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Subject Areas on Research
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A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect.
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A dual-emissive-materials design concept enables tumour hypoxia imaging.
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A pilot study of cerebral and haemodynamic physiological changes during sedation with dexmedetomidine or propofol in patients with acute brain injury.
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ATM deficiency promotes progression of CRPC by enhancing Warburg effect.
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Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism.
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Adjuvanted poly(lactic-co-glycolic) acid nanoparticle-entrapped inactivated porcine reproductive and respiratory syndrome virus vaccine elicits cross-protective immune response in pigs.
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Adrenomedullin and its binding protein attenuate the proinflammatory response after hemorrhage.
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Age-related metabolic fatigue during low glucose conditions in rat hippocampus.
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Allosteric modulation of Callinectes sapidus hemocyanin by binding of L-lactate.
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Alternative fuels for cancer cells.
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An in vitro system to evaluate the effects of ischemia on survival of cells used for cell therapy.
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An innovative approach to induce cross-protective immunity against porcine reproductive and respiratory syndrome virus in the lungs of pigs through adjuvanted nanotechnology-based vaccination.
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Analysis of volatile free fatty acids in human urine by capillary column gas chromatography/mass spectrometry.
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Analyte flux through chronically implanted subcutaneous polyamide membranes differs in humans and rats.
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Beta 1-selective and non-selective beta-adrenoceptor blockade, anaerobic threshold and respiratory gas exchange during exercise.
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Biomaterials directed in vivo osteogenic differentiation of mesenchymal cells derived from human embryonic stem cells.
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Blood lactate: biochemistry, laboratory methods, and clinical interpretation.
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Can Exercise-Induced Modulation of the Tumor Physiologic Microenvironment Improve Antitumor Immunity?
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Cardiac and muscle fatigue due to relative functional overload induced by excessive stimulation, hypersensitive excitation-contraction coupling, or diminished performance capacity correlates with sarcoplasmic reticulum failure.
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Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.
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Cerebral blood flow changes during sodium-lactate-induced panic attacks.
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Changes in brain biochemistry and oxygenation in the zone surrounding primary intracerebral hemorrhage.
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Comprehensive metabolic modeling of multiple 13C-isotopomer data sets to study metabolism in perfused working hearts.
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Computational design of receptor and sensor proteins with novel functions.
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Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment.
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Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host.
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Current Controversies in Caring for the Critically Ill Pulmonary Embolism Patient.
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Cytochrome P450 2C9 plays an important role in the regulation of exercise-induced skeletal muscle blood flow and oxygen uptake in humans.
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Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine.
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Delivery of glucose-6-phosphatase in a canine model for glycogen storage disease, type Ia, with adeno-associated virus (AAV) vectors.
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Determination of L-lactate binding stoichiometry and differences in allosteric interactions of structurally distinct homohexamers from Panulirus interruptus hemocyanin.
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Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.
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Development of selective tolerance to interleukin-1beta by human chondrocytes in vitro.
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Dialysate and blood flow dependence of diffusive solute clearance during CVVHD.
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Directed axonal outgrowth using a propagating gradient of IGF-1.
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Do newer-generation bioabsorbable screws become incorporated into bone at two years after ACL reconstruction with patellar tendon graft?: A cohort study.
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Early metabolite levels predict long-term matrix accumulation for chondrocytes in elastin-like polypeptide biopolymer scaffolds.
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Effect of reduced inspired oxygen on fetal growth and maternal glucose metabolism in rat pregnancy.
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Effects of 10-hydroxycamptothecin, delivered from locally injectable poly(lactide-co-glycolide) microspheres, in a murine human oral squamous cell carcinoma regression model.
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Effects of epinephrine and lactate on the increase in oxygen consumption of nonexercising skeletal muscle after aerobic exercise.
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Effects of in vivo and in vitro production of lactic acid on ionized, protein-bound, and complex-bound calcium in blood.
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Effects of storage temperature and time before centrifugation on ionized calcium in blood collected in plain vacutainer tubes and silicone-separator (SST) tubes.
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Effects of temperature changes on cerebral biochemistry in spontaneous intracerebral hematoma.
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Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release.
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Efficacy and pharmacokinetics of a modified acid-labile docetaxel-PRINT(®) nanoparticle formulation against non-small-cell lung cancer brain metastases.
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Efficient hepatic glycogen synthesis in refeeding rats requires continued carbon flow through the gluconeogenic pathway.
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Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
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Elevations in blood lactate: overview of use in critical care.
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Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling.
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Evaluation of poly(L-lactic acid) as a material for intravascular polymeric stents.
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Evolution of adverse changes in stored RBCs.
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Exercise training increases electron and substrate shuttling proteins in muscle of overweight men and women with the metabolic syndrome.
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Exogenous pyruvate prevents stress-evoked suppression of mitogen-stimulated proliferation.
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Extrusion of tibial tunnel bioabsorbable screw 15 months after anterior cruciate ligament reconstruction.
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Fabrication of combinatorial polymer scaffold libraries.
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Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality.
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Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta.
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Follow-up of a child with pyruvate dehydrogenase deficiency on a less restrictive ketogenic diet.
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Formulation of diblock polymeric nanoparticles through nanoprecipitation technique.
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Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck.
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From dietary glucose to liver glycogen: the full circle round.
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Fundamental metabolic differences between hepatocytes and islet beta-cells revealed by glucokinase overexpression.
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Glucokinase overexpression restores glucose utilization and storage in cultured hepatocytes from male Zucker diabetic fatty rats.
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Glycogen-targeting subunits and glucokinase differentially affect pathways of glycogen metabolism and their regulation in hepatocytes.
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Glycogenic Hepatopathy Causing Elevated Lactic Acid and Liver Enzymes.
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Heart rate and metabolic response to competitive squash in veteran players: identification of risk factors for sudden cardiac death.
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Hedgehog controls hepatic stellate cell fate by regulating metabolism.
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Hydrophobic nanoparticles improve permeability of cell-encapsulating poly(ethylene glycol) hydrogels while maintaining patternability.
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Hypercapnia is essential to reduce the cerebral oxidative metabolism during extreme apnea in humans.
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Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery.
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In vitro and in vivo characterization of porous poly-L-lactic acid coatings for subcutaneously implanted glucose sensors.
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In vitro characterization of vascular endothelial growth factor and dexamethasone releasing hydrogels for implantable probe coatings.
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Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel.
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Influence of editing pulse flip angle on J-difference MR spectroscopy.
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Inter-relations between 3-hydroxypropionate and propionate metabolism in rat liver: relevance to disorders of propionyl-CoA metabolism.
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Interpretation of blood lactate measurements in paediatric open-heart surgery and in extracorporeal membrane oxygenation.
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Intestinal fatty acid binding protein (I-FABP) for the detection of strangulated mechanical small bowel obstruction.
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Intravital microscopy evaluation of angiogenesis and its effects on glucose sensor performance.
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Lack of effect of increased inspired oxygen concentrations on maximal exercise capacity or ventilation in stable heart failure.
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Lactate measured in diluted and undiluted whole blood and plasma: comparison of methods and effect of hematocrit.
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Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices.
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Left ventricular assist device effects on metabolic substrates in the failing heart.
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Lipids and lactate in human immunodeficiency virus-1 infected pregnancies with or without protease inhibitor-based therapy.
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Liver transplantation for glycogen storage disease type Ia.
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Major hepatic trauma: warm ischemic tolerance of the liver after hemorrhagic shock.
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Menorrhagia in patients with type I glycogen storage disease.
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Metabolic Teamwork in the Stem Cell Niche.
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Metabolic and functional characterization of human adipose-derived stem cells in tissue engineering.
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Metabolic and ventilatory responses to steady state exercise relative to lactate thresholds.
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Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.
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Metabolic profiling of muscle contraction in lean compared with obese rodents.
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Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion.
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Monitoring metabolite gradients in the blood, liver, and tumor after induced hyperglycemia in rats with R3230 flank tumors using microdialysis and bioluminescence imaging.
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Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas.
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Myocardial energetics and blood flow in acute rapid ventricular pacing.
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NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment.
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Normal Range for Maternal Lactic Acid during Pregnancy and Labor: A Systematic Review and Meta-Analysis of Observational Studies.
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Novel anisotropic engineered cardiac tissues: studies of electrical propagation.
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Numerical simulation of PRESS localized MR spectroscopy.
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One-stop-shop tumor imaging: buy hypoxia, get lactate free.
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PGC-1alpha mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle.
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PLG scaffold delivered antigen-specific regulatory T cells induce systemic tolerance in autoimmune diabetes.
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PLGA and PHBV Microsphere Formulations and Solid-State Characterization: Possible Implications for Local Delivery of Fusidic Acid for the Treatment and Prevention of Orthopaedic Infections
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PLGA nanoparticle entrapped killed porcine reproductive and respiratory syndrome virus vaccine helps in viral clearance in pigs.
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Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma.
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Peripheral nerve regeneration with entubulation repair: comparison of biodegradeable nerve guides versus polyethylene tubes and the effects of a laminin-containing gel.
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Phase separation behavior of fusidic acid and rifampicin in PLGA microspheres.
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Physiological responses to exercise at 47 and 66 ATA.
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Plasma lactate as a marker of metabolic health: Implications of elevated lactate for impairment of aerobic metabolism in the metabolic syndrome.
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Polarographic cerebral oxygen availability, fluorocarbon blood levels and efficacy of oxygen transport by emulsions.
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Polycyclic aromatic hydrocarbon and hypoxia exposures result in mitochondrial dysfunction in zebrafish.
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Programming the magnitude and persistence of antibody responses with innate immunity.
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Prolonged propofol anesthesia is not associated with an increase in blood lactate.
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Proton magnetic resonance spectroscopic imaging in childhood ataxia with diffuse central nervous system hypomyelination.
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Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step.
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Quantitative proton spectroscopy and histology of a canine brain tumor model.
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Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations.
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Reinforcement and Fatigue of a Bioinspired Mineral-Organic Bioresorbable Bone Adhesive.
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Relationship between fat-to-fat-free mass ratio and decrements in leg strength after downhill running.
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Relationship between serum lactate and ionized calcium in open-heart surgery.
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Role of nitrogen and carbon transport, regulation, and metabolism genes for Saccharomyces cerevisiae survival in vivo.
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Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury.
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Skeletal muscle pH assessed by biochemical and 31P-MRS methods during exercise and recovery in men.
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Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat.
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Stability of cerebral metabolism and substrate availability in humans during hypoxia and hyperoxia.
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Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation.
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Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. A direct or an indirect pathway?
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Sustained VEGF delivery via PLGA nanoparticles promotes vascular growth.
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Sustained release of nerve growth factor from biodegradable polymer microspheres.
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Synovial fluid metabolites in osteonecrosis.
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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
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Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.
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The Effect of sex steroid hormones on substrate oxidation during prolonged submaximal exercise in women.
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The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma.
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The consequences of enhanced cell-autonomous glucose metabolism.
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The design of a heterocellular 3D architecture and its application to monitoring the behavior of cancer cells in response to the spatial distribution of endothelial cells.
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The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment.
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The effect of furosemide on intravascular volume status and electrolytes in patients receiving mannitol: an intraoperative safety analysis.
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The effects of high intensity exercise on muscle and plasma levels of alpha-ketoisocaproic acid.
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The genomic analysis of lactic acidosis and acidosis response in human cancers.
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Theophylline produces an adverse effect on myocardial lactate metabolism at a therapeutic serum concentration: an effect blocked by verapamil.
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Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model.
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Toxic actions of dinoseb in medaka (Oryzias latipes) embryos as determined by in vivo 31P NMR, HPLC-UV and 1H NMR metabolomics.
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Transpulmonary lactate gradient after hypothermic cardiopulmonary bypass.
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Treatment of pyruvate carboxylase deficiency with high doses of citrate and aspartate.
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Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation.
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Urea as a passive transport marker for arthritis biomarker studies.
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[BMP-2 gene carried by biodegradable scaffold and fibrinous gel for repairing segmental radial defect in rabbit].
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Keywords of People
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Charles, Hal Cecil,
Adjunct Associate Professor in the Department of Radiology,
Radiology
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Choi, Steven Sok,
Associate Professor of Medicine,
Medicine, Gastroenterology
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Palmer, Gregory M.,
Associate Professor of Radiation Oncology,
Radiation Oncology