Iron Overload

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  Subject Areas on Research

  • A mouse model of juvenile hemochromatosis. 
  • Analysis of the E399D mutation in SLC11A2. 
  • Automated liver sampling using a gradient dual-echo Dixon-based technique. 
  • Automated patient-tailored screening of the liver for diffuse steatosis and iron overload using MRI. 
  • Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. 
  • Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration. 
  • Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. 
  • Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. 
  • Disparity in the management of iron overload between patients with sickle cell disease and thalassemia who received transfusions. 
  • Distribution of transferrin saturations in the African-American population. 
  • Echocardiography-derived tricuspid regurgitant jet velocity is an important marker for the progression of sickle-cell disease. 
  • Examination of diverse iron-chelating agents for the protection of differentiated PC12 cells against oxidative injury induced by 6-hydroxydopamine and dopamine. 
  • Experimental detection of iron overload in liver through neutron stimulated emission spectroscopy. 
  • Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. 
  • Hepatic MR imaging for in vivo differentiation of steatosis, iron deposition and combined storage disorder: single-ratio in/opposed phase analysis vs. dual-ratio Dixon discrimination. 
  • Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. 
  • Iron accumulation in lung allografts after transplantation. 
  • Iron homeostasis and eye disease. 
  • Iron homeostasis and inherited iron overload disorders: an overview. 
  • Iron in skin of mice with three etiologies of systemic iron overload. 
  • Iron metabolism: iron deficiency and iron overload. 
  • Iron overload and allogeneic hematopoietic stem-cell transplantation. 
  • Iron overload due to X-linked sideroblastic anemia in an African American man. 
  • Iron overload following red blood cell transfusion and its impact on disease severity. 
  • Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis. 
  • Mammalian iron transport: an unexpected link between metal homeostasis and host defense. 
  • Molecular insights into mechanisms of iron transport. 
  • Morbidity and mortality in chronically transfused subjects with thalassemia and sickle cell disease: A report from the multi-center study of iron overload. 
  • Myelodysplastic syndromes. 
  • Organ iron accumulation in chronically transfused children with sickle cell anaemia: baseline results from the TWiTCH trial. 
  • Pain and other non-neurological adverse events in children with sickle cell anemia and previous stroke who received hydroxyurea and phlebotomy or chronic transfusions and chelation: results from the SWiTCH clinical trial. 
  • Pilot study assessing differentiation of steatosis hepatis, hepatic iron overload, and combined disease using two-point dixon MRI at 3 T: in vitro and in vivo results of a 2D decomposition technique. 
  • Potential role of increased iron stores in diabetes. 
  • Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study. 
  • Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. 
  • Role of HFE gene mutations in liver diseases other than hereditary hemochromatosis. 
  • Sickle cell disease is associated with iron mediated hypercoagulability. 
  • The ins and outs of iron homeostasis. 
  • The kinetics of dimethylhydroxypyridinone interactions with iron(iii) and the catalysis of iron(iii) ligand exchange reactions: implications for bacterial iron transport and combination chelation therapies. 
  • The molecular regulation of iron metabolism. 
  • The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration. 
  • The oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice. 
  • The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. 
  • Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice. 
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  Keywords of People

  • Grambow, Steven C., Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics