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Subject Areas on Research
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4D11: The Second Mouse?
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A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation.
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A novel monoclonal antibody to CD40 prolongs islet allograft survival.
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A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis.
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Activated B cells modified by electroporation of multiple mRNAs encoding immune stimulatory molecules are comparable to mature dendritic cells in inducing in vitro antigen-specific T-cell responses.
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Alternative immunomodulatory strategies for xenotransplantation: CD40/154 pathway-sparing regimens promote xenograft survival.
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Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice.
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Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting.
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Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis.
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Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade.
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Association of CSF CD40 levels and synaptic degeneration across the Alzheimer's disease spectrum.
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B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation.
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B lymphocytes contribute to autoimmune disease pathogenesis: current trends and clinical implications.
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CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction.
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CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells.
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CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model.
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CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis.
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CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates.
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CTLA4Ig prevents alloantibody formation following nonhuman primate islet transplantation using the CD40-specific antibody 3A8.
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Characterization of metabolic alterations of chronic lymphocytic leukemia in the lymph node microenvironment.
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Costimulation blockade: towards clinical application.
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Costimulation, coinhibition and cancer.
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Dendritic cells cultured in anti-CD40 antibody-immobilized plates elicit a highly efficient peptide-specific T-cell response.
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Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation.
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Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients.
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Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40.
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Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation.
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Enhanced activation of human dendritic cells by inducible CD40 and Toll-like receptor-4 ligation.
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Evaluation of CD86/CD28 and CD40/CD154 pathways in regulating monocyte-derived CD80 expression during their interaction with allogeneic endothelium.
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Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor.
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Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma.
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GPI-defective monocytes from paroxysmal nocturnal hemoglobinuria patients show impaired in vitro dendritic cell differentiation.
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Hepatic enrichment and activation of myeloid dendritic cells during chronic hepatitis C virus infection.
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Hyper IgM syndrome associated with defective CD40-mediated B cell activation.
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In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells.
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In vivo expansion, persistence, and function of peptide vaccine-induced CD8 T cells occur independently of CD4 T cells.
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Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans.
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Inhibition of endothelial activation: a new way to treat cerebral malaria?
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Macrophages driven to a novel state of activation have anti-inflammatory properties in mice.
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Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest.
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Monocyte-derived CD40 expression is regulated by interferon-γ/interferon-γ receptor-1 pathway when acting as a bridge during their interaction with T cells and allogeneic endothelial cells.
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Mononuclear cells from patients with the hyper-IgE syndrome produce little IgE when they are stimulated with recombinant human interleukin-4.
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Natural IgM Switches the Function of Lipopolysaccharide-Activated Murine Bone Marrow-Derived Dendritic Cells to a Regulatory Dendritic Cell That Suppresses Innate Inflammation.
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Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates.
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Optimization of the sequence of antigen loading and CD40-ligand-induced maturation of dendritic cells.
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Phase I study of ABBV-428, a mesothelin-CD40 bispecific, in patients with advanced solid tumors.
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Phenotypic and functional differences between human saphenous vein (HSVEC) and umbilical vein (HUVEC) endothelial cells.
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Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation.
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Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo.
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Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions.
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Renal epithelial cell-derived monocyte colony stimulating factor as a local informant of renal injury and means of monocyte activation.
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Reprogramming tumor-associated dendritic cells in vivo using miRNA mimetics triggers protective immunity against ovarian cancer.
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Role of JAK3 in CD40-mediated signaling.
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Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicity.
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Superiority in Rhesus Macaques of Targeting HIV-1 Env gp140 to CD40 versus LOX-1 in Combination with Replication-Competent NYVAC-KC for Induction of Env-Specific Antibody and T Cell Responses.
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The contribution of Fc effector mechanisms in the efficacy of anti-CD154 immunotherapy depends on the nature of the immune challenge.
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The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals.
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The interleukin-2 receptor α chain (CD25) plays an important role in regulating monocyte-derived CD40 expression during anti-porcine cellular responses.
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The road to tolerance: renal transplant tolerance induction in nonhuman primate studies and clinical trials.
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Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway.
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When you hear hoof beats...do not forget the zebras.
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Keywords of People