Telomerase

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  Subject Areas on Research

  • A functional variant of tandem repeats in human telomerase gene was associated with survival of patients with early stages of non-small cell lung cancer. 
  • A genetically defined normal human somatic cell system to study ras oncogenesis in vivo and in vitro. 
  • A genetically tractable model of human glioma formation. 
  • A network of genetic events sufficient to convert normal human cells to a tumorigenic state. 
  • A novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells. 
  • A novel human cancer culture model for the study of prostate cancer. 
  • A novel neoplastic primary tumor-derived human prostate epithelial cell line. 
  • A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer. 
  • A telomerase-immortalized primary human prostate cancer clonal cell line with neoplastic phenotypes. 
  • Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction. 
  • Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT. 
  • An efficient targeted radiotherapy/gene therapy strategy utilising human telomerase promoters and radioastatine and harnessing radiation-mediated bystander effects. 
  • Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studies. 
  • Androgen and androgen receptor antagonist responsive primary African-American benign prostate epithelial cell line. 
  • Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer. 
  • Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a Chinese population. 
  • Blood vessels engineered from human cells. 
  • Blood vessels engineered from human cells. 
  • Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression. 
  • C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity. 
  • Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer. 
  • Characterization of Individual Isopropylated and tert-Butylated Triarylphosphate (ITP and TBPP) Isomers in Several Commercial Flame Retardant Mixtures and House Dust Standard Reference Material SRM 2585. 
  • Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR. 
  • Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny. 
  • Conditional telomerase induction causes proliferation of hair follicle stem cells. 
  • Creation of human tumour cells with defined genetic elements. 
  • Cyst Fluid Analysis in Pancreatic Intraductal Papillary Mucinous Neoplasms. 
  • DNA hypermethylation within TERT promoter upregulates TERT expression in cancer. 
  • Detection of human telomerase reverse transcriptase mRNA in cells obtained by lavage of the pleura is not associated with worse outcome in patients with stage I/II non-small cell lung cancer: results from Cancer and Leukemia Group B 159902. 
  • Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner. 
  • Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. 
  • Distinct Responses of Stem Cells to Telomere Uncapping-A Potential Strategy to Improve the Safety of Cell Therapy. 
  • Emerging roles for telomerase in neuronal development and apoptosis. 
  • Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". 
  • Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. 
  • Expression of telomerase reverse transcriptase (TERT) in malignant mesotheliomas. 
  • Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. 
  • Genetic modeling of human rhabdomyosarcoma. 
  • Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis. 
  • Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck. 
  • Genetically engineered human cancer models utilizing mammalian transgene expression. 
  • Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer. 
  • Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors. 
  • HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis. 
  • Human arteries engineered in vitro. 
  • IFN-α inhibits telomerase in human CD8⁺ T cells by both hTERT downregulation and induction of p38 MAPK signaling. 
  • Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells. 
  • Improved methods and standards for telomerase detection: quantitative histopathology using antibody staining. 
  • In perspective: An update on telomere targeting in cancer. 
  • In vivo regulation of hTERT expression and telomerase activity by androgen. 
  • In vivo reprogramming of hTERT by trans-splicing ribozyme to target tumor cells. 
  • Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells. 
  • Influence of ATM function on telomere metabolism. 
  • Inhibition of telomerase is related to the life span and tumorigenicity of human prostate cancer cells. 
  • Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. 
  • Lung Transplant Outcomes in Patients With Pulmonary Fibrosis With Telomere-Related Gene Variants. 
  • Lung transplantation in telomerase mutation carriers with pulmonary fibrosis. 
  • Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species. 
  • Mechanism of apoptosis and determination of cellular fate in chromium(VI)-exposed populations of telomerase-immortalized human fibroblasts. 
  • Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage. 
  • Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. 
  • Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma. 
  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. 
  • Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process. 
  • Mutational analysis defines a minimum level of telomerase activity required for tumourigenic growth of human cells. 
  • Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas. 
  • N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo. 
  • NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer-Initiating Cells. 
  • Novel human bronchial epithelial cell lines for cystic fibrosis research. 
  • Pan-cancer analysis of whole genomes. 
  • Perifosine as a potential novel anti-telomerase therapy. 
  • Prognostic significance of reactivation of telomerase in breast core biopsy specimens. 
  • Promoting a new brain tumor mutation: TERT promoter mutations in CNS tumors. 
  • Putative telomere-recruiting domain in the catalytic subunit of human telomerase. 
  • Rapid telomere shortening in children. 
  • Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation. 
  • Relevance and safety of telomerase for human tissue engineering. 
  • Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells. 
  • Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1. 
  • Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis. 
  • Resistance to apoptosis, increased growth potential, and altered gene expression in cells that survived genotoxic hexavalent chromium [Cr(VI)] exposure. 
  • Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer. 
  • Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma. 
  • Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas. 
  • Sex-specific gene and pathway modeling of inherited glioma risk. 
  • Stretching the surface epithelium. 
  • Survival prediction in patients with glioblastoma multiforme by human telomerase genetic variation. 
  • TERC is not a major gene in human neural tube defects. 
  • TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma. 
  • TERT promoter mutations contribute to IDH mutations in predicting differential responses to adjuvant therapies in WHO grade II and III diffuse gliomas. 
  • TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. 
  • Telomerase activity and prognosis in primary breast cancers. 
  • Telomerase activity in ductal carcinoma in situ and invasive breast cancer. 
  • Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. 
  • Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer. 
  • Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells. 
  • Telomerase, cell immortality, and cancer. 
  • Telomere length and TERT functional polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck. 
  • Telomere structure and maintenance gene variants and risk of five cancer types. 
  • Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation. 
  • The catalytic subunit of yeast telomerase. 
  • The detection of telomerase activity in patients with adenocarcinoma of the pancreas by fine needle aspiration. 
  • The genetic landscape of gliomas arising after therapeutic radiation. 
  • The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma. 
  • The nucleolar localization domain of the catalytic subunit of human telomerase. 
  • The roles of telomeres and telomerase in cell life span. 
  • The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair. 
  • Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. 
  • Use of human gametes obtained from anonymous donors for the production of human embryonic stem cell lines. 
  • Utility of telomerase-pot1 fusion protein in vascular tissue engineering. 
  • Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes. 
  • Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. 
  • ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation. 
  • hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. 
  • iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Pharmacology & Cancer Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Moorman, Patricia Gripka, Professor in Family Medicine and Community Health, Duke Cancer Institute
  • Yan, Hai, Henry S. Friedman Distinguished Professor of Neuro-Oncology in the School of Medicine, Pathology