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Subject Areas on Research
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A novel alternative splice domain in zebrafish tenascin-C.
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A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost.
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A tenascin knockout with a phenotype.
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Antitenascin antibody 81C6 armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands.
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Antitenascin-C monoclonal antibody radioimmunotherapy for malignant glioma patients.
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Articular chondrocyte tenascin-C production and assembly into de novo extracellular matrix.
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Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS.
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Backbone dynamics of homologous fibronectin type III cell adhesion domains from fibronectin and tenascin.
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Binding of hexabrachion (tenascin) to the extracellular matrix and substratum and its effect on cell adhesion.
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Binding of tenascin-C to soluble fibronectin and matrix fibrils.
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Biochemical and structural studies of tenascin/hexabrachion proteins.
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Bronchial epithelial injury in the context of alloimmunity promotes lymphocytic bronchiolitis through hyaluronan expression.
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Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response.
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Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response.
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Cell surface annexin II is a high affinity receptor for the alternatively spliced segment of tenascin-C.
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Cell- and heparin-binding domains of the hexabrachion arm identified by tenascin expression proteins.
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Chimeric anti-tenascin antibody 81C6: increased tumor localization compared with its murine parent.
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Clinical experience with alpha-particle emitting 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6.
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Colocalization of tenascin with versican, a hyaluronate-binding chondroitin sulfate proteoglycan.
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Comparison of intratumoral bolus injection and convection-enhanced delivery of radiolabeled antitenascin monoclonal antibodies.
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Cytotoxicity of alpha-particle-emitting astatine-211-labelled antibody in tumour spheroids: no effect of hyperthermia.
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Designing an extracellular matrix protein with enhanced mechanical stability.
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Determinants of Tenascin-C and HIV-1 envelope binding and neutralization.
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Differential DNA methylation patterns in human Schlemm's canal endothelial cells with glaucoma.
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Distribution and dosimetry of I-123-labeled monoclonal antibody 81C6 in patients with anaplastic glioma.
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Dosimetry and dose-response relationships in newly diagnosed patients with malignant gliomas treated with iodine-131-labeled anti-tenascin monoclonal antibody 81C6 therapy.
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Dosimetry and radiographic analysis of 131I-labeled anti-tenascin 81C6 murine monoclonal antibody in newly diagnosed patients with malignant gliomas: a phase II study.
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Dosimetry of 131I-labeled 81C6 monoclonal antibody administered into surgically created resection cavities in patients with malignant brain tumors.
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Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascin.
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Enhanced tumor localization and in vivo stability of a monoclonal antibody radioiodinated using N-succinimidyl 3-(tri-n-butylstannyl)benzoate.
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Enhanced tumour uptake of radiolabelled antibodies by hyperthermia: Part I: Timing of injection relative to hyperthermia.
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Epithelial cells are an important source of tenascin in normal and malignant human breast tissue.
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Evolution of the tenascin family--implications for function of the C-terminal fibrinogen-like domain.
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Extracellular annexin II.
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Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin.
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Gene knockouts of c-src, transforming growth factor beta 1, and tenascin suggest superfluous, nonfunctional expression of proteins.
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Generation and characterization of a mouse/human chimeric antibody directed against extracellular matrix protein tenascin.
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Glioma-associated antigen expression in oligodendroglial neoplasms. Tenascin and epidermal growth factor receptor.
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Glycosaminoglycans modulate fibronectin matrix assembly and are essential for matrix incorporation of tenascin-C.
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High-level production of alpha-particle-emitting (211)At and preparation of (211)At-labeled antibodies for clinical use.
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Human IgG2 constant region enhances in vivo stability of anti-tenascin antibody 81C6 compared with its murine parent.
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Identification of amino acid sequences in fibrinogen gamma -chain and tenascin C C-terminal domains critical for binding to integrin alpha vbeta 3.
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Improved therapeutic efficacy of a monoclonal antibody radioiodinated using N-succinimidyl-3-(tri-n-butylstannyl)benzoate.
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Induction of human tenascin (neuronectin) by growth factors and cytokines: cell type-specific signals and signalling pathways.
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Induction of tenascin in rat lungs undergoing bleomycin-induced pulmonary fibrosis.
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Iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with recurrent malignant gliomas: phase I trial results.
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Labeling monoclonal antibodies and F(ab')2 fragments with the alpha-particle-emitting nuclide astatine-211: preservation of immunoreactivity and in vivo localizing capacity.
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Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model.
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Localization and quantitation of hexabrachion (tenascin) in skin, embryonic brain, tumors, and plasma.
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Localization of a cryptic binding site for tenascin on fibronectin.
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Localization of tenascin in uterine sarcomas and partially transformed endometrial stromal cells.
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Locally increased uptake of fluorine-18-fluorodeoxyglucose after intracavitary administration of iodine-131-labeled antibody for primary brain tumors.
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Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells.
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Mitogenesis, cell migration, and loss of focal adhesions induced by tenascin-C interacting with its cell surface receptor, annexin II.
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Mitogenic and adhesive effects of tenascin-C on human hematopoietic cells are mediated by various functional domains.
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Oxidative stress mediates monocrotaline-induced alterations in tenascin expression in pulmonary artery endothelial cells.
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Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain.
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Pharmacokinetics and tumor localization of 131I-labeled anti-tenascin monoclonal antibody 81C6 in patients with gliomas and other intracranial malignancies.
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Phase 1 trial study of 131I-labeled chimeric 81C6 monoclonal antibody for the treatment of patients with non-Hodgkin lymphoma.
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Phase I studies of treatment of malignant gliomas and neoplastic meningitis with 131I-radiolabeled monoclonal antibodies anti-tenascin 81C6 and anti-chondroitin proteoglycan sulfate Me1-14 F (ab')2--a preliminary report.
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Phase I trial results of iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with newly diagnosed malignant gliomas.
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Phase II trial of murine (131)I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas.
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Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease.
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Preparation and characterization of anti-tenascin monoclonal antibody-streptavidin conjugates for pretargeting applications.
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Prognostic marker analysis in pediatric intracranial ependymomas.
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Purification of hexabrachion (tenascin) from cell culture conditioned medium, and separation from a cell adhesion factor.
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Rare variants in tenascin genes in a cohort of children with primary vesicoureteric reflux.
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Relevance for neurobiology and neurooncology of antigens of malignant gliomas as defined by monoclonal antibodies.
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Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: phase II study results.
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Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats.
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Structural organization of the human insulin receptor ectodomain.
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Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein.
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TGF-beta regulates expression of tenascin alternative-splicing isoforms in fetal rat lung.
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TNXB mutations can cause vesicoureteral reflux.
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Tenascin and microvessel stromal changes in patients with non-Hodgkin's lymphoma are isolated to the sites of disease and vary in correlation to disease activity.
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Tenascin expression in human glioma cell lines and normal tissues.
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Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma.
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Tenascin in rat lung development: in situ localization and cellular sources.
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Tenascin is induced at implantation sites in the mouse uterus and interferes with epithelial cell adhesion.
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Tenascin knockout mice: barrels, boundary molecules, and glial scars.
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Tenascin supports lymphocyte rolling.
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Tenascin-C expression and distribution in cultured human chondrocytes and chondrosarcoma cells.
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Tenascin-C expression in dystrophin-related muscular dystrophy.
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Tenascin-C in rat lung: distribution, ontogeny and role in branching morphogenesis.
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Tenascin-C inhibits extracellular matrix-dependent gene expression in mammary epithelial cells. Localization of active regions using recombinant tenascin fragments.
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Tenascin-C is an innate broad-spectrum, HIV-1-neutralizing protein in breast milk.
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Tenascin-C knockout mouse has no detectable tenascin-C protein.
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Tenascin-C splice variant adhesive/anti-adhesive effects on chondrosarcoma cell attachment to fibronectin.
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Tenascin-C, over expressed in lung cancer down regulates effector functions of tumor infiltrating lymphocytes.
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Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions.
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Tenascin/hexabrachion in human skin: biochemical identification and localization by light and electron microscopy.
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Tenascin: an extracellular matrix protein prominent in specialized embryonic tissues and tumors.
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The CXC chemokine cCAF stimulates precocious deposition of ECM molecules by wound fibroblasts, accelerating development of granulation tissue.
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The Presence and Anti-HIV-1 Function of Tenascin C in Breast Milk and Genital Fluids.
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The clinical significance of tenascin-C splice variant expression in chondrosarcoma.
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The effects of local hyperthermia on the catabolism of a radioiodinated chimeric monoclonal antibody.
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The molecular elasticity of the extracellular matrix protein tenascin.
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Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131I-radiolabeled murine monoclonal antibody in a human glioma xenograft model.
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Transcriptional response to hypoxia in human tumors.
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Treatment of intracranial human glioma xenografts with 131I-labeled anti-tenascin monoclonal antibody 81C6.
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Treatment of newly diagnosed glioblastoma multiforme.
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Tumor antigens in astrocytic gliomas.
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Tumor microenvironment tenascin-C promotes glioblastoma invasion and negatively regulates tumor proliferation.
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Tumor resection cavity administered iodine-131-labeled antitenascin 81C6 radioimmunotherapy in patients with malignant glioma: neuropathology aspects.
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Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C.
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Vascular targeted endoradiotherapy of tumors using alpha-particle-emitting compounds: theoretical analysis.
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Keywords of People
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Erickson, Harold Paul,
Professor Emeritus of Cell Biology,
Cell Biology
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Liu, Yutao,
Adjunct Assistant Professor in the Department of Medicine,
Medicine, Medical Genetics
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Biomedical Engineering