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Subject Areas on Research
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A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1.
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A barrier-type insulator forms a boundary between active and inactive chromatin at the murine TCRβ locus.
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A chemical glycoproteomics platform reveals O-GlcNAcylation of mitochondrial voltage-dependent anion channel 2.
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A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1.
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A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes.
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A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury.
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A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1.
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A retroviral-derived peptide phosphorylates protein kinase D/protein kinase Cmu involving phospholipase C and protein kinase C.
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A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses.
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A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.
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A signature in HIV-1 envelope leader peptide associated with transition from acute to chronic infection impacts envelope processing and infectivity.
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A small molecule inhibitor of alpha4 integrin-dependent cell migration.
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Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.
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Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.
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An array of 60,000 antibodies for proteome-scale antibody generation and target discovery.
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An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus.
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Analysis of mRNA partitioning between the cytosol and endoplasmic reticulum compartments of mammalian cells.
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Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal.
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Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.
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BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis.
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Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression.
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Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation.
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Bioactive hydrogel substrates: probing leukocyte receptor-ligand interactions in parallel plate flow chamber studies.
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Biomimetic, synthetic HDL nanostructures for lymphoma.
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CBF, Myb, and Ets binding sites are important for activity of the core I element of the murine retrovirus SL3-3 in T lymphocytes.
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CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation.
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CD28 ligation induces tyrosine phosphorylation of Pyk2 but not Fak in Jurkat T cells.
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CD69 gene is differentially regulated in T and B cells by evolutionarily conserved promoter-distal elements.
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CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor.
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Caspase cleavage is not for everyone.
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Cell cycle dependence of group VIA calcium-independent phospholipase A2 activity.
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Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia.
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Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1.
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Conversion of Bcl-2 to a Bax-like death effector by caspases.
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Coordinated posttranscriptional mRNA population dynamics during T-cell activation.
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DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress.
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Distinct roles for c-Myb and core binding factor/polyoma enhancer-binding protein 2 in the assembly and function of a multiprotein complex on the TCR delta enhancer in vivo.
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Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells.
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Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.
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Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia.
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Effects of Immunosuppressive Medications on Mitochondrial Function.
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Effects of in vitro brevetoxin exposure on apoptosis and cellular metabolism in a leukemic T cell line (Jurkat).
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Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release.
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Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix.
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Endoplasmic reticulum-bound ribosomes reside in stable association with the translocon following termination of protein synthesis.
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Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genes.
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Equalizing cDNA subtraction based on selective suppression of polymerase chain reaction: cloning of Jurkat cell transcripts induced by phytohemaglutinin and phorbol 12-myristate 13-acetate.
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Esterified Trehalose Analogues Protect Mammalian Cells from Heat Shock.
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Ex vivo pediatric brain tumors express Fas (CD95) and FasL (CD95L) and are resistant to apoptosis induction.
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Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer.
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Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse.
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Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.
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Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif.
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Functional coordination and HuR-mediated regulation of mRNA stability during T cell activation.
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GREAT improves functional interpretation of cis-regulatory regions.
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Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.
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Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades.
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Heterotropic modulation of selectin affinity by allosteric antibodies affects leukocyte rolling.
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Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity.
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Hypophosphorylation of the architectural chromatin protein DEK in death-receptor-induced apoptosis revealed by the isotope coded protein label proteomic platform.
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Identification of S-nitrosylated targets of thioredoxin using a quantitative proteomic approach.
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Induction of apoptosis by the novel retinoid AHPN in human T-cell lymphoma cells involves caspase-dependent and independent pathways.
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Integrated analysis identifies a class of androgen-responsive genes regulated by short combinatorial long-range mechanism facilitated by CTCF.
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Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression.
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Intracellular CMTM2 negatively regulates human immunodeficiency virus type-1 transcription through targeting the transcription factors AP-1 and CREB.
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Involvement of linker for activation of T cells in the costimulatory signaling pathways.
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K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation.
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LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
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LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.
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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
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Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding.
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MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.
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Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury.
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Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival.
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Modeling nuclear molecule release during in vitro cell death.
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NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway.
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Naturally occurring amino acid polymorphisms in human immunodeficiency virus type 1 (HIV-1) Gag p7(NC) and the C-cleavage site impact Gag-Pol processing by HIV-1 protease.
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Negative regulation of TCR signaling by linker for activation of X cells via phosphotyrosine-dependent and -independent mechanisms.
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Negative regulation of lymphocyte activation by the adaptor protein LAX.
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Nitrosative stress-induced apoptosis through inhibition of NF-kappa B.
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Oncogenic CARD11 mutations in human diffuse large B cell lymphoma.
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Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1.
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Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes.
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Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.
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Pim-1 kinase inhibits the activation of reporter gene expression in Elk-1 and c-Fos reporting systems but not the endogenous gene expression: an artifact of the reporter gene assay by transient co-transfection.
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Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis.
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Post-transplantation B cell function in different molecular types of SCID.
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Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference.
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Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506.
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Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis.
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RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation.
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Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo.
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Red blood cell arginase suppresses Jurkat (T cell) proliferation by depleting arginine.
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Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases.
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Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta.
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Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein.
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Release of DNA from dead and dying lymphocyte and monocyte cell lines in vitro.
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Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells.
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Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells.
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Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling.
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Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells.
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SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling.
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Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity.
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Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation.
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Single-Cell Analysis of Quiescent HIV Infection Reveals Host Transcriptional Profiles that Regulate Proviral Latency.
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Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes.
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T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+.
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T cell inactivation by poxviral B22 family proteins increases viral virulence.
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TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death.
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The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1.
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The Use of Poly-L-Lysine as a Capture Agent to Enhance the Detection of Antinuclear Antibodies by ELISA.
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The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.
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The content of DNA and RNA in microparticles released by Jurkat and HL-60 cells undergoing in vitro apoptosis.
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The effect of dexamethasone on the generation of plasma DNA from dead and dying cells.
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The effect of inflammation on the generation of plasma DNA from dead and dying cells in the peritoneum.
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The expression of HMGB1 on microparticles from Jurkat and HL-60 cells undergoing apoptosis in vitro.
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The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death.
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The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes.
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The generation of extracellular DNA in SLE: the role of death and sex.
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The immune response to cell death in SLE.
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The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB.
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The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles.
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The origin of extracellular DNA during the clearance of dead and dying cells.
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The relationship between apoptosis and high-mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic-polycytidylic acid.
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The release of microparticles by Jurkat leukemia T cells treated with staurosporine and related kinase inhibitors to induce apoptosis.
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The release of microparticles by apoptotic cells and their effects on macrophages.
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The role of macrophages in the in vitro generation of extracellular DNA from apoptotic and necrotic cells.
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The role of membrane lipids in the induction of macrophage apoptosis by microparticles.
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The role of microparticles in the generation of immune complexes in murine lupus.
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Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.
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Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus.
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Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway.
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Transcription factor NF-kappaB regulates inducible CD83 gene expression in activated T lymphocytes.
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Transcription of the RelB gene is regulated by NF-kappaB.
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Transcriptional Circuit Fragility Influences HIV Proviral Fate.
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Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elements.
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Unselected mutations in the human immunodeficiency virus type 1 genome are mostly nonsynonymous and often deleterious.
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Upstream regulatory role for XIAP in receptor-mediated apoptosis.
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Use of SYTO 13, a fluorescent dye binding nucleic acids, for the detection of microparticles in in vitro systems.
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ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis.
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ZAP-70-dependent and -independent activation of Erk in Jurkat T cells. Differences in signaling induced by H2o2 and Cd3 cross-linking.
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[Expression of presenilin 1 on the cell surface in motile polarized cells].
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sCD44 overexpression increases intraocular pressure and aqueous outflow resistance.
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Keywords of People