GTP-Binding Proteins

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  Subject Areas on Research

  • 4-oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I. 
  • 5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools. 
  • 5-Hydroxytryptamine2A receptors expressed in rat renal mesangial cells inhibit cyclic AMP accumulation. 
  • A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. 
  • A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol. 
  • A Rapidly Evolving Polybasic Motif Modulates Bacterial Detection by Guanylate Binding Proteins. 
  • A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation. 
  • A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. 
  • A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation. 
  • A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types. 
  • A family of candidate taste receptors in human and mouse. 
  • A family of receptors coupled to guanine nucleotide regulatory proteins. 
  • A guanine nucleotide regulatory protein controls polyphosphoinositide metabolism, Ca2+ mobilization, and cellular responses to chemoattractants in human monocytes. 
  • A high endothelial cell-derived chemokine induces rapid, efficient, and subset-selective arrest of rolling T lymphocytes on a reconstituted endothelial substrate. 
  • A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration. 
  • A mathematical model quantifying GnRH-induced LH secretion from gonadotropes. 
  • A molecular analysis of G proteins and control of early gene expression by the cell-surface cAMP receptor in Dictyostelium. 
  • A multigene family encoding a diverse array of putative pheromone receptors in mammals. 
  • A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice. 
  • A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs. 
  • A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. 
  • A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism. 
  • A pertussis/choleratoxin-sensitive N protein may mediate chemoattractant receptor signal transduction. 
  • A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits. 
  • A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy. 
  • A role for Ni in the hormonal stimulation of adenylate cyclase. 
  • A role for Rac3 GTPase in the regulation of autophagy. 
  • A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor. 
  • A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation. 
  • A specific domain of Gialpha required for the transactivation of Gialpha by tubulin is implicated in the organization of cellular microtubules. 
  • Acidic stimuli activates two distinct pathways in taste receptor cells from rat fungiform papillae. 
  • Actin regulation and surface catalysis. 
  • Activating mutations of Gs protein in monostotic fibrous lesions of bone. 
  • Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells. 
  • Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. 
  • Acute in vivo genetic rescue demonstrates that phosphorylation of RIM1alpha serine 413 is not required for mossy fiber long-term potentiation. 
  • Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase. 
  • Adrenergic desensitization in left ventricle from streptozotocin diabetic swine. 
  • Adrenergic receptors in premenstrual dysphoric disorder. II. Neutrophil beta2-adrenergic receptors: Gs protein coupling, phase of menstrual cycle and prediction of luteal phase symptom severity. 
  • Adrenergic receptors. Models for regulation of signal transduction processes. 
  • Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins. 
  • Adrenergic receptors: molecular mechanisms of clinically relevant regulation. 
  • Adrenergic receptors: recent insights into their mechanism of activation and desensitization. 
  • Aging and glucocorticoids: effects on cell signaling mediated through adenylyl cyclase. 
  • Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C. 
  • Agonist-specific regulation of delta-opioid receptor trafficking by G protein-coupled receptor kinase and beta-arrestin. 
  • Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism. 
  • Alterations in an inositol phosphate code through synergistic activation of a G protein and inositol phosphate kinases. 
  • Altered cyclic AMP-dependent human chorionic gonadotropin production in cultured human placental trophoblasts exposed to ethanol. 
  • Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism. 
  • Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro. 
  • Amino acid substitutions in the Dictyostelium G alpha subunit G alpha 2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase, and phospholipase C. 
  • An Arabidopsis kinase cascade influences auxin-responsive cell expansion. 
  • An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits. 
  • An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. 
  • Analysis of small GTP-binding proteins of the lens by GTP overlay assay reveals the presence of unique GTP-binding proteins associated with fiber cells. 
  • Analysis of the mouse transcriptome for genes involved in the function of the nervous system. 
  • Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors. 
  • Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors. 
  • Arachidonate and related unsaturated fatty acids selectively inactivate the guanine nucleotide-binding regulatory protein, Gz. 
  • Arresting developments in heptahelical receptor signaling and regulation. 
  • Assay of G-protein beta gamma-subunit complex by catalytic support of ADP-ribosylation of Go alpha. 
  • Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling. 
  • Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins. 
  • Astringency: a more stringent definition. 
  • Atomic structures of tubulin and FtsZ. 
  • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. 
  • Baclofen induces spontaneous, rhythmic sharp waves in the rat hippocampal slice. 
  • Bacterial cell division protein FtsZ assembles into protofilament sheets and minirings, structural homologs of tubulin polymers. 
  • Balance of Irgm protein activities determines IFN-gamma-induced host defense. 
  • Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. 
  • Beta-adrenergic inhibition of cardiac sodium channels by dual G-protein pathways. 
  • Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization. 
  • Beta-adrenergic receptor overexpression in the fetal rat: distribution, receptor subtypes, and coupling to adenylate cyclase activity via G-proteins. 
  • Beta-adrenoceptor control of G protein function in the neonate: determinant of desensitization or sensitization. 
  • Beta-adrenoceptor control of cardiac adenylyl cyclase during development: agonist pretreatment in the neonate uniquely causes heterologous sensitization, not desensitization. 
  • Beta-adrenoceptor-mediated cell signaling in the neonatal heart and liver: responses to terbutaline. 
  • Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. 
  • Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. 
  • Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. 
  • Beyond counting photons: trials and trends in vertebrate visual transduction. 
  • Biased agonism as a mechanism for differential signaling by chemokine receptors. 
  • Biased agonists of the chemokine receptor CXCR3 differentially signal through Gαi:β-arrestin complexes. 
  • Biased signalling: from simple switches to allosteric microprocessors. 
  • Binding of G protein beta gamma-subunits to pleckstrin homology domains. 
  • Binding, coupling, and mRNA subtype heterogeneity of alpha 1-adrenergic receptors in cultured human RPE. 
  • Biochemical characterization of the adrenergic receptors: affinity labeling, purification, and reconstitution studies. 
  • Both stimulatory and inhibitory GDP/GTP exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins. 
  • CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice. 
  • CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells. 
  • COPII-cargo interactions direct protein sorting into ER-derived transport vesicles. 
  • Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues. 
  • Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. 
  • Cardiac hypertrophy: role of G protein-coupled receptors. 
  • Cardiac muscarinic potassium channel activity is attenuated by inhibitors of G beta gamma. 
  • Case 4--1997. The role of ischemic preconditioning during minimally invasive coronary artery bypass surgery. 
  • Catecholamine receptors: structure, function, and regulation. 
  • Celiac disease is not more prevalent in patients undergoing in vitro fertilization and does not affect reproductive outcomes with or without treatment: a large prospective cohort study. 
  • Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma: the role of gelsolin expression. 
  • Cell wall remodeling and vesicle trafficking mediate the root clock in Arabidopsis . 
  • Cellular and molecular alterations in the beta adrenergic system with cardiomyopathy induced by tachycardia. 
  • Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. 
  • Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade. 
  • Cellular requirements for the small molecule forchlorfenuron to stabilize the septin cytoskeleton. 
  • Cellular trafficking of G protein-coupled receptor/beta-arrestin endocytic complexes. 
  • Cellularization in Drosophila melanogaster is disrupted by the inhibition of rho activity and the activation of Cdc42 function. 
  • Characteristics of norepinephrine and clonidine displacement of [3H]yohimbine binding to platelet alpha2-adrenoreceptors in healthy volunteers. 
  • Characterization of G25K, a GTP-binding protein containing a novel putative nucleotide binding domain. 
  • Characterization of GRK2-catalyzed phosphorylation of the human substance P receptor in Sf9 membranes. 
  • Characterization of RanBP2-associated molecular components in neuroretina. 
  • Characterization of a rat type 2 angiotensin II receptor stably expressed in 293 cells. 
  • Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line. 
  • Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4. 
  • Characterization of the energy-dependent, mating factor-activated Ca2+ influx in Saccharomyces cerevisiae. 
  • Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein. 
  • Chemoattractant receptors activate distinct pathways for chemotaxis and secretion. Role of G-protein usage. 
  • Chemoattractant-induced activation of c-fos gene expression in human monocytes. 
  • Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT. 
  • Chemokines and B-cell homing to follicles. 
  • Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. 
  • Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells. 
  • Chromosomal assignment of the murine Gi alpha and Gs alpha genes. Implications for the obese mouse. 
  • Chronic ethanol consumption disturbs G-protein expression and inhibits cyclic AMP-dependent signaling in regenerating rat liver. 
  • Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice. 
  • Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation. 
  • Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors. 
  • Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain. 
  • Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. 
  • Combining location and expression data for principled discovery of genetic regulatory network models. 
  • Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. 
  • Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling. 
  • Conformational changes at the carboxyl terminus of Galpha occur during G protein activation. 
  • Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses. 
  • Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. 
  • Constitutively active mutants of the alpha 2-adrenergic receptor. 
  • Control of K+ channels by G proteins. 
  • Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit. 
  • Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole. 
  • Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process. 
  • Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. 
  • Coupling of the expressed alpha 1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes. The role of Go. 
  • Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues. 
  • Cross-desensitization among receptors for platelet activating factor and peptide chemoattractants. Evidence for independent regulatory pathways. 
  • Cross-desensitization of receptors for peptide chemoattractants. Characterization of a new form of leukocyte regulation. 
  • Cryptococcal titan cell formation is regulated by G-protein signaling in response to multiple stimuli. 
  • Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP. 
  • Cutaneous endothelial cell activation in normal skin of patients with dermatitis herpetiformis associated with increased serum levels of IL-8, sE-Selectin, and TNF-alpha. 
  • Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. 
  • DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast. 
  • Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity. 
  • Decreased S -Nitrosylation of Tissue Transglutaminase Contributes to Age-Related Increases in Vascular Stiffness 
  • Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. 
  • Desensitization of G protein-coupled receptors. 
  • Desensitization of myocardial beta-adrenergic receptors and deterioration of left ventricular function after brain death. 
  • Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility. 
  • Determination of the G beta gamma-binding domain of phosducin. A regulatable modulator of G beta gamma signaling. 
  • Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. 
  • Differential Requirement for IRGM Proteins during Tuberculosis Infection in Mice. 
  • Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors. 
  • Differential effects of cholera toxin on guanine nucleotide regulation of beta-adrenergic agonist high affinity binding and adenylate cyclase activation in frog erythrocyte membranes. 
  • Differential expression of guanine nucleotide-binding proteins enhances cAMP synthesis in regenerating rat liver. 
  • Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins. 
  • Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants. 
  • Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions. 
  • Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras. 
  • Diseased G protein-coupled receptors. 
  • Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. 
  • Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties. 
  • Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation. 
  • Distinct regions of the cadherin cytoplasmic domain are essential for functional interaction with Galpha 12 and beta-catenin. 
  • Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein. 
  • Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization. 
  • Early effects of right ventricular volume overload on ventricular performance and beta-adrenergic signaling. 
  • Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations. 
  • Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling. 
  • Effect of preexposure to ultrafine carbon black on respiratory syncytial virus infection in mice. 
  • Effect of tissue transglutaminase on the solubility of proteins containing expanded polyglutamine repeats. 
  • Effects of fetal dexamethasone exposure on postnatal control of cardiac adenylate cyclase: beta-adrenergic receptor coupling to Gs regulatory protein. 
  • Effects of mutant Ran/TC4 proteins on cell cycle progression. 
  • Electrical pacing induces adenylyl cyclase in skeletal muscle independent of the beta-adrenergic receptor. 
  • Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. 
  • Endothelial cell-surface tissue transglutaminase inhibits neutrophil adhesion by binding and releasing nitric oxide. 
  • Endothelin activates voltage-dependent Ca2+ current by a G protein-dependent mechanism in rabbit cardiac myocytes. 
  • Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction. 
  • Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. 
  • Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine. 
  • Enhanced morphine analgesia in mice lacking beta-arrestin 2. 
  • Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice. 
  • Enzymatic modification of proteins with a geranylgeranyl isoprenoid. 
  • Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding. 
  • Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. 
  • Evidence for a second alpha 2-macroglobulin receptor. 
  • Evidence of a role for heterotrimeric GTP-binding proteins in endosome fusion. 
  • Evidence that a beta-adrenergic receptor-associated guanine nucleotide regulatory protein conveys guanosine 5'-O-(3-thiotriphosphate)- dependent adenylate cyclase activity. 
  • Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation. 
  • Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking. 
  • Expression and regulation of alpha 1-adrenergic receptors in human tissues. 
  • Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors. 
  • Expression cloning of type 2 angiotension II receptor reveals a unique class of seven-transmembrane receptors. 
  • Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase. 
  • Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB. 
  • Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. 
  • Fetal nicotine exposure alters ontogeny of M1-receptors and their link to G-proteins. 
  • From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors. 
  • FtsZ from Escherichia coli, Azotobacter vinelandii, and Thermotoga maritima--quantitation, GTP hydrolysis, and assembly. 
  • FtsZ, a prokaryotic homolog of tubulin? 
  • Function and regulation of chemoattractant receptors. 
  • Functional consequences of A1 adenosine-receptor phosphorylation by the beta-adrenergic receptor kinase. 
  • Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). 
  • Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein. 
  • Functional high efficiency expression of cloned leukocyte chemoattractant receptor cDNAs. 
  • Functional interaction between Galpha(z) and Rap1GAP suggests a novel form of cellular cross-talk. 
  • Functional interactions of recombinant alpha 2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles. 
  • Functional modification of the guanine nucleotide regulatory protein after desensitization of turkey erythrocytes by catecholamines. 
  • Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. 
  • Functional selectivity in adrenergic and angiotensin signaling systems. 
  • Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. 
  • G Protein and β-arrestin signaling bias at the ghrelin receptor. 
  • G beta gamma interactions with PH domains and Ras-MAPK signaling pathways. 
  • G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. 
  • G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha. 
  • G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein. 
  • G protein coupling of receptors to ionic channels and other effector systems. 
  • G protein coupling of receptors to ionic channels and other effector systems. 
  • G protein gamma subunits contain a 20-carbon isoprenoid. 
  • G protein involvement in receptor-effector coupling. 
  • G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development. 
  • G protein- and β-arrestin Signaling Profiles of Endothelin Derivatives at the Type A Endothelin Receptor. 
  • G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95. 
  • G protein-coupled receptor kinase mediates desensitization of norepinephrine-induced Ca2+ channel inhibition. 
  • G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor. 
  • G protein-coupled receptor kinases. 
  • G protein-coupled receptor kinases. 
  • G protein-coupled receptor signalling in in vivo cardiac overload. 
  • G protein-coupled receptors and receptor kinases: from molecular biology to potential therapeutic applications. 
  • G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases. 
  • G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization. 
  • G protein-linked signal transduction in aggregating Dictyostelium. 
  • G proteins and phototransduction. 
  • G proteins control diverse pathways of transmembrane signaling. 
  • G proteins in medicine. 
  • G proteins. The subunit story thickens. 
  • G proteins. Visual differences. 
  • G-protein-coupled receptor function in heart failure. 
  • G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. 
  • G-protein-coupled receptor kinases and arrestins: regulators of G-protein-coupled receptor sequestration. 
  • G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins. 
  • G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors. 
  • G-protein-coupled receptors. Turned on to ill effect. 
  • G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins. 
  • G-protein-linked signal transduction systems control development in Dictyostelium. 
  • G-protein-linked signaling pathways mediate development in Dictyostelium. 
  • GPCR desensitization: Acute and prolonged phases. 
  • Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems. 
  • Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation. 
  • Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells. 
  • Genetic evidence that the meiotic recombination hotspot at the HIS4 locus of Saccharomyces cerevisiae does not represent a site for a symmetrically processed double-strand break. 
  • Genome sequencing unveils a regulatory landscape of platelet reactivity. 
  • Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans. 
  • Glucocorticoid-targeting of the adenylyl cyclase signaling pathway in the cerebellum of young vs. aged rats. 
  • Glucocorticoids enhance intracellular signaling via adenylate cyclase at three distinct loci in the fetus: a mechanism for heterologous teratogenic sensitization? 
  • Glucocorticoids regulate the development of intracellular signaling: enhanced forebrain adenylate cyclase catalytic subunit activity after fetal dexamethasone exposure. 
  • Granulocyte-macrophage colony-stimulating factor primes neutrophils by activating a pertussis toxin-sensitive G protein not associated with phosphatidylinositol turnover. 
  • Guanine nucleotide regulatory proteins in receptor-mediated polyphosphoinositide hydrolysis in human leukocytes. 
  • Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer. 
  • Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components. 
  • Guanylate Binding Proteins Restrict Leishmania donovani Growth in Nonphagocytic Cells Independent of Parasitophorous Vacuolar Targeting. 
  • Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages. 
  • Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. 
  • Gz, a guanine nucleotide-binding protein with unique biochemical properties. 
  • HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas. 
  • Hepatic fibrogenesis requires sympathetic neurotransmitters. 
  • Heptahelical receptor signaling: beyond the G protein paradigm. 
  • Homologous desensitization of beta-adrenergic receptor coupled adenylate cyclase. Resensitization by polyethylene glycol treatment. 
  • How did we get here? Insights into mechanisms of immunity-related GTPase targeting to intracellular pathogens. 
  • How do chemokines navigate neutrophils to the target site: Dissecting the structural mechanisms and signaling pathways. 
  • Human G(alpha q): cDNA and tissue distribution. 
  • Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii. 
  • Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA. 
  • Human IRGM induces autophagy to eliminate intracellular mycobacteria. 
  • Human guanylate binding proteins: nanomachines orchestrating host defense. 
  • Human neural progenitors express functional lysophospholipid receptors that regulate cell growth and morphology. 
  • Human ovarian cancer of the surface epithelium. 
  • Human substance P receptor expressed in Chinese hamster ovary cells directly activates G(alpha q/11), G(alpha s), G(alpha o). 
  • Human substance P receptor expressed in Sf9 cells couples with multiple endogenous G proteins. 
  • Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro. 
  • Hypothyroidism modulates beta adrenergic receptor adenylate cyclase interactions in rat reticulocytes. 
  • IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver. 
  • IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins. 
  • IRGM1 links mitochondrial quality control to autoimmunity. 
  • IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria. 
  • Identification of a 43-kilodalton human T lymphocyte membrane protein as a receptor for pertussis toxin. 
  • Identification of a region at the N-terminus of phospholipase C-beta 3 that interacts with G protein beta gamma subunits. 
  • Identification of additional members of human G-protein-coupled receptor kinase multigene family. 
  • Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. 
  • Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor. 
  • Identification of the ral and rac1 gene products, low molecular mass GTP-binding proteins from human platelets. 
  • Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. 
  • Immune control of tuberculosis by IFN-gamma-inducible LRG-47. 
  • Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy. 
  • Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47). 
  • Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5. 
  • Importance of voltage-dependent inactivation in N-type calcium channel regulation by G-proteins. 
  • In vitro processing of recombinant G protein gamma subunits. Requirements for assembly of an active beta gamma complex. 
  • Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. 
  • Increased sensitivity to mu opiate antinociception in the neonatal rat despite weaker receptor-guanyl nucleotide binding protein coupling. 
  • Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. 
  • Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins. 
  • Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor. 
  • Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. 
  • Inhibitory and excitatory mechanisms underlying auditory responses to learned vocalizations in the songbird nucleus HVC. 
  • Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions. 
  • Interactions between propofol and lipid mediator receptors: inhibition of lysophosphatidate signaling. 
  • Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate. 
  • Irgm1 (LRG-47), a regulator of cell-autonomous immunity, does not localize to mycobacterial or listerial phagosomes in IFN-γ-induced mouse cells. 
  • Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. 
  • Irgm1 regulates metabolism and function in T cell subsets. 
  • Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium. 
  • Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation. 
  • Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi. 
  • Isolation of GTP-binding proteins from myeloid HL-60 cells. Identification of two pertussis toxin substrates. 
  • Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases. 
  • Isoprenylation of the low molecular mass GTP-binding proteins rac 1 and rac 2: possible role in membrane localization. 
  • Kinetic mechanism of RGS9-1 potentiation by R9AP. 
  • LPS-aggregating proteins GBP1 and GBP2 are each sufficient to enhance caspase-4 activation both in cellulo and in vitro. 
  • Large candidate gene association study reveals genetic risk factors and therapeutic targets for fibromyalgia. 
  • Leukocyte activation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism. 
  • Lifetime regulation of G protein-effector complex: emerging importance of RGS proteins. 
  • Lipid modifications of G proteins. 
  • Liver regeneration 3: Regulation of signal transduction during liver regeneration. 
  • Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast. 
  • Location bias contributes to functionally selective responses of biased CXCR3 agonists. 
  • Loss of biased signaling at a G protein-coupled receptor in overexpressed systems. 
  • Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration. 
  • Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. 
  • Lysophosphatidic acid stimulates cell growth by different mechanisms in SKOV-3 and Caov-3 ovarian cancer cells: distinct roles for Gi- and Rho-dependent pathways. 
  • MRCK-1 Drives Apical Constriction in C. elegans by Linking Developmental Patterning to Force Generation. 
  • Maleylated-BSA induces hydrolysis of PIP2, fluxes of Ca2+, NF-kappaB binding, and transcription of the TNF-alpha gene in murine macrophages. 
  • Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements. 
  • Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4. 
  • Mapping of effector binding sites of transducin alpha-subunit using G alpha t/G alpha i1 chimeras. 
  • Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system. 
  • Mechanisms of beta-adrenergic receptor desensitization and resensitization. 
  • Mechanisms of excitation and adaptation in Dictyostelium. 
  • Mechanisms of hormone receptor-effector coupling: the beta-adrenergic receptor and adenylate cyclase. 
  • Mechanisms of protein prenylation and role in G protein function. 
  • Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration. 
  • Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages. 
  • Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth. 
  • Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia. 
  • Microinjection of a 19-kDa guanine nucleotide-binding protein inhibits maturation of Xenopus oocytes. 
  • Microsomal membranes contain a high affinity binding site for prenylated peptides. 
  • Microtubule dynamic instability and GTP hydrolysis. 
  • Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila. 
  • Mitochondrial FtsZ in a chromophyte alga 
  • Mitogenic signaling via G protein-coupled receptors. 
  • Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. 
  • Model for leukocyte regulation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism. 
  • Model systems for the study of seven-transmembrane-segment receptors. 
  • Modeling of sequestration and down regulation in cells containing beta2-adrenergic receptors. 
  • Molecular analysis of proteins associated with the synaptic vesicle membrane. 
  • Molecular basis for interactions of G protein betagamma subunits with effectors. 
  • Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor. 
  • Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families. 
  • Molecular cloning of a novel human GTP-binding protein and its potential role in chemoattractant stimulus-response coupling. 
  • Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling. 
  • Molecular determinants of selectivity in 5-hydroxytryptamine1B receptor-G protein interactions. 
  • Molecular manipulation and analysis of inositol phosphate and pyrophosphate levels in Mammalian cells. 
  • Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor. 
  • Molecular mechanisms of G protein-coupled receptor desensitization and resensitization. 
  • Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization. 
  • Molecular mechanisms of coupling in hormone receptor-adenylate cyclase systems. 
  • Molecular mechanisms of leukocyte activation by chemoattractants. 
  • Molecular mechanisms of receptor desensitization using the beta-adrenergic receptor-coupled adenylate cyclase system as a model. 
  • Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases. 
  • Morphogenesis: multitalented GTPases seeking new jobs. 
  • Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. 
  • Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling. 
  • Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium. 
  • Multiple chromatographic forms of the formylpeptide chemoattractant receptor and their relationship to GTP-binding proteins. 
  • Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium. 
  • Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. 
  • Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release. 
  • Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells. 
  • Multiple signaling pathways of human interleukin-8 receptor A. Independent regulation by phosphorylation. 
  • Munc13-1 is required for presynaptic long-term potentiation. 
  • Murine Irgm Paralogs Regulate Nonredundant Functions To Execute Host Defense to Toxoplasma gondii. 
  • Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice. 
  • Mutants of FtsZ targeting the protofilament interface: effects on cell division and GTPase activity. 
  • Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2. 
  • Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding. 
  • Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration. 
  • Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice. 
  • Myocardial overexpression of adrenergic receptors and receptor kinases. 
  • Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins. 
  • N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase. 
  • Neonatal dexamethasone treatment leads to alterations in cell signaling cascades controlling hepatic and cardiac function in adulthood. 
  • Network integration of the adrenergic system in cardiac hypertrophy. 
  • Networking ionic channels by G proteins. 
  • Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain. 
  • New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. 
  • Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go. 
  • Noncatalytic cGMP-binding sites of amphibian rod cGMP phosphodiesterase control interaction with its inhibitory gamma-subunits. A putative regulatory mechanism of the rod photoresponse. 
  • Novel human alpha1a-adrenoceptor single nucleotide polymorphisms alter receptor pharmacology and biological function. 
  • Novel localization of a G protein, Gz-alpha, in neurons of brain and retina. 
  • Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters. 
  • Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins. 
  • Olfactory marker protein mRNA is found in axons of olfactory receptor neurons. 
  • Oncogenes in ovarian cancer. 
  • Ontogeny of G-protein expression: control by beta-adrenoceptors. 
  • Ontogeny of cardiac beta-adrenoceptor desensitization mechanisms: agonist treatment enhances receptor/G-protein transduction rather than eliciting uncoupling. 
  • Ontogeny of regulatory mechanisms for beta-adrenoceptor control of rat cardiac adenylyl cyclase: targeting of G-proteins and the cyclase catalytic subunit. 
  • Opsin, G-protein and 48-kDa protein in normal and rd mouse retinas: developmental expression of mRNAs and proteins and light/dark cycling of mRNAs. 
  • Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells attenuates mitogenic signaling via G protein-coupled and platelet-derived growth factor receptors. 
  • Overexpression of G11alpha and isoforms of phospholipase C in islet beta-cells reveals a lack of correlation between inositol phosphate accumulation and insulin secretion. 
  • Overexpression of pp60c-src is associated with altered regulation of adenylyl cyclase. 
  • PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells. 
  • PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. 
  • Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6. 
  • Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. 
  • Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission. 
  • Pathogenesis of myositis in children. 
  • Pathogenesis of ovarian cancers. 
  • Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. 
  • Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2. 
  • Phenylalanine-stimulated secretion of cholecystokinin is calcium dependent. 
  • Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. 
  • Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity. 
  • Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. 
  • Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complex. 
  • Phosphorylation of Gz in human platelets. Selectivity and site of modification. 
  • Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. 
  • Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence. 
  • Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein. 
  • Phosphorylation of the platelet-derived growth factor receptor-beta and epidermal growth factor receptor by G protein-coupled receptor kinase-2. Mechanisms for selectivity of desensitization. 
  • Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C. 
  • Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor. 
  • Platelet-activating factor induces tyrosine phosphorylation in human neutrophils. 
  • Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid. 
  • Potential role for G-protein coupled receptors in HIV-associated nephropathy. 
  • Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes. 
  • Pregnancy and estradiol modulate myometrial G-protein pathways in the guinea pig. 
  • Prenylated peptides in identification of specific binding proteins. 
  • Prenylation and G protein signaling. 
  • Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor. 
  • Protein expression of p53, bcl-2, and KI-67 (MIB-1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer. 
  • Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways. 
  • Protein kinases that phosphorylate activated G protein-coupled receptors. 
  • Protein lipidation in cell signaling. 
  • Protein prenylation: molecular mechanisms and functional consequences. 
  • Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione. 
  • RGS10 is a selective activator of G alpha i GTPase activity. 
  • RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha. 
  • Rac1, a low-molecular-mass GTP-binding-protein with high intrinsic GTPase activity and distinct biochemical properties. 
  • Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo. 
  • Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway. 
  • Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase. 
  • Recent perspectives on the molecular structure and regulation of the beta 2-adrenoceptor. 
  • Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases. 
  • Receptor crosstalk: effects of prolonged carbachol exposure on beta 1-adrenoceptors and adenylyl cyclase activity in neonatal rat ventricular myocytes. 
  • Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. 
  • Receptor-coupled activation of phosphoinositide-specific phospholipase C by an N protein. 
  • Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems. 
  • Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. 
  • Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway. 
  • Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. 
  • Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit. 
  • Reconstitution of the beta-adrenergic receptor. 
  • Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin. 
  • Regulation of G protein-coupled receptors by agonist-dependent phosphorylation. 
  • Regulation of adenylyl cyclase-coupled beta-adrenergic receptors. 
  • Regulation of arachidonic acid release in vascular endothelium. Ca(2+)-dependent and -independent pathways. 
  • Regulation of arrestin-3 phosphorylation by casein kinase II. 
  • Regulation of fetal cardiac and hepatic beta-adrenoceptors and adenylyl cyclase signaling: terbutaline effects. 
  • Regulation of hormone receptors and adenylyl cyclases by guanine nucleotide binding N proteins. 
  • Regulation of inositol phospholipid and inositol phosphate metabolism in chemoattractant-activated human polymorphonuclear leukocytes. 
  • Regulation of ionic channels by G proteins. 
  • Regulation of macrophage motility by Irgm1. 
  • Regulation of mitogen-activated protein kinase pathways by catecholamine receptors. 
  • Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation. 
  • Regulation of tyrosine kinase cascades by G-protein-coupled receptors. 
  • Regulators of G protein signaling proteins as determinants of the rate of desensitization of presynaptic calcium channels. 
  • Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains. 
  • Rodbell and Gilman win 1994 Nobel Prize for Physiology and Medicine. 
  • Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness. 
  • Role of G proteins in transmembrane signaling. 
  • Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants. 
  • Role of autophagy genetic variants for the risk of Candida infections. 
  • Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors. 
  • Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. 
  • Role of beta-arrestins in the intracellular trafficking of G-protein-coupled receptors. 
  • Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases. 
  • Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. 
  • Role of guanine nucleotide regulatory protein in polyphosphoinositide degradation and activation of phagocytic leukocytes by chemoattractants. 
  • Role of phosphate-magnesium-binding regions in the high GTPase activity of rac1 protein. 
  • Role of presynaptic input in the ontogeny of adrenergic cell signaling in rat brain: beta receptors, adenylate cyclase and c-fos protooncogene expression. 
  • Role of septins in the orientation of forespore membrane extension during sporulation in fission yeast. 
  • Role of small GTP-binding proteins in lovastatin-induced cataracts. 
  • Role of the beta-adrenergic receptor kinase in desensitization of the alpha 2-adrenergic receptor. 
  • SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development. 
  • STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection. 
  • Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus. 
  • Septin ring size scaling and dynamics require the coiled-coil region of Shs1p. 
  • Seropositivity to celiac antigens in asymptomatic children with type 1 diabetes mellitus: association with weight, height, and bone mineralization. 
  • Serotonergic cell signaling in an animal model of aging and depression: olfactory bulbectomy elicits different adaptations in brain regions of young adult vs aging rats. 
  • Seven-transmembrane-spanning receptors and heart function. 
  • Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling. 
  • Shigella IpaH9.8 limits GBP1-dependent LPS release from intracytosolic bacteria to suppress caspase-4 activation. 
  • Signal transduction cascades regulating fungal development and virulence. 
  • Signal transduction in cells following binding of chemoattractants to membrane receptors. 
  • Signaling at the endosome: cryo-EM structure of a GPCR-G protein-beta-arrestin megacomplex. 
  • Signaling, desensitization, and trafficking of G protein-coupled receptors revealed by green fluorescent protein conjugates. 
  • Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins. 
  • Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling. 
  • Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism. 
  • Sites of interaction between rod G-protein alpha-subunit and cGMP-phosphodiesterase gamma-subunit. Implications for the phosphodiesterase activation mechanism. 
  • Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries. 
  • Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder. 
  • Specific peptide probes for G-protein interaction with effectors. 
  • Specificity of G protein-RGS protein recognition is regulated by affinity adapters. 
  • Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. 
  • Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. 
  • Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. 
  • Stimulation of mitogen-activated protein kinase by G protein-coupled alpha(2)-adrenergic receptors does not require agonist-elicited endocytosis. 
  • Straight and curved conformations of FtsZ are regulated by GTP hydrolysis. 
  • Structure and function of the adrenergic receptor family. 
  • Structure and mechanism of the G protein-coupled receptor kinases. 
  • Structure and regulation of G protein-coupled receptors: the beta 2-adrenergic receptor as a model. 
  • Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex. 
  • Subtype-specific binding of azidoanilido-GTP by purified G protein alpha subunits. 
  • Sweet host revenge: Galectins and GBPs join forces at broken membranes. 
  • Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. 
  • Synthetic peptides of the hamster beta 2-adrenoceptor as substrates and inhibitors of the beta-adrenoceptor kinase. 
  • Targeting G protein-coupled receptor kinases to their receptor substrates. 
  • Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis. 
  • Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. 
  • The 2.0 A crystal structure of a heterotrimeric G protein. 
  • The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. 
  • The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy. 
  • The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance. 
  • The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. 
  • The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity. 
  • The GBP1 microcapsule interferes with IcsA-dependent septin cage assembly around Shigella flexneri. 
  • The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. 
  • The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit. 
  • The Gordon Wilson lecture. Adrenergic receptors: regulation at the biochemical, physiological and clinical levels. 
  • The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia. 
  • The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae. 
  • The Ras-related protein AGS1/RASD1 suppresses cell growth. 
  • The adrenergic receptors. 
  • The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity. 
  • The alpha-helical domain of Galphat determines specific interaction with regulator of G protein signaling 9. 
  • The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins. 
  • The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. 
  • The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor. 
  • The formylpeptide chemoattractant receptor copurifies with a GTP-binding protein containing a distinct 40-kDa pertussis toxin substrate. 
  • The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor. 
  • The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway. 
  • The impact of aging on adrenergic receptor function: clinical and biochemical aspects. 
  • The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system. 
  • The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi. 
  • The ontogeny of mu opiate tolerance and dependence in the rat: antinociceptive and biochemical studies. 
  • The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. 
  • The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition. 
  • The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase. 
  • The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13. 
  • The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. 
  • The role of prenylation in G-protein assembly and function. 
  • The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification. 
  • The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation. 
  • The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2. 
  • The third beta is not the charm. 
  • Therapeutic potential of β-arrestin- and G protein-biased agonists. 
  • Thrombin primes responsiveness of selective chemoattractant receptors at a site distal to G protein activation. 
  • Thrombin receptor. Variations on a theme. 
  • Tissue transglutaminase expression in human breast cancer. 
  • Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis. 
  • Tissue transglutaminase regulates focal adhesion kinase/AKT activation by modulating PTEN expression in pancreatic cancer cells. 
  • Tissue-specific alterations in G protein expression in genetic versus diet-induced models of non-insulin-dependent diabetes mellitus in the mouse. 
  • Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. 
  • Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae. 
  • Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems. 
  • Transgenic manipulation of myocardial G protein-coupled receptors and receptor kinases. 
  • Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling. 
  • Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA. 
  • Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta, and attenuates HIF1 signaling. 
  • Transglutaminase 2 protects against ischemic stroke. 
  • Triphenylmethane dye activation of beta-arrestin. 
  • Tyrosine phosphorylation in human neutrophil. 
  • Tyrosine phosphorylation of G protein alpha subunits by pp60c-src. 
  • Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins. 
  • Uncoupling of G-protein coupled receptors in vivo: insights from transgenic mice. 
  • Upregulation of macrophage plasma membrane and nuclear phospholipase D activity on ligation of the alpha2-macroglobulin signaling receptor: involvement of heterotrimeric and monomeric G proteins. 
  • VEGF stimulates MAPK through a pathway that is unique for receptor tyrosine kinases. 
  • Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma. 
  • Visualization of arrestin recruitment by a G-protein-coupled receptor. 
  • Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization. 
  • Wnt pathway activation: new relations and locations. 
  • Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog. 
  • beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation. 
  • beta-arrestin-biased agonism at the beta2-adrenergic receptor. 
  • beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. 
  • beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. 
  • cAMP receptor and G-protein interactions control development in Dictyostelium. 
  • cGMP signal termination. 
  • mRNAs coding for proteins of the cGMP cascade in the degenerative retina of the rd mouse. 
  • p47 GTPases regulate Toxoplasma gondii survival in activated macrophages. 
• 

  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • Lee, Walter T, Professor of Head and Neck Surgery & Communication Sciences, Radiation Oncology
  • Middleton, John Paul, Professor of Medicine, Medicine, Nephrology
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology