NADPH Oxidase

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  Subject Areas on Research

  • A differential role for endocytosis in receptor-mediated activation of Nox1. 
  • A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity. 
  • AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: role of the AT1 receptor and NADPH oxidase. 
  • Abrogation of adenosine A1 receptor signalling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses. 
  • Activation of NAD(P)H oxidase by lipid hydroperoxides: mechanism of oxidant-mediated smooth muscle cytotoxicity. 
  • Activation of neuronal NADPH oxidase NOX2 promotes inflammatory neurodegeneration. 
  • Activation of the respiratory burst enzyme from human neutrophils in a cell-free system. Evidence for a soluble cofactor. 
  • Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli. Evidence that the same oxidase is activated by different transductional mechanisms. 
  • Airway smooth muscle relaxation is impaired in mice lacking the p47phox subunit of NAD(P)H oxidase. 
  • Assessing activation states in microglia. 
  • CaMKII is essential for the proasthmatic effects of oxidation. 
  • Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. 
  • Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy. 
  • Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species. 
  • Cell wall remodeling and vesicle trafficking mediate the root clock in Arabidopsis . 
  • Chemiluminescence and the Nox1-Nox2-Nox4 Triple Knockout. 
  • Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis. 
  • Clinical application of whole-genome sequencing in patients with primary immunodeficiency. 
  • Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta -microglobulin-/- repopulating mobilized human peripheral blood CD34+ cells. 
  • Curcumin Ameliorates Heat-Induced Injury through NADPH Oxidase-Dependent Redox Signaling and Mitochondrial Preservation in C2C12 Myoblasts and Mouse Skeletal Muscle. 
  • Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3. 
  • Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase. 
  • Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. 
  • Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion. 
  • Drebrin regulates angiotensin II-induced aortic remodelling. 
  • Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4. 
  • Evidence for association of SNPs in ABCB1 and CBR3, but not RAC2, NCF4, SLC28A3 or TOP2B, with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines. 
  • Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21. 
  • Expression of nonphagocytic NADPH oxidase system in the ocular lens. 
  • Functional evaluation of nonphagocytic NAD(P)H oxidases. 
  • Gp91phox contributes to NADPH oxidase activity in aortic fibroblasts but not smooth muscle cells. 
  • Granulocyte-macrophage colony-stimulating factor primes neutrophils by activating a pertussis toxin-sensitive G protein not associated with phosphatidylinositol turnover. 
  • Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. 
  • H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury. 
  • HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration. 
  • HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease. 
  • Hydrogen peroxide promotes aging-related platelet hyperactivation and thrombosis. 
  • Identifying new small molecule anti-invasive compounds for glioma treatment. 
  • Increased epidermal growth factor-like ligands are associated with elevated vascular nicotinamide adenine dinucleotide phosphate oxidase in a primate model of atherosclerosis. 
  • Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis. 
  • Inorganic nitrite attenuates NADPH oxidase-derived superoxide generation in activated macrophages via a nitric oxide-dependent mechanism. 
  • Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans. 
  • L-Met Activates Arabidopsis GLR Ca²⁺ Channels Upstream of ROS Production and Regulates Stomatal Movement. 
  • L-arginine or tempol supplementation improves renal and cardiovascular function in rats with reduced renal mass and chronic high salt intake. 
  • Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis. 
  • Luminal alkalinization attenuates proteinuria-induced oxidative damage in proximal tubular cells. 
  • Manganese superoxide dismutase-mediated inside-out signaling in HaCaT human keratinocytes and SKH-1 mouse skin. 
  • Mechanisms of regulating the respiratory burst in leukocytes. 
  • Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme. 
  • Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis. 
  • Microglial oxyradical production: causes and consequences. 
  • Mn porphyrins as a novel treatment targeting sickle cell NOXs to reverse and prevent acute vaso-occlusion in vivo. 
  • NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment. 
  • NADPH oxidase 4: walking the walk with Poldip2. 
  • NADPH oxidase AtrbohD and AtrbohF genes function in ROS-dependent ABA signaling in Arabidopsis. 
  • NADPH oxidase in the renal microvasculature is a primary target for blood pressure-lowering effects by inorganic nitrate and nitrite. 
  • NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability. 
  • NADPH oxidase promotes NF-kappaB activation and proliferation in human airway smooth muscle. 
  • NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment. 
  • NOX2 protects against prolonged inflammation, lung injury, and mortality following systemic insults. 
  • NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells. 
  • Nanostring-based multigene assay to predict recurrence for gastric cancer patients after surgery. 
  • Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. 
  • Nitric oxide reduces NADPH oxidase 5 (Nox5) activity by reversible S-nitrosylation. 
  • Nox1 in cardiovascular diseases: regulation and pathophysiology. 
  • Nox4 NADPH oxidase contributes to smooth muscle cell phenotypes associated with unstable atherosclerotic plaques. 
  • Nox4 NADPH oxidase: emerging from the veil of darkness. 
  • Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. 
  • Opportunity nox: the future of NADPH oxidases as therapeutic targets in cardiovascular disease. 
  • Organ uptake and release of inorganic nitrate and nitrite in the pig. 
  • Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling. 
  • Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4. 
  • Patients with chronic granulomatous disease have a reduced peripheral blood memory B cell compartment. 
  • Pattern-recognition receptors are required for NLR-mediated plant immunity. 
  • Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. 
  • Phorbol myristate acetate mediates redistribution of protein kinase C in human neutrophils: potential role in the activation of the respiratory burst enzyme. 
  • Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after nonmyeloablative transplantation with transduced autologous peripheral blood progenitor cells. 
  • Potentially functional variants of ERAP1, PSMF1 and NCF2 in the MHC-I-related pathway predict non-small cell lung cancer survival. 
  • Production of superoxide anion by an NADPH-oxidase from rat pulmonary macrophages. 
  • Rare and low-frequency coding variants alter human adult height. 
  • Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection. 
  • Reactive oxygen species: from health to disease. 
  • Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47phox in Vascular Smooth Muscle Cells. 
  • Regression of atherosclerosis in monkeys reduces vascular superoxide levels. 
  • Renal denervation attenuates NADPH oxidase-mediated oxidative stress and hypertension in rats with hydronephrosis. 
  • Requirement for reactive oxygen species in serum-induced and platelet-derived growth factor-induced growth of airway smooth muscle. 
  • Role of NADPH oxidase and xanthine oxidase in mediating inducible VT/VF and triggered activity in a canine model of myocardial ischemia. 
  • Role of oxidative stress in a rat model of radiation-induced erectile dysfunction. 
  • Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis. 
  • Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation. 
  • Successful renal transplantation in patients with chronic granulomatous disease. 
  • Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. 
  • Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice. 
  • Tetrahydroindenoindole inhibits the progression of diabetes in mice. 
  • Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice. 
  • The NADPH oxidase of human polymorphonuclear leukocytes. Evidence for regulation by multiple signals. 
  • The genetic underpinnings of anthracycline-induced cardiomyopathy predisposition. 
  • The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression. 
  • Unsaturated fatty acids and lipoxygenase products regulate phagocytic NADPH oxidase activity by a nondetergent mechanism. 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Miller Jr., Francis Joseph, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Schickling, Brandon, Affiliate, Medicine, Cardiology