Phosphatidylinositol 4,5-Diphosphate
-
Subject Areas on Research
-
A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1.
-
Actin filament assembly and actin-myosin contractility are necessary for anchorage- and EGF-dependent activation of phospholipase Cgamma.
-
Activation and signaling of the Abl tyrosine kinase: bidirectional link with phosphoinositide signaling.
-
Activation of epidermal growth factor receptor inhibits KCNQ2/3 current through two distinct pathways: membrane PtdIns(4,5)P2 hydrolysis and channel phosphorylation.
-
Arachidonic acid activates Kir2.3 channels by enhancing channel-phosphatidyl-inositol 4,5-bisphosphate interactions.
-
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition.
-
Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.
-
Guanosine-5'-(3-O-thio)triphosphate-mediated stimulation of phosphoinositidase C in solubilized rat peripheral nerve myelin and its alteration in streptozotocin-induced diabetes.
-
INP51, a yeast inositol polyphosphate 5-phosphatase required for phosphatidylinositol 4,5-bisphosphate homeostasis and whose absence confers a cold-resistant phenotype.
-
Identification and characterization of an essential family of inositol polyphosphate 5-phosphatases (INP51, INP52 and INP53 gene products) in the yeast Saccharomyces cerevisiae.
-
Inhibition by nicardipine of endothelin-mediated inositol phosphate formation and Ca2+ mobilization in smooth muscle cell.
-
Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate.
-
Lipid binding to the tail domain of vinculin: specificity and the role of the N and C termini.
-
Localization of a binding site for phosphatidylinositol 4,5-bisphosphate on human profilin.
-
Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis.
-
Maleylated-BSA induces hydrolysis of PIP2, fluxes of Ca2+, NF-kappaB binding, and transcription of the TNF-alpha gene in murine macrophages.
-
Mechanisms of beta-adrenergic receptor desensitization and resensitization.
-
Modulation of inositol phospholipid metabolism by polyamines.
-
Molecular basis for genistein-induced inhibition of Kir2.3 currents.
-
Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A.
-
Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding.
-
Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters.
-
Phosphatidic acid modulates Cl- secretion in T84 cells: varying effects depending on mode of stimulation.
-
Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies.
-
Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion.
-
Phosphatidylinositol 4,5-bisphosphate hydrolysis mediates histamine-induced KCNQ/M current inhibition.
-
Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells.
-
Regulation of phospholipase C-gamma 1 by profilin and tyrosine phosphorylation.
-
Role of GAP-43 in sequestering phosphatidylinositol 4,5-bisphosphate to Raft bilayers.
-
Selective inhibition of Kir currents by antihistamines.
-
Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.
-
The actin-binding protein profilin binds to PIP2 and inhibits its hydrolysis by phospholipase C.
-
The affinities of human platelet and Acanthamoeba profilin isoforms for polyphosphoinositides account for their relative abilities to inhibit phospholipase C.
-
The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells.
-
UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans.
-
alpha-Actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitro.
-
Keywords of People