Troponin C

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  Subject Areas on Research

  • A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillation. 
  • Calcium control of muscle phosphorylase kinase through the combined action of calmodulin and troponin. 
  • Calmodulin as an integral subunit of phosphorylase kinase from rabbit skeletal muscle. 
  • Calmodulin is intrinsically LESS effective than troponin C in activating skeletal muscle contraction. 
  • Calmodulin-cardiac troponin C chimeras. Effects of domain exchange on calcium binding and enzyme activation. 
  • Chimeric calmodulin-cardiac troponin C proteins differentially activate calmodulin target enzymes. 
  • Co-operative activation of skeletal muscle thin filaments by rigor crossbridges. The effect of troponin C extraction. 
  • Co-operative interactions between troponin-tropomyosin units extend the length of the thin filament in skeletal muscle. 
  • Development and cardiac contractility: cardiac troponin T isoforms and cytosolic calcium in rabbit. 
  • Differential activation of nitric-oxide synthase isozymes by calmodulin-troponin C chimeras. 
  • Early detection and prediction of cardiotoxicity in chemotherapy-treated patients. 
  • Electron microscopy and x-ray diffraction evidence for two Z-band structural states. 
  • Identification of troponin C antagonists from a phage-displayed random peptide library. 
  • Interactions of calmodulin with coated vesicles from brain. 
  • Molecular analysis of calmodulin and smooth muscle myosin light chain kinase. 
  • Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C. 
  • Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras. 
  • Noise versus signal: the clinical implications of an increasingly sensitive troponin assay for patients with suspected acute coronary syndrome. 
  • Putting the Acute Coronary Syndrome in Context After 80 Years of Age. 
  • Reduced force production during low blood flow to the heart correlates with altered troponin I phosphorylation. 
  • Simplified Predictive Instrument to Rule Out Acute Coronary Syndromes in a High-Risk Population. 
  • The nontranscribed chicken calmodulin pseudogene cross-hybridizes with mRNA from the slow-muscle troponin C gene. 
  • The troponin I: inhibitory peptide uncouples force generation and the cooperativity of contractile activation in mammalian skeletal muscle. 
  • The utility of troponin measurement to detect myocardial infarction: review of the current findings. 
  • Three-dimensional structure of calmodulin. 
  • Troponin C modulates the activation of thin filaments by rigor cross-bridges. 
  • What is the role of biomarker measurement after cardiac surgery?