Somites

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  Subject Areas on Research

  • BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium. 
  • BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. 
  • Congenital abnormalities of the thoracic and lumbar spine. 
  • Heterochrony and developmental timing mechanisms: changing ontogenies in evolution. 
  • Heterochrony in somitogenesis rate in a model marsupial, Monodelphis domestica. 
  • Mouse Mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction by sonic hedgehog during somitogenesis. 
  • Oesophageal and sternohyal muscle fibres are novel Pax3-dependent migratory somite derivatives essential for ingestion. 
  • Reconstruction and deconstruction of human somitogenesis in vitro. 
  • Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors. 
  • Sertoli cells of the mouse testis originate from the coelomic epithelium. 
  • Spine Patterning Is Guided by Segmentation of the Notochord Sheath. 
  • The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate. 
  • The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. 
  • The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish. 
  • The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. 
  • Viral sequences enable efficient and tissue-specific expression of transgenes in Xenopus. 
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  Keywords of People

  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology