Phosphotyrosine
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Subject Areas on Research
- A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction.
- A positive addition to a negative tail's tale.
- Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation.
- Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C.
- Altered expression of pp60c-src induced by peripheral nerve injury.
- Autocrine growth stimulation by transforming growth factor alpha in asbestos-transformed rat mesothelial cells.
- BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner.
- Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release.
- CD9 plays a role in Schwann cell migration in vitro.
- CRP: Cleavage of Radiolabeled Phosphoproteins.
- Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast.
- Characterization of avian and viral p60src proteins expressed in yeast.
- Crk is required for apoptosis in Xenopus egg extracts.
- Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation.
- Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.
- Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.
- Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation.
- En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase.
- Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region.
- Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor.
- Global Identification of Small Ubiquitin-related Modifier (SUMO) Substrates Reveals Crosstalk between SUMOylation and Phosphorylation Promotes Cell Migration.
- Global phosphotyrosinylated protein profile of cell-matrix adhesion complexes of trabecular meshwork cells.
- Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation.
- Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells.
- Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase.
- Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation.
- Insulin receptor substrate-1 (IRS-1) expression in rat brain.
- Interaction of estrogen receptor alpha with protein kinase C alpha and c-Src in osteoblasts during differentiation.
- Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766.
- Involvement of linker for activation of T cells in the costimulatory signaling pathways.
- Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22.
- Involvement of protein tyrosine phosphorylation in immunotoxin effects on T lymphocytes.
- Knock-down of LAR protein tyrosine phosphatase induces insulin resistance.
- LAD-1, the Caenorhabditis elegans L1CAM homologue, participates in embryonic and gonadal morphogenesis and is a substrate for fibroblast growth factor receptor pathway-dependent phosphotyrosine-based signaling.
- Lipopolysaccharide up-regulates platelet-derived growth factor (PDGF) alpha-receptor expression in rat lung myofibroblasts and enhances response to all PDGF isoforms.
- Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure.
- Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets.
- Modified SH2 domain to phototrap and identify phosphotyrosine proteins from subcellular sites within cells.
- Molecular basis of T cell inactivation by CTLA-4.
- Negative regulation of TCR signaling by linker for activation of X cells via phosphotyrosine-dependent and -independent mechanisms.
- Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries.
- Phosphorylation of an alpha-synuclein peptide fragment enhances metal binding.
- Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases.
- Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle.
- The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes.
- Transcription factor TFII-I causes transcriptional upregulation of GRP78 synthesis in prostate cancer cells.
- Treatment of human spermatozoa with seminal plasma inhibits protein tyrosine phosphorylation.
- Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin.
- Tyrosine phosphorylation in human neutrophil.
- Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants.
- Tyrosine phosphorylation of G protein alpha subunits by pp60c-src.
- Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts.
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