Palmitic Acid
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Subject Areas on Research
- A comparison of in vitro acylcarnitine profiling methods for the diagnosis of classical and variant short chain acyl-CoA dehydrogenase deficiency.
- A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults.
- A shift in protein S-palmitoylation, with persistence of growth-associated substrates, marks a critical period for synaptic plasticity in developing brain.
- Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor.
- Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function.
- COOH-terminal requirements for the correct processing of a phosphatidylinositol-glycan anchored membrane protein.
- Characterization of the insulinotropic potency of polyunsaturated fatty acids.
- Cysteines in the transmembrane region of major histocompatibility complex antigens are fatty acylated via thioester bonds.
- Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans.
- Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments.
- Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.
- Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell.
- Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity.
- Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation.
- Inhibition of dynamic protein palmitoylation in intact cells with tunicamycin.
- Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway.
- Ligatin: a peripheral membrane protein with covalently bound palmitic acid.
- Lipid modifications of G proteins.
- Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells.
- Mechanisms of accumulation of arachidonic acid in cultured myocardial cells during ATP depletion.
- Methotrexate-induced alterations in beta-oxidation correlate with cognitive abilities in children with acute lymphoblastic leukemia.
- Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs administered new generation lipid emulsions.
- Neuronal growth cone collapse and inhibition of protein fatty acylation by nitric oxide.
- Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6.
- Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family.
- Palmitoylation of neurofascin at a site in the membrane-spanning domain highly conserved among the L1 family of cell adhesion molecules.
- Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.
- Posttranslational membrane attachment and dynamic fatty acylation of a neuronal growth cone protein, GAP-43.
- Priming for virus-specific CD8+ but not CD4+ cytotoxic T lymphocytes with synthetic lipopeptide is influenced by acylation units and liposome encapsulation.
- Regulation of membrane release in apoptosis.
- Regulation of the skeletal muscle ryanodine receptor/Ca2+-release channel RyR1 by S-palmitoylation.
- Short-term effects of dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human subjects.
- Sphingolipid biosynthesis by rat liver cells: effects of serine, fatty acids and lipoproteins.
- Stereochemistry of the reactions catalyzed by chicken liver fatty acid synthase.
- Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
- Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood.
- The 25 kDa synaptosomal-associated protein SNAP-25 is the major methionine-rich polypeptide in rapid axonal transport and a major substrate for palmitoylation in adult CNS.
- Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.
- Unsaturated fatty acid requirement in Escherichia coli: mechanism of palmitate-induced inhibition of growth of strain WN1.
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Keywords of People
- Bennett, Vann, George B. Geller Distinguished Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute