethylation in the muscle lineage.
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Early specialization of the superfast myosin in extraocular and laryngeal muscles.
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Effect of p38 MAP kinases on contractility and ischemic injury in intact heart.
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Endothelial cell-conditioned medium downregulates smooth muscle contractile protein expression.
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Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy.
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Familial hypertrophic cardiomyopathy and atrial fibrillation caused by Arg663His beta-cardiac myosin heavy chain mutation.
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Fiber-type phenotype of the jaw-closing muscles in Gorilla gorilla, Pan troglodytes, and Pan paniscus: A test of the Frequent Recruitment Hypothesis.
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G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency.
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Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model.
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Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis.
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Genotype-phenotype correlation in MYH9-related thrombocytopenia.
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In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress.
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Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders.
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Involvement of an actomyosin contractile ring in Saccharomyces cerevisiae cytokinesis.
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MYH9 E1841K Mutation Augments Proteinuria and Podocyte Injury and Migration.
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MYH9 and APOL1 are both associated with sickle cell disease nephropathy.
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Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme.
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Modulation of gene expression in neonatal rat cardiomyocytes by surface modification of polylactide-co-glycolide substrates.
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Molecular organization and alternative splicing in zipper, the gene that encodes the Drosophila non-muscle myosin II heavy chain.
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Monocytes prime autoreactive T cells after myocardial infarction.
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Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A.
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Mouse transgenic lines that selectively label Type I, Type IIA, and Types IIX+B skeletal muscle fibers.
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Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly.
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Myocardial overexpression of adrenergic receptors and receptor kinases.
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Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo.
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Myosins motor Miranda.
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Native nonmuscle myosin II stability and light chain binding in Drosophila melanogaster.
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Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closure.
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Normal cardiac function in mice with supraphysiological cardiac creatine levels.
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Novel Genetic Triggers and Genotype-Phenotype Correlations in Patients With Left Ventricular Noncompaction.
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Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block.
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PIP5K1α promotes myogenic differentiation via AKT activation and calcium release.
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Peptide elongation factor eEF1A-2/S1 expression in cultured differentiated myotubes and its protective effect against caspase-3-mediated apoptosis.
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Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations.
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Phylogenetic implications of the superfast myosin in extraocular muscles.
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Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi.
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Potential donor-recipient MYH9 genotype interactions in posttransplant nephrotic syndrome after pediatric kidney transplantation.
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Protein kinase C phosphorylates nonmuscle myosin-II heavy chain from Drosophila but regulation of myosin function by this enzyme is not required for viability in flies.
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Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity.
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Proteomics and immunohistochemistry identify the expression of α-cardiac myosin heavy chain in the jaw-closing muscles of sooty mangabeys (order Primates).
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Regional variation in IIM myosin heavy chain expression in the temporalis muscle of female and male baboons (Papio anubis).
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Report of a young girl with MYH9 mutation and review of the literature.
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SHP-2 is required for the maintenance of cardiac progenitors.
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Second-site noncomplementation identifies genomic regions required for Drosophila nonmuscle myosin function during morphogenesis.
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Sexually dimorphic myofilament function and cardiac troponin I phosphospecies distribution in hypertrophic cardiomyopathy mice.
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Targeted overexpression of phospholamban to mouse atrium depresses Ca2+ transport and contractility.
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The conserved phosphoinositide 3-kinase pathway determines heart size in mice.
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The developmental switch in ventricular myosin expression in vivo is not triggered by an increase in cyclic AMP.
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The human extraocular muscle myosin heavy chain gene (MYH13) maps to the cluster of fast and developmental myosin genes on chromosome 17.
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The use of micropatterning to control smooth muscle myosin heavy chain expression and limit the response to transforming growth factor β1 in vascular smooth muscle cells.
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Tissue engineering of functional cardiac muscle: molecular, structural, and electrophysiological studies.
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Transdifferentiation of human endothelial progenitors into smooth muscle cells.
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Vaccination with 73kDa recombinant heavy chain myosin generates high level of protection against Brugia malayi challenge in jird and mastomys models.
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WNT3A promotes myogenesis of human embryonic stem cells and enhances in vivo engraftment.
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p38γ activity is required for maintenance of slow skeletal muscle size.
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Keywords of People
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Gunn, Michael Dee,
Professor of Medicine,
Immunology
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Kiehart, Daniel P.,
Professor of Biology,
Duke Science & Society
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Milano, Carmelo Alessio,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery,
Surgery, Cardiovascular and Thoracic Surgery