Nitric Oxide Synthase

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  Subject Areas on Research

  • A central role for S-nitrosylation in apoptosis. 
  • A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. 
  • A mechanism of paraquat toxicity involving nitric oxide synthase. 
  • A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children. 
  • A novel model system for studying the double-edged roles of nitric oxide production in pancreatic cancer growth and metastasis. 
  • A novel role for erythropoietin during fibrin-induced wound-healing response. 
  • A novel, clinically relevant animal model of metastatic pancreatic adenocarcinoma biology and therapy. 
  • APOE genotype-specific differences in human and mouse macrophage nitric oxide production. 
  • Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: noninvasive assessment with doppler echocardiography and contribution of the nitric oxide pathway. 
  • Abnormal pattern of Tie-2 and vascular endothelial growth factor receptor expression in human cerebral arteriovenous malformations. 
  • Acute local subcutaneous VEGF165 injection for augmentation of skin flap viability: efficacy and mechanism. 
  • Acute pancreatitis associated with administration of a nitric oxide synthase inhibitor in tumor-bearing dogs. 
  • Addition of nitric oxide donor S-nitroso-N-acetylcysteine to selective iNOS inhibitor 1400W further improves contractile function in reperfused skeletal muscle. 
  • Adenoviral gene transfer of nitric oxide synthase: high level expression in human vascular cells. 
  • Age-dependent augmentation of cardiac endothelial NOS in a genetic rat model of heart failure. 
  • Alteration in regulation of inflammatory response to influenza a virus and endotoxin in suckling rat pups: a potential relationship to sudden infant death syndrome. 
  • Ambient temperature and dietary supplementation interact to shape mosquito vector competence for malaria. 
  • Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis. 
  • Analysis of responses to bradykinin in the pulmonary vascular bed of the cat. 
  • Antioxidant lazaroid U-74006F improves renal function and reduces the expression of cytokines, inducible nitric oxide synthase, and MHC antigens in a syngeneic renal transplant model. Partial support for the response-to-injury hypothesis. 
  • Anxiolytic effects of acute morphine can be modulated by nitric oxide systems. 
  • Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport. 
  • Assessment and application of the biotin switch technique for examining protein S-nitrosylation under conditions of pharmacologically induced oxidative stress. 
  • Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery. 
  • Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO-. 
  • Autocrine inhibition of Na+/K(+)-ATPase by nitric oxide in mouse proximal tubule epithelial cells. 
  • Basal and stimulated protein S-nitrosylation in multiple cell types and tissues. 
  • Beta-adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells. 
  • Bicarbonate-dependent superoxide release and pulmonary artery tone. 
  • Biochemistry of nitric oxide and its redox-activated forms. 
  • Biosynthesis of nitric oxide and citrulline from L-arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum. 
  • Blood mononuclear cell nitric oxide production and plasma cytokine levels in healthy gabonese children with prior mild or severe malaria. 
  • CD14-dependent mechanism for endotoxin-mediated nitric oxide synthesis in murine macrophages. 
  • CLL cell apoptosis induced by nitric oxide synthase inhibitors: correlation with lipid solubility and NOS1 dissociation constant. 
  • Ca(2+)-dependent nitric oxide release in endothelial but not R3230Ac rat mammary adenocarcinoma cells. 
  • Calmodulin overexpression causes Ca(2+)-dependent apoptosis of pancreatic beta cells, which can be prevented by inhibition of nitric oxide synthase. 
  • Cellular and physiological effects of arginine. 
  • Characterization of key residues in the subdomain encoded by exons 8 and 9 of human inducible nitric oxide synthase: a critical role for Asp-280 in substrate binding and subunit interactions. 
  • Cholesterol feeding reduces vascular endothelial growth factor signaling in rabbit corporal tissues. 
  • Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N-terminal kinase and caspase 3 activation. 
  • Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2. 
  • Cold-induced brain edema in mice. Involvement of extracellular superoxide dismutase and nitric oxide. 
  • Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice. 
  • Commentaries on Viewpoint: Anemia contributes to cardiovascular disease through reductions in nitric oxide. 
  • Comparative effects of L-NNA and alkyl esters of L-NNA on pulmonary vasodilator responses to ACh, BK, and SP. 
  • Comparison of biochemical disturbances in hippocampal slices of gerbil and rat during and after in vitro ischemia. 
  • Complex effects of temperature on mosquito immune function. 
  • Complex environmental drivers of immunity and resistance in malaria mosquitoes. 
  • Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide. 
  • Concurrent production of reactive oxygen and nitrogen species by airway epithelial cells in vitro. 
  • Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. 
  • Contribution of monocytes/macrophages to compensatory neovascularization: the drilling of metalloelastase-positive tunnels in ischemic myocardium. 
  • Contributions of endothelial and neuronal nitric oxide synthases to cerebrovascular responses to hyperoxia. 
  • Cytochrome P450IIIA activity and cytokine-mediated synthesis of nitric oxide. 
  • Cytokine-induced mobilization of circulating endothelial progenitor cells enhances repair of injured arteries. 
  • Cytokine-mediated production of nitric oxide in isolated rat hepatocytes is dependent on cytochrome P-450III activity. 
  • Decreases in corporeal vascular endothelial growth factor expression precede vasoreactivity changes in cholesterol fed rabbits. 
  • Derangements of the nitric oxide synthase pathway, L-arginine, and cardiovascular diseases. 
  • Dietary glycine inhibits angiogenesis during wound healing and tumor growth. 
  • Differential activation of nitric-oxide synthase isozymes by calmodulin-troponin C chimeras. 
  • Differential expression of arginase and iNOS in the lung in sepsis. 
  • Differential localization of allograft nitric oxide synthesis: comparison of liver and heart transplantation in the rat model. 
  • Differential regulation of inducible nitric oxide synthase gene expression by ethanol in the human intestinal epithelial cell line DLD-1. 
  • Disrupted spermine homeostasis: a novel mechanism in polyglutamine-mediated aggregation and cell death. 
  • Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function. 
  • Effect of a NOS inhibitor, L-NMMA, on the contractile function of reperfused skeletal muscle. 
  • Effect of ethanol on tumor necrosis factor signaling during liver regeneration. 
  • Effect of nitric oxide synthase inhibition on bleeding time in humans. 
  • Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study. 
  • Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial. 
  • Effects of age and parasitemia on nitric oxide production/leukocyte nitric oxide synthase type 2 expression in asymptomatic, malaria-exposed children. 
  • Effects of arginase isoforms on NO Production by nNOS. 
  • Effects of cardiopulmonary bypass and circulatory arrest on endothelium-dependent vasodilation in the lung. 
  • Effects of progesterone and estrogen on endothelial dysfunction in porcine coronary arteries. 
  • Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2. 
  • Elevated nitric oxide production in children with malarial anemia: hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells. 
  • Endothelial nitric oxide synthase increases in left atria of dogs with pacing-induced heart failure. 
  • Endothelial type nitric oxide synthase in skeletal muscle fibers: mitochondrial relationships. 
  • Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt. 
  • Endothelium-derived nitric oxide regulates systemic and pulmonary vascular resistance during acute hypoxia in humans. 
  • Endotoxin-mediated S-nitrosylation of p50 alters NF-kappa B-dependent gene transcription in ANA-1 murine macrophages. 
  • Endotoxin-mediated nitric oxide synthesis inhibits IL-1beta gene transcription in ANA-1 murine macrophages. 
  • Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction. 
  • Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease. 
  • Enhanced gastric nitric oxide synthase activity in duodenal ulcer patients. 
  • Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells. 
  • Essential role of AT1A receptor in the development of 2K1C hypertension. 
  • Estrogen blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries(1,2). 
  • Exhaled nitric oxide (NO), NO synthase activity, and regulation of nuclear factor (NF)-kappaB. 
  • Expression of peptides, nitric oxide synthase and NPY receptor in trigeminal and nodose ganglia after nerve lesions. 
  • Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines. 
  • Fas-induced caspase denitrosylation. 
  • Fatty liver vulnerability to endotoxin-induced damage despite NF-kappaB induction and inhibited caspase 3 activation. 
  • Galbraith Award: simvastatin attenuates experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: a dose-response effect dependent on endothelial nitric oxide synthase. 
  • Gastroschisis increases small bowel nitric oxide synthase activity. 
  • Gender and estrogen supplementation increases severity of experimental choroidal neovascularization. 
  • Gene and protein expressions of nitric oxide synthases in ischemia-reperfused peripheral nerve of the rat. 
  • Gene expression profiles of the rat brain both immediately and 3 months following acute sarin exposure. 
  • Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. 
  • Gene transfer of endothelial nitric oxide synthase improves relaxation of carotid arteries from diabetic rabbits. 
  • Gene transfer of endothelial nitric oxide synthase reduces angiotensin II-induced endothelial dysfunction. 
  • Genetic association analyses of nitric oxide synthase genes and neural tube defects vary by phenotype. 
  • Genetic targeting for cardiovascular therapeutics: are we near the summit or just beginning the climb? 
  • Growth factors for therapeutic angiogenesis in hypercholesterolemic erectile dysfunction. 
  • Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation. 
  • Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription. 
  • Host response to infection: the role of CpG DNA in induction of cyclooxygenase 2 and nitric oxide synthase 2 in murine macrophages. 
  • Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages. 
  • Hyaluronan fragments induce nitric-oxide synthase in murine macrophages through a nuclear factor kappaB-dependent mechanism. 
  • Hypersecretion of mucin in response to inflammatory mediators by guinea pig tracheal epithelial cells in vitro is blocked by inhibition of nitric oxide synthase. 
  • Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury. 
  • IL-4 and interferon gamma regulate expression of inducible nitric oxide synthase in chronic lymphocytic leukemia cells. 
  • Identification of S-nitrosylated proteins in endotoxin-stimulated RAW264.7 murine macrophages. 
  • Identification of a novel repressive element that contributes to neuron-specific gene expression. 
  • Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart. 
  • Immune control of tuberculosis by IFN-gamma-inducible LRG-47. 
  • Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41. 
  • Impaired innate host defense causes susceptibility to respiratory virus infections in cystic fibrosis. 
  • Impaired liver regeneration in inducible nitric oxide synthasedeficient mice. 
  • In vivo gene transfer of nitric oxide synthase enhances vasomotor function in carotid arteries from normal and cholesterol-Fed rabbits. 
  • Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome. 
  • Increased expression of blood mononuclear cell nitric oxide synthase type 2 in rheumatoid arthritis patients. 
  • Increased nitric oxide production and protection from malaria. 
  • Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population. 
  • Inducible nitric oxide synthase expression by peritoneal macrophages in endometriosis-associated infertility. 
  • Inducible nitric oxide synthase promotes cytokine expression in cardiac allografts but is not required for efficient rejection. 
  • Induction of arginase isoforms in the lung during hyperoxia. 
  • Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway. 
  • Induction of nitric oxide in cultured microglia: evidence for a cytoprotective role. 
  • Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. 
  • Influence of group B streptococci on piglet pulmonary artery response to bradykinin. 
  • Inhibition of NF-kappa B by S-nitrosylation. 
  • Inhibition of iNOS attenuates skeletal muscle reperfusion injury in extracellular superoxide dismutase knockout mice. 
  • Inhibition of iNOS with 1400W improves contractile function and alters nos gene and protein expression in reperfused skeletal muscle. 
  • Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia. 
  • Inhibition of nitric oxide synthase on brain oxygenation in anesthetized rats exposed to hyperbaric oxygen. 
  • Inhibition of nitric oxide synthesis attenuates alcohol consumption in two strains of alcohol-preferring rats. 
  • Inhibition of nitric oxide synthesis increases mortality in Sindbis virus encephalitis. 
  • Inhibition of sphincter of Oddi function by the nitric oxide carrier S-nitroso-N-acetylcysteine in rabbits and humans. 
  • Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma. 
  • Interferon (IFN)-alpha activation of human blood mononuclear cells in vitro and in vivo for nitric oxide synthase (NOS) type 2 mRNA and protein expression: possible relationship of induced NOS2 to the anti-hepatitis C effects of IFN-alpha in vivo. 
  • Interleukin 1-induced production of nitric oxide inhibits benzenetriol-mediated oxidative injury in rat hepatocytes. 
  • Interleukin 1beta-stimulated production of nitric oxide in rat hepatocytes is mediated through endogenous synthesis of interferon gamma. 
  • Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci. 
  • Intermittent pneumatic compression regulates expression of nitric oxide synthases in skeletal muscles. 
  • Is there anything for NOS to SNO in the Antarctic? 
  • L-arginine enhances injury in the isolated rabbit lung during hyperoxia. 
  • Leukocyte-derived IL-10 reduces subepithelial fibrosis associated with chronically inhaled endotoxin. 
  • Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis. 
  • Lung epithelial cell-released nitric oxide protects against PMN-mediated cell injury. 
  • Manganese porphyrin reduces retinal injury induced by ocular hypertension in rats. 
  • Measuring nitric oxide production in human clinical studies. 
  • Mechanical stress and nitric oxide influence leukotriene production in cartilage. 
  • Mechanisms and structural determinants of HIV-1 coat protein, gp41-induced neurotoxicity. 
  • Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability. 
  • Mechanisms of cell death governed by the balance between nitrosative and oxidative stress. 
  • Metabolic disturbances in hippocampal slices of fetal guinea pigs during and after oxygen-glucose deprivation: is nitric oxide involved? 
  • Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment. 
  • Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells. 
  • Mitochondria and nitric oxide. 
  • Molecular manipulations of extracellular superoxide dismutase: functional importance for learning. 
  • Molecular mechanisms of increased nitric oxide (NO) in asthma: evidence for transcriptional and post-translational regulation of NO synthesis. 
  • Myocardial immediate early gene activation after cardiopulmonary bypass with cardiac ischemia-reperfusion. 
  • NF-kappa B and transcriptional control of renal epithelial-inducible nitric oxide synthase. 
  • NF-kappaB p65 involves in reperfusion injury and iNOS gene regulation in skeletal muscle. 
  • NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression. 
  • NO and superoxide: opposite ends of the seesaw in cardiac contractility. 
  • NO is necessary and sufficient for egg activation at fertilization. 
  • NO waiting to exhale in asthma. 
  • NOS: modulator, not mediator of cardiac performance. 
  • Nascent nitrosylases. 
  • Neuroanatomical evidence for a putative autocrine/paracrine signaling system involving nicotinic acetylcholine receptors, purinergic receptors, and nitric oxide synthase in the airways. 
  • Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras. 
  • Nitric oxide and acetaminophen-mediated oxidative injury: modulation of interleukin-1-induced nitric oxide synthesis in cultured rat hepatocytes. 
  • Nitric oxide and differential effects of ATP on mitochondrial permeability transition. 
  • Nitric oxide as an inflammatory mediator in autoimmune MRL-lpr/lpr mice. 
  • Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. 
  • Nitric oxide in plant immunity. 
  • Nitric oxide in skeletal muscle. 
  • Nitric oxide inhalation and nitric oxide synthase inhibitor supplement for endotoxin-induced hypotension. 
  • Nitric oxide inhibits Fas-induced apoptosis. 
  • Nitric oxide involvement in reperfusion injury of denervated muscle. 
  • Nitric oxide is necessary for CC-class chemokine expression in endotoxin-stimulated ANA-1 murine macrophages. 
  • Nitric oxide is necessary for visual learning in Octopus vulgaris. 
  • Nitric oxide is required for tactile learning in Octopus vulgaris. 
  • Nitric oxide modulates HIV-1 replication. 
  • Nitric oxide modulates branching morphogenesis in fetal rat lung explants. 
  • Nitric oxide modulates excitation-contraction coupling in the diaphragm. 
  • Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation. 
  • Nitric oxide production and mononuclear cell nitric oxide synthase activity in malaria-tolerant Papuan adults. 
  • Nitric oxide production and nitric oxide synthase activity in malaria-exposed Papua New Guinean children and adults show longitudinal stability and no association with parasitemia. 
  • Nitric oxide production and nitric oxide synthase type 2 expression by human mononuclear phagocytes: a review. 
  • Nitric oxide production and regulation of neuronal NOS in tyrosine hydroxylase containing neurons. 
  • Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. 
  • Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. 
  • Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases. 
  • Nitric oxide signaling: no longer simply on or off. 
  • Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammation. 
  • Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans. 
  • Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria. 
  • Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair. 
  • Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine. 
  • Nitric oxide synthase in gastric mucosa. 
  • Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. 
  • Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. 
  • Nitric oxide synthase inhibition irreversibly decreases perfusion in the R3230Ac rat mammary adenocarcinoma. 
  • Nitric oxide synthase inhibitors decrease coronary sinus-free radical concentration and ameliorate myocardial stunning in an ischemia-reperfusion model. 
  • Nitric oxide synthase is an active enzyme in the spiral ganglion cells of the rat cochlea. 
  • Nitric oxide synthase is deficient in the aganglionic colon of patients with Hirschsprung's disease. 
  • Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria. 
  • Nitric oxide synthase: role in the genesis of vascular disease. 
  • Nitric oxide--friend or foe in arthritis? 
  • Nitric oxide-associated regulation of hepatocyte glutathione synthesis is a guanylyl cyclase-independent event. 
  • Nitric oxide-dependent osteopontin expression induces metastatic behavior in HepG2 cells. 
  • Nitric-oxide synthase output state. Design and properties of nitric-oxide synthase oxygenase/FMN domain constructs. 
  • Nitrosylation. the prototypic redox-based signaling mechanism. 
  • Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. 
  • Obesity, insulin resistance, and skeletal muscle nitric oxide synthase. 
  • Oxidants, antioxidants and the ischemic brain. 
  • Oxidative metabolism in rat hepatocytes and mitochondria during sepsis. 
  • Oxidative stress increases hepatocyte iNOS gene transcription and promoter activity. 
  • Oxygen seizure latency and peroxynitrite formation in mice lacking neuronal or endothelial nitric oxide synthases. 
  • Pacing-induced heart failure: a model to study the mechanism of disease progression and novel therapy in heart failure. 
  • Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP. 
  • Peroxide-mediated chromatin remodelling of a nuclear factor kappa B site in the mouse inducible nitric oxide synthase promoter. 
  • Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis. 
  • Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. 
  • Pharmacokinetics and pharmacodynamics of L-arginine in rats: a model of stimulated neuronal nitric oxide synthesis. 
  • Physiology of nitric oxide in skeletal muscle. 
  • Plasma interleukin-12 in malaria-tolerant papua new guineans: inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity. 
  • Plasma nitrite and nitrate levels as a noninvasive marker of pathology after human small bowel transplantation. 
  • Polyribonucleotides induce nitric oxide production by human monocyte-derived macrophages. 
  • Post-transcriptional inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by Gö6976 in murine microglia. 
  • Postnatal estradiol up-regulates lung nitric oxide synthases and improves lung function in bronchopulmonary dysplasia. 
  • Predicted effects of nitric oxide and superoxide on the vasoactivity of the afferent arteriole. 
  • Predictors of 30-day mortality in patients with refractory cardiogenic shock following acute myocardial infarction despite a patent infarct artery. 
  • Prostate-Confined Radiation Decreased Pelvic Ganglia Neuronal Survival and Outgrowth. 
  • Protection from experimental asthma by an endogenous bronchodilator. 
  • Proteomic analysis of the NOS2 interactome in human airway epithelial cells. 
  • Pulmonary expression of iNOS and HO-1 protein is upregulated in a rat model of prehepatic portal hypertension. 
  • Rate and severity of HIV-associated dementia (HAD): correlations with Gp41 and iNOS. 
  • Redox regulation of the rat hepatocyte iNOS promoter. 
  • Redox-mediated upregulation of hepatocyte iNOS transcription requires coactivator PC4. 
  • Reduction of NOS2 overexpression in rheumatoid arthritis patients treated with anti-tumor necrosis factor alpha monoclonal antibody (cA2). 
  • Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression. 
  • Regulation of Ca(2+)-dependent nitric oxide synthase in bovine aortic endothelial cells. 
  • Regulation of nitric oxide synthesis by oxygen in vascular endothelial cells. 
  • Regulation of ryanodine receptors by reactive nitrogen species. 
  • Regulation of the brain's vascular responses to oxygen. 
  • Relative contribution of preload and afterload to the reduction in cardiac output caused by nitric oxide synthase inhibition with L-N(G)-methylarginine hydrochloride 546C88. 
  • Reperfusion injury in skeletal muscle is reduced in inducible nitric oxide synthase knockout mice. 
  • Reperfusion injury is reduced in skeletal muscle by inhibition of inducible nitric oxide synthase. 
  • Requirement for reactive oxygen species in serum-induced and platelet-derived growth factor-induced growth of airway smooth muscle. 
  • Role of K+ATP channels and EDRF in reactive hyperemia in the hindquarters vascular bed of cats. 
  • Role of epithelial nitric oxide in airway viral infection. 
  • Role of nitric oxide in human esophageal circular smooth muscle in vitro. 
  • Role of nitric oxide in the development of distant metastasis from squamous cell carcinoma. 
  • Role of nitric oxide in vasodilation in upstream muscle during intermittent pneumatic compression. 
  • Role of vagus nerve in postprandial antropyloric coordination in conscious dogs. 
  • S-nitrosothiol signaling in respiratory biology. 
  • S-nitrosylation in health and disease. 
  • STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection. 
  • Screening for nitric oxide-dependent protein-protein interactions. 
  • Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity. 
  • Selective activation and inhibition of calmodulin-dependent enzymes by a calmodulin-like protein found in human epithelial cells. 
  • Selenomethionine inhibits IL-1β inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) expression in primary human chondrocytes. 
  • Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. 
  • Sex hormones and renal nitric oxide synthases. 
  • Shear stress-triggered nitric oxide release from Schlemm's canal cells. 
  • Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide. 
  • Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage. 
  • Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production. 
  • Stimulation of inducible nitric oxide synthase in rat liver by hyaluronan fragments. 
  • Stretch-induced nitric oxide modulates mechanical properties of skeletal muscle cells. 
  • Superoxide dismutase potentiates platelet-activating factor-induced injury in perfused lung. 
  • Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. 
  • Superoxide enhances interleukin 1beta-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene. 
  • Suppression of interleukin-1 beta-induced nitric oxide production in RINm5F cells by inhibition of glucose-6-phosphate dehydrogenase. 
  • Systemic nitric oxide production in human malaria. II. Analysis of mononuclear cell nitric oxide synthase type 2 antigen expression. 
  • TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure. 
  • Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide. 
  • Targeting VE-PTP phosphatase protects the kidney from diabetic injury. 
  • The biology of nitrogen oxides in the airways. 
  • The calmodulin-nitric oxide synthase interaction. Critical role of the calmodulin latch domain in enzyme activation. 
  • The development of morphine antinociceptive tolerance in nitric oxide synthase-deficient mice. 
  • The dichotomous role of nitric oxide in the pathogenesis of accelerated atherosclerosis associated with systemic lupus erythematosus. 
  • The dose-related effects of nitric oxide synthase inhibition on cerebral blood flow during isoflurane and pentobarbital anesthesia. 
  • The effect of dynamic mechanical compression on nitric oxide production in the meniscus. 
  • The effects of N(omega)-propyl-L-arginine on reperfusion injury of skeletal muscle. 
  • The effects of cyclic mechanical strain and tumor necrosis factor alpha on the response of cells of the meniscus. 
  • The effects of static and intermittent compression on nitric oxide production in articular cartilage explants. 
  • The indolocarbazole Gö6976 protects neurons from lipopolysaccharide/interferon-gamma-induced cytotoxicity in murine neuron/glia co-cultures. 
  • The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases defibrillation-induced free radical generation. 
  • The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases defibrillation-induced free radical generation. 
  • The role of endogenous nitric oxide in the sympathetic and hemodynamic response to platelet activating factor-induced hypotension in anesthetized dogs. 
  • The role of endothelial nitric oxide synthase expression in the development of pulmonary hypertension in chronically hypoxic infant swine. 
  • The role of endothelium-derived hyperpolarizing factor in the regulation of the uterine circulation in pregnant rats. 
  • The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine. 
  • Therapeutic potential of nitric oxide synthase gene manipulation. 
  • Thermodynamics of oxidation-reduction reactions in mammalian nitric-oxide synthase isoforms. 
  • Transforming growth factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3. 
  • Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission. 
  • Treatment with the nitric oxide synthase inhibitor L-NAME provides a survival advantage in a mouse model of Kras mutation-positive, non-small cell lung cancer. 
  • Tumor necrosis factor-alpha (TNF-alpha) stimulates mucin secretion and gene expression in airway epithelium in vitro. 
  • Tumor necrosis factor-alpha and interferon-gamma inhibit insulin secretion and cause DNA damage in unweaned-rat islets. Extent of nitric oxide involvement. 
  • Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro. 
  • Tunicamycin increases intracellular calcium levels in bovine aortic endothelial cells. 
  • Vanadyl sulfate inhibits NO production via threonine phosphorylation of eNOS. 
  • Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide. 
  • [Ginsenoside Rg1 protects rat hippocampal neurons from radiation injury by regulating NOS activity]. 
  • beta(3)-adrenoceptor deficiency blocks nitric oxide-dependent inhibition of myocardial contractility. 
  • eNOS-overexpressing endothelial cells inhibit platelet aggregation and smooth muscle cell proliferation in vitro. 
  • l-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells. 
  • β2- and β3-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines. 
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  Keywords of People

  • Alexander, John Hunter Peel, Professor of Medicine, Medicine, Cardiology
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Swaminathan, Madhav, Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Taylor, Gregory Alan, Professor in Medicine, Immunology
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology