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Subject Areas on Research
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A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice.
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A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels.
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A phase 2 study of KX2-391, an oral inhibitor of Src kinase and tubulin polymerization, in men with bone-metastatic castration-resistant prostate cancer.
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A phase I trial of dasatinib, an SRC-family kinase inhibitor, in combination with paclitaxel and carboplatin in patients with advanced or recurrent ovarian cancer.
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A rapid cytoplasmic mechanism for PI3 kinase regulation by the nuclear thyroid hormone receptor, TRβ, and genetic evidence for its role in the maturation of mouse hippocampal synapses in vivo.
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Abl kinases are required for invadopodia formation and chemokine-induced invasion.
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Activation and signaling of the Abl tyrosine kinase: bidirectional link with phosphoinositide signaling.
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Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation.
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Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes.
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An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models.
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An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer.
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Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels.
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Association of p62c-yes with polyomavirus middle T-antigen mutants correlates with transforming ability.
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CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation.
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CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation.
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CD19 and CD22 regulate a B lymphocyte signal transduction pathway that contributes to autoimmunity.
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CD19 regulates B lymphocyte responses to transmembrane signals.
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CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.
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CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes.
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CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification.
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CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction.
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CD19-CD21 complex regulates an intrinsic Src family kinase amplification loop that links innate immunity with B-lymphocyte intracellular calcium responses.
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CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction.
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Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor.
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Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa.
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Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling.
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Dasatinib (BMS-35482) interacts synergistically with docetaxel, gemcitabine, topotecan, and doxorubicin in ovarian cancer cells with high SRC pathway activation and protein expression.
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Development of a precision medicine pipeline to identify personalized treatments for colorectal cancer.
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Dual inhibition of αV integrins and Src kinase activity as a combination therapy strategy for colorectal cancer.
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Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation.
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Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.
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FAK/Src family of kinases: protective or aggravating factor for ischemia reperfusion injury in nervous system?
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Functional screen identifies kinases driving prostate cancer visceral and bone metastasis.
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Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation.
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HIV infection--induced posttranslational modification of T cell signaling molecules associated with disease progression.
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Heart hypertrophy during pregnancy: a better functioning heart?
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ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration.
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Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor.
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Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model.
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Invasive prostate carcinoma driven by c-Src and androgen receptor synergy.
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Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22.
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Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.
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Lipid raft- and SRC family kinase-dependent entry of coxsackievirus B into human placental trophoblasts.
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Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.
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Manganese superoxide dismutase-mediated inside-out signaling in HaCaT human keratinocytes and SKH-1 mouse skin.
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Maximal beta3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation.
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MicroRNA-146a-5p Attenuates Fibrosis-related Molecules in Irradiated and TGF-beta1-Treated Human Hepatic Stellate Cells by Regulating PTPRA-SRC Signaling.
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Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop.
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Molecular and functional signature of heart hypertrophy during pregnancy.
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Molecular editing of cellular responses by the high-affinity receptor for IgE.
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Mutual regulation of Src family kinases and the neurotrophin receptor TrkB.
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N-terminal tyrosine modulation of the endocytic adaptor function of the beta-arrestins.
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Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways.
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Neuroprotective effects of reactive oxygen species mediated by BDNF-independent activation of TrkB.
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Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling.
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Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration.
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Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells.
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Phase I safety, pharmacokinetics, and inhibition of SRC activity study of saracatinib in patients with solid tumors.
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Phase I study of dasatinib in combination with capecitabine, oxaliplatin and bevacizumab followed by an expanded cohort in previously untreated metastatic colorectal cancer.
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Phase II Study of Dasatinib in Previously Treated Patients with Advanced Non-Small Cell Lung Cancer.
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Phase II study of saracatinib (AZD0530) in patients with previously treated metastatic colorectal cancer.
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Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation.
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Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases.
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Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways.
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Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor.
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Reelin signals survival through Src-family kinases that inactivate BAD activity.
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Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation.
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Regulation of epidermal growth factor receptor internalization by G protein-coupled receptors.
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Regulation of tyrosine kinase cascades by G-protein-coupled receptors.
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Replication and meta-analysis of GWAS identified susceptibility loci in Kawasaki disease confirm the importance of B lymphoid tyrosine kinase (BLK) in disease susceptibility.
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Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases.
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Role of the cytoplasmic tails of CXCR1 and CXCR2 in mediating leukocyte migration, activation, and regulation.
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SRC family kinase inhibition as a novel strategy to augment melphalan-based regional chemotherapy of advanced extremity melanoma.
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Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways.
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Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor.
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Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling.
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Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress.
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TBCRC-010: Phase I/II Study of Dasatinib in Combination with Zoledronic Acid for the Treatment of Breast Cancer Bone Metastasis.
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The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system.
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The inhibitory coreceptor CD22 restores B cell signaling by developmentally regulating Cd45-/- immunodeficient B cells.
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The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition.
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The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling.
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The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals.
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The role of protein phosphorylation in therapy resistance and disease progression in chronic myelogenous leukemia.
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The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells.
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Transcription factor TFII-I causes transcriptional upregulation of GRP78 synthesis in prostate cancer cells.
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Tumor Cell-Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells.
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Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases.
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alpha-Crystallin localizes to the leading edges of migrating lens epithelial cells.
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beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport.
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beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis.
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c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF.
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p53lyn and p56lyn: a new signaling pathway in human endometrium and endometrial adenocarcinomas.
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Keywords of People