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Subject Areas on Research
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A functional variant of tandem repeats in human telomerase gene was associated with survival of patients with early stages of non-small cell lung cancer.
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A genetically defined normal human somatic cell system to study ras oncogenesis in vivo and in vitro.
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A genetically tractable model of human glioma formation.
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A network of genetic events sufficient to convert normal human cells to a tumorigenic state.
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A novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells.
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A novel human cancer culture model for the study of prostate cancer.
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A novel neoplastic primary tumor-derived human prostate epithelial cell line.
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A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer.
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A telomerase-immortalized primary human prostate cancer clonal cell line with neoplastic phenotypes.
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Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction.
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Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT.
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An efficient targeted radiotherapy/gene therapy strategy utilising human telomerase promoters and radioastatine and harnessing radiation-mediated bystander effects.
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Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studies.
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Androgen and androgen receptor antagonist responsive primary African-American benign prostate epithelial cell line.
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Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells.
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Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer.
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Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a Chinese population.
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Blood vessels engineered from human cells.
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Blood vessels engineered from human cells.
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Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression.
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C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity.
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Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.
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Characterization of Individual Isopropylated and tert-Butylated Triarylphosphate (ITP and TBPP) Isomers in Several Commercial Flame Retardant Mixtures and House Dust Standard Reference Material SRM 2585.
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Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR.
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Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny.
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Conditional telomerase induction causes proliferation of hair follicle stem cells.
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Creation of human tumour cells with defined genetic elements.
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Cyst Fluid Analysis in Pancreatic Intraductal Papillary Mucinous Neoplasms.
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DNA hypermethylation within TERT promoter upregulates TERT expression in cancer.
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Detection of human telomerase reverse transcriptase mRNA in cells obtained by lavage of the pleura is not associated with worse outcome in patients with stage I/II non-small cell lung cancer: results from Cancer and Leukemia Group B 159902.
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Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner.
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Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization.
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Distinct Responses of Stem Cells to Telomere Uncapping-A Potential Strategy to Improve the Safety of Cell Therapy.
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Emerging roles for telomerase in neuronal development and apoptosis.
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Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
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Expression of TERT in early premalignant lesions and a subset of cells in normal tissues.
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Expression of telomerase reverse transcriptase (TERT) in malignant mesotheliomas.
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Extended passaging, but not aldehyde dehydrogenase activity, increases the chondrogenic potential of human adipose-derived adult stem cells.
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Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans.
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Genetic modeling of human rhabdomyosarcoma.
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Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis.
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Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck.
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Genetically engineered human cancer models utilizing mammalian transgene expression.
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Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors.
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HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis.
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Human arteries engineered in vitro.
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Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells.
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Improved methods and standards for telomerase detection: quantitative histopathology using antibody staining.
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In perspective: An update on telomere targeting in cancer.
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In vivo regulation of hTERT expression and telomerase activity by androgen.
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In vivo reprogramming of hTERT by trans-splicing ribozyme to target tumor cells.
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Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells.
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Influence of ATM function on telomere metabolism.
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Inhibition of telomerase is related to the life span and tumorigenicity of human prostate cancer cells.
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Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae.
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Lung transplantation in telomerase mutation carriers with pulmonary fibrosis.
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Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species.
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Mechanism of apoptosis and determination of cellular fate in chromium(VI)-exposed populations of telomerase-immortalized human fibroblasts.
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Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage.
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Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis.
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Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.
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Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process.
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Mutational analysis defines a minimum level of telomerase activity required for tumourigenic growth of human cells.
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Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas.
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N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo.
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NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer-Initiating Cells.
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Novel human bronchial epithelial cell lines for cystic fibrosis research.
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Perifosine as a potential novel anti-telomerase therapy.
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Premature Aging in Fibromyalgia.
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Prognostic significance of reactivation of telomerase in breast core biopsy specimens.
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Promoting a new brain tumor mutation: TERT promoter mutations in CNS tumors.
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Putative telomere-recruiting domain in the catalytic subunit of human telomerase.
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Rapid telomere shortening in children.
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Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation.
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Relevance and safety of telomerase for human tissue engineering.
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Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells.
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Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1.
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Resistance to apoptosis, increased growth potential, and altered gene expression in cells that survived genotoxic hexavalent chromium [Cr(VI)] exposure.
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Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer.
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Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma.
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Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
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Stretching the surface epithelium.
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Survival prediction in patients with glioblastoma multiforme by human telomerase genetic variation.
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TERC is not a major gene in human neural tube defects.
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TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.
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TERT promoter mutations contribute to IDH mutations in predicting differential responses to adjuvant therapies in WHO grade II and III diffuse gliomas.
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TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.
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Telomerase activity and prognosis in primary breast cancers.
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Telomerase activity in ductal carcinoma in situ and invasive breast cancer.
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Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase.
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Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer.
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Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells.
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Telomerase, cell immortality, and cancer.
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Telomere length and TERT functional polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck.
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Telomere structure and maintenance gene variants and risk of five cancer types.
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Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation.
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The catalytic subunit of yeast telomerase.
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The detection of telomerase activity in patients with adenocarcinoma of the pancreas by fine needle aspiration.
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The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.
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The nucleolar localization domain of the catalytic subunit of human telomerase.
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The roles of telomeres and telomerase in cell life span.
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The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair.
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Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma.
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Use of human gametes obtained from anonymous donors for the production of human embryonic stem cell lines.
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Utility of telomerase-pot1 fusion protein in vascular tissue engineering.
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Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes.
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Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.
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ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation.
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hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization.
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iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Linardic, Corinne Mary,
Associate Professor of Pediatrics,
Pharmacology & Cancer Biology
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Moorman, Patricia Gripka,
Professor in Family Medicine and Community Health,
Duke Cancer Institute
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Yan, Hai,
Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine,
Pathology