Phosphotyrosine

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  Subject Areas on Research

  • A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction. 
  • A positive addition to a negative tail's tale. 
  • Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C. 
  • Autocrine growth stimulation by transforming growth factor alpha in asbestos-transformed rat mesothelial cells. 
  • BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. 
  • Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release. 
  • CD9 plays a role in Schwann cell migration in vitro. 
  • CRP: Cleavage of Radiolabeled Phosphoproteins. 
  • Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast. 
  • Cellular signaling by tyrosine phosphorylation in keloid and normal human dermal fibroblasts. 
  • Characterization of avian and viral p60src proteins expressed in yeast. 
  • Crk is required for apoptosis in Xenopus egg extracts. 
  • Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation. 
  • Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. 
  • Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation. 
  • En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase. 
  • Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region. 
  • Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor. 
  • Global Identification of Small Ubiquitin-related Modifier (SUMO) Substrates Reveals Crosstalk between SUMOylation and Phosphorylation Promotes Cell Migration. 
  • Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation. 
  • Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells. 
  • Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase. 
  • Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation. 
  • Insulin receptor substrate-1 (IRS-1) expression in rat brain. 
  • Interaction of estrogen receptor alpha with protein kinase C alpha and c-Src in osteoblasts during differentiation. 
  • Involvement of linker for activation of T cells in the costimulatory signaling pathways. 
  • Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22. 
  • Involvement of protein tyrosine phosphorylation in immunotoxin effects on T lymphocytes. 
  • Knock-down of LAR protein tyrosine phosphatase induces insulin resistance. 
  • LAD-1, the Caenorhabditis elegans L1CAM homologue, participates in embryonic and gonadal morphogenesis and is a substrate for fibroblast growth factor receptor pathway-dependent phosphotyrosine-based signaling. 
  • Lipopolysaccharide up-regulates platelet-derived growth factor (PDGF) alpha-receptor expression in rat lung myofibroblasts and enhances response to all PDGF isoforms. 
  • Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure. 
  • Modified SH2 domain to phototrap and identify phosphotyrosine proteins from subcellular sites within cells. 
  • Molecular basis of T cell inactivation by CTLA-4. 
  • Negative regulation of TCR signaling by linker for activation of X cells via phosphotyrosine-dependent and -independent mechanisms. 
  • Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries. 
  • Phosphorylation of an alpha-synuclein peptide fragment enhances metal binding. 
  • Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases. 
  • Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle. 
  • The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. 
  • Transcription factor TFII-I causes transcriptional upregulation of GRP78 synthesis in prostate cancer cells. 
  • Treatment of human spermatozoa with seminal plasma inhibits protein tyrosine phosphorylation. 
  • Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin. 
  • Tyrosine phosphorylation in human neutrophil. 
  • Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants. 
  • Tyrosine phosphorylation of G protein alpha subunits by pp60c-src. 
  • Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts. 
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  Keywords of People

  • Yan, Hai, Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine, Pathology