E-Selectin

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  Subject Areas on Research

  • A PCR-RFLP typing method for adhesion molecule gene polymorphisms and allele frequencies in a normal UK population. 
  • A randomized clinical trial of the efficacy and safety of rivipansel for sickle cell vaso-occlusive crisis. 
  • Adhesion molecules, platelet activation, and cardiovascular risk. 
  • Antibody binding to a conformation-dependent epitope induces L-selectin association with the detergent-resistant cytoskeleton. 
  • Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons. 
  • Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation. 
  • Are inflammatory factors related to retinal vessel caliber? The Beaver Dam Eye Study. 
  • Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgery. 
  • Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. 
  • Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors. 
  • Circulating markers of inflammation and endothelial function, and their relationship to diabetic retinopathy. 
  • Circulating markers of vascular injury and angiogenesis in antineutrophil cytoplasmic antibody-associated vasculitis. 
  • Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein. 
  • Cutaneous endothelial cell activation in normal skin of patients with dermatitis herpetiformis associated with increased serum levels of IL-8, sE-Selectin, and TNF-alpha. 
  • Cytokine-induced mobilization of circulating endothelial progenitor cells enhances repair of injured arteries. 
  • Direct-contact co-culture between smooth muscle and endothelial cells inhibits TNF-alpha-mediated endothelial cell activation. 
  • Directing and Potentiating Stem Cell-Mediated Angiogenesis and Tissue Repair by Cell Surface E-Selectin Coating. 
  • Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone. 
  • E-selectin can mediate the arrest type of adhesion of colon cancer cells under physiological shear flow. 
  • Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. 
  • Erythrocyte-Derived Microparticles Activate Pulmonary Endothelial Cells in a Murine Model of Transfusion. 
  • Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction. 
  • Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone. 
  • Expression of E-selectin messenger RNA and protein in rheumatoid arthritis. 
  • Human colon cancer cells express multiple glycoprotein ligands for E-selectin. 
  • IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells. 
  • In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment. 
  • Increased E-selectin, IL-8 and IL-10 gene expression in human skin after minimal trauma. 
  • Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. 
  • Inhibition of nuclear factor-kappaB-mediated adhesion molecule expression in human endothelial cells. 
  • L-selectin can mediate leukocyte rolling in untreated mesenteric venules in vivo independent of E- or P-selectin. 
  • Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. 
  • Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and rolling. 
  • MEK1/2 inhibitors reverse acute vascular occlusion in mouse models of sickle cell disease. 
  • Mast cells augment adaptive immunity by orchestrating dendritic cell trafficking through infected tissues. 
  • Novel role for endogenous hepatocyte growth factor in the pathogenesis of intracranial aneurysms. 
  • Phase 1 study of the E-selectin inhibitor GMI 1070 in patients with sickle cell anemia. 
  • Phase I study of recombinant human endostatin in patients with advanced solid tumors. 
  • Plasma and urinary soluble adhesion molecule expression is increased during first documented acute pyelonephritis. 
  • Plasmodium falciparum malaria in south-west Nigerian children: is the polymorphism of ICAM-1 and E-selectin genes contributing to the clinical severity of malaria? 
  • Proinflammatory cytokines increase in sepsis after anti-adhesion molecule therapy. 
  • Relationship between resolution of non-alcoholic steatohepatitis and changes in lipoprotein sub-fractions: a post-hoc analysis of the PIVENS trial. 
  • Relative contributions of selectins and intercellular adhesion molecule-1 to tissue injury induced by immune complex deposition. 
  • Role of selectins in development of adult respiratory distress syndrome. 
  • Selectins: a family of adhesion receptors. 
  • Serum protein expression predicts recurrence in patients with early-stage lung cancer after resection. 
  • Soluble VCAM-1 and E-selectin, but not ICAM-1 discriminate endothelial injury in patients with documented coronary artery disease. 
  • Soluble vascular cell adhesion molecule-1 and E-selectin in patients with acute myocardial infarction treated with thrombolytic agents. 
  • Sustained stress response after oxidative stress in trabecular meshwork cells. 
  • Tenascin supports lymphocyte rolling. 
  • The NF-kappa B inhibitor, tepoxalin, suppresses surface expression of the cell adhesion molecules CD62E, CD11b/CD18 and CD106. 
  • The effect of chronic azithromycin therapy on soluble endothelium-derived adhesion molecules in patients with coronary artery disease. 
  • The expression of microvesicles in the blood of patients with Graves' disease and its relationship to treatment. 
  • The potential of monoclonal antibodies to reduce reperfusion injury in myocardial infarction. 
  • The role of adhesion molecules in human leukocyte attachment to porcine vascular endothelium: implications for xenotransplantation. 
  • The selectins: vascular adhesion molecules. 
  • Tumor necrosis factor-α pathway plays a critical role in regulating interferon-γ induced protein-10 production in initial allogeneic human monocyte-endothelial cell interactions. 
  • Ultrastructure and function of the fractalkine mucin domain in CX(3)C chemokine domain presentation. 
  • VEGF increases retinal vascular ICAM-1 expression in vivo. 
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  Keywords of People

  • Erickson, Harold Paul, Professor Emeritus of Cell Biology, Cell Biology
  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery