Brain-Derived Neurotrophic Factor

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  Subject Areas on Research

  • A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. 
  • A relationship between behavior, neurotrophin expression, and new neuron survival. 
  • ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. 
  • Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF. 
  • Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1. 
  • Acute injections of brain-derived neurotrophic factor in a vocal premotor nucleus reversibly disrupt adult birdsong stability and trigger syllable deletion. 
  • Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression. 
  • Altered morphology of hippocampal dentate granule cell presynaptic and postsynaptic terminals following conditional deletion of TrkB. 
  • Altered regulation of brain-derived neurotrophic factor protein in hippocampus following slice preparation. 
  • Antillatoxin-Stimulated Neurite Outgrowth Involves the Brain-Derived Neurotrophic Factor (BDNF) - Tropomyosin Related Kinase B (TrkB) Signaling Pathway. 
  • Appetite regulatory hormones in women with anorexia nervosa: binge-eating/purging versus restricting type. 
  • Associations between smoking behavior-related alleles and the risk of melanoma. 
  • Autocrine BDNF-TrkB signalling within a single dendritic spine. 
  • BDNF Val66Met and spontaneous dyskinesias in non-clinical psychosis. 
  • BDNF Val66Met genotype and 6-month remission rates in late-life depression. 
  • BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin. 
  • BDNF profoundly and specifically increases KCNQ4 expression in neurons derived from embryonic stem cells. 
  • BDNF promotes mouse follicular development and reverses ovarian aging by promoting cell proliferation. 
  • BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. 
  • BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. 
  • Biological functions and transcriptional targets of CaRF in neurons. 
  • Biological functions of activity-dependent transcription revealed. 
  • Bipolar disorder, brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and brain morphology. 
  • Blue Genes, Exercise, and Cognition in Late-Life Depression: A Lot of Moving Parts. 
  • Brain-derived neurotrophic factor (BDNF) Val66Met and adulthood chronic stress interact to affect depressive symptoms. 
  • Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress. 
  • Brain-derived neurotrophic factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo. 
  • Brain-derived neurotrophic factor overexpression induces precocious critical period in mouse visual cortex. 
  • Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort. 
  • Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. 
  • Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks. 
  • Brain-derived neurotrophic factor-activated astrocytes produce mechanical allodynia in neuropathic pain. 
  • Calcium regulation of neuronal gene expression. 
  • Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. 
  • Chondroitin Sulfate Glycosaminoglycan Hydrogels Create Endogenous Niches for Neural Stem Cells. 
  • Concomitant BDNF and sleep slow wave changes indicate ketamine-induced plasticity in major depressive disorder. 
  • Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model. 
  • Cytosolic branched chain aminotransferase (BCATc) mRNA is up-regulated in restricted brain areas of BDNF transgenic mice. 
  • Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. 
  • Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenal. 
  • Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. 
  • Does Meditation Enhance Cognition and Brain Longevity? 
  • Does neurotropin-3 have a therapeutic implication in major depression? 
  • Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease. 
  • Early biomarkers of stroke. 
  • Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood. 
  • Effect of growth factors on substance P mRNA expression in axotomized dorsal root ganglia. 
  • Environmental enrichment alters glial antigen expression and neuroimmune function in the adult rat hippocampus. 
  • Epigenetics and psychostimulant addiction. 
  • Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression. 
  • Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. 
  • Exposure to Perfluoroalkyl Substances During Pregnancy and Fetal BDNF Level: A Prospective Cohort Study. 
  • Fiber tract-specific white matter lesion severity Findings in late-life depression and by AGTR1 A1166C genotype. 
  • Fibroblast growth factors regulate calcitonin gene-related peptide mRNA expression in rat motoneurons after lesion and in culture. 
  • Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death. 
  • Genetic polymorphisms: a cornerstone of translational biobehavioral research. 
  • Genetic variants associated with severe retinopathy of prematurity in extremely low birth weight infants. 
  • Genetic variants in 5-HTTLPR, BDNF, HTR1A, COMT, and FKBP5 and risk for treated depression after cancer diagnosis. 
  • Genomics in the neonatal nursery: Focus on ROP. 
  • Glutamatergic neuronal differentiation of mouse embryonic stem cells after transient expression of neurogenin 1 and treatment with BDNF and GDNF: in vitro and in vivo studies. 
  • Gαz regulates BDNF-induction of axon growth in cortical neurons. 
  • Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation. 
  • Impact of BDNF Val66Met and 5-HTTLPR polymorphism variants on neural substrates related to sadness and executive function. 
  • In situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injury. 
  • In vitro survival and differentiation of neurons derived from epidermal growth factor-responsive postnatal hippocampal stem cells: inducing effects of brain-derived neurotrophic factor. 
  • Increased expression of brain-derived neurotrophic factor induces formation of basal dendrites and axonal branching in dentate granule cells in hippocampal explant cultures. 
  • International randomized-controlled trial of transcranial Direct Current Stimulation in depression. 
  • Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. 
  • Is lithium neuroprotective? An updated mechanistic illustrated review. 
  • LTD at mossy fiber synapses onto stratum lucidum interneurons requires TrkB and retrograde endocannabinoid signaling. 
  • Localization of brain-derived neurotrophic factor to distinct terminals of mossy fiber axons implies regulation of both excitation and feedforward inhibition of CA3 pyramidal cells. 
  • Long-term enhancement of central synaptic transmission by chronic brain-derived neurotrophic factor treatment. 
  • Long-term regulation of excitatory and inhibitory synaptic transmission in hippocampal cultures by brain-derived neurotrophic factor. 
  • Low catechol-O-methyltransferase and stress potentiate functional pain and depressive behavior, especially in female mice. 
  • Lower brain-derived neurotrophic factor in patients with prader-willi syndrome compared to obese and lean control subjects. 
  • Mechanisms of specificity in neuronal activity-regulated gene transcription. 
  • Members of the myocyte enhancer factor 2 transcription factor family differentially regulate Bdnf transcription in response to neuronal depolarization. 
  • Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. 
  • Mutual regulation of Src family kinases and the neurotrophin receptor TrkB. 
  • Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 levels in human amniotic fluid. 
  • Neurite outgrowth from progeny of epidermal growth factor-responsive hippocampal stem cells is significantly less robust than from fetal hippocampal cells following grafting onto organotypic hippocampal slice cultures: effect of brain-derived neurotrophic factor. 
  • Neurogenetic plasticity and sex influence the link between corticolimbic structural connectivity and trait anxiety. 
  • Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroimmune regulation. 
  • Neuroprotective effects of reactive oxygen species mediated by BDNF-independent activation of TrkB. 
  • Neurotrophins affect the pattern of DRG neurite growth in a bioassay that presents a choice of CNS and PNS substrates. 
  • Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity. 
  • Neurotrophins: transcription and translation. 
  • Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma. 
  • Ontogeny of seizure-induced increases in BDNF immunoreactivity and TrkB receptor activation in rat hippocampus. 
  • Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels. 
  • Perfluoroalkyl Substance Exposure and the BDNF Pathway in the Placental Trophoblast. 
  • Positive feedback loop of autocrine BDNF from microglia causes prolonged microglia activation. 
  • Postnatal TrkB ablation in corticolimbic interneurons induces social dominance in male mice. 
  • RNA aptamer-based functional ligands of the neurotrophin receptor, TrkB. 
  • Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice. 
  • Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit. 
  • Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats. 
  • Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity. 
  • Serum brain-derived neurotrophic factor concentrations in lean and overweight children and adolescents. 
  • Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland. 
  • Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF. 
  • Social support in older individuals: the role of the BDNF Val66Met polymorphism. 
  • Specific agrin isoforms induce cAMP response element binding protein phosphorylation in hippocampal neurons. 
  • Suppression of trkB expression by antisense oligonucleotides alters a neuronal phenotype in the rod pathway of the developing rat retina. 
  • Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction. 
  • Sustained delivery of activated Rho GTPases and BDNF promotes axon growth in CSPG-rich regions following spinal cord injury. 
  • Systematic review and meta-analysis of the effect of adverse childhood experiences (ACEs) on brain-derived neurotrophic factor (BDNF) levels. 
  • Targeting BDNF/TrkB pathways for preventing or suppressing epilepsy. 
  • Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro. 
  • The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription. 
  • The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression. 
  • The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression. 
  • The effect of intrathecal administration of glial activation inhibitors on dorsal horn BDNF overexpression and hind paw mechanical allodynia in spinal nerve ligated rats. 
  • The transcription factor calcium-response factor limits NMDA receptor-dependent transcription in the developing brain. 
  • TrkB-Shc Signaling Protects against Hippocampal Injury Following Status Epilepticus. 
  • Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro model. 
  • Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons. 
  • Visual cortex is rescued from the effects of dark rearing by overexpression of BDNF. 
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  Keywords of People

  • Cabeza, Roberto, Professor of Psychology and Neuroscience, Duke Science & Society
  • Velkey, John Matthew, Assistant Professor of the Practice of Medical Education in the Department of Cell Biology, Cell Biology