Proto-Oncogene Proteins c-kit
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Subject Areas on Research
- A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation.
- Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency.
- Antibodies to stem cell marker antigens reduce engraftment of hematopoietic stem cells.
- Astrocyte apoptosis induced by HIV-1 transactivation of the c-kit protooncogene.
- Can binimetinib, encorafenib and masitinib be more efficacious than currently available mutation-based targeted therapies for melanoma treatment?
- Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1.
- Cloning and structural analysis of the human c-kit gene.
- Correlation of Long-term Results of Imatinib in Advanced Gastrointestinal Stromal Tumors With Next-Generation Sequencing Results: Analysis of Phase 3 SWOG Intergroup Trial S0033.
- Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III Trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group.
- Diagnosis of posttransplant granulocytic sarcoma by fine-needle aspiration cytology and flow cytometry.
- Differential effects of vascular endothelial growth factor receptor-2 inhibitor ZD6474 on circulating endothelial progenitors and mature circulating endothelial cells: implications for use as a surrogate marker of antiangiogenic activity.
- Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture.
- Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit.
- Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction.
- Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas.
- Gastrointestinal stromal tumors, version 2.2014.
- Genetic heterogeneity of diffuse large B-cell lymphoma.
- How the zebrafish gets its stripes.
- Identification of c-kit-positive cells in the mouse ureter: the interstitial cells of Cajal of the urinary tract.
- Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues.
- Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program.
- KIT mutations and CD117 overexpression are markers of better progression-free survival in vulvar melanomas.
- Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia.
- Mast cell regulation of inflammation and gene expression during antigen-induced bladder inflammation in mice.
- Oncogenic mutations in melanomas and benign melanocytic nevi of the female genital tract.
- Pathologic and molecular features correlate with long-term outcome after adjuvant therapy of resected primary GI stromal tumor: the ACOSOG Z9001 trial.
- Phase II study of the oral MEK inhibitor selumetinib in advanced acute myelogenous leukemia: a University of Chicago phase II consortium trial.
- Proliferative nodules arising within congenital melanocytic nevi: a histologic, immunohistochemical, and molecular analyses of 43 cases.
- RNA-Mediated Reprogramming of Primary Adult Human Dermal Fibroblasts into c-kit(+) Cardiac Progenitor Cells.
- Requirements for the kit receptor tyrosine kinase during regeneration of zebrafish fin melanocytes.
- SRC family kinase inhibition as a novel strategy to augment melphalan-based regional chemotherapy of advanced extremity melanoma.
- Stem cell factor and c-kit are expressed by and may affect vascular SMCs through an autocrine pathway.
- Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors.
- Systemic mastocytosis with associated clonal hematologic nonmast cell lineage disease: a clinicopathologic review.
- Temporal and molecular separation of the kit receptor tyrosine kinase's roles in zebrafish melanocyte migration and survival.
- The Prognostic Value of BRAF, C-KIT, and NRAS Mutations in Melanoma Patients With Brain Metastases.
- The c-kit proto-oncogene receptor is expressed on a subset of human CD3-CD4-CD8- (triple-negative) thymocytes.
- The spectrum of Kit (CD117) immunoreactivity in lung and pleural tumors: a study of 96 cases using a single-source antibody with a review of the literature.
- Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice.
- Ulcerative keratitis in gastrointestinal stromal tumor patients treated with perifosine.
- Usefulness of translocation-associated immunohistochemical stains in the fine-needle aspiration diagnosis of salivary gland neoplasms.
- Zebrafish kit mutation reveals primary and secondary regulation of melanocyte development during fin stripe regeneration.
- Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development.
- c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice.
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Keywords of People
- Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
- Luftig, Micah Alan, Associate Professor of Molecular Genetics and Microbiology, Immunology