Leukocyte Elastase

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  Subject Areas on Research

  • 2-O, 3-O-desulfated heparin inhibits neutrophil elastase-induced HMGB-1 secretion and airway inflammation. 
  • Activated neutrophils impair gastric cytoprotection role of neutrophil elastase. 
  • Aerosol alpha 1-antitrypsin treatment for cystic fibrosis. 
  • Aging and dietary modulation of elastase and interleukin-1 beta secretion. 
  • Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism. 
  • Alterations in L-selectin expression and elastase activity in neutrophils from patients receiving granulocyte colony-stimulating factor alone or in conjunction with high-dose chemotherapy with autologous bone marrow transplantation. 
  • An unusual specificity in the activation of neutrophil serine proteinase zymogens. 
  • Complexes between serpins and inactive proteinases are not thermodynamically stable but are recognized by serpin receptors. 
  • Deficiency of neutrophilic granule membrane glycoproteins in the myelodysplastic syndromes: a common deficiency in 216 patients studied by the Cancer and Leukemia Group B. 
  • Effect of ONO-5046, a specific neutrophil elastase inhibitor, on the phorbol myristate acetate-induced injury in isolated dog lung. 
  • Elastase inhibitory activity of airway α1-antitrypsin is protected by treatment with a catalytic antioxidant in a baboon model of severe bronchopulmonary dysplasia. 
  • Equine leukocyte elastase inhibitor. Primary structure and identification as a thymosin-binding protein. 
  • ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposure. 
  • In vivo catabolism of heparin cofactor II and its complex with thrombin: evidence for a common receptor-mediated clearance pathway for three serine proteinase inhibitors. 
  • Increased expression of senescence markers in cystic fibrosis airways. 
  • Leukocyte effects of C5a-receptor blockade during simulated extracorporeal circulation. 
  • Lymphadenopathy as the primary manifestation of malignant transformation in two patients with severe congenital neutropenia. 
  • MARCKS-related peptide modulates in vivo the secretion of airway Muc5ac. 
  • Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. 
  • Miropin, a novel bacterial serpin from the periodontopathogen Tannerella forsythia, inhibits a broad range of proteases by using different peptide bonds within the reactive center loop. 
  • NAD(P)H quinone oxidoreductase 1 regulates neutrophil elastase-induced mucous cell metaplasia. 
  • Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain. 
  • Neutrophil elastase increases MUC4 expression in normal human bronchial epithelial cells. 
  • Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. 
  • Neutrophil elastase increases airway epithelial nonheme iron levels. 
  • Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species. 
  • Neutrophil elastase induces MUC5AC messenger RNA expression by an oxidant-dependent mechanism. 
  • Neutrophil elastase induces mucus cell metaplasia in mouse lung. 
  • Neutrophil elastase inhibition of cell cycle progression in airway epithelial cells in vitro is mediated by p27kip1. 
  • Neutrophil-Related Gene Expression and Low-Density Granulocytes Associated With Disease Activity and Response to Treatment in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. 
  • Proteases and cystic fibrosis. 
  • Regulation of MUC5AC expression by NAD(P)H:quinone oxidoreductase 1. 
  • Role of granulocyte elastase in indomethacin-induced gastric mucosal lesion formation in rats. 
  • Role of neutrophil elastase in stress-induced gastric mucosal injury in rats. 
  • Secretory leukocyte proteinase inhibitor is preferentially increased in patients with acute respiratory distress syndrome. 
  • Selective blockade of membrane attack complex formation during simulated extracorporeal circulation inhibits platelet but not leukocyte activation. 
  • Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase. 
  • The effects of heparin cofactor II-derived chemotaxins on neutrophil actin conformation and cyclic AMP levels. 
  • The effects of hypochlorous acid and neutrophil proteases on the structure and function of extracellular superoxide dismutase. 
  • The primary elastase inhibitor (elastasin) and trypsin inhibitor (contrapsin) in the goat are serpins related to human alpha 1-anti-chymotrypsin. 
  • Tumor necrosis factor, natural killer activity and other measures of immune function and inflammation in elderly men with heart failure. 
  • Zymogen activation specificity and genomic structures of human neutrophil elastase and cathepsin G reveal a new branch of the chymotrypsinogen superfamily of serine proteinases.