Jurkat Cells

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  Subject Areas on Research

  • A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. 
  • A barrier-type insulator forms a boundary between active and inactive chromatin at the murine TCRβ locus. 
  • A chemical glycoproteomics platform reveals O-GlcNAcylation of mitochondrial voltage-dependent anion channel 2. 
  • A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. 
  • A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes. 
  • A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury. 
  • A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1. 
  • A retroviral-derived peptide phosphorylates protein kinase D/protein kinase Cmu involving phospholipase C and protein kinase C. 
  • A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. 
  • A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A. 
  • A signature in HIV-1 envelope leader peptide associated with transition from acute to chronic infection impacts envelope processing and infectivity. 
  • A small molecule inhibitor of alpha4 integrin-dependent cell migration. 
  • Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. 
  • Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. 
  • An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus. 
  • Analysis of mRNA partitioning between the cytosol and endoplasmic reticulum compartments of mammalian cells. 
  • Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. 
  • Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression. 
  • Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation. 
  • Bioactive hydrogel substrates: probing leukocyte receptor-ligand interactions in parallel plate flow chamber studies. 
  • Biomimetic, synthetic HDL nanostructures for lymphoma. 
  • CBF, Myb, and Ets binding sites are important for activity of the core I element of the murine retrovirus SL3-3 in T lymphocytes. 
  • CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation. 
  • CD28 ligation induces tyrosine phosphorylation of Pyk2 but not Fak in Jurkat T cells. 
  • CD69 gene is differentially regulated in T and B cells by evolutionarily conserved promoter-distal elements. 
  • CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor. 
  • Caspase cleavage is not for everyone. 
  • Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia. 
  • Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1. 
  • Conversion of Bcl-2 to a Bax-like death effector by caspases. 
  • Coordinated posttranscriptional mRNA population dynamics during T-cell activation. 
  • Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation. 
  • Distinct roles for c-Myb and core binding factor/polyoma enhancer-binding protein 2 in the assembly and function of a multiprotein complex on the TCR delta enhancer in vivo. 
  • Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells. 
  • Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. 
  • Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia. 
  • Effects of in vitro brevetoxin exposure on apoptosis and cellular metabolism in a leukemic T cell line (Jurkat). 
  • Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. 
  • Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix. 
  • Endoplasmic reticulum-bound ribosomes reside in stable association with the translocon following termination of protein synthesis. 
  • Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genes. 
  • Esterified Trehalose Analogues Protect Mammalian Cells from Heat Shock. 
  • Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer. 
  • Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. 
  • Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. 
  • Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif. 
  • Functional coordination and HuR-mediated regulation of mRNA stability during T cell activation. 
  • GREAT improves functional interpretation of cis-regulatory regions. 
  • Genetic engineering of murine CD8+ and CD4+ T cells for preclinical adoptive immunotherapy studies. 
  • Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. 
  • Heterotropic modulation of selectin affinity by allosteric antibodies affects leukocyte rolling. 
  • High expression of long non-coding RNA H19 is required for efficient tumorigenesis induced by Bcr-Abl oncogene. 
  • Identification of S-nitrosylated targets of thioredoxin using a quantitative proteomic approach. 
  • Intracellular CMTM2 negatively regulates human immunodeficiency virus type-1 transcription through targeting the transcription factors AP-1 and CREB. 
  • Involvement of linker for activation of T cells in the costimulatory signaling pathways. 
  • K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation. 
  • LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. 
  • LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. 
  • LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. 
  • Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding. 
  • MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. 
  • Membrane compartmentation is required for efficient T cell activation. 
  • Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. 
  • Modeling nuclear molecule release during in vitro cell death. 
  • NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. 
  • Naturally occurring amino acid polymorphisms in human immunodeficiency virus type 1 (HIV-1) Gag p7(NC) and the C-cleavage site impact Gag-Pol processing by HIV-1 protease. 
  • Negative regulation of TCR signaling by linker for activation of X cells via phosphotyrosine-dependent and -independent mechanisms. 
  • Negative regulation of lymphocyte activation by the adaptor protein LAX. 
  • Nitrosative stress-induced apoptosis through inhibition of NF-kappa B. 
  • Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. 
  • Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. 
  • Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. 
  • Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes. 
  • Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. 
  • Pim-1 kinase inhibits the activation of reporter gene expression in Elk-1 and c-Fos reporting systems but not the endogenous gene expression: an artifact of the reporter gene assay by transient co-transfection. 
  • Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis. 
  • Post-transplantation B cell function in different molecular types of SCID. 
  • Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference. 
  • Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506. 
  • Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. 
  • RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. 
  • Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo. 
  • Red blood cell arginase suppresses Jurkat (T cell) proliferation by depleting arginine. 
  • Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins. 
  • Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases. 
  • Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta. 
  • Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein. 
  • Release of DNA from dead and dying lymphocyte and monocyte cell lines in vitro. 
  • Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. 
  • Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. 
  • Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling. 
  • Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells. 
  • SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling. 
  • Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity. 
  • Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation. 
  • Single-Cell Analysis of Quiescent HIV Infection Reveals Host Transcriptional Profiles that Regulate Proviral Latency. 
  • Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes. 
  • T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+. 
  • T cell inactivation by poxviral B22 family proteins increases viral virulence. 
  • TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. 
  • The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1. 
  • The Use of Poly-L-Lysine as a Capture Agent to Enhance the Detection of Antinuclear Antibodies by ELISA. 
  • The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival. 
  • The content of DNA and RNA in microparticles released by Jurkat and HL-60 cells undergoing in vitro apoptosis. 
  • The effect of dexamethasone on the generation of plasma DNA from dead and dying cells. 
  • The effect of inflammation on the generation of plasma DNA from dead and dying cells in the peritoneum. 
  • The expression of HMGB1 on microparticles from Jurkat and HL-60 cells undergoing apoptosis in vitro. 
  • The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death. 
  • The generation of extracellular DNA in SLE: the role of death and sex. 
  • The immune response to cell death in SLE. 
  • The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB. 
  • The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles. 
  • The origin of extracellular DNA during the clearance of dead and dying cells. 
  • The relationship between apoptosis and high-mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic-polycytidylic acid. 
  • The release of microparticles by Jurkat leukemia T cells treated with staurosporine and related kinase inhibitors to induce apoptosis. 
  • The release of microparticles by apoptotic cells and their effects on macrophages. 
  • The role of macrophages in the in vitro generation of extracellular DNA from apoptotic and necrotic cells. 
  • The role of membrane lipids in the induction of macrophage apoptosis by microparticles. 
  • The role of microparticles in the generation of immune complexes in murine lupus. 
  • Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells. 
  • Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway. 
  • Transcription factor NF-kappaB regulates inducible CD83 gene expression in activated T lymphocytes. 
  • Transcription of the RelB gene is regulated by NF-kappaB. 
  • Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elements. 
  • Unselected mutations in the human immunodeficiency virus type 1 genome are mostly nonsynonymous and often deleterious. 
  • Use of SYTO 13, a fluorescent dye binding nucleic acids, for the detection of microparticles in in vitro systems. 
  • ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis. 
  • ZAP-70-dependent and -independent activation of Erk in Jurkat T cells. Differences in signaling induced by H2o2 and Cd3 cross-linking. 
  • [Expression of presenilin 1 on the cell surface in motile polarized cells]. 
  • sCD44 overexpression increases intraocular pressure and aqueous outflow resistance. 
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  Keywords of People

  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Krangel, Michael S., Mary Bernheim Distinguished Professor of Immunology, Immunology
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology