Myosin Heavy Chains

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  Subject Areas on Research

  • A Mec17-Myosin II Effector Axis Coordinates Microtubule Acetylation and Actin Dynamics to Control Primary Cilium Biogenesis. 
  • A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury. 
  • APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy. 
  • Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. 
  • Altered expression of myosin heavy chain in human skeletal muscle in chronic heart failure. 
  • Altered expression of myosin heavy chain in the vastus lateralis muscle in patients with COPD. 
  • An MYH9 human disease model in flies: site-directed mutagenesis of the Drosophila non-muscle myosin II results in hypomorphic alleles with dominant character. 
  • Angiotensin-II mediates nonmuscle myosin II activation and expression and contributes to human keloid disease progression. 
  • BRG1 is a biomarker of hypertrophic cardiomyopathy in human heart specimens. 
  • Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels. 
  • Carbon monoxide, skeletal muscle oxidative stress, and mitochondrial biogenesis in humans. 
  • Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes. 
  • Cell Density and Joint microRNA-133a and microRNA-696 Inhibition Enhance Differentiation and Contractile Function of Engineered Human Skeletal Muscle Tissues. 
  • Correction of multiple striated muscles in murine Pompe disease through adeno-associated virus-mediated gene therapy. 
  • Cultivation in rotating bioreactors promotes maintenance of cardiac myocyte electrophysiology and molecular properties. 
  • Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain. 
  • Differential effects of exercise training in men and women with chronic heart failure. 
  • Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization. 
  • Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo. 
  • Early de novo DNA methylation and prolonged demethylation in the muscle lineage. 
  • Early specialization of the superfast myosin in extraocular and laryngeal muscles. 
  • Endothelial cell-conditioned medium downregulates smooth muscle contractile protein expression. 
  • Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy. 
  • Familial hypertrophic cardiomyopathy and atrial fibrillation caused by Arg663His beta-cardiac myosin heavy chain mutation. 
  • Fiber-type phenotype of the jaw-closing muscles in Gorilla gorilla, Pan troglodytes, and Pan paniscus: A test of the Frequent Recruitment Hypothesis. 
  • G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency. 
  • Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis. 
  • Genotype-phenotype correlation in MYH9-related thrombocytopenia. 
  • In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress. 
  • Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders. 
  • Involvement of an actomyosin contractile ring in Saccharomyces cerevisiae cytokinesis. 
  • MYH9 E1841K Mutation Augments Proteinuria and Podocyte Injury and Migration. 
  • MYH9 and APOL1 are both associated with sickle cell disease nephropathy. 
  • Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme. 
  • Modulation of gene expression in neonatal rat cardiomyocytes by surface modification of polylactide-co-glycolide substrates. 
  • Molecular organization and alternative splicing in zipper, the gene that encodes the Drosophila non-muscle myosin II heavy chain. 
  • Monocytes prime autoreactive T cells after myocardial infarction. 
  • Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A. 
  • Mouse transgenic lines that selectively label Type I, Type IIA, and Types IIX+B skeletal muscle fibers. 
  • Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly. 
  • Myocardial overexpression of adrenergic receptors and receptor kinases. 
  • Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo. 
  • Myosins motor Miranda. 
  • Native nonmuscle myosin II stability and light chain binding in Drosophila melanogaster. 
  • Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closure. 
  • Normal cardiac function in mice with supraphysiological cardiac creatine levels. 
  • Novel Genetic Triggers and Genotype-Phenotype Correlations in Patients With Left Ventricular Noncompaction. 
  • Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block. 
  • PIP5K1α promotes myogenic differentiation via AKT activation and calcium release. 
  • Peptide elongation factor eEF1A-2/S1 expression in cultured differentiated myotubes and its protective effect against caspase-3-mediated apoptosis. 
  • Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations. 
  • Phylogenetic implications of the superfast myosin in extraocular muscles. 
  • Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi. 
  • Potential donor-recipient MYH9 genotype interactions in posttransplant nephrotic syndrome after pediatric kidney transplantation. 
  • Protein kinase C phosphorylates nonmuscle myosin-II heavy chain from Drosophila but regulation of myosin function by this enzyme is not required for viability in flies. 
  • Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity. 
  • Proteomics and immunohistochemistry identify the expression of α-cardiac myosin heavy chain in the jaw-closing muscles of sooty mangabeys (order Primates). 
  • Regional variation in IIM myosin heavy chain expression in the temporalis muscle of female and male baboons (Papio anubis). 
  • Report of a young girl with MYH9 mutation and review of the literature. 
  • SHP-2 is required for the maintenance of cardiac progenitors. 
  • Second-site noncomplementation identifies genomic regions required for Drosophila nonmuscle myosin function during morphogenesis. 
  • Sexually dimorphic myofilament function and cardiac troponin I phosphospecies distribution in hypertrophic cardiomyopathy mice. 
  • Targeted overexpression of phospholamban to mouse atrium depresses Ca2+ transport and contractility. 
  • The conserved phosphoinositide 3-kinase pathway determines heart size in mice. 
  • The developmental switch in ventricular myosin expression in vivo is not triggered by an increase in cyclic AMP. 
  • The human extraocular muscle myosin heavy chain gene (MYH13) maps to the cluster of fast and developmental myosin genes on chromosome 17. 
  • The use of micropatterning to control smooth muscle myosin heavy chain expression and limit the response to transforming growth factor β1 in vascular smooth muscle cells. 
  • Tissue engineering of functional cardiac muscle: molecular, structural, and electrophysiological studies. 
  • Transdifferentiation of human endothelial progenitors into smooth muscle cells. 
  • Vaccination with 73kDa recombinant heavy chain myosin generates high level of protection against Brugia malayi challenge in jird and mastomys models. 
  • WNT3A promotes myogenesis of human embryonic stem cells and enhances in vivo engraftment. 
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  Keywords of People

  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Kiehart, Daniel P., Professor of Biology, Duke Science & Society
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery