Lactic Acid

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  Subject Areas on Research

  • A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect. 
  • A dual-emissive-materials design concept enables tumour hypoxia imaging. 
  • A pilot study of cerebral and haemodynamic physiological changes during sedation with dexmedetomidine or propofol in patients with acute brain injury. 
  • Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism. 
  • Age-related metabolic fatigue during low glucose conditions in rat hippocampus. 
  • Allosteric modulation of Callinectes sapidus hemocyanin by binding of L-lactate. 
  • Alternative fuels for cancer cells. 
  • An in vitro system to evaluate the effects of ischemia on survival of cells used for cell therapy. 
  • Analysis of volatile free fatty acids in human urine by capillary column gas chromatography/mass spectrometry. 
  • Analyte flux through chronically implanted subcutaneous polyamide membranes differs in humans and rats. 
  • Beta 1-selective and non-selective beta-adrenoceptor blockade, anaerobic threshold and respiratory gas exchange during exercise. 
  • Biomaterials directed in vivo osteogenic differentiation of mesenchymal cells derived from human embryonic stem cells. 
  • Blood lactate: biochemistry, laboratory methods, and clinical interpretation. 
  • Cardiac and muscle fatigue due to relative functional overload induced by excessive stimulation, hypersensitive excitation-contraction coupling, or diminished performance capacity correlates with sarcoplasmic reticulum failure. 
  • Cardiac biomarkers, electrolytes, and other analytes in collapsed marathon runners: implications for the evaluation of runners following competition. 
  • Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer. 
  • Changes in brain biochemistry and oxygenation in the zone surrounding primary intracerebral hemorrhage. 
  • Comprehensive metabolic modeling of multiple 13C-isotopomer data sets to study metabolism in perfused working hearts. 
  • Computational design of receptor and sensor proteins with novel functions. 
  • Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. 
  • Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host. 
  • Cytochrome P450 2C9 plays an important role in the regulation of exercise-induced skeletal muscle blood flow and oxygen uptake in humans. 
  • Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine. 
  • Delivery of glucose-6-phosphatase in a canine model for glycogen storage disease, type Ia, with adeno-associated virus (AAV) vectors. 
  • Determination of L-lactate binding stoichiometry and differences in allosteric interactions of structurally distinct homohexamers from Panulirus interruptus hemocyanin. 
  • Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation. 
  • Development of selective tolerance to interleukin-1beta by human chondrocytes in vitro. 
  • Dialysate and blood flow dependence of diffusive solute clearance during CVVHD. 
  • Early metabolite levels predict long-term matrix accumulation for chondrocytes in elastin-like polypeptide biopolymer scaffolds. 
  • Effect of equiosmolar solutions of mannitol versus hypertonic saline on intraoperative brain relaxation and electrolyte balance. 
  • Effect of reduced inspired oxygen on fetal growth and maternal glucose metabolism in rat pregnancy. 
  • Effects of 10-hydroxycamptothecin, delivered from locally injectable poly(lactide-co-glycolide) microspheres, in a murine human oral squamous cell carcinoma regression model. 
  • Effects of a phonologically driven treatment for dyslexia on lactate levels measured by proton MR spectroscopic imaging. 
  • Effects of epinephrine and lactate on the increase in oxygen consumption of nonexercising skeletal muscle after aerobic exercise. 
  • Effects of in vivo and in vitro production of lactic acid on ionized, protein-bound, and complex-bound calcium in blood. 
  • Effects of storage temperature and time before centrifugation on ionized calcium in blood collected in plain vacutainer tubes and silicone-separator (SST) tubes. 
  • Effects of temperature changes on cerebral biochemistry in spontaneous intracerebral hematoma. 
  • Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. 
  • Efficient hepatic glycogen synthesis in refeeding rats requires continued carbon flow through the gluconeogenic pathway. 
  • Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. 
  • Elevations in blood lactate: overview of use in critical care. 
  • Encapsulation of peptides in biodegradable microspheres prolongs their MHC class-I presentation by dendritic cells and macrophages in vitro. 
  • Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling. 
  • Evaluation of poly(L-lactic acid) as a material for intravascular polymeric stents. 
  • Evolution of adverse changes in stored RBCs. 
  • Exercise training increases electron and substrate shuttling proteins in muscle of overweight men and women with the metabolic syndrome. 
  • Exogenous pyruvate prevents stress-evoked suppression of mitogen-stimulated proliferation. 
  • Extracellular Calcium Modulates Chondrogenic and Osteogenic Differentiation of Human Adipose-Derived Stem Cells: A Novel Approach for Osteochondral Tissue Engineering Using a Single Stem Cell Source. 
  • Fast spectroscopic imaging strategies for potential applications in fMRI. 
  • Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. 
  • Follow-up of a child with pyruvate dehydrogenase deficiency on a less restrictive ketogenic diet. 
  • Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. 
  • From dietary glucose to liver glycogen: the full circle round. 
  • Fundamental metabolic differences between hepatocytes and islet beta-cells revealed by glucokinase overexpression. 
  • Glucokinase overexpression restores glucose utilization and storage in cultured hepatocytes from male Zucker diabetic fatty rats. 
  • Glycerol as an indicator of lipid degradation in bicuculline-induced seizures and experimental cerebral ischemia. 
  • Glycogen-targeting subunits and glucokinase differentially affect pathways of glycogen metabolism and their regulation in hepatocytes. 
  • Heart rate and metabolic response to competitive squash in veteran players: identification of risk factors for sudden cardiac death. 
  • Hedgehog controls hepatic stellate cell fate by regulating metabolism. 
  • Hypercapnia is essential to reduce the cerebral oxidative metabolism during extreme apnea in humans. 
  • Hyperoxia decreases muscle glycogenolysis, lactate production, and lactate efflux during steady-state exercise. 
  • Hyperoxia during reperfusion is a factor in reperfusion injury. 
  • Identification of a 21 amino acid peptide conferring 3-hydroxypropionic acid stress-tolerance to Escherichia coli. 
  • In vitro and in vivo characterization of porous poly-L-lactic acid coatings for subcutaneously implanted glucose sensors. 
  • In vitro characterization of vascular endothelial growth factor and dexamethasone releasing hydrogels for implantable probe coatings. 
  • Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel. 
  • Influence of oxygen on the proliferation and metabolism of adipose derived adult stem cells. 
  • Inter-relations between 3-hydroxypropionate and propionate metabolism in rat liver: relevance to disorders of propionyl-CoA metabolism. 
  • Interpretation of blood lactate measurements in paediatric open-heart surgery and in extracorporeal membrane oxygenation. 
  • Intravital microscopy evaluation of angiogenesis and its effects on glucose sensor performance. 
  • Lack of effect of increased inspired oxygen concentrations on maximal exercise capacity or ventilation in stable heart failure. 
  • Lactate and pH in the brain: association and dissociation in different pathophysiological states. 
  • Lactate measured in diluted and undiluted whole blood and plasma: comparison of methods and effect of hematocrit. 
  • Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices. 
  • Left ventricular assist device effects on metabolic substrates in the failing heart. 
  • Lipids and lactate in human immunodeficiency virus-1 infected pregnancies with or without protease inhibitor-based therapy. 
  • Liver transplantation for glycogen storage disease type Ia. 
  • Major hepatic trauma: warm ischemic tolerance of the liver after hemorrhagic shock. 
  • Menorrhagia in patients with type I glycogen storage disease. 
  • Metabolic Teamwork in the Stem Cell Niche. 
  • Metabolic and functional characterization of human adipose-derived stem cells in tissue engineering. 
  • Metabolic and ventilatory responses to steady state exercise relative to lactate thresholds. 
  • Metabolic imaging in microregions of tumors and normal tissues with bioluminescence and photon counting. 
  • Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia. 
  • Metabolic products of [2-(13) C]ethanol in the rat brain after chronic ethanol exposure. 
  • Metabolic profiling of muscle contraction in lean compared with obese rodents. 
  • Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion. 
  • Modeling glucose metabolism and lactate production in the kidney. 
  • Monitoring metabolite gradients in the blood, liver, and tumor after induced hyperglycemia in rats with R3230 flank tumors using microdialysis and bioluminescence imaging. 
  • Myocardial energetics and blood flow in acute rapid ventricular pacing. 
  • NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment. 
  • Novel anisotropic engineered cardiac tissues: studies of electrical propagation. 
  • Numerical simulation of PRESS localized MR spectroscopy. 
  • One-stop-shop tumor imaging: buy hypoxia, get lactate free. 
  • Outcomes after extracorporeal cardiopulmonary resuscitation (ECPR) following refractory pediatric cardiac arrest in the intensive care unit. 
  • PGC-1alpha mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle. 
  • PLG scaffold delivered antigen-specific regulatory T cells induce systemic tolerance in autoimmune diabetes. 
  • PLGA and PHBV microsphere formulations and solid-state characterization: possible implications for local delivery of fusidic acid for the treatment and prevention of orthopaedic infections. 
  • Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma. 
  • Peripheral nerve regeneration by microbraided poly(L-lactide-co-glycolide) biodegradable polymer fibers. 
  • Peripheral nerve regeneration with entubulation repair: comparison of biodegradeable nerve guides versus polyethylene tubes and the effects of a laminin-containing gel. 
  • Phase separation behavior of fusidic acid and rifampicin in PLGA microspheres. 
  • Physiological responses to exercise at 47 and 66 ATA. 
  • Polarographic cerebral oxygen availability, fluorocarbon blood levels and efficacy of oxygen transport by emulsions. 
  • Polyphosphoester microspheres for sustained release of biologically active nerve growth factor. 
  • Prognostic implications of lactate, bilirubin, and etiology in German patients with acute liver failure. 
  • Programming the magnitude and persistence of antibody responses with innate immunity. 
  • Proton magnetic resonance spectroscopic imaging in childhood ataxia with diffuse central nervous system hypomyelination. 
  • Pull-out and shear failure strengths of arthroscopic meniscal repair systems. 
  • Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. 
  • Quantitative proton spectroscopy and histology of a canine brain tumor model. 
  • Rapid dissection of a complex phenotype through genomic-scale mapping of fitness altering genes. 
  • Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations. 
  • Regional metabolism of experimental brain tumors. 
  • Regional quantitative determination of lactate in brain sections. A bioluminescent approach. 
  • Relationship between fat-to-fat-free mass ratio and decrements in leg strength after downhill running. 
  • Relationship between serum lactate and ionized calcium in open-heart surgery. 
  • Role of nitrogen and carbon transport, regulation, and metabolism genes for Saccharomyces cerevisiae survival in vivo. 
  • Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure. 
  • Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury. 
  • Skeletal muscle pH assessed by biochemical and 31P-MRS methods during exercise and recovery in men. 
  • Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat. 
  • Stability of cerebral metabolism and substrate availability in humans during hypoxia and hyperoxia. 
  • Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation. 
  • Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. A direct or an indirect pathway? 
  • Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity. 
  • Sustained VEGF delivery via PLGA nanoparticles promotes vascular growth. 
  • Sustained release of nerve growth factor from biodegradable polymer microspheres. 
  • Synovial fluid metabolites in osteonecrosis. 
  • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. 
  • Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. 
  • The Effect of sex steroid hormones on substrate oxidation during prolonged submaximal exercise in women. 
  • The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma. 
  • The association of lactate and vasopressor need for mortality prediction in survivors of cardiac arrest. 
  • The consequences of enhanced cell-autonomous glucose metabolism. 
  • The contribution of both extracellular and intracellular calcium to the action of alpha-adrenergic agonists in perfused rat liver. 
  • The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment. 
  • The effect of furosemide on intravascular volume status and electrolytes in patients receiving mannitol: an intraoperative safety analysis. 
  • The effects of high intensity exercise on muscle and plasma levels of alpha-ketoisocaproic acid. 
  • The genomic analysis of lactic acidosis and acidosis response in human cancers. 
  • Theophylline produces an adverse effect on myocardial lactate metabolism at a therapeutic serum concentration: an effect blocked by verapamil. 
  • Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model. 
  • Toxic actions of dinoseb in medaka (Oryzias latipes) embryos as determined by in vivo 31P NMR, HPLC-UV and 1H NMR metabolomics. 
  • Treatment of pyruvate carboxylase deficiency with high doses of citrate and aspartate. 
  • Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation. 
  • Urea as a passive transport marker for arthritis biomarker studies. 
  • WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation. 
  • [BMP-2 gene carried by biodegradable scaffold and fibrinous gel for repairing segmental radial defect in rabbit]. 
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  Keywords of People

  • Charles, Hal Cecil, Associate Professor of Radiology, Radiology
  • Chen, Nan-kuei, Adjunct Associate Professor in the Department of Radiology, Radiology
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology