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Subject Areas on Research
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A beta-arrestin 2 signaling complex mediates lithium action on behavior.
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A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors.
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A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.
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A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation.
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A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types.
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A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
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A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.
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Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds.
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Activation-dependent conformational changes in {beta}-arrestin 2.
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Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.
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Agonist-specific regulation of delta-opioid receptor trafficking by G protein-coupled receptor kinase and beta-arrestin.
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Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.
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An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.
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Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations.
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Angiotensin II-stimulated signaling through G proteins and beta-arrestin.
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Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways.
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Arrestin interaction with E3 ubiquitin ligases and deubiquitinases: functional and therapeutic implications.
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Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4.
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Arresting developments in heptahelical receptor signaling and regulation.
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Arrestins and protein ubiquitination.
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Arrestins as signaling molecules involved in apoptotic pathways: a real eye opener.
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Arrestins come of age: a personal historical perspective.
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Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization.
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Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands.
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Beta-Arrestins: new roles in regulating heptahelical receptors' functions.
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Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization.
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Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling.
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Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway.
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Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis.
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Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.
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Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression.
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Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor.
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Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.
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Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7.
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Beta-arrestin-2 regulates the development of allergic asthma.
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Beta-arrestin-biased ligands at seven-transmembrane receptors.
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Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
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Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2.
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Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.
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Beta-arrestin-mediated localization of smoothened to the primary cilium.
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Beta-arrestin-mediated signaling in the heart.
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Beta-arrestin-mediated signaling regulates protein synthesis.
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Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis.
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Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.
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Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes.
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Beta-arrestins and cell signaling.
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Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration.
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Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle.
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Beta-arrestins: multifunctional cellular mediators.
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Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.
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BiPS, a photocleavable, isotopically coded, fluorescent cross-linker for structural proteomics.
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Biased agonism as a mechanism for differential signaling by chemokine receptors.
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Both Hematopoietic- and Non-hematopoietic-derived {beta}-arrestin-2 Regulates Murine Allergic Airway Disease.
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Cellular trafficking of G protein-coupled receptor/beta-arrestin endocytic complexes.
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Chronic loss of noradrenergic tone produces β-arrestin2-mediated cocaine hypersensitivity and alters cellular D2 responses in the nucleus accumbens.
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Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors.
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Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors.
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Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1.
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Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling.
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Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus.
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Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2.
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Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features.
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Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.
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Deletion of GSK3β in D2R-expressing neurons reveals distinct roles for β-arrestin signaling in antipsychotic and lithium action.
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Desensitization of G protein-coupled receptors and neuronal functions.
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Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference.
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Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones.
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Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity.
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Deubiquitinases and their emerging roles in β-arrestin-mediated signaling.
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Diesel exhaust particles activate the matrix-metalloproteinase-1 gene in human bronchial epithelia in a beta-arrestin-dependent manner via activation of RAS.
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Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.
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Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors.
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Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor.
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Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.
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Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins.
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Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation.
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Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics.
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Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy.
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Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.
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Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.
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Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.
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Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.
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Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking.
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Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody.
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Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization.
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Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice.
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Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling.
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Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins.
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Enhanced morphine analgesia in mice lacking beta-arrestin 2.
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Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice.
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Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase.
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Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking.
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Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases.
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Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling.
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Functional selectivity in adrenergic and angiotensin signaling systems.
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Functional specialization of beta-arrestin interactions revealed by proteomic analysis.
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G protein- and β-arrestin Signaling Profiles of Endothelin Derivatives at the Type A Endothelin Receptor.
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G protein-coupled receptor desensitization as a measure of signaling: modeling of arrestin recruitment to activated CCK-B receptors.
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G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95.
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G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics.
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G protein-coupled receptor kinase function is essential for chemosensation in C. elegans.
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G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation.
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G protein-coupled receptor signaling: transducers and effectors.
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G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization.
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G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR.
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G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer.
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G-protein-coupled receptor kinases and arrestins: regulators of G-protein-coupled receptor sequestration.
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GPCR signaling: conformational activation of arrestins.
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GPCRs and arrestins in airways: implications for asthma.
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GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling.
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Genetic Deletion of β-Arrestin-2 and the Mitigation of Established Airway Hyperresponsiveness in a Murine Asthma Model.
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Genetic mapping of the beta-arrestin 1 and 2 genes on mouse chromosomes 7 and 11 respectively.
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Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).
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Heptahelical terpsichory. Who calls the tune?
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Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.
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Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize.
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Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions.
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Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation.
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Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3.
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Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine.
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Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.
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Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor.
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Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions.
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Modeling of bias for the analysis of receptor signaling in biochemical systems.
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Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*.
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Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor.
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Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor.
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Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors.
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Molecular mechanisms of G protein-coupled receptor desensitization and resensitization.
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Morphine side effects in beta-arrestin 2 knockout mice.
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Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence.
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Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling.
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Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment.
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Myosin III illuminates the mechanism of arrestin translocation.
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N-formyl peptide receptors internalize but do not recycle in the absence of arrestins.
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N-terminal tyrosine modulation of the endocytic adaptor function of the beta-arrestins.
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Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor.
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New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors.
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Odorant receptors and desensitization proteins colocalize in mammalian sperm.
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Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling.
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Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.
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Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model.
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Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2.
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Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex.
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Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase.
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Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors.
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Physiologic and cardiac roles of beta-arrestins.
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Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor.
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Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.
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Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways.
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Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor.
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Receptor regulation: beta-arrestin moves up a notch.
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Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems.
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Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes.
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Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.
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Regulated expression of G protein-coupled receptor kinases (GRK's) and beta-arrestins in osteoblasts.
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Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization.
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Regulation of G protein-coupled receptor signaling by scaffold proteins.
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Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination.
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Regulation of arrestin-3 phosphorylation by casein kinase II.
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Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2.
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Regulation of epidermal growth factor receptor internalization by G protein-coupled receptors.
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Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.
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Regulation of tyrosine kinase cascades by G-protein-coupled receptors.
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Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery.
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Resonating to the music of ubiquitination.
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Role for β-arrestin in mediating paradoxical β2AR and PAR2 signaling in asthma.
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Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment.
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Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization.
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Role of beta-arrestins in the intracellular trafficking of G-protein-coupled receptors.
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Role of the cytoplasmic tails of CXCR1 and CXCR2 in mediating leukocyte migration, activation, and regulation.
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Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.
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S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking.
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Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands.
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Seven transmembrane receptors: something old, something new.
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Seven-transmembrane receptor signaling through beta-arrestin.
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Signaling at the endosome: cryo-EM structure of a GPCR-G protein-beta-arrestin megacomplex.
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Signaling, desensitization, and trafficking of G protein-coupled receptors revealed by green fluorescent protein conjugates.
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Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.
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SnapShot: β-Arrestin Functions.
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Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function.
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Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors.
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Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2.
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Strategy for the development of a matched set of transport-competent, angiotensin receptor-deficient proximal tubule cell lines.
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Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
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Structure-functional selectivity relationship studies of β-arrestin-biased dopamine Dâ‚‚ receptor agonists.
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Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization.
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Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth.
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Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.
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Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins.
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Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity.
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Teaching old receptors new tricks: biasing seven-transmembrane receptors.
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The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2.
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The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor.
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The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.
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The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.
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The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits.
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The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells.
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The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals.
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The role of the prostaglandin EP4 receptor in the regulation of human outflow facility.
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The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome.
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The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.
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The stem cell-expressed receptor Lgr5 possesses canonical and functionally active molecular determinants critical to β-arrestin-2 recruitment.
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The superfamily of heptahelical receptors.
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The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation.
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The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors.
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The type III TGF-beta receptor regulates epithelial and cancer cell migration through beta-arrestin2-mediated activation of Cdc42.
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The type III TGFbeta receptor regulates directional migration: new tricks for an old dog.
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The type III transforming growth factor-beta receptor negatively regulates nuclear factor kappa B signaling through its interaction with beta-arrestin2.
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Therapeutic potential of β-arrestin- and G protein-biased agonists.
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Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination.
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Transduction of receptor signals by beta-arrestins.
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Triphenylmethane dye activation of beta-arrestin.
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Troglitazone stimulates beta-arrestin-dependent cardiomyocyte contractility via the angiotensin II type 1A receptor.
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TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells.
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Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation.
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Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation.
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Vasoactive intestinal polypeptide type-1 receptor regulation. Desensitization, phosphorylation, and sequestration.
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Visualization of arrestin recruitment by a G-protein-coupled receptor.
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beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport.
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beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation.
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beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking.
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beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.
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beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.
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beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.
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beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling.
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beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation.
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beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress.
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beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation.
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beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6.
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beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis.
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beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
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beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.
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beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.
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beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.
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beta-arrestin-biased agonism at the beta2-adrenergic receptor.
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beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.
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beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis.
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beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor.
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beta-arrestins: traffic cops of cell signaling.
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{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.
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{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation.
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Β-arrestin: a signaling molecule and potential therapeutic target for heart failure.
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β-Arrestin and dishevelled coordinate biased signaling.
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β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration.
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β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration.
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β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel.
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β-Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway.
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β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury.
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β-Arrestin-mediated receptor trafficking and signal transduction.
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β-Arrestin2 mediates the initiation and progression of myeloid leukemia.
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β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix.
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β-arrestin-biased signaling by the β-adrenergic receptors.
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β-arrestin1-biased β1-adrenergic receptor signaling regulates microRNA processing.
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