Leukocyte Elastase
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Subject Areas on Research
- 2-O, 3-O-desulfated heparin inhibits neutrophil elastase-induced HMGB-1 secretion and airway inflammation.
- Activated neutrophils impair gastric cytoprotection role of neutrophil elastase.
- Aerosol alpha 1-antitrypsin treatment for cystic fibrosis.
- Aging and dietary modulation of elastase and interleukin-1 beta secretion.
- Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism.
- Alterations in L-selectin expression and elastase activity in neutrophils from patients receiving granulocyte colony-stimulating factor alone or in conjunction with high-dose chemotherapy with autologous bone marrow transplantation.
- An unusual specificity in the activation of neutrophil serine proteinase zymogens.
- Complexes between serpins and inactive proteinases are not thermodynamically stable but are recognized by serpin receptors.
- Elastase inhibitory activity of airway α1-antitrypsin is protected by treatment with a catalytic antioxidant in a baboon model of severe bronchopulmonary dysplasia.
- Equine leukocyte elastase inhibitor. Primary structure and identification as a thymosin-binding protein.
- ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposure.
- In vivo catabolism of heparin cofactor II and its complex with thrombin: evidence for a common receptor-mediated clearance pathway for three serine proteinase inhibitors.
- Increased expression of senescence markers in cystic fibrosis airways.
- Leukocyte effects of C5a-receptor blockade during simulated extracorporeal circulation.
- Lymphadenopathy as the primary manifestation of malignant transformation in two patients with severe congenital neutropenia.
- MARCKS-related peptide modulates in vivo the secretion of airway Muc5ac.
- Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis.
- Miropin, a novel bacterial serpin from the periodontopathogen Tannerella forsythia, inhibits a broad range of proteases by using different peptide bonds within the reactive center loop.
- NAD(P)H quinone oxidoreductase 1 regulates neutrophil elastase-induced mucous cell metaplasia.
- Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.
- Neutrophil elastase increases MUC4 expression in normal human bronchial epithelial cells.
- Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells.
- Neutrophil elastase increases airway epithelial nonheme iron levels.
- Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species.
- Neutrophil elastase induces MUC5AC messenger RNA expression by an oxidant-dependent mechanism.
- Neutrophil elastase induces mucus cell metaplasia in mouse lung.
- Neutrophil elastase inhibition of cell cycle progression in airway epithelial cells in vitro is mediated by p27kip1.
- Neutrophil-Related Gene Expression and Low-Density Granulocytes Associated With Disease Activity and Response to Treatment in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
- Proteases and cystic fibrosis.
- Regulation of MUC5AC expression by NAD(P)H:quinone oxidoreductase 1.
- Selective blockade of membrane attack complex formation during simulated extracorporeal circulation inhibits platelet but not leukocyte activation.
- Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase.
- The effects of heparin cofactor II-derived chemotaxins on neutrophil actin conformation and cyclic AMP levels.
- The primary elastase inhibitor (elastasin) and trypsin inhibitor (contrapsin) in the goat are serpins related to human alpha 1-anti-chymotrypsin.
- Tumor necrosis factor, natural killer activity and other measures of immune function and inflammation in elderly men with heart failure.