Polypharmacy

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  Subject Areas on Research

  • A pharmacy management intervention for optimizing drug therapy for nursing home patients. 
  • A summary of the FDA-NIMH-MATRICS workshop on clinical trial design for neurocognitive drugs for schizophrenia. 
  • A systematic review of treatments for refractory depression in older people. 
  • Addressing Polypharmacy in Older Adults Living With HIV. 
  • Adverse drug events in high risk older outpatients. 
  • Adverse drug reaction risk factors in older outpatients. 
  • Analysis of the North Carolina long-term care polypharmacy initiative: a multiple-cohort approach using propensity-score matching for both evaluation and targeting. 
  • Association of Nondisease-Specific Problems with Mortality, Long-Term Care, and Functional Impairment among Older Adults Who Require Skilled Nursing Care after Dialysis Initiation. 
  • Baseline Parameters in Clinical Trials for Nonalcoholic Steatohepatitis: Recommendations From the Liver Forum. 
  • Blood Pressure, Antihypertensive Polypharmacy, Frailty, and Risk for Serious Fall Injuries Among Older Treated Adults With Hypertension. 
  • Clinical Update on Nursing Home Medicine: 2016. 
  • Clinicians' utilization of child mental health telephone consultation in primary care: findings from Massachusetts. 
  • Combination drug therapy for Alzheimer's disease: what is evidence-based, and what is not? 
  • Common comorbidity scales were similar in their ability to predict health care costs and mortality. 
  • Continue or not to continue? Attitudes towards deprescribing among community-dwelling older adults in China. 
  • Cumulative Cardiovascular Polypharmacy Is Associated With the Risk of Acute Kidney Injury in Elderly Patients. 
  • Descriptive analysis of concomitant prescription medication patterns from 1999 to 2004 among US women receiving daily or weekly oral bisphosphonate therapy. 
  • Drug-drug interactions in older adults: which ones matter? 
  • Effectiveness of switching from antipsychotic polypharmacy to monotherapy. 
  • Electrocardiogram Characteristics and Their Association With Psychotropic Drugs Among Patients With Schizophrenia. 
  • Exploring Patient Decision Making Regarding Discontinuation of Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia. 
  • High Prevalence of Fall-Related Medication Use in Older Veterans at Risk for Falls. 
  • Impact of Polypharmacy and P-Glycoprotein- and CYP3A4-Modulating Drugs on Safety and Efficacy of Oral Anticoagulation Therapy in Patients with Atrial Fibrillation. 
  • Impact of inappropriate drug use on mortality and functional status in representative community dwelling elders. 
  • Inappropriate drug use among community-dwelling elderly. 
  • Measuring Underuse and Overuse of Medications. 
  • Medication Initiation Burden Required to Comply With Heart Failure Guideline Recommendations and Hospital Quality Measures. 
  • Medication Use Quality and Safety in Older Adults: 2019 Update. 
  • Medication use quality and safety in older adults: 2020 update. 
  • Nonantiretroviral polypharmacy and adverse health outcomes among HIV-infected and uninfected individuals. 
  • Older Adults in the Cardiac Intensive Care Unit: Factoring Geriatric Syndromes in the Management, Prognosis, and Process of Care: A Scientific Statement From the American Heart Association. 
  • Outcomes of apixaban versus warfarin in patients with atrial fibrillation and multi-morbidity: Insights from the ARISTOTLE trial. 
  • Patient perspectives on having multiple versus single prescribers of chronic disease medications: results of a qualitative study in a veteran population. 
  • Perspectives on Implementing a Multidomain Approach to Caring for Older Adults With Heart Failure. 
  • Pharmacotherapy in Older Adults with Cardiovascular Disease: Report from an American College of Cardiology, American Geriatrics Society, and National Institute on Aging Workshop. 
  • Physician agreement with pharmacist-suggested drug therapy changes for elderly outpatients. 
  • Polypharmacy and effects of apixaban versus warfarin in patients with atrial fibrillation: post hoc analysis of the ARISTOTLE trial. 
  • Polypharmacy and the Efficacy and Safety of Rivaroxaban Versus Warfarin in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation. 
  • Polypharmacy in Heart Failure with Reduced Ejection Fraction: Progress, Not Problem. 
  • Polypharmacy in Palliative Care for Advanced Heart Failure: The PAL-HF Experience. 
  • Polypharmacy in patients with advanced cancer and the role of medication discontinuation. 
  • Polypharmacy in pregnant women with major psychiatric illness: a pilot study. 
  • Polypharmacy management in Medicare managed care: changes in prescribing by primary care physicians resulting from a program promoting medication reviews. 
  • Prescriber Continuity and Disease Control of Older Adults. 
  • Prescriber continuity and medication adherence for complex patients. 
  • Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients. 
  • Psychometric Properties of the Four-Item Morisky Green Levine Medication Adherence Scale among Atherosclerosis Risk in Communities (ARIC) Study Participants. 
  • Psychotropic Polypharmacy Among Children and Youth Receiving Medicaid, 2012-2015. 
  • QT interval prolongation and torsades de pointes in a patient undergoing treatment with vorinostat: a case report and review of the literature. 
  • Quantifying the utility of taking pills for cardiovascular prevention. 
  • Randomized Controlled Trial of Screening, Risk Modification, and Physical Therapy to Prevent Falls Among the Elderly Recently Discharged From the Emergency Department to the Community: The Steps to Avoid Falls in the Elderly Study. 
  • Recent Literature Update on Medication Risk in Older Adults, 2015-2016. 
  • Reducing medication regimen complexity: a controlled trial. 
  • Reducing polypharmacy: evidence from a simple quality improvement initiative. 
  • Response by Piccini et al to Letters Regarding Article, "Polypharmacy and the Efficacy and Safety of Rivaroxaban Versus Warfarin in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation". 
  • The Burden of Overmedication: What Are the Real Issues? 
  • The Burden of Polypharmacy in Patients Near the End of Life. 
  • The OPTIMIZE patient- and family-centered, primary care-based deprescribing intervention for older adults with dementia or mild cognitive impairment and multiple chronic conditions: study protocol for a pragmatic cluster randomized controlled trial. 
  • The prevalence, predictors and outcomes of guideline-directed medical therapy in patients with acute myocardial infarction undergoing PCI, an analysis from the PROMETHEUS registry. 
  • Treatment considerations for elderly and frail patients with neuropathic pain. 
  • Underuse of indicated medications among physically frail older US veterans at the time of hospital discharge: results of a cross-sectional analysis of data from the Geriatric Evaluation and Management Drug Study. 
  • Unnecessary drug use in frail older people at hospital discharge. 
  • Update on Medication Use Quality and Safety in Older Adults, 2017. 
  • Updates in nutrition and polypharmacy. 
  • Usability of mobile technology to screen for drug-drug interactions in kidney transplant patients. 
  • Use of QT Prolonging Medications by Hemodialysis Patients and Individuals Without End-Stage Kidney Disease. 
  • Use of psychotropic medications by youths in therapeutic foster care and group homes. 
  • What types of inappropriate prescribing predict adverse drug reactions in older adults? 
  • Whatever happened to the polypill? 
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  Keywords of People

  • Pavon, Juliessa, Associate Professor of Medicine, Medicine, Geriatrics