Phosphatidylinositol 4,5-Diphosphate
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Subject Areas on Research
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A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1.
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Actin filament assembly and actin-myosin contractility are necessary for anchorage- and EGF-dependent activation of phospholipase Cgamma.
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Activation and signaling of the Abl tyrosine kinase: bidirectional link with phosphoinositide signaling.
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Activation of epidermal growth factor receptor inhibits KCNQ2/3 current through two distinct pathways: membrane PtdIns(4,5)P2 hydrolysis and channel phosphorylation.
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Arachidonic acid activates Kir2.3 channels by enhancing channel-phosphatidyl-inositol 4,5-bisphosphate interactions.
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Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition.
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Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.
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INP51, a yeast inositol polyphosphate 5-phosphatase required for phosphatidylinositol 4,5-bisphosphate homeostasis and whose absence confers a cold-resistant phenotype.
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Identification and characterization of an essential family of inositol polyphosphate 5-phosphatases (INP51, INP52 and INP53 gene products) in the yeast Saccharomyces cerevisiae.
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Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate.
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Lipid binding to the tail domain of vinculin: specificity and the role of the N and C termini.
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Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis.
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Maleylated-BSA induces hydrolysis of PIP2, fluxes of Ca2+, NF-kappaB binding, and transcription of the TNF-alpha gene in murine macrophages.
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Mechanisms of beta-adrenergic receptor desensitization and resensitization.
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Modulation of inositol phospholipid metabolism by polyamines.
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Molecular basis for genistein-induced inhibition of Kir2.3 currents.
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Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding.
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Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters.
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Phosphatidic acid modulates Cl- secretion in T84 cells: varying effects depending on mode of stimulation.
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Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies.
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Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion.
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Phosphatidylinositol 4,5-bisphosphate hydrolysis mediates histamine-induced KCNQ/M current inhibition.
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Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells.
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Regulation of phospholipase C-gamma 1 by profilin and tyrosine phosphorylation.
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Role of GAP-43 in sequestering phosphatidylinositol 4,5-bisphosphate to Raft bilayers.
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Selective inhibition of Kir currents by antihistamines.
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Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.
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The actin-binding protein profilin binds to PIP2 and inhibits its hydrolysis by phospholipase C.
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The affinities of human platelet and Acanthamoeba profilin isoforms for polyphosphoinositides account for their relative abilities to inhibit phospholipase C.
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The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells.
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UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans.
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alpha-Actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitro.
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