Adoptive Transfer
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Subject Areas on Research
- A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome.
- A crucial role of L-selectin in C protein-induced experimental polymyositis in mice.
- A functional genomics predictive network model identifies regulators of inflammatory bowel disease.
- A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo.
- A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis.
- Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice.
- Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis.
- Activation of decidual invariant natural killer T cells promotes lipopolysaccharide-induced preterm birth.
- Adaptive NK cell responses in HIV/SIV infections: A roadmap to cell-based therapeutics?
- Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens.
- Allogeneic Stem-Cell Transplantation - A T-Cell Balancing ACT.
- Allogeneic splenocyte transfer and lipopolysaccharide inhalations induce differential T cell expansion and lung injury: a novel model of pulmonary graft-versus-host disease.
- An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells.
- An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus.
- Antibody is critical for the clearance of murine norovirus infection.
- Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment.
- B cells are required for optimal CD4+ and CD8+ T cell tumor immunity: therapeutic B cell depletion enhances B16 melanoma growth in mice.
- Blocking CCR7 at the ocular surface impairs the pathogenic contribution of dendritic cells in allergic conjunctivitis.
- Both Hematopoietic- and Non-hematopoietic-derived {beta}-arrestin-2 Regulates Murine Allergic Airway Disease.
- C-C Motif Chemokine Receptor 7 Exacerbates Hypertension Through Effects on T Lymphocyte Trafficking.
- CD19 expression in B cells is important for suppression of contact hypersensitivity.
- CD19 expression in B cells regulates atopic dermatitis in a mouse model.
- CD22 expression mediates the regulatory functions of peritoneal B-1a cells during the remission phase of contact hypersensitivity reactions.
- CD83 expression influences CD4+ T cell development in the thymus.
- CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.
- Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-Induced Myeloid-Derived Suppressor Cells.
- Cellular and biological therapies of gastrointestinal tumors: overview of clinical trials.
- Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection.
- Chronic dry eye disease is principally mediated by effector memory Th17 cells.
- Critical role for mouse marginal zone B cells in PF4/heparin antibody production.
- Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses.
- Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life.
- Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses.
- Deficiency of Mucosal-Associated Invariant T Cells in TCRJα18 Germline Knockout Mice.
- Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma.
- Dependence of germinal center B cells on expression of CD21/CD35 for survival.
- Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance.
- Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses.
- Direct MHC class I complementary DNA transfer to thymus induces donor-specific unresponsiveness, which involves multiple immunologic mechanisms.
- Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease.
- E2A promotes the survival of precursor and mature B lymphocytes.
- EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss.
- EGFRvIII-specific chimeric antigen receptor T cells migrate to and kill tumor deposits infiltrating the brain parenchyma in an invasive xenograft model of glioblastoma.
- ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.
- Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis.
- Engineering challenges for brain tumor immunotherapy
- Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis.
- Ethylenecarbodiimide-fixed donor splenocyte infusions differentially target direct and indirect pathways of allorecognition for induction of transplant tolerance.
- Galectin-1 is essential for the induction of MOG35-55 -based intravenous tolerance in experimental autoimmune encephalomyelitis.
- Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂.
- High-frequency alloreactive T cells augment effector function of low-frequency CD8+ T-cell responses under CD28/CD154 blockade.
- Human CD4+CD25low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance.
- IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection.
- IL-7 is essential for homeostatic control of T cell metabolism in vivo.
- IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria.
- Id2 Collaborates with Id3 To Suppress Invariant NKT and Innate-like Tumors.
- Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages.
- Identifying regulatory B cells (B10 cells) that produce IL-10 in mice.
- IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF.
- Immunologic suppression mediated by genetically modified hepatocytes expressing secreted allo-MHC class I molecules.
- Immunological disruption of antiangiogenic signals by recruited allospecific T cells leads to corneal allograft rejection.
- Immunotherapy for gynaecological malignancies.
- Impaired CD8(+) T cell immunity after allogeneic bone marrow transplantation leads to persistent and severe respiratory viral infection.
- In-vivo impaired T helper 1 cell development in submandibular lymph nodes due to IL-12 deficiency following antigen injection into the anterior chamber of the eye.
- Induced sensitization of tumor stroma leads to eradication of established cancer by T cells.
- Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.
- Infection with Mycobacterium bovis BCG diverts traffic of myelin oligodendroglial glycoprotein autoantigen-specific T cells away from the central nervous system and ameliorates experimental autoimmune encephalomyelitis.
- Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression.
- Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response.
- L-selectin is not required for T cell-mediated autoimmune diabetes.
- Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes.
- Massive clonal expansion of medulloblastoma-specific T cells during adoptive cellular therapy.
- Mesothelin, a novel immunotherapy target for triple negative breast cancer.
- Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.
- Mst1/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1/Foxo3 stability in autoimmune disease.
- NFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis.
- Nasal vaccination with troponin reduces troponin specific T-cell responses and improves heart function in myocardial ischemia-reperfusion injury.
- Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons.
- Notch 1 signaling regulates peripheral T cell activation.
- PG27, an extract of Tripterygium wilfordii hook f, induces antigen-specific tolerance in bone marrow transplantation in mice.
- PLG scaffold delivered antigen-specific regulatory T cells induce systemic tolerance in autoimmune diabetes.
- PP6 controls T cell development and homeostasis by negatively regulating distal TCR signaling.
- Patient-Reported Neuropsychiatric Outcomes of Long-Term Survivors after Chimeric Antigen Receptor T Cell Therapy.
- Perforin knockout mice, but not mice with MAIDS, show protection against experimental cytomegalovirus retinitis after adoptive transfer of immune cells with a functional perforin cytotoxic pathway.
- Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-γ+CD4+ T cell numbers during colitis development in mice.
- Prospective randomized comparative study on rivaroxaban and LMWH for prophylaxis of post-apheresis thrombosis in adoptive T cell immunotherapy cancer patients.
- Protective immunity in recurrent Staphylococcus aureus infection reflects localized immune signatures and macrophage-conferred memory.
- Protective immunosurveillance and therapeutic antitumor activity of gammadelta T cells demonstrated in a mouse model of prostate cancer.
- Quantitative 1H magnetic resonance spectroscopic imaging determines therapeutic immunization efficacy in an animal model of Parkinson's disease.
- Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo.
- Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice.
- Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice.
- Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis.
- Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease.
- Regulatory T cells decrease invariant natural killer T cell-mediated pregnancy loss in mice.
- Role of interleukin 12 and costimulators in T cell anergy in vivo.
- Role of natural killer cell function in dendritic cell-based vaccines.
- Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder.
- Successful treatment of disseminated BCG in a patient with severe combined immunodeficiency.
- Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer.
- Systemic interleukin-2 and adoptive transfer of lymphokine-activated killer cells improves antibody-dependent cellular cytotoxicity in patients with relapsed B-cell lymphoma treated with rituximab.
- T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis.
- T cell traffic and the inflammatory response in experimental autoimmune uveoretinitis.
- T-Cell Mediation of Pregnancy Analgesia Affecting Chronic Pain in Mice.
- TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection.
- The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation.
- The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair.
- Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease.
- Transfer of CD8+ T cell memory using Bcl-2 as a marker.
- Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease.
- Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.
- α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin.
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Keywords of People
- Chen, Jun, Professor of Medicine, Duke Cancer Institute
- Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
- Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology