Nucleic Acid Synthesis Inhibitors
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Subject Areas on Research
- 3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase.
- Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells.
- Arabidopsis BRCA2 and RAD51 proteins are specifically involved in defense gene transcription during plant immune responses.
- Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways.
- Cost-effectiveness considerations in the treatment of essential thrombocythemia.
- Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase zeta.
- Differential actions of PAR2 and PAR1 in stimulating human endothelial cell exocytosis and permeability: the role of Rho-GTPases.
- Differential impact of ionic and coordinate covalent chromium (Cr)-DNA binding on DNA replication.
- Dynamics of neutrophil membrane compliance and microstructure probed with a micropipet-based piconewton force transducer.
- Effect of different classes of inhibitors on DNA gyrase from Mycobacterium smegmatis.
- Heat-shock-specific phosphorylation and transcriptional activity of RNA polymerase II.
- Induction of cyclooxygenase-2 synthesis by ligation of the macrophage alpha(2)-macroglobulin signalling receptor.
- Interaction between the T4 helicase loading protein (gp59) and the DNA polymerase (gp43): unlocking of the gp59-gp43-DNA complex to initiate assembly of a fully functional replisome.
- Medical and surgical treatment of placenta percreta to optimize bladder preservation.
- Modulation of RNA polymerase II elongation efficiency by C-terminal heptapeptide repeat domain kinase I.
- Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos.
- Nucleotide excision repair functions in the removal of chromium-induced DNA damage in mammalian cells.
- Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.
- Pre-clinical evaluation of SN-38 and novel camptothecin analogs against human chronic B-cell lymphocytic leukemia lymphocytes.
- Requirement of the prolyl isomerase Pin1 for the replication checkpoint.
- Two-photon molecular excitation imaging of Ca2+ transients in Langendorff-perfused mouse hearts.
- Viscoelastic behaviour of human mesenchymal stem cells.