Cell Lineage

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  Subject Areas on Research

  • 2010 Nicolas Andry Award: Multipotent adult stem cells from adipose tissue for musculoskeletal tissue engineering. 
  • A CD91-positive subset of CD11c+ blood dendritic cells: characterization of the APC that functions to enhance adaptive immune responses against CD91-targeted antigens. 
  • A CRISPR/Cas9-based system for reprogramming cell lineage specification. 
  • A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes. 
  • A cell-intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation. 
  • A genomic regulatory network for development. 
  • A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer. 
  • A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells. 
  • A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. 
  • A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. 
  • A three-generation approach in biodemography is based on the developmental profiles and the epigenetics of female gametes. 
  • Absolute values of dendritic cell subsets in bone marrow, cord blood, and peripheral blood enumerated by a novel method. 
  • Antigen-specific T-lymphocyte function after cord blood transplantation. 
  • Antimetabolite therapy for lesser-risk B-lineage acute lymphoblastic leukemia of childhood: a report from Children's Oncology Group Study P9201. 
  • ApoA-I induced CD31 in bone marrow-derived vascular progenitor cells increases adhesion: implications for vascular repair. 
  • Arterial pole progenitors interpret opposing FGF/BMP signals to proliferate or differentiate. 
  • Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS. 
  • B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study. 
  • Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium. 
  • Biomimetic hydrogels with pro-angiogenic properties. 
  • Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos. 
  • Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells. 
  • CD40 mediated activation of gingival and periodontal ligament fibroblasts. 
  • CD83 expression influences CD4+ T cell development in the thymus. 
  • Calcitonin driven v-Ha-ras induces multilineage pulmonary epithelial hyperplasias and neoplasms. 
  • Cell fate commitment during mammalian sex determination. 
  • Cell identity regulators link development and stress responses in the Arabidopsis root. 
  • Cell lineage mapping of taste bud cells and keratinocytes in the mouse tongue and soft palate. 
  • Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. 
  • Cell signalling by microRNA165/6 directs gene dose-dependent root cell fate. 
  • Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease 
  • Cellular plasticity: 1712 to the present day. 
  • Centrifugal migration of mesenchymal cells in embryonic lung. 
  • Characterization of adipose-derived mesenchymal stem cell combinations for vascularized bone engineering. 
  • Chromatin architecture reorganization during stem cell differentiation. 
  • Clinical course and origin of epithelium in cases of epithelial downgrowth after Descemet stripping automated endothelial keratoplasty. 
  • Clonally dominant cardiomyocytes direct heart morphogenesis. 
  • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. 
  • Collapsing glomerulopathy: an inflammatory podocytopathy? 
  • Combined deletion of Id2 and Id3 genes reveals multiple roles for E proteins in invariant NKT cell development and expansion. 
  • Combining topographical and genetic cues to promote neuronal fate specification in stem cells. 
  • Common endothelial progenitor cell assays identify discrete endothelial progenitor cell populations. 
  • Comparative Developmental Transcriptomics Reveals Rewiring of a Highly Conserved Gene Regulatory Network during a Major Life History Switch in the Sea Urchin Genus Heliocidaris. 
  • Comparison of the Viability and Yield of Adipose-Derived Stem Cells (ASCs) from Different Donor Areas. 
  • Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral disc. 
  • Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. 
  • Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model. 
  • Critical roles of RasGRP1 for invariant NKT cell development. 
  • Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice. 
  • Cytokine expression by invariant natural killer T cells is tightly regulated throughout development and settings of type-2 inflammation. 
  • Cytokine-induced mobilization of circulating endothelial progenitor cells enhances repair of injured arteries. 
  • Cytokine-regulated expression of activated leukocyte cell adhesion molecule (CD166) on monocyte-lineage cells and in rheumatoid arthritis synovium. 
  • Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. 
  • Derivation of chondrogenically-committed cells from human embryonic cells for cartilage tissue regeneration. 
  • Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. 
  • Detection of clonal lymphoid receptor gene rearrangements in langerhans cell histiocytosis. 
  • Determining γδ versus αß T cell development. 
  • Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity. 
  • Developmental regulation of V(D)J recombination at the TCR alpha/delta locus. 
  • Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes. 
  • Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors. 
  • Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions. 
  • Divergent gene regulation and growth effects by NF-kappa B in epithelial and mesenchymal cells of human skin. 
  • E2A promotes the survival of precursor and mature B lymphocytes. 
  • Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new. 
  • Elaboration of tubules with active hedgehog drives parenchymal fibrogenesis in gestational alloimmune liver disease. 
  • Elevated PTH induces endothelial-to-chondrogenic transition in aortic endothelial cells. 
  • Engineering musculoskeletal tissues with human embryonic germ cell derivatives. 
  • Engineering skeletal myoblasts: roles of three-dimensional culture and electrical stimulation. 
  • Enhanced MyoD-induced transdifferentiation to a myogenic lineage by fusion to a potent transactivation domain. 
  • Enhanced chondrogenic differentiation of embryonic stem cells by coculture with hepatic cells. 
  • Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. 
  • Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. 
  • Epithelial progenitor cells in lung development, maintenance, repair, and disease. 
  • Epstein-Barr virus-negative diffuse large B cell lymphoma with aberrant expression of CD3 and other T cell-associated antigens: report of three cases with a review of the literature. 
  • Erythropoietin mediates terminal granulocytic differentiation of committed myeloid cells with ectopic erythropoietin receptor expression. 
  • Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia. 
  • Evidence for and against epithelial-to-mesenchymal transition in the liver. 
  • Ex vivo expansion of murine and human hematopoietic stem cells. 
  • Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours. 
  • Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. 
  • Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB. 
  • G protein signaling governing cell fate decisions involves opposing Galpha subunits in Cryptococcus neoformans. 
  • GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. 
  • Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers. 
  • Generation of Dhx9-deficient clones in T-cell development with a mitotic recombination technique. 
  • Genetic diversity of the Cryptococcus species complex suggests that Cryptococcus gattii deserves to have varieties. 
  • Germ cells are not required to establish the female pathway in mouse fetal gonads. 
  • Glioblastoma stem-like cells give rise to tumour endothelium. 
  • Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia. 
  • Graft-extrinsic cells predominate in vein graft arterialization. 
  • Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish. 
  • Histiocytic/dendritic cell transformation of B-cell neoplasms: pathologic evidence of lineage conversion in differentiated hematolymphoid malignancies. 
  • How does the mouse get its trunk? 
  • Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish. 
  • Human immunodeficiency virus type 1 (HIV-1) induces activation of multiple STATs in CD4+ cells of lymphocyte or monocyte/macrophage lineages. 
  • Human lung stem cells: has the future arrived? 
  • Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm. 
  • Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells. 
  • IL-15 regulates homeostasis and terminal maturation of NKT cells. 
  • Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like γδ T cells. 
  • Id3 restricts the developmental potential of gamma delta lineage during thymopoiesis. 
  • Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome. 
  • Identification of regulators of germ stem cell enwrapment by its niche in C. elegans. 
  • Image segmentation and dynamic lineage analysis in single-cell fluorescence microscopy. 
  • Immunohistochemical and ultrastructural markers suggest different origins for cuboidal and polygonal cells in pulmonary sclerosing hemangioma. 
  • In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics. 
  • In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations. 
  • Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. 
  • Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness. 
  • Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. 
  • Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations. 
  • Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages. 
  • Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations. 
  • Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents posttraumatic arthritis. 
  • Intratumor heterogeneity in evolutionary models of tumor progression. 
  • Is the shoot a root with a view? 
  • Isogenic normal basal and luminal mammary epithelial isolated by a novel method show a differential response to ionizing radiation. 
  • Isolation of oligodendrocyte-like cells from human umbilical cord blood. 
  • Leukocyte composition of human breast cancer. 
  • Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds. 
  • Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters. 
  • Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element. 
  • Lineage-specific trisomy 21 in a neonate with resolving transient myeloproliferative syndrome. 
  • Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. 
  • Long-term survival of influenza virus infected club cells drives immunopathology. 
  • Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determination. 
  • Lymphoid precursors. 
  • Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species. 
  • Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. 
  • Mechanism of apoptosis and determination of cellular fate in chromium(VI)-exposed populations of telomerase-immortalized human fibroblasts. 
  • Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype. 
  • Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development. 
  • Metabolic pathways in T cell fate and function. 
  • Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells. 
  • MicroRNAs and Cardiac Regeneration. 
  • Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide. 
  • Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity. 
  • Molecular analysis of the SCARECROW gene in maize reveals a common basis for radial patterning in diverse meristems. 
  • Morphogenesis and Compartmentalization of the Intestinal Crypt. 
  • Morphogenesis in sea urchin embryos: linking cellular events to gene regulatory network states. 
  • Multi-site evaluation of the BD Stem Cell Enumeration Kit for CD34(+) cell enumeration on the BD FACSCanto II and BD FACSCalibur flow cytometers. 
  • Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand. 
  • Murine CMV induces type 1 IFN that impairs differentiation of MDSCs critical for transplantation tolerance. 
  • Murine bone marrow stromal cells pulsed with homologous tumor-derived exosomes inhibit proliferation of liver cancer cells. 
  • Myocardial volume and organization are changed by failure of addition of secondary heart field myocardium to the cardiac outflow tract. 
  • Neural crest and cardiovascular development: a 20-year perspective. 
  • New insights into E-protein function in lymphocyte development. 
  • New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes. 
  • Notch1 perturbation of hemopoiesis involves non-cell- autonomous modifications. 
  • Novel mutations target distinct subgroups of medulloblastoma. 
  • Numb regulates somatic cell lineage commitment during early gonadogenesis in mice. 
  • Oct4 RNA interference induces trophectoderm differentiation in mouse embryonic stem cells. 
  • Orchestration of invariant natural killer T cell development by E and Id proteins. 
  • Out of Eden: stem cells and their niches. 
  • P-selectin glycoprotein ligand-1 is broadly expressed in cells of myeloid, lymphoid, and dendritic lineage and in some nonhematopoietic cells. 
  • PLP1 alternative splicing in differentiating oligodendrocytes: characterization of an exonic splicing enhancer. 
  • Pairing of competitive and topologically distinct regulatory modules enhances patterned gene expression. 
  • Paracrine signals from mesenchymal cell populations govern the expansion and differentiation of human hepatic stem cells to adult liver fates. 
  • Patterns of microRNA expression characterize stages of human B-cell differentiation. 
  • Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture. 
  • Plasticity in the lung: making and breaking cell identity. 
  • Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. 
  • Postnatal development and plasticity of specialized muscle fiber characteristics in the hindlimb. 
  • Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain. 
  • Prospective of Ras signaling in stem cells. 
  • Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. 
  • Quantification of normal cell death in the rat retina: implications for clone composition in cell lineage analysis. 
  • Rapid and Efficient Generation of Transgene-Free iPSC from a Small Volume of Cryopreserved Blood. 
  • Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection. 
  • Receptor-like kinase ACR4 restricts formative cell divisions in the Arabidopsis root. 
  • Regeneration of amputated zebrafish fin rays from de novo osteoblasts. 
  • Regulation of E2A gene expression in B-lymphocyte development. 
  • Regulation of T-helper-cell lineage development by osteopontin: the inside story. 
  • Regulatory Circuits and Bi-directional Signaling between Stem Cells and Their Progeny. 
  • Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. 
  • Repression of mesodermal fate by foxa, a key endoderm regulator of the sea urchin embryo. 
  • Reprogramming after chromosome transfer into mouse blastomeres. 
  • Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage. 
  • SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. 
  • SOX9: a useful marker for pancreatic ductal lineage of pancreatic neoplasms. 
  • Sam-pointed domain containing Ets transcription factor in luminal breast cancer pathogenesis. 
  • Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis. 
  • Sequential roles of Hedgehog and Wnt signaling in osteoblast development. 
  • Single-molecule analysis of myocyte differentiation reveals bimodal lineage commitment. 
  • Sources of human and murine hematopoietic stem cells. 
  • Specification of chondrocytes and cartilage tissues from embryonic stem cells. 
  • Specification of endoderm and mesoderm in the sea urchin. 
  • Sry induces cell proliferation in the mouse gonad. 
  • Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation. 
  • Stem cells for the ischaemic heart. 
  • Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development. 
  • Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors. 
  • Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage. 
  • Systemic mastocytosis with associated clonal hematologic nonmast cell lineage disease: a clinicopathologic review. 
  • Systems biological analyses reveal the hepatitis C virus (HCV)-specific regulation of hematopoietic development. 
  • TBX3 Directs Cell-Fate Decision toward Mesendoderm. 
  • TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection. 
  • Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic. 
  • Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice. 
  • Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad. 
  • The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration. 
  • The Macrophage-Specific Promoter mfap4 Allows Live, Long-Term Analysis of Macrophage Behavior during Mycobacterial Infection in Zebrafish. 
  • The autophagy gene ATG5 plays an essential role in B lymphocyte development. 
  • The battle of the sexes. 
  • The effects of molecular noise and size control on variability in the budding yeast cell cycle. 
  • The hand that rocks the spindle. 
  • The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo. 
  • The human fetal lymphocyte lineage: identification by CD27 and LIN28B expression in B cell progenitors. 
  • The role of single-cell analyses in understanding cell lineage commitment. 
  • The thymus as an inductive site for T lymphopoiesis. 
  • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. 
  • The vascular niche: home for normal and malignant hematopoietic stem cells. 
  • The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. 
  • Thymus transplantation restores the repertoires of forkhead box protein 3 (FoxP3)+ and FoxP3- T cells in complete DiGeorge anomaly. 
  • To branch or not to branch: the role of pre-patterning in lateral root formation. 
  • Topical lineage-negative progenitor-cell therapy for diabetic wounds. 
  • Toward a blueprint for regeneration. 
  • Transcriptional Timers Regulating Mitosis in Early Drosophila Embryos. 
  • Transcriptional control of tissue formation throughout root development. 
  • Transcriptional diversity during lineage commitment of human blood progenitors. 
  • Transcriptional networks in root cell fate specification. 
  • Transcriptional switches direct plant organ formation and patterning. 
  • Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. 
  • Two distinct origins for Leydig cell progenitors in the fetal testis. 
  • Type 2 alveolar cells are stem cells in adult lung. 
  • Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice. 
  • WNT3 is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCs. 
  • Wnt-signaling in retinal development and disease. 
  • Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies. 
  • Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. 
  • Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function. 
  • hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane glycoprotein potentially involved in the regulation of recombination activating gene 1 (RAG1). 
  • iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions. 
  • mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination. 
  • mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development. 
  • tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. 
  • β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium. 
  • β-Catenin-regulated myeloid cell adhesion and migration determine wound healing. 
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  Keywords of People

  • Abbruzzese, James, D. C. I. Professor of Medical Oncology, Medicine, Medical Oncology
  • Allori, Alexander C, Assistant Professor of Surgery, Surgery, Plastic, Maxillofacial, and Oral Surgery
  • Baugh, L. Ryan, Associate Professor of Biology, Biology
  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Ciofani, Maria, Assistant Professor of Immunology, Immunology
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Hilton, Matthew James, Associate Professor in Orthopaedic Surgery, Cell Biology
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • Hutson, Mary Redmond, Assistant Professor of Pediatrics, Pediatrics, Neonatology
  • Krangel, Michael S., Mary Bernheim Professor of Immunology, Immunology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology
  • Stoecker, Maggie Marie, Assistant Professor of Pathology, Pathology
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology
  • Velkey, John Matthew, Assistant Professor of the Practice of Medical Education in the Department of Cell Biology, Cell Biology
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology