Tight Junctions
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Subject Areas on Research
- A CRISPR Screen Identifies the Cell Polarity Determinant Crumbs 3 as an Adeno-associated Virus Restriction Factor in Hepatocytes.
- Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.
- Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology.
- Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis.
- Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia.
- Calcium signals and calpain-dependent necrosis are essential for release of coxsackievirus B from polarized intestinal epithelial cells.
- Cell biology and physiology of the uroepithelium.
- Chlamydia repurposes the actin-binding protein EPS8 to disassemble epithelial tight junctions and promote infection.
- Chronic alcohol exposure renders epithelial cells vulnerable to bacterial infection.
- Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations.
- Correlation of the tight junction-like distribution of Claudin-1 to the cellular tropism of hepatitis C virus.
- Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5.
- Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases.
- Dengue virus-elicited tryptase induces endothelial permeability and shock.
- Developmental stratification of the mammary epithelium occurs through symmetry-breaking vertical divisions of apically positioned luminal cells.
- Different mechanisms preclude mutant CLDN14 proteins from forming tight junctions in vitro.
- Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia.
- Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity.
- E-cadherin is downregulated in benign prostatic hyperplasia and required for tight junction formation and permeability barrier in the prostatic epithelial cell monolayer.
- Enhancement of Outflow Facility in the Murine Eye by Targeting Selected Tight-Junctions of Schlemm's Canal Endothelia.
- Gpr124 is essential for blood-brain barrier integrity in central nervous system disease.
- ILDR1 null mice, a model of human deafness DFNB42, show structural aberrations of tricellular tight junctions and degeneration of auditory hair cells.
- Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases.
- Interendothelial claudin-5 expression depends on cerebral endothelial cell-matrix adhesion by β(1)-integrins.
- Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution.
- Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation.
- Phenotypes of trypsin- and collagenase-prepared bovine corneal endothelial cells in the presence of a selective Rho kinase inhibitor, Y-27632.
- Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity.
- Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis.
- Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b.
- Repeated primary blast injury causes delayed recovery, but not additive disruption, in an in vitro blood-brain barrier model.
- Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain.
- The Chlamydia trachomatis Protease CPAF Contains a Cryptic PDZ-Like Domain with Similarity to Human Cell Polarity and Tight Junction PDZ-Containing Proteins.
- The Disruption of the Endothelial Barrier Contributes to Acute Lung Injury Induced by Coxsackievirus A2 Infection in Mice.
- The actin cytoskeleton as a barrier to virus infection of polarized epithelial cells.
- The blood-brain barrier/neurovascular unit in health and disease.
- Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection.
- β1-integrin-matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability.
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Keywords of People
- McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology