Proto-Oncogene Proteins c-kit
-
Subject Areas on Research
-
A Phase II Trial of Imatinib Mesylate as Maintenance Therapy for Patients With Newly Diagnosed C-kit-positive Acute Myeloid Leukemia.
-
A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation.
-
Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation.
-
Adult c-Kit(+) progenitor cells are necessary for maintenance and regeneration of olfactory neurons.
-
Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency.
-
Antibodies to stem cell marker antigens reduce engraftment of hematopoietic stem cells.
-
Astrocyte apoptosis induced by HIV-1 transactivation of the c-kit protooncogene.
-
Can binimetinib, encorafenib and masitinib be more efficacious than currently available mutation-based targeted therapies for melanoma treatment?
-
Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1.
-
Cloning and structural analysis of the human c-kit gene.
-
Complex regulation of human c-kit transcription by promoter repressors, activators, and specific myb elements.
-
Contribution of Polycomb group proteins to olfactory basal stem cell self-renewal in a novel c-KIT+ culture model and in vivo.
-
Correlation of Long-term Results of Imatinib in Advanced Gastrointestinal Stromal Tumors With Next-Generation Sequencing Results: Analysis of Phase 3 SWOG Intergroup Trial S0033.
-
Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III Trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group.
-
Diagnosis of posttransplant granulocytic sarcoma by fine-needle aspiration cytology and flow cytometry.
-
Differential effects of vascular endothelial growth factor receptor-2 inhibitor ZD6474 on circulating endothelial progenitors and mature circulating endothelial cells: implications for use as a surrogate marker of antiangiogenic activity.
-
Differential expression of microRNAs among cell populations in the regenerating adult mouse olfactory epithelium.
-
Differentiation potential of individual olfactory c-Kit+ progenitors determined via multicolor lineage tracing.
-
Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture.
-
Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit.
-
Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction.
-
Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas.
-
Gastrointestinal stromal tumors, version 2.2014.
-
Genetic heterogeneity of diffuse large B-cell lymphoma.
-
How the zebrafish gets its stripes.
-
Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues.
-
Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program.
-
Insights from molecular signature of in vivo cardiac c-Kit(+) cells following cardiac injury and β-catenin inhibition.
-
KIT mutations and CD117 overexpression are markers of better progression-free survival in vulvar melanomas.
-
Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia.
-
Mast cell regulation of inflammation and gene expression during antigen-induced bladder inflammation in mice.
-
Myeloblast phenotypic changes in myelodysplasia. CD34 and CD117 expression abnormalities are common.
-
NCCN Guidelines® Insights: Gastrointestinal Stromal Tumors, Version 2.2022.
-
Oncogenic mutations in melanomas and benign melanocytic nevi of the female genital tract.
-
Optimal Avapritinib Treatment Strategies for Patients with Metastatic or Unresectable Gastrointestinal Stromal Tumors.
-
Pathologic and molecular features correlate with long-term outcome after adjuvant therapy of resected primary GI stromal tumor: the ACOSOG Z9001 trial.
-
Phase II study of the oral MEK inhibitor selumetinib in advanced acute myelogenous leukemia: a University of Chicago phase II consortium trial.
-
Prognostic Roles of BRAF, KIT, NRAS, IGF2R and SF3B1 Mutations in Mucosal Melanomas.
-
Proliferative nodules arising within congenital melanocytic nevi: a histologic, immunohistochemical, and molecular analyses of 43 cases.
-
RNA-Mediated Reprogramming of Primary Adult Human Dermal Fibroblasts into c-kit(+) Cardiac Progenitor Cells.
-
Requirements for the kit receptor tyrosine kinase during regeneration of zebrafish fin melanocytes.
-
SRC family kinase inhibition as a novel strategy to augment melphalan-based regional chemotherapy of advanced extremity melanoma.
-
Systemic Mastocytosis, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.
-
Systemic mastocytosis with associated clonal hematologic nonmast cell lineage disease: a clinicopathologic review.
-
Temporal and molecular separation of the kit receptor tyrosine kinase's roles in zebrafish melanocyte migration and survival.
-
The Prognostic Value of BRAF, C-KIT, and NRAS Mutations in Melanoma Patients With Brain Metastases.
-
The c-kit proto-oncogene receptor is expressed on a subset of human CD3-CD4-CD8- (triple-negative) thymocytes.
-
The secreted metalloprotease ADAMTS20 is required for melanoblast survival.
-
The spectrum of Kit (CD117) immunoreactivity in lung and pleural tumors: a study of 96 cases using a single-source antibody with a review of the literature.
-
Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice.
-
Triple negative breast cancer: outcome correlation with immunohistochemical detection of basal markers.
-
Two new polymorphisms but no mutations of the KIT gene in patients with myelodysplasia at positions corresponding to human FMS and murine W locus mutational hot spots.
-
Ulcerative keratitis in gastrointestinal stromal tumor patients treated with perifosine.
-
Usefulness of translocation-associated immunohistochemical stains in the fine-needle aspiration diagnosis of salivary gland neoplasms.
-
Zebrafish kit mutation reveals primary and secondary regulation of melanocyte development during fin stripe regeneration.
-
Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development.
-
c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice.
-
Keywords of People