Peptide Library

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  Subject Areas on Research

  • A CDC6 protein-binding peptide selected using a bacterial two-hybrid-like system is a cell cycle inhibitor. 
  • A bidirectional phage display vector for the selection and mass transfer of polyclonal antibody libraries. 
  • A powerful combinatorial screen to identify high-affinity terbium(III)-binding peptides. 
  • Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41. 
  • An entirely cell-based system to generate single-chain antibodies against cell surface receptors. 
  • Analysis of the substrate specificity of the Staphylococcus aureus sortase transpeptidase SrtA. 
  • Application of random peptide phage display to the study of nuclear hormone receptors. 
  • Combinatorial chemistry. 
  • Computational design of protein antigens that interact with the CDR H3 loop of HIV broadly neutralizing antibody 2F5. 
  • Construction of polyclonal antibody libraries using phage display. 
  • Cross-reactive HIV-1 neutralizing monoclonal antibodies selected by screening of an immune human phage library against an envelope glycoprotein (gp140) isolated from a patient (R2) with broadly HIV-1 neutralizing antibodies. 
  • Definition of the molecular basis for estrogen receptor-related receptor-alpha-cofactor interactions. 
  • Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease. 
  • Development of mammalian serum albumin affinity purification media by peptide phage display. 
  • Development of novel tumor imaging agents with phage-display combinatorial peptide libraries. 
  • Development of peptide antagonists for the androgen receptor using combinatorial peptide phage display. 
  • Development of peptide antagonists that target estrogen receptor beta-coactivator interactions. 
  • Directed evolution of a pyruvate aldolase to recognize a long chain acyl substrate. 
  • Discovery and characterization of human antibody inhibitors of pregnancy-associated plasma protein-A. 
  • Discovery of high-affinity peptide binders to BLyS by phage display. 
  • Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta. 
  • Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia. 
  • Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix. 
  • Found in translation: applications of protein and peptide molecular diversity. 
  • Functional interrogation and mining of natively paired human VH:VL antibody repertoires. 
  • Generation of a polyclonal Fab phage display library to the protozoan parasite Cryptosporidium parvum. 
  • Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity. 
  • Generation of species cross-reactive aptamers using "toggle" SELEX. 
  • HDAC6 and Ubp-M BUZ domains recognize specific C-terminal sequences of proteins. 
  • High-throughput affinity ranking of antibodies using surface plasmon resonance microarrays. 
  • Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody. 
  • Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics. 
  • Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists. 
  • Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate. 
  • Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display. 
  • Identification of recombinant antibodies against multiple distinct toll-like receptors by homolog mining a single immune scFv phage library. 
  • Identification of troponin C antagonists from a phage-displayed random peptide library. 
  • Immunotoxins with increased activity against epidermal growth factor receptor vIII-expressing cells produced by antibody phage display. 
  • Improved non-chromatographic purification of a recombinant protein by cationic elastin-like polypeptides. 
  • Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening. 
  • Isolation of a mycoplasma-specific binding peptide from an unbiased phage-displayed peptide library. 
  • Isolation of monoclonal antibodies with predetermined conformational epitope specificity. 
  • Iterative in situ click chemistry creates antibody-like protein-capture agents. 
  • Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators. 
  • Molprobity's ultimate rotamer-library distributions for model validation. 
  • Novel approach for differential diagnosis of HIV infections in the face of vaccine-generated antibodies: utility for detection of diverse HIV-1 subtypes. 
  • Novel peptide inhibitors of angiotensin-converting enzyme 2. 
  • Parallel Glyco-SPOT Synthesis of Glycopeptide Libraries. 
  • Peptide antagonists of the human estrogen receptor. 
  • Peptide array X-linking (PAX): a new peptide-protein identification approach. 
  • Peptide-mediated targeting of the islets of Langerhans. 
  • Phage display screening for peptides that inhibit polyglutamine aggregation. 
  • Phospholipid vesicles interfere with the binding of antibody fragments to the light chain of factor VIII. 
  • Predicting PY motif-mediated protein-protein interactions in the Nedd4 family of ubiquitin ligases. 
  • Quantification of the binding affinity of a specific hydroxyapatite binding peptide. 
  • Rapid analysis of protein farnesyltransferase substrate specificity using peptide libraries and isoprenoid diphosphate analogues. 
  • Rapid cross-linking of elastin-like polypeptides with (hydroxymethyl)phosphines in aqueous solution. 
  • Rapid generation of potent antibodies by autonomous hypermutation in yeast. 
  • Rapid kinetic-based screening of human Fab fragments. 
  • Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs. 
  • Recombinant polyclonal antibody libraries. 
  • Selection of peptides binding to the amyloid b-protein reveals potential inhibitors of amyloid formation. 
  • Tandem Mass Tag Labeling Facilitates Reversed-Phase Liquid Chromatography-Mass Spectrometry Analysis of Hydrophilic Phosphopeptides. 
  • The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator-activated receptors. 
  • The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs. 
  • Use of phage display to identify novel mineralocorticoid receptor-interacting proteins. 
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  Keywords of People

  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology