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Subject Areas on Research
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A comprehensive guide to genetic variants and post-translational modifications of cardiac troponin C.
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A rapid troponin I assay is not optimal for determination of troponin status and prediction of subsequent cardiac events at suspicion of unstable coronary syndromes.
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Adhesion molecules, platelet activation, and cardiovascular risk.
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Association of Cardiac Injury and Malignant Left Ventricular Hypertrophy With Risk of Heart Failure in African Americans: The Jackson Heart Study.
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Association of cardiac biomarkers with acute kidney injury after cardiac surgery: A multicenter cohort study.
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Association of novel biomarkers of cardiovascular stress with left ventricular hypertrophy and dysfunction: implications for screening.
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Baseline Q waves as a prognostic modulator in patients with ST-segment elevation: insights from the PLATO trial.
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Bedside multimarker testing for risk stratification in chest pain units: The chest pain evaluation by creatine kinase-MB, myoglobin, and troponin I (CHECKMATE) study.
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Biomarker-based risk prediction in the community.
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Biomarkers in atrial fibrillation: a clinical review.
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Biomarkers in cardiovascular clinical trials: past, present, future.
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Cardiac Troponin I-Interacting Kinase Affects Cardiomyocyte S-Phase Activity but Not Cardiomyocyte Proliferation.
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Cardiac markers: point of care testing.
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Cardiac troponin I for prediction of clinical outcomes and cardiac function through 3-month follow-up after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction.
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Cardiac troponin T and I, echocardiographic [correction of electrocardiographic] wall motion analyses, and ejection fractions in athletes participating in the Hawaii Ironman Triathlon.
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Cardiac troponin T and cardiac troponin I: relative values in short-term risk stratification of patients with acute coronary syndromes. GUSTO-IIa Investigators.
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Cardiac troponin after percutaneous coronary intervention and 1-year mortality in non-ST-segment elevation acute coronary syndrome using systematic evaluation of biomarker trends.
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Cardiac troponin is associated with cardiac outcomes in men and women with atrial fibrillation, insights from the ARISTOTLE trial.
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Cardiac troponin release following hybrid coronary revascularization versus off-pump coronary artery bypass surgery.
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Cardiac troponins in congestive heart failure.
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Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.
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Circulating Cardiac Troponin I Levels Measured by a Novel Highly Sensitive Assay in Acute Decompensated Heart Failure: Insights From the ASCEND-HF Trial.
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Combination of Goldman risk and initial cardiac troponin I for emergency department chest pain patient risk stratification.
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Comparison of cardiac troponins I and T measured with high-sensitivity methods for evaluation of prognosis in atrial fibrillation: an ARISTOTLE substudy.
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Comparison of the prognostic value of peak creatine kinase-MB and troponin levels among patients with acute myocardial infarction: a report from the Acute Coronary Treatment and Intervention Outcomes Network Registry-get with the guidelines.
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Copeptin helps in the early detection of patients with acute myocardial infarction: primary results of the CHOPIN trial (Copeptin Helps in the early detection Of Patients with acute myocardial INfarction).
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Copeptin to rule out myocardial infarction in Blacks versus Caucasians.
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Coronary Atherosclerosis, Cardiac Troponin, and Interleukin-6 in Patients With Chest Pain: The PROMISE Trial Results.
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Cystatin C and estimated glomerular filtration rate as predictors for adverse outcome in patients with ST-elevation and non-ST-elevation acute coronary syndromes: results from the Platelet Inhibition and Patient Outcomes study.
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Development and Validation of Machine Learning-Based Race-Specific Models to Predict 10-Year Risk of Heart Failure: A Multicohort Analysis.
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Do cardiac troponins provide prognostic insight in hemodialysis patients?
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Drosophila as a model for the identification of genes causing adult human heart disease.
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Effect of a Triage-Based Screening Protocol on Diagnosis and Treatment of Acute Coronary Syndrome in a Tanzanian Emergency Department: A Prospective Pre-Post Study.
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Effectiveness of practices for improving the diagnostic accuracy of Non ST Elevation Myocardial Infarction in the Emergency Department: A Laboratory Medicine Best Practices™ systematic review.
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Elevated Cardiac Troponin I in Preservation Solution Is Associated With Primary Graft Dysfunction.
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Fibroblast growth factor 23, high-sensitivity cardiac troponin, and left ventricular hypertrophy in CKD.
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G alpha(q)-coupled receptors in human atrium function through protein kinase C epsilon and delta.
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Heart failure with preserved left ventricular systolic function among patients with non-ST-segment elevation acute coronary syndromes.
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High-Sensitivity Troponin I and Coronary Computed Tomography in Symptomatic Outpatients With Suspected CAD: Insights From the PROMISE Trial.
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High-Sensitivity Troponin I in Hospitalized and Ambulatory Patients With Heart Failure With Preserved Ejection Fraction: Insights From the Heart Failure Clinical Research Network.
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High-sensitivity troponin I for risk assessment in patients with atrial fibrillation: insights from the Apixaban for Reduction in Stroke and other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial.
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Ideal high sensitivity troponin baseline cutoff for patients with renal dysfunction.
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Ideal high sensitivity troponin baseline cutoff for patients with renal dysfunction.
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Implications of High-Sensitivity Troponin Testing: Learning From Those Who Came Before Us.
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Incidence and clinical significance of cardiac biomarker elevation during stem cell mobilization, apheresis, and intramyocardial delivery: an analysis from ACT34-CMI.
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Influence of imprecision on ROC curve analysis for cardiac markers.
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Inhibition of delta-protein kinase C by delcasertib as an adjunct to primary percutaneous coronary intervention for acute anterior ST-segment elevation myocardial infarction: results of the PROTECTION AMI Randomized Controlled Trial.
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Interpreting cardiac troponin results from high-sensitivity assays in chronic kidney disease without acute coronary syndrome.
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Lack of Relationship Between Serum Cardiac Troponin I Level and Giant Cell Myocarditis Diagnosis and Outcomes.
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Longitudinal Changes in Cardiac Troponin and Risk of Heart Failure Among Black Adults.
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Measurement of troponin and natriuretic peptides shortly after admission in patients with heart failure-does it add useful prognostic information? An analysis of the Value of Endothelin Receptor Inhibition with Tezosentan in Acute heart failure Studies (VERITAS).
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Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hot spots that are associated with worse clinical outcomes.
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Moving toward a new definition of acute myocardial infarction for the 21st century: status of the ESC/ACC consensus conference. European Society of Cardiology and American College of Cardiology.
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Multiparametric Early Detection and Prediction of Cardiotoxicity Using Myocardial Strain, T1 and T2 Mapping, and Biochemical Markers: A Longitudinal Cardiac Resonance Imaging Study During 2 Years of Follow-Up.
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Multiple-analyte fluoroimmunoassay using an integrated optical waveguide sensor.
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Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I.
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Myocardial Infarction Risk Stratification With a Single Measurement of High-Sensitivity Troponin I.
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Myocardial infarction in thrombotic thrombocytopenic purpura: a single-center experience and literature review.
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National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical characteristics and utilization of biochemical markers in acute coronary syndromes.
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National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: Analytical issues for biochemical markers of acute coronary syndromes.
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Necessity of hospitalization and stress testing in low risk chest pain patients.
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Outpatient versus observation/inpatient management of emergency department patients rapidly ruled-out for acute myocardial infarction: Findings from the HIGH-US study.
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Peptide Functionalized Gold Nanorods for the Sensitive Detection of a Cardiac Biomarker Using Plasmonic Paper Devices.
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Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties.
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Physical Activity, Subclinical Myocardial Injury, and Risk of Heart Failure Subtypes in Black Adults.
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Pivotal findings for a high-sensitivity cardiac troponin assay: Results of the HIGH-US study.
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Platelet PlA2 polymorphism and platelet activation are associated with increased troponin I release after cardiopulmonary bypass.
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Predicting a late positive serum troponin in initially troponin-negative patients with non-ST-elevation acute coronary syndrome: clinical predictors and validated risk score results from the TIMI IIIB and GUSTO IIA studies.
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Preliminary report on cardiac dysfunction after isolated traumatic brain injury.
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Prevalence, Profile, and Prognosis of Severe Obesity in Contemporary Hospitalized Heart Failure Trial Populations.
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Prognosis is worse with elevated cardiac troponin in nonacute coronary syndrome compared with acute coronary syndrome.
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Prognostic significance of elevated troponin I after percutaneous coronary intervention.
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Prognostic value of isolated troponin elevation across the spectrum of chest pain syndromes.
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Prognostic value of troponins in patients with non-ST-segment elevation acute coronary syndromes and chronic kidney disease.
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Providing Rapid Out of Hospital Acute Cardiovascular Treatment 4 (PROACT-4).
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Radiographic and Clinical Predictors of Cardiac Dysfunction Following Isolated Traumatic Brain Injury.
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Rapid assay brain natriuretic peptide and troponin I in patients hospitalized with decompensated heart failure (from the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness Trial).
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Rationale and design of the pilot randomized study of nesiritide versus dobutamine in heart failure (PRESERVD-HF).
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Redefining Cardiac Biomarkers in Predicting Mortality of Inpatients With COVID-19.
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Relation of level of B-type natriuretic peptide with outcomes in patients with infective endocarditis.
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Repeated Measurements of Cardiac Biomarkers in Atrial Fibrillation and Validation of the ABC Stroke Score Over Time.
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Reply: hs-cTnI in Stable Chest Pain.
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Sensitive troponin I assay in patients with suspected acute coronary syndrome.
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Serum Troponin Level in Acute Ischemic Stroke Identifies Patients with Visceral Infarcts.
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Sexually dimorphic myofilament function and cardiac troponin I phosphospecies distribution in hypertrophic cardiomyopathy mice.
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Single-Molecule hsTnI and Short-Term Risk in Stable Patients With Chest Pain.
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The Pilot Randomized Study of Nesiritide Versus Dobutamine in Heart Failure (PRESERVD-HF).
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The emerging role of myoglobin for risk stratification.
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The troponin I: inhibitory peptide uncouples force generation and the cooperativity of contractile activation in mammalian skeletal muscle.
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The utility of gestures in patients with chest discomfort.
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Thresholds for the electrocardiographic change range of biochemical markers of acute myocardial infarction (GUSTO-IIa data).
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Time course of degradation of cardiac troponin I in patients with acute ST-elevation myocardial infarction: the ASSENT-2 troponin substudy.
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Tissue-Engineered Human Myobundle System as a Platform for Evaluation of Skeletal Muscle Injury Biomarkers.
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Top-down quantitative proteomics identified phosphorylation of cardiac troponin I as a candidate biomarker for chronic heart failure.
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Transthyretin V142I Genetic Variant and Cardiac Remodeling, Injury, and Heart Failure Risk in Black Adults.
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Trends in Use of Biomarker Protocols for the Evaluation of Possible Myocardial Infarction.
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Troponin I and NT-proBNP and the association of systolic blood pressure with outcomes in incident hemodialysis patients: the Choices for Healthy Outcomes in Caring for ESRD (CHOICE) Study.
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Troponin I in acute decompensated heart failure: insights from the ASCEND-HF study.
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Troponin I in cardiac surgery: marking the future.
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Troponin and other cardiac markers: role in management of acute coronary syndromes.
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Troponins in pericarditis: implications for diagnosis and management of chest pains patients.
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Usefulness of an elevated troponin-I in predicting clinical events in patients admitted with acute heart failure and acute coronary syndrome (from the RITZ-4 trial).
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Usefulness of combining necrosis and platelet markers in triaging patients presenting with chest pain to the emergency department.
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Utility of High-Sensitivity Troponin Among Stable Patients With Chest Pain Undergoing Stress Imaging (from PROMISE).
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Visualization of discrete microinfarction after percutaneous coronary intervention associated with mild creatine kinase-MB elevation.
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p38 Mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes.
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p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity.
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Keywords of People
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Alexander, John Hunter Peel,
Professor of Medicine,
Medicine, Cardiology
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Limkakeng Jr., Alexander Tan,
Professor of Emergency Medicine,
Emergency Medicine
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O'Connor, Christopher Michael,
Richard Sean Stack, M.D. Distinguished Professor,
Medicine, Clinical Pharmacology