Proto-Oncogene Proteins c-kit

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  Subject Areas on Research

  • A Phase II Trial of Imatinib Mesylate as Maintenance Therapy for Patients With Newly Diagnosed C-kit-positive Acute Myeloid Leukemia. 
  • A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation. 
  • Adult c-Kit(+) progenitor cells are necessary for maintenance and regeneration of olfactory neurons. 
  • Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency. 
  • Antibodies to stem cell marker antigens reduce engraftment of hematopoietic stem cells. 
  • Astrocyte apoptosis induced by HIV-1 transactivation of the c-kit protooncogene. 
  • Can binimetinib, encorafenib and masitinib be more efficacious than currently available mutation-based targeted therapies for melanoma treatment? 
  • Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1. 
  • Cloning and structural analysis of the human c-kit gene. 
  • Complex regulation of human c-kit transcription by promoter repressors, activators, and specific myb elements. 
  • Contribution of Polycomb group proteins to olfactory basal stem cell self-renewal in a novel c-KIT+ culture model and in vivo. 
  • Correlation of Long-term Results of Imatinib in Advanced Gastrointestinal Stromal Tumors With Next-Generation Sequencing Results: Analysis of Phase 3 SWOG Intergroup Trial S0033. 
  • Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III Trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group. 
  • Diagnosis of posttransplant granulocytic sarcoma by fine-needle aspiration cytology and flow cytometry. 
  • Differential effects of vascular endothelial growth factor receptor-2 inhibitor ZD6474 on circulating endothelial progenitors and mature circulating endothelial cells: implications for use as a surrogate marker of antiangiogenic activity. 
  • Differential expression of microRNAs among cell populations in the regenerating adult mouse olfactory epithelium. 
  • Differentiation potential of individual olfactory c-Kit+ progenitors determined via multicolor lineage tracing. 
  • Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture. 
  • Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit. 
  • Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction. 
  • Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas. 
  • Gastrointestinal stromal tumors, version 2.2014. 
  • Genetic heterogeneity of diffuse large B-cell lymphoma. 
  • How the zebrafish gets its stripes. 
  • Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. 
  • Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program. 
  • Insights from molecular signature of in vivo cardiac c-Kit(+) cells following cardiac injury and β-catenin inhibition. 
  • KIT mutations and CD117 overexpression are markers of better progression-free survival in vulvar melanomas. 
  • Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia. 
  • Mast cell regulation of inflammation and gene expression during antigen-induced bladder inflammation in mice. 
  • Myeloblast phenotypic changes in myelodysplasia. CD34 and CD117 expression abnormalities are common. 
  • Oncogenic mutations in melanomas and benign melanocytic nevi of the female genital tract. 
  • Optimal Avapritinib Treatment Strategies for Patients with Metastatic or Unresectable Gastrointestinal Stromal Tumors. 
  • Pathologic and molecular features correlate with long-term outcome after adjuvant therapy of resected primary GI stromal tumor: the ACOSOG Z9001 trial. 
  • Phase II study of the oral MEK inhibitor selumetinib in advanced acute myelogenous leukemia: a University of Chicago phase II consortium trial. 
  • Prognostic Roles of BRAF, KIT, NRAS, IGF2R and SF3B1 Mutations in Mucosal Melanomas. 
  • Proliferative nodules arising within congenital melanocytic nevi: a histologic, immunohistochemical, and molecular analyses of 43 cases. 
  • RNA-Mediated Reprogramming of Primary Adult Human Dermal Fibroblasts into c-kit(+) Cardiac Progenitor Cells. 
  • Requirements for the kit receptor tyrosine kinase during regeneration of zebrafish fin melanocytes. 
  • SRC family kinase inhibition as a novel strategy to augment melphalan-based regional chemotherapy of advanced extremity melanoma. 
  • Stem cell factor and c-kit are expressed by and may affect vascular SMCs through an autocrine pathway. 
  • Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors. 
  • Systemic Mastocytosis, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology. 
  • Systemic mastocytosis with associated clonal hematologic nonmast cell lineage disease: a clinicopathologic review. 
  • Temporal and molecular separation of the kit receptor tyrosine kinase's roles in zebrafish melanocyte migration and survival. 
  • The Prognostic Value of BRAF, C-KIT, and NRAS Mutations in Melanoma Patients With Brain Metastases. 
  • The c-kit proto-oncogene receptor is expressed on a subset of human CD3-CD4-CD8- (triple-negative) thymocytes. 
  • The secreted metalloprotease ADAMTS20 is required for melanoblast survival. 
  • The spectrum of Kit (CD117) immunoreactivity in lung and pleural tumors: a study of 96 cases using a single-source antibody with a review of the literature. 
  • Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice. 
  • Two new polymorphisms but no mutations of the KIT gene in patients with myelodysplasia at positions corresponding to human FMS and murine W locus mutational hot spots. 
  • Ulcerative keratitis in gastrointestinal stromal tumor patients treated with perifosine. 
  • Usefulness of translocation-associated immunohistochemical stains in the fine-needle aspiration diagnosis of salivary gland neoplasms. 
  • Zebrafish kit mutation reveals primary and secondary regulation of melanocyte development during fin stripe regeneration. 
  • Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development. 
  • c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice. 
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  Keywords of People

  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
  • Luftig, Micah Alan, Associate Professor of Molecular Genetics and Microbiology, Immunology