Staurosporine

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  Subject Areas on Research

  • Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells. 
  • Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism. 
  • Analysis of calcium homeostasis in activated human polymorphonuclear leukocytes. Evidence for two distinct mechanisms for lowering cytosolic calcium. 
  • Angiotensin II can regulate gene expression by the AP-1 binding sequence via a protein kinase C-dependent pathway. 
  • Benzo(a)pyrene inhibits expression of inducible heat shock protein 70 in vascular endothelial cells. 
  • Caspase-3 dependent cleavage and activation of skeletal muscle phosphorylase b kinase. 
  • Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis. 
  • Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis. 
  • Characterization of PDK2 activity against protein kinase B gamma. 
  • Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor. 
  • Control of lens epithelial cell survival. 
  • Cross-desensitization among receptors for platelet activating factor and peptide chemoattractants. Evidence for independent regulatory pathways. 
  • Cross-desensitization of receptors for peptide chemoattractants. Characterization of a new form of leukocyte regulation. 
  • Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization. 
  • Differences in phosphorylation of formylpeptide and C5a chemoattractant receptors correlate with differences in desensitization. 
  • Effects of JC virus infection on anti-apoptotic protein survivin in progressive multifocal leukoencephalopathy. 
  • Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels. 
  • G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction. 
  • Haem oxygenase-1 prevents cell death by regulating cellular iron. 
  • Interleukin-3-induced activation of the JAK/STAT pathway is prolonged by proteasome inhibitors. 
  • Ligation of the alpha 2-macroglobulin signaling receptor on macrophages induces synthesis of platelet activating factor. 
  • Phorbol ester inhibits granulocyte-macrophage colony-stimulating factor binding and tyrosine phosphorylation. 
  • Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor. 
  • Regulation of arachidonic acid release in vascular endothelium. Ca(2+)-dependent and -independent pathways. 
  • Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions. 
  • Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation. 
  • Release of DNA from dead and dying lymphocyte and monocyte cell lines in vitro. 
  • Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor. 
  • Staurosporine inhibition of zipper-interacting protein kinase contractile effects in gastrointestinal smooth muscle. 
  • Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance. 
  • Targeting slow-proliferating ovarian cancer cells. 
  • The cell and molecular basis of leukocyte common antigen (CD45)-triggered, lymphocyte function-associated antigen-1-/intercellular adhesion molecule-1-dependent, leukocyte adhesion. 
  • The expression of HMGB1 on microparticles from Jurkat and HL-60 cells undergoing apoptosis in vitro. 
  • The extracellular release of HMGB1 during apoptotic cell death. 
  • The properties of microparticles from RAW 264.7 macrophage cells undergoing in vitro activation or apoptosis. 
  • The release of microparticles and mitochondria from RAW 264.7 murine macrophage cells undergoing necroptotic cell death in vitro. 
  • The release of microparticles by Jurkat leukemia T cells treated with staurosporine and related kinase inhibitors to induce apoptosis. 
  • The role of macrophages in the in vitro generation of extracellular DNA from apoptotic and necrotic cells. 
  • Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. 
  • c-FLIP protects T lymphocytes from apoptosis in the intrinsic pathway. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology