Proto-Oncogene Proteins c-bcl-2

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  Subject Areas on Research

  • A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation. 
  • A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. 
  • A pathway of neuronal apoptosis induced by hypoxia/reoxygenation: roles of nuclear factor-kappaB and Bcl-2. 
  • A phase I clinical trial of navitoclax, a targeted high-affinity Bcl-2 family inhibitor, in combination with gemcitabine in patients with solid tumors. 
  • A phase I study of AT-101, a BH3 mimetic, in combination with paclitaxel and carboplatin in solid tumors. 
  • Aberrant expression of p53, p21, cyclin D1, and Bcl2 and their clinicopathological correlation in ampullary adenocarcinoma. 
  • Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78. 
  • Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells. 
  • Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. 
  • Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. 
  • Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. 
  • Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. 
  • An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation. 
  • Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells. 
  • Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. 
  • Antiapoptotic Bcl-2 family proteins BCL-xL and MCL-1 integrate neural progenitor survival and proliferation during postnatal cerebellar neurogenesis. 
  • Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway. 
  • Apoptosis and B cell tolerance. 
  • Apoptosis and autophagy in the regulation of T lymphocyte function. 
  • Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm). 
  • Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c. 
  • Apoptosis signaling and BCL-2 pathways provide opportunities for novel targeted therapeutic strategies in hematologic malignances. 
  • Apoptosis: inhibitor or instigator of carcinogenesis? 
  • Autophagy in age-related macular degeneration. 
  • BCL2 inhibits cell adhesion, spreading, and motility by enhancing actin polymerization. 
  • BCL2 interaction with actin in vitro may inhibit cell motility by enhancing actin polymerization. 
  • BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia. 
  • Basic fibroblast growth factor downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast cancer cells. 
  • Bcl-2 accelerates multistep prostate carcinogenesis in vivo. 
  • Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. 
  • Bcl-2 suppresses sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression in cystic fibrosis airways: role in oxidant-mediated cell death. 
  • Biological responses to TGF-β in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression. 
  • Biostatistical modeling using traditional variables and genetic biomarkers for predicting the risk of prostate carcinoma recurrence after radical prostatectomy. 
  • C-myc-induced apoptosis in polycystic kidney disease is Bcl-2 and p53 independent. 
  • Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. 
  • Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance. 
  • Can you tBID on it? 
  • Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension. 
  • Caspase-3 activation in rat frontal cortex following treatment with typical and atypical antipsychotics. 
  • Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c. 
  • Cell proliferation and apoptosis in human uterine leiomyomas and myometria. 
  • Changes in sphingomyelinases, ceramide, Bax, Bcl(2), and caspase-3 during and after experimental status epilepticus. 
  • Clinicopathologic Features and Genomic Signature of De Novo CD5 + Diffuse Large B-Cell Lymphoma : A Multicenter Collaborative Study. 
  • Combined expression of A1 and A20 achieves optimal protection of renal proximal tubular epithelial cells. 
  • Complex response of breast epithelial cell lines to topoisomerase inhibitors. 
  • Composite lymphoma of follicular B-cell and peripheral T-cell types with distinct zone distribution in a 75-year-old male patient: a case study. 
  • Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor. 
  • Conversion of Bcl-2 to a Bax-like death effector by caspases. 
  • Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. 
  • Correlating notch signaling with thymocyte maturation. 
  • Coupling endoplasmic reticulum stress to cell death program in isolated human pancreatic islets: effects of gene transfer of Bcl-2. 
  • Cytokine regulation of liver injury and repair. 
  • Cytokine-dependent and cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes. 
  • Cytoprotective effects of hematopoietic growth factors on primary human acute myeloid leukemias are not mediated through changes in BCL-2, bax, or p21WAF1/CIP1. 
  • Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. 
  • Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers. 
  • Differences in susceptibility to tumor necrosis factor alpha-induced apoptosis among MCF-7 breast cancer cell variants. 
  • Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade. 
  • Diffuse Large B-Cell Lymphoma Version 1.2016. 
  • Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy. 
  • EBV⁺ high-grade B cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: a multi-institutional study. 
  • Effects of Long-Term Vagus Nerve Electrical Stimulation Therapy on Acute Cerebral Infarction and Neurological Function Recovery in Post MCAO Mice. 
  • Elevated levels of apoptosis regulator proteins p53 and bcl-2 are independent prognostic biomarkers in surgically treated clinically localized prostate cancer. 
  • Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production. 
  • Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection. 
  • Evaluation of NF-κB subunit expression and signaling pathway activation demonstrates that p52 expression confers better outcome in germinal center B-cell-like diffuse large B-cell lymphoma in association with CD30 and BCL2 functions. 
  • Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers. 
  • Fatty liver vulnerability to endotoxin-induced damage despite NF-kappaB induction and inhibited caspase 3 activation. 
  • First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway. 
  • Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. 
  • Frequent detection of bcl-2/JH translocations in human blood and organ samples by a quantitative polymerase chain reaction assay. 
  • Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene. 
  • Generation of neuronal intranuclear inclusions by polyglutamine-GFP: analysis of inclusion clearance and toxicity as a function of polyglutamine length. 
  • Genetic Subtyping and Phenotypic Characterization of the Immune Microenvironment and MYC/BCL2 Double Expression Reveal Heterogeneity in Diffuse Large B-cell Lymphoma. 
  • Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck. 
  • Genome-defined African ancestry is associated with distinct mutations and worse survival in patients with diffuse large B-cell lymphoma. 
  • Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation. 
  • Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. 
  • HDAC inhibitor chidamide synergizes with venetoclax to inhibit the growth of diffuse large B-cell lymphoma via down-regulation of MYC, BCL2, and TP53 expression. 
  • Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis. 
  • Hepatitis C virus positive diffuse large B-cell lymphomas have distinct molecular features and lack BCL2 translocations. 
  • Homeostatic control of lymphocyte survival: potential origins and implications. 
  • Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1. 
  • Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. 
  • Human IAP-like protein regulates programmed cell death downstream of Bcl-xL and cytochrome c. 
  • Human RPE expression of cell survival factors. 
  • IL-7 enhances the survival and maintains the size of naive T cells. 
  • Immunohistochemical and mutational analysis of the p53 tumour suppressor gene and the bcl-2 oncogene in primary testicular germ cell tumours. 
  • Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. 
  • In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein. 
  • In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. 
  • In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer. 
  • In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats. 
  • Induction of CD56 and TCR-independent activation of T cells with aging. 
  • Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis. 
  • Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma. 
  • Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program. 
  • Integrated genomic profiling of chronic lymphocytic leukemia identifies subtypes of deletion 13q14. 
  • Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. 
  • Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification. 
  • Limitations of tissue microarrays in the evaluation of focal alterations of bcl-2 and p53 in whole mount derived prostate tissues. 
  • Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses. 
  • Lymphomatosis Cerebri: A Diagnostic Challenge. 
  • MYC or BCL2 copy number aberration is a strong predictor of outcome in patients with diffuse large B-cell lymphoma. 
  • MYC/BCL2 double-hit high-grade B-cell lymphoma. 
  • MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program. 
  • Mantle Cell Lymphoma With Mantle Zone Growth Pattern. 
  • Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2. 
  • Mcl-1 rescues a glitch in the matrix. 
  • Mechanisms and methods in glucose metabolism and cell death. 
  • Melanoma proliferation and chemoresistance controlled by the DEK oncogene. 
  • Mitochondria in apoptosis and human disease. 
  • Mitochondria, cell death, and B cell tolerance. 
  • Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade. 
  • Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. 
  • Modulation of cell death by Bcl-XL through caspase interaction. 
  • Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x. 
  • Molecular and cellular mechanism of angiotensin II-mediated apoptosis. 
  • Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. 
  • Mutation of bcl-x gene in non-Hodgkin's lymphoma. 
  • NCCN Guidelines® Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 3.2022. 
  • Necrosis and apoptosis of tumor cells in embolized meningiomas: histopathology and P53, BCL-2, CD-68 immunohistochemistry. 
  • Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. 
  • Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition. 
  • Notch promotes radioresistance of glioma stem cells. 
  • Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. 
  • Orphan nuclear receptors in T lymphocyte development. 
  • Overcoming MCL-1-driven adaptive resistance to targeted therapies. 
  • Overexpression of basic fibroblast growth factor (FGF-2) downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast cancer cells. 
  • PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation. 
  • Patients with diffuse large B-cell lymphoma of germinal center origin with BCL2 translocations have poor outcome, irrespective of MYC status: a report from an International DLBCL rituximab-CHOP Consortium Program Study. 
  • Perineal seeding of prostate cancer as the only evidence of clinical recurrence 14 years after needle biopsy and radical prostatectomy: molecular correlation. 
  • Pharmacokinetics of the BCL-2 Inhibitor Venetoclax in Healthy Chinese Subjects. 
  • Pharmacokinetics of the BCL-2 Inhibitor Venetoclax in Subjects with Hepatic Impairment. 
  • Prognostic factors in resectable pancreatic cancer: p53 and bcl-2. 
  • Prognostic impact of concurrent MYC and BCL6 rearrangements and expression in de novo diffuse large B-cell lymphoma. 
  • Prognostic risk factors that identify patients with clinical stage I nonseminomatous germ cell tumors at low risk and high risk for metastasis. 
  • Prognostic significance of mucin and p53 expression in stage IB non-small cell lung cancer: a laboratory companion study to CALGB 9633. 
  • Prostate-specific expression of p53(R172L) differentially regulates p21, Bax, and mdm2 to inhibit prostate cancer progression and prolong survival. 
  • Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. 
  • Protein expression of p53, bcl-2, and KI-67 (MIB-1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer. 
  • Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation. 
  • Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. 
  • Quantitative analysis of biomarkers defines an optimal biological dose for recombinant human endostatin in primary human tumors. 
  • RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis. 
  • Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer. 
  • Reaper-induced apoptosis in a vertebrate system. 
  • Regulation of apoptosis in S49 cells. 
  • Regulation of mast cell survival and function by tuberous sclerosis complex 1. 
  • Regulation of membrane release in apoptosis. 
  • Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes. 
  • Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice. 
  • Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA. 
  • Role of p38alpha MAPK in cardiac apoptosis and remodeling after myocardial infarction. 
  • Roles of cytoplasmic Ca2+ and intracellular Ca2+ stores in induction and suppression of apoptosis in S49 cells. 
  • SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target. 
  • Selective ERBB2 and BCL2 Inhibition Is Synergistic for Mitochondrial-Mediated Apoptosis in MDS and AML Cells. 
  • Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. 
  • Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity. 
  • Signaling pathway for apoptosis: a racetrack for life or death. 
  • Significance of familial history of prostate cancer to traditional prognostic variables, genetic biomarkers, and recurrence after radical prostatectomy. 
  • Single-nucleotide polymorphisms at the TP53-binding or responsive promoter regions of BAX and BCL2 genes and risk of squamous cell carcinoma of the head and neck. 
  • Sorafenib, a multikinase inhibitor, enhances the response of melanoma to regional chemotherapy. 
  • Stalling in mitosis and releasing the apoptotic brake. 
  • Strategic Therapeutic Targeting to Overcome Venetoclax Resistance in Aggressive B-cell Lymphomas. 
  • Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors. 
  • Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity. 
  • Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity. 
  • Targeting BCL-2 with venetoclax and dexamethasone in patients with relapsed/refractory t(11;14) multiple myeloma. 
  • Tempol therapy attenuates medial smooth muscle cell apoptosis and neointima formation after balloon catheter injury in carotid artery of diabetic rats. 
  • Tepoxalin enhances the activity of an antioxidant, pyrrolidine dithiocarbamate, in attenuating tumor necrosis factor alpha-induced apoptosis in WEHI 164 cells. 
  • Testosterone in prostate cancer: the Bethesda consensus. 
  • The Association of Intratumoral Germinal Centers with early-stage non-small cell lung cancer. 
  • The BCL2 inhibitor ABT-199 significantly enhances imatinib-induced cell death in chronic myeloid leukemia progenitors. 
  • The C-terminal domain of A1/Bfl-1 regulates its anti-inflammatory function in human endothelial cells. 
  • The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast. 
  • The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages. 
  • The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes. 
  • The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. 
  • The central effectors of cell death in the immune system. 
  • The channel of death. 
  • The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. 
  • The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies. 
  • The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis. 
  • The impact of bcl-2 expression and bax deficiency on prostate homeostasis in vivo. 
  • The presence of human papillomavirus-16/-18 E6, p53, and Bcl-2 protein in cervicovaginal smears from patients with invasive cervical cancer. 
  • The role of apoptosis in the development and function of T lymphocytes. 
  • The tangled circuitry of metabolism and apoptosis. 
  • Transfer of CD8+ T cell memory using Bcl-2 as a marker. 
  • Transglutaminase 2 protects against ischemic stroke. 
  • Triple-hit B-cell Lymphoma With MYC, BCL2, and BCL6 Translocations/Rearrangements: Clinicopathologic Features of 11 Cases. 
  • Tumor Lysis, Adverse Events, and Dose Adjustments in 297 Venetoclax-Treated CLL Patients in Routine Clinical Practice. 
  • Up-regulation of GRP78 and antiapoptotic signaling in murine peritoneal macrophages exposed to insulin. 
  • Upstream regulatory role for XIAP in receptor-mediated apoptosis. 
  • VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation. 
  • Venetoclax for patients with chronic lymphocytic leukemia who progressed during or after idelalisib therapy. 
  • Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase. 
  • Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. 
  • XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis. 
  • [Bcl-2 and bax expression in rat cerebral ischemic preconditioning]. 
  • bcl-2 and p53 expression in resectable pancreatic adenocarcinomas: association with clinical outcome. 
  • mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. 
  • p53 and bcl-2 immunohistochemistry in pretreatment prostate needle biopsies to predict recurrence of prostate cancer after radical prostatectomy. 
  • p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology